• locus
  • Through the use of DNA microarrays in conjunction with CGH techniques, the more specific form of array CGH (aCGH) has been developed, allowing for a locus-by-locus measure of CNV with increased resolution as low as 100 kilobases. (wikipedia.org)
  • alterations
  • We hypothesized that genomic copy number alterations are enriched in metastatic cells compared to autologous primary tumors, which may inform on cancer-related pathways possibly serving as potential targets for specific therapies. (biomedcentral.com)
  • The technology has been used extensively in the HapMap project for large-scale SNP genotyping as well as for studying gene copy alterations and characteristics of specific genomic loci to identify biomarkers for different diseases such as cancer. (wikipedia.org)
  • sequences
  • In this linearized probe the universal PCR primer sequences are located at the 5' and 3' ends and the captured genomic target becomes part of the internal segment of the probe. (wikipedia.org)
  • chromosomes
  • The authors painted a series of individual human chromosomes from a DNA library with two different fluorophores in different proportions to test the technique, and also applied CGH to genomic DNA from patients affected with either Downs syndrome or T-cell prolymphocytic leukemia as well as cells of a renal papillary carcinoma cell line. (wikipedia.org)
  • clinical
  • The second study was a prospective study of over 5000 pregnancies and again additional clinical significant findings were found using aCGH. (pacificu.edu)
  • single
  • A major drawback of genomic profiling for embryo quality is that the results generally rely on the assessment of a single cell, PGP has inherent limitations as the tested cell may not be representative of the embryo because of mosaicism. (wikipedia.org)
  • process
  • As the father's versions are inactivated by a process known as genomic imprinting, no functional version of the gene remains. (wikipedia.org)
  • identify
  • Genomic, transcriptional, and phenotypic characterization of Prnp ZH3/ZH3 mice failed to identify phenotypes previously described in non-co-isogenic Prnp −/− mice. (rupress.org)