AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesTechnology, Industry, AgricultureInformation Science
LipoxygenaseArachidonate 12-LipoxygenaseLipoxygenasesArachidonate 5-LipoxygenaseArachidonate 15-LipoxygenaseArachidonate LipoxygenasesLipoxygenase Inhibitors5-Lipoxygenase-Activating ProteinsArachidonic Acid12-Hydroxy-5,8,10,14-eicosatetraenoic AcidArachidonic AcidsLeukotrienesMasoprocolHydroxyeicosatetraenoic AcidsLinoleic AcidsLipid Peroxides4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amineEicosanoids5,8,11,14-Eicosatetraynoic AcidLeukotriene B4SoybeansLinoleic AcidProstaglandin-Endoperoxide SynthasesLipoxinsChromatography, High Pressure LiquidFatty Acids, UnsaturatedCalcimycinCyclooxygenase InhibitorsPhospholipases APhospholipases A2Blood PlateletsLeukotriene A4IndomethacinLinolenic AcidsEicosanoic AcidsKineticsFlavanonesCorylusSolanum tuberosumFatty AcidsCyclooxygenase 1SRS-AReticulocytesIsoenzymesIchthyosiform Erythroderma, CongenitalOxidation-ReductionGas Chromatography-Mass SpectrometryThromboxane B2Substrate SpecificityRabbitsProstaglandins ELeukocytesOxylipinsProstaglandinsMolecular Sequence DataPhospholipidsDinoprostoneNeutrophilsOxygenStereoisomerismEpoxide HydrolasesQuinacrinePhospholipasesCyclopentanesLipid PeroxidationThromboxanesAmino Acid SequenceCells, CulturedPlatelet Activating FactorFatty Acids, EssentialEpoprostenolEnzyme ActivationBiocatalysisAnthozoaPhosphatidylinositols8,11,14-Eicosatrienoic AcidCloning, MolecularBase SequenceSeedsCyclooxygenase 2Mass SpectrometryDNA, ComplementaryRNA, MessengerCell LinePhosphatidylcholinesMembrane ProteinsMutagenesis, Site-DirectedRecombinant ProteinsCatalysisIchthyosisPlatelet AggregationLeukotriene C4ThrombinCarrier ProteinsMolecular StructurePyrazolesGroup IV Phospholipases A2BradykininZymosanN-Formylmethionine Leucyl-Phenylalanine
GeneNormal
Gene4
  • The Alox15 gene was recently identified as a negative regulator of peak BMD in mice. (nih.gov)
  • Arachidonate 15-lipoxygenase type II is an enzyme that in humans is encoded by the ALOX15B gene. (wikipedia.org)
  • This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. (wikipedia.org)
  • Entrez Gene: ALOX15B arachidonate 15-lipoxygenase, type B". Human ALOX15B genome location and ALOX15B gene details page in the UCSC Genome Browser. (wikipedia.org)
Normal2
  • Polymorphisms in human ALOX12, but not ALOX15, were significantly associated with spine BMD in white men and women, suggesting that ALOX12 may contribute to normal variation in BMD. (nih.gov)
  • To assess the contribution of lipoxygenase genes to normal BMD variation in healthy white men and women, we performed population- and family-based association studies of two arachidonate lipoxygenase genes: ALOX15, which is the human homolog of mouse Alox15, and ALOX12, which is functionally similar to Alox15. (nih.gov)