• hexyl
  • Here we show that dopamine-mediated enhancement of spike firing in NAcb shell medium spiny neurons was prevented by the PKC inhibitor bisindolylmaleimide but not by the phospholipase C inhibitor 1-[6-((17b-3-methoxyestra-1,3,5(10)-trien-17-yl) amino)hexyl]-1H-pyrrole-2,5-dione, suggesting a role for a diacylglycerol-independent atypical PKC (aPKC) isoform. (jneurosci.org)
  • For experiments with bisindolylmaleimide and 1-[6-((17b-3-methoxyestra-1,3,5(10)-trien-17-yl) amino)hexyl]-1H-pyrrole-2,5-dione ( U73122 ), slices were pre-exposed for 30-60 min to enable adequate penetration, and whole-cell patch was achieved 10-15 min before dopamine application. (jneurosci.org)
  • antagonist
  • α 2 antagonists yohimbine (10 -5 M) and idazoxan (10 -5 M) blocked the response to DA in a competitive manner, while α 1 antagonist prazosin (10 -5 M) completely blocked the response to DA. (pcom.edu)
  • SCH 23390 (10 -5 M), a D 1 DA antagonist potentiated the response to DA. (pcom.edu)
  • An orally active clinical candidate of corticotropin-releasing factor 1 (CRF 1) antagonist 1 showed a significant positive food effect in dog and human after oral administration. (biomedsearch.com)
  • wherein
  • 3. The DNA construct as claimed in claim 1, wherein said 5' promoter element is selected from the group consisting of cytomegalovirus promoter element, metallothionein promoter element, SV40 promoter element, and heat shock promoter element. (google.com)
  • 4. The DNA construct as claimed in claim 1, wherein said 3' polyadenylation signal sequence is selected from the group consisting of bovine growth hormone polyadenylation signal sequences and thymidine kinase polyadenylation signal sequences. (google.com)
  • The term `C 1-6 alkoxy` as used herein refers to an --O--C 1-6 alkyl group wherein C 1-6 alkyl is as defined herein. (patentsencyclopedia.com)
  • regulation
  • Dopaminergic neurotransmission is prominently implicated in emergence from the minimal conscious state, 1 , 2 general anesthesia, 3 and in sleep-wake regulation. (asahq.org)
  • Animals
  • [ 2 ] (R)-6-Br-APB and similar D 1 -selective full agonists like SKF-81297 and SKF-82958 produce characteristic anorectic effects, stereotyped behaviour and self-administration in animals, with a similar but not identical profile to that of dopaminergic stimulant drugs such as amphetamine. (thefullwiki.org)
  • gene
  • 5. The DNA construct as claimed in claim 1, further comprising at least one selectable marker gene, said at least one selectable marker gene being disposed within said construct so as not to disrupt expression of said DNA segment and encoding a protein conferring resistance to a selection agent. (google.com)
  • term
  • The term `C 1-6 alkyl` as used herein as a group or a part of the group refers to a linear or branched saturated hydrocarbon group containing from 1 to 6 carbon atoms. (patentsencyclopedia.com)
  • Journal
  • This article was published in Indian journal of experimental biology , Volume 32, Issue 3, Pages 176-179. (pcom.edu)