Wolff G, Truse R, Decking U. Extracellular Adenosine Formation by Ecto-5'-Nucleotidase (CD73) Is No Essential Trigger for Early Phase Ischemic Preconditioning. (medscape.com)
Alternative splicing of human NT5E in cirrhosis and hepatocellular carcinoma produces a negative regulator of ecto-5'-nucleotidase (CD73). (medscape.com)
Crystal Structure of the Human Ecto-5'-Nucleotidase (CD73): Insights Into the Regulation of Purinergic Signaling. (atomistry.com)
Ecto-5'-nucleotidase (NT5E, also known as CD73) hydrolyzes extracellular adenosine 5'-monophosphate (AMP) to adenosine in nociceptive circuits. (biomedcentral.com)
ecto-5′-Nucleotidase (eN, CD73) plays a major role in controlling extracellular adenosine levels. (elsevierpure.com)
Cytosolic2
Cloning of a mouse cytosolic 5'-nucleotidase-I identifies a new gene related to human autoimmune infertility-related protein. (nih.gov)
Cytosolic 5′-nucleotidase 1A as a target of circulating autoantibodies in autoimmune diseases. (nature.com)
Deficiency12
Mutations in this gene are a cause of hemolytic anemia due to uridine 5-prime monophosphate hydrolase deficiency. (nih.gov)
A) in NT5C3A associated with hereditary pyrimidine 5'-nucleotidase deficiency: two cases report and literature review]. (nih.gov)
A New Homozygous Mutation (c.393-394del TA/c.393-394del TA) in the NT5C3 Gene Associated With Pyrimidine-5'-Nucleotidase Deficiency: A Case Report. (nih.gov)
Hemolytic anemia due to pyrimidine 5′ nucleotidase deficiency is a rare hereditary hemolytic anemia due to an erythrocyte nucleotide metabolism disorder characterized by mild to moderate hemolytic anemia associated with basophilic stippling and the accumulation of high concentrations of pyrimidine nucleotides within the erythrocyte. (globalgenes.org)
To diagnose 5-nucleotidase deficiency syndrome, doctors may perform blood and urine tests to measure the levels of purines and their byproducts. (mellaly.com)
There is no cure for 5-nucleotidase deficiency syndrome, but there are treatments that can help manage symptoms and prevent complications. (mellaly.com)
Scientists have tested gene therapy in animal models of 5-nucleotidase deficiency syndrome and are now exploring the safety and efficacy of the technique in clinical trials. (mellaly.com)
Precision medicine, which uses genetic and molecular data to personalize healthcare, may also play a role in the future treatment of 5-nucleotidase deficiency syndrome. (mellaly.com)
Living with 5-nucleotidase deficiency syndrome can be challenging, especially for those with severe symptoms. (mellaly.com)
Patient support groups and resources can also provide valuable information and emotional support for those affected by 5-nucleotidase deficiency syndrome. (mellaly.com)
Patients with 5-nucleotidase deficiency syndrome can benefit from healthy lifestyle habits and patient support groups to manage their symptoms and improve their overall well-being. (mellaly.com)
While severe zinc deficiency is rare, mild to moderate deficiency is more common worldwide ( 5 ). (frontiersin.org)
Adenosine5
In mammalian cells the enzyme is predominantly located in the plasma membrane and its primary role is in the conversion of extracellular nucleotides (e.g. 5'-AMP), which are generally impermeable, to the corresponding nucleoside (e.g. adenosine) which can readily enter most cells. (wikipedia.org)
Holmes AP, Nunes AR, Cann MJ, Kumar P. Ecto-5'-Nucleotidase, Adenosine and Transmembrane Adenylyl Cyclase Signalling Regulate Basal Carotid Body Chemoafferent Outflow and Establish the Sensitivity to Hypercapnia. (medscape.com)
The K-m value for 5'-adenosine monophosphate (5-AMP) was determined with 77 mu M at pH 7.45. (gazi.edu.tr)
Therefore, I investigated the distribution of ecto-50-nucleotidase (50-NT), the key enzyme for the production of extracellular adenosine. (uaeu.ac.ae)
Ecto-5'-nucleotidase (NT5E) is a glycosyl phosphatidylinositol (GPI)-anchored membrane protein that catalyzes the hydrolysis of extracellular AMP to adenosine [ 1 ]. (biomedcentral.com)
Pyrimidine3
Numerous studies have shown that erythrocyte pyrimidine 5′-nucleotidase activity is significantly lowered in patients with lead poisoning, and that pyrimidine 5′-nucleotidase activity can be used as an index of lead poisoning. (wikipedia.org)
The encoded protein is the type 1 isozyme of pyrimidine 5' nucleotidase and catalyzes the dephosphorylation of pyrimidine 5' monophosphates. (nih.gov)
The intracellular pyrimidine 5'-nucleotidase NT5C3A is a negative epigenetic factor in interferon and cytokine signaling. (nih.gov)
Enzyme9
5′-Nucleotidase (EC 3.1.3.5) is an enzyme which catalyzes the phosphorylytic cleavage of 5′-nucleotides. (wikipedia.org)
The enzyme has a wide substrate specificity for nucleotides and has been shown to hydrolyze 5'nucleotides rapidly, ribose-5-phosphate slowly, and other phosphate esters extremely slowly (if at all). (wikipedia.org)
Studies of mammalian 5′-nucleotidases have shown that there exist at least four different forms of the 5′-nucleotidase enzyme: one membrane-bound form and three soluble forms. (wikipedia.org)
This is due to the fact that the enzyme activity is approximately 10-times higher for peripheral T cells than thymocytes, 5-6 times higher in adult peripheral B cells than fetal B cells, and largely absent in non-T cell and non-B cell lymphocytes. (wikipedia.org)
5′-Nucleotidase (5NT) is an intrinsic membrane glycoprotein that is present as an enzyme in a wide variety of mammalian cells. (medscape.com)
It is caused by a mutation in the NT5C2 gene, which leads to the loss of the enzyme known as 5-nucleotidase. (mellaly.com)
The enzyme 5-nucleotidase is responsible for breaking down and recycling purines, which are building blocks of DNA and RNA. (mellaly.com)
The mutation in the NT5C2 gene causes the loss of a specific enzyme called 5-nucleotidase. (mellaly.com)
The 5'-nucleotidase (NT5) family of enzyme dephosphorylates non-cyclic nucleoside monophosphates to produce nucleosides and inorganic phosphates. (diva-portal.org)
Alkaline1
In addition to AST and ALT, alkaline phosphatase , 5' nucleotidase, and gamma-glutamyl transpeptidase (GGT) are a few of the other enzymes located in the liver. (medicinenet.com)
Inhibitors5
Myricetin and quercetin were the most potent inhibitors for 5'-NT with IC50 values of 1.1 and 1.4 mu M, respectively. (gazi.edu.tr)
The results demonstrate that some flavonoids are strong inhibitors of 5'-NT activity which can be correlated to their pharmacological effects. (gazi.edu.tr)
eN inhibitors have potential as novel drugs, for example, for the treatment of cancer. (elsevierpure.com)
In the present study, we synthesized and investigated a series of 55 anthraquinone derivatives as potential inhibitors of eN, 11 of which are novel compounds and another 11 of which had previously been described but have now been synthesized by an improved method. (elsevierpure.com)
We identified several potent inhibitors of rat eN. (elsevierpure.com)
5-Nucleotidase Syndrome is a rare genetic disorder that affects a small number of people worldwide. (mellaly.com)
This article will explore the science behind 5-Nucleotidase Syndrome, including its symptoms, causes, treatment, and everyday life. (mellaly.com)
5-Nucleotidase Syndrome is a rare genetic disorder that affects the way our body processes and eliminates waste. (mellaly.com)
Soluble form1
Studies of the soluble form of human ecto-5′-nucleotidase, without a GPI anchor, have shown that the C-terminal domain holds the substrate-binding pocket, and that the aromatic purine motif of the substrate is stacked between two phenylalanine residues. (wikipedia.org)
Nucleoside1
This gene encodes a member of the 5'-nucleotidase family of enzymes that catalyze the dephosphorylation of nucleoside 5'-monophosphates. (nih.gov)
Endothelial1
The role of ecto-5'-nucleotidase in endothelial dysfunction and vascular pathologies. (medscape.com)
One of the soluble forms appears to be derived from the GPI-anchored ex-5'-nucleotidase and has an extracellular location. (wikipedia.org)
Acid1
Rutin, naringin, hyperosid, (+/-)catechin, caffeic acid and rosmarinic acid had no inhibitory effect on the 5'-NT activity. (gazi.edu.tr)
Serum2
Serum levels of 5′-nucleotidase in disease. (medscape.com)
The normal range of values for AST (SGOT) is about 5 to 40 units per liter of serum (the liquid part of the blood). (medicinenet.com)
Potent1
The most potent compounds were l-amino-4-[4-fluoro-2-carboxyphenylamino]-9,10-dioxo-9,10-dihydroanthracene-2- sulfonate (45, PSB-0952, K 1 = 260 nM) and 1-amino-4-[2- anthracenylamino]-9,10-dioxo-9,10dihydroanthracene-2-sulfonate (52, PSB-0963, 150 nM), with 52 being the most potent eN inhibitor described to date. (elsevierpure.com)
Proteins1
SVEVs isolated from lyophilized venoms collected from four different species of snakes ( Agkistrodon contortrix contortrix , Crotalus atrox , Crotalus viridis and Crotalus cerberus oreganus ) were analyzed by mass spectrometry-based proteomic, which allowed the identification of proteins belonging to eight main functional protein classes such as SVMPs, serine proteinases, PLA 2 , LAAO, 5′nucleotidase, C-type lectin, CRISP and Disintegrin. (nature.com)
Metabolic1
Reduction of 5'-nucleotidase expression or activity may promote metabolic flexibility in type 2 diabetes. (diva-portal.org)
siRNA silencing of NT5C2 expression increased palmitate oxidation by 2-fold in the absence and by 8-fold in the presence of 5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside. (diva-portal.org)
Time1
This time period includes the transit time for us to receive your return from the shipper (5 to 10 business days), the time it takes us to process your return once we receive it (3 to 5 business days), and the time it takes your bank to process our refund request (5 to 10 business days). (biomatik.com)
Years1
51% had 5 years of schooling, 26% were illiterate, and 15.4% of husbands were illiterate. (who.int)