• allele
  • We distinguished the polymorphism at the ADH2 and ALDH2 loci in Japanese individuals'white cell DNAs using allele-specific oligonucleotide probes directed at their single base pair differences. (nii.ac.jp)
  • Homozygous individuals with the mutant allele have almost no ALDH2 activity, and those heterozygous for the mutation have reduced activity. (wikipedia.org)
  • ALDH1
  • Although the two isozymes (ALDH1 and ALDH2) do not share a common subunit, the homology between the human ALDH1 and ALDH2 proteins is 66% at the coding nucleotide level and 69% at the amino acid level, which is found to be lower than the 91% homology between human ALDH1 and horse ALDH1. (wikipedia.org)
  • gene
  • Using restriction fragment length polymorphism (RFLP) analysis, we have examined a cohort of 597 French VC workers for polymorphisms in CYP2E1, ALDH2, GSTM1 and GSTT1 in relation to the occurrence of mutant oncogene and tumor suppressor gene biomarkers that are attributable to VC exposure. (cdc.gov)
  • The ALDH2 gene is about 44 kbp in length and contains at least 13 exons which encode 517 amino acid residues. (wikipedia.org)
  • A single point mutation (G → A) at exon 12 of the ALDH2 gene causes a replacement of glutamine with lysine at residue 487, resulting in the ALDH2K enzyme. (wikipedia.org)
  • liver
  • Except for the signal NH2-terminal peptide, which is absent in the mature enzyme, the amino acid sequence deduced from the exons coincided with the reported primary structure of human liver ALDH2. (wikipedia.org)
  • genetic
  • Evidence suggests that ALDH2 Glu504Lys SNP is a potential candidate genetic risk factor for a variety of chronic diseases such as cardiovascular disease, cancer, and late-onset Alzheimer's disease. (hindawi.com)
  • In addition, the association between ALDH2 Glu504Lys SNP and the development of these chronic diseases appears to be affected by the interaction between the SNP and lifestyle factors such as alcohol consumption as well as by the presence of other genetic variations. (hindawi.com)
  • The association between ALDH2 Glu504Lys SNP and the development of these diseases is also related to the effect of the SNP on lifestyle factors such as alcohol consumption and its interaction with other genetic variations. (hindawi.com)
  • In addition, certain genetic factors can amplify the negative effects of acetaldehyde. (wikipedia.org)
  • variant
  • The variant increases the efficiency of the enzyme by up to 100 times and, as acetaldehyde is a toxic carcinogenic, means Asian drinkers may not experience the euphoric buzz that comes with a drink but instead get a headache and feel nauseous. (diffordsguide.com)
  • reactive
  • ALDH2 also metabolizes other reactive aldehydes such as 4-hydroxy-2-nonenal and acrolein. (hindawi.com)
  • In addition, ALDH2 is important for the detoxification of reactive aldehydes such as 4-HNE and acrolein [ 2 ]. (hindawi.com)
  • ALDH2 may be one of the essential mechanisms for the removal of these reactive aldehydes and protecting cells and organs from these toxic aldehydes. (hindawi.com)
  • enzymes
  • Although there is a recognizable Rossmann fold, the coenzyme-binding region of ALDH2 binds NAD+ in a manner not seen in other NAD+-binding enzymes. (wikipedia.org)
  • individuals
  • The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. (wikipedia.org)
  • The metabolized acetaldehyde in the blood, which is six times higher than in individuals without the mutation, has shown to be a carcinogen in lab animals. (wikipedia.org)
  • blood
  • So acetaldehyde stays in our system much longer and the overproduction of it causes blood vessels to dilate, resulting in the deep blush that rises to the surface of the skin. (bustle.com)
  • human
  • Epidemiological studies have linked ALDH2 Glu504Lys SNP with increased risk for human diseases including cardiovascular disease (CVD), cancer, and late-onset Alzheimer's disease (AD) [ 5 - 8 ]. (hindawi.com)