• The function of ALOX12 is further clouded by human ALOX15 which metabolizes arachidonic acid primarily to 15(S)-HpETE but also makes lesser but still significant amounts of 12(S)-HpETE (see ALOX15). (wikipedia.org)
  • ALOX12 is also distinguished from arachidonate 12-lipoxygenase, 12R type (ALOX12B), which metabolizes arachidonic acid to the R stereoisomer of 12(S)-HpETE viz. (wikipedia.org)
  • Pathways in biosynthesis of eicosanoid s from arachidonic acid: there are parallel paths from EPA & DGLA . (thcscience.wiki)
  • Arachidonic acid ( AA ), i.e. 5 Z , 8 Z ,11 Z ,14 Z -eicosatetraenoic acid is an ω-6 fatty acid with four double bonds in the cis configuration (see Cis-trans isomerism ), each located between carbons 5-6, 8-9, 11-12, and 14-15. (thcscience.wiki)
  • Glutathione peroxidase 4 (Gpx4) and arachidonic acid 15 lipoxygenase (Alox15) are counterplayers in oxidative lipid metabolism and both enzymes have been implicated in spermatogenesis. (bvsalud.org)
  • While arachidonate and 12(S)-HETE are the predominant substrates and products, respectively, of ALOX12, the enzyme also metabolizes other PUFA. (wikipedia.org)
  • see Icosahedron ) is the collective term [6] for straight-chain polyunsaturated fatty acids (PUFAs) of 20 carbon units in length that have been metabolized or otherwise converted to oxygen-containing products. (thcscience.wiki)