3 oxo 5 alpha steroid 4 dehydrogenase. Medical search. Frequent questions

Specifically, the steroid 5-alpha reductase 2 enzyme is responsible for a chemical reaction that converts the hormone testosterone to DHT. (medlineplus.gov)
Variants in the SRD5A2 gene prevent steroid 5-alpha reductase 2 from effectively converting testosterone to DHT in the developing reproductive tissues. (medlineplus.gov)
Converts testosterone (T) into 5-alpha-dihydrotestosterone (DHT) and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. (bicnirrh.res.in)
Dihydrotestosterone (DHT) is generated by a 5-alpha reduction of testosterone. (foodb.ca)
Unlike testosterone, DHT cannot be aromatized to estradiol therefore DHT is considered a pure androgenic steroid. (foodb.ca)
Dihydrotestosterone (DHT) (INN: androstanolone) is a biologically active metabolite of the hormone testosterone, formed primarily in the prostate gland, testes, hair follicles, and adrenal glands by the enzyme 5-alpha-reductase by means of reducing the alpha 4,5 double-bond. (foodb.ca)

5-alpha reductase deficiency is a condition that affects sexual development before birth and during puberty. (medlineplus.gov)
Many people with 5-alpha reductase deficiency are assigned female at birth based on their external genitalia. (medlineplus.gov)
People with 5-alpha reductase deficiency do not develop much facial or body hair. (medlineplus.gov)
Variants (also called mutations) in the SRD5A2 gene cause 5-alpha reductase deficiency. (medlineplus.gov)
These hormonal factors underlie the changes in sexual development seen in infants with 5-alpha reductase deficiency. (medlineplus.gov)
Researchers believe that people with 5-alpha reductase deficiency develop secondary male sex characteristics in response to higher levels of this hormone. (medlineplus.gov)
in each cell) will have the characteristic signs of 5-alpha reductase deficiency. (medlineplus.gov)
Short-chain acyl-coenzyme A dehydrogenase deficiency. (harvard.edu)
Development of a newborn screening follow-up algorithm for the diagnosis of isobutyryl-CoA dehydrogenase deficiency. (harvard.edu)
Coordinated and reversible reduction of enzymes involved in terminal oxidative metabolism in skeletal muscle mitochondria from a riboflavin-responsive, multiple acyl-CoA dehydrogenase deficiency patient. (harvard.edu)
Anesthetic considerations for a patient with compound heterozygous medium-chain Acyl-CoA dehydrogenase deficiency. (harvard.edu)
Neonatal screening for medium--chain acyl-CoA dehydrogenase deficiency. (harvard.edu)
Compound heterozygosity in four asymptomatic siblings with medium-chain acyl-CoA dehydrogenase deficiency. (harvard.edu)
Short-chain acyl-CoA dehydrogenase deficiency: a cause of ophthalmoplegia and multicore myopathy. (harvard.edu)

The SRD5A2 gene provides instructions for making an enzyme called steroid 5-alpha reductase 2. (medlineplus.gov)

Steroid 5-alpha-reductase 3, also known as 3-oxo-5-alpha-steroid 4-dehydrogenase 3, is an enzyme that in humans is encoded by the SRD5A3 gene. (wikipedia.org)
An adrenal microsomal cytochrome P450 enzyme that catalyzes the 21-hydroxylation of steroids in the presence of molecular oxygen and NADPH-FERRIHEMOPROTEIN REDUCTASE. (lookformedical.com)

Expert Rev Respir Med 2018 Apr;12(4):283-292. (nih.gov)

These are 3-hydroxylated C19 steroid hormones. (foodb.ca)

Considered essential for the stabilization of biological membranes (especially those with high amounts of polyunsaturated fatty acids), d-alpha-Tocopherol is a potent peroxyl radical scavenger and inhibits noncompetitively cyclooxygenase activity in many tissues, resulting in a decrease in prostaglandin production. (medindex.am)

An oxidoreductase that catalyzes the conversion of 3-oxo-delta4 steroids into their corresponding 5alpha form. (jefferson.edu)

Acta Dermatovenerol Alp Pannonica Adriat 2020 Dec;29(4):193-199. (nih.gov)

108(5): 895-900, 2023 05 03. (bvsalud.org)
Arch Dis Child 2023 Apr;108(4):276-281. (nih.gov)

Adv Respir Med 2017;85(5):277-289. (nih.gov)

JAAPA 2019 May;32(5):30-35. (nih.gov)

The encoded protein is active at acidic pH and is sensitive to the 4-azasteroid inhibitor finasteride. (bicnirrh.res.in)

Some affected people also retain a small amount of 5-alpha reductase 2 activity, which may produce DHT and contribute to the development of secondary sex characteristics during puberty. (medlineplus.gov)
The development of female sex characteristics does not require DHT, so a lack of steroid 5-alpha reductase 2 activity does not cause physical changes in these individuals. (medlineplus.gov)

It has a preference for acyl derivatives with carbon chain length from 4 to 16. (umassmed.edu)

The various cytochrome subclasses are organized by the type of HEME and by the wavelength range of their reduced alpha-absorption bands. (lookformedical.com)

This graph shows the total number of publications written about "Acyl-CoA Dehydrogenases" by people in Harvard Catalyst Profiles by year, and whether "Acyl-CoA Dehydrogenases" was a major or minor topic of these publication. (harvard.edu)
Below are the most recent publications written about "Acyl-CoA Dehydrogenases" by people in Profiles. (harvard.edu)
Below are the most recent publications written about "Cholestenone 5 alpha-Reductase" by people in Profiles. (jefferson.edu)

Steroid 5α-reductase (S5αR) plays an important role in metabolizing testosterone into active androgen dihydrotestosterone (DHT) which is involved in many androgen dependent disorders, such as androgenic alopecia, benign prostatic hyperplasia and acne. (nih.gov)

It is involved in the production of androgen 5-alpha-dihydrotestosterone (DHT) from testosterone, and maintenance of the androgen-androgen receptor activation pathway. (nih.gov)
Steroid 5-alpha-reductase (EC 1.3.99.5) catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone (DHT). (antibodies-online.com)

In aerobic bacteria, azelaic acid reversibly inhibits several oxidoreductive enzymes including tyrosinase, mitochondrial enzymes of the respiratory chain, thioredoxin reductase, 5-alpha-reductase, and DNA polymerases. (drugbank.com)
A subclass of enzymes which includes all dehydrogenases acting on carbon-carbon bonds. (nih.gov)
[3] Sulfation or acetylation of 7-keto at the 3-position does not appear to interfere with the induction of fat burning enzymes (mentioned in section on fat mass and obesity). (examine.com)
[16] [17] Due to the irreversibility of the Oxysterol 7α-hydroxylase and CYP3A4/5 enzymes, there is no conversion of these three molecules back into parent DHEA, and the metabolism of DHEA into androgenic or estrogenic precursors (into androstenedione via 3β-HSD) cannot occur following 7-keto supplementation. (examine.com)

Both finasteride and dutasteride are competitive inhibitors of the type II steroid 5 alpha-reductase that have been effectively used for the treatment of benign prostatic hyperplasia. (nih.gov)
Our systematic pharmacogenetic analysis shows that both finasteride and dutasteride are slow, time-dependent inhibitors of steroid 5 alpha-reductase type II, and that the inhibition kinetics depend on the 5 alpha-reductase genotype. (nih.gov)
DESIGN: We conducted a randomized study in 12 healthy male volunteers with detailed metabolic phenotyping performed before and after a 3-week treatment with finasteride (5 mg od) or dutasteride (0.5 mg od). (ox.ac.uk)

From NCBI Gene: The protein encoded by this gene belongs to the steroid 5-alpha reductase family, and polyprenol reductase subfamily. (nih.gov)
C2950 Chromosome Abnormality C99147 Neonatal Research Network Terminology C98683 3-Methylglutaconic Aciduria Type 1 3-Methylglutaconic Aciduria Type 1 3-methylglutaconic aciduria inherited in an autosomal recessive pattern and caused by mutations in the AUH gene. (nih.gov)
Inborn Error of Metabolism C99147 Neonatal Research Network Terminology C84585 Barth Syndrome 3-Methylglutaconic Aciduria Type 2 A rare X-linked syndrome caused by mutations in TAZ1 gene. (nih.gov)
The protein encoded by this gene contains a ubiquitin-like domain in the N-terminal region, three transmembrane segments and a C-terminal 3-oxo-5-alpha steroid 4-dehydrogenase domain. (nih.gov)
Mutations in this gene result in ventricular tachycardia, catecholaminergic polymorphic, 3. (nih.gov)

HN - 2011 MH - 5-Lipoxygenase-Activating Protein Inhibitors UI - D058946 MN - D27.505.519.389.86 MS - Compounds that bind to and inhibit the action of 5-LIPOXYGENASE-ACTIVATING PROTEINS. (nih.gov)
The protein belongs to the steroid 5-alpha reductase family. (nih.gov)

The 5alpha-Reductase-3alpha-hydroxysteroid dehydrogenase complex is present in the human brain, suggesting that the complex may be involved in the synthesis of neuroactive steroids or the catabolism of neurotoxic steroids. (thermofisher.com)

[3] Supplementation of 7-keto is sometimes used in place of supplementation of DHEA if the androgenic and estrogenic effects of DHEA are not desired, as 7-keto is incapable of converting to these active steroid hormones. (examine.com)

5,10-Methylenetetrahydrofolate reductase deficiency is the most prevalent inborn error of folate metabolism, and has variable clinical manifestations from asymptomatic to severe psychomotor retardation, microcephalus and seizure. (nih.gov)
Tsuyoshi Goto, Scope: Peroxisome proliferator-activated receptor alpha (PPAR-α) is a ligand-activated transcription factor that regulates lipid and carbohydrate metabolism. (nara-wu.ac.jp)

The hub metabolites reviewed here are- Nicotinamide adenine dinucleotide (NAD+), reduced nicotinamide dinucleotide phosphate (NADPH), alpha ketoglutarate (aKG) and beta-hydroxybutyrate (βHB). (biomed.news)

Methylenetetrahydrofolate reductase catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a cosubstrate for homocysteine remethylation to methionine. (nih.gov)

8/9/2010) TOTAL 2011 NEW DESCRIPTORS = 573 MH - 14-alpha Demethylase Inhibitors UI - D058888 MN - D27.505.519.389.49 MS - Compounds that specifically inhibit STEROL 14-DEMETHYLASE. (nih.gov)

HN - 2011 MH - 5-Lipoxygenase-Activating Proteins UI - D058927 MN - D12.644.360.24.32 MN - D12.776.476.24.34 MN - D12.776.543.19 MS - Scaffolding proteins that play an important role in the localization and activation of 5-LIPOXYGENASES. (nih.gov)

Wif1 mutant male UGSs exhibit increased (Sfrp)2 and (Sfrp)3 expression and form the same number of prostatic buds as the wild-type control males. (nih.gov)

Dual-5α-Reductase Inhibition Promotes Hepatic Lipid Accumulation in Man. (ox.ac.uk)

Approximately 4% of the topically applied azelaic acid is systemically absorbed. (drugbank.com)
An essential fatty acid belonging to the omega-3 fatty acids group. (medindex.am)

Considered essential for the stabilization of biological membranes (especially those with high amounts of polyunsaturated fatty acids), d-alpha-Tocopherol is a potent peroxyl radical scavenger and inhibits noncompetitively cyclooxygenase activity in many tissues, resulting in a decrease in prostaglandin production. (medindex.am)

Western blot analysis was performed on whole cell extracts (30µg lysate) of A-431 (Lane 1), COS-7 (Lane 2), MDCK (Lane 3), C2C12 (Lane 4), PC-3 (Lane 5), L6 (Lane 6), RSC96 (Lane 7), tissue extracts (30µg lysate) of Mouse Lung (Lane 8), Rat Stomach (Lane 9), Mouse Pancreas (Lane 10) and Rat Brain (Lane 11). (thermofisher.com)

Some affected people also retain a small amount of 5-alpha reductase 2 activity, which may produce DHT and contribute to the development of secondary sex characteristics during puberty. (medlineplus.gov)
The development of female sex characteristics does not require DHT, so a lack of steroid 5-alpha reductase 2 activity does not cause physical changes in these individuals. (medlineplus.gov)

The foremost impact these studies have had is establishing the role of androgens, namely testosterone, in this disease [ 5 ]. (ijbs.com)

5,11,12,22 We suggested that many cells appearing as TAM within GBM could be neoplastic with properties of macrophages/ microglia. (touchoncology.com)

Subsequent data, however, indicated that it may actually occur in as many as 5-15% of patients with HTN. (medscape.com)
[5] ) with free 7-ketoDHEA as an intermediate, as the acetate group and the sulfate group occur on the same carbon. (examine.com)

Anatomy8

Organisms8

Diseases3

Chemicals and Drugs177

Analytical, Diagnostic and Therapeutic Techniques and Equipment17

Phenomena and Processes39

Disciplines and Occupations2

Information Science3

Health Care1

Testosterone6

Deficiency14

SRD5A21

Enzyme2

20181

Hormones1

Polyunsaturated fatty1

5alpha1

20201

20232

20171

20191

Finasteride1

Activity2

Derivatives1

Type1

People3

Metabolizing testosterone1

Androgen2

Enzymes4

Dutasteride3

Gene5

Protein2

5Alpha1

Active steroid hormones1

Metabolism2

NADPH1

Homocysteine1

Sterol1

Proteins1

Type1

Lipid1

Acid2

Acids1

Extracts1

Characteristics2

Androgens1

Cells1

Occur2