25 hydroxyvitamin d 2. Medical search. Frequent questions

Vitamin D deficiency is defined by most experts as a serum 25(OH)D level of less than 20 ng/mL (50 nmol/L). (medscape.com)
Vitamin D insufficiency has been defined as a serum 25(OH)D level of 21-29 ng/mL (52-72 nmol/L). This is based on the observed physiological changes in calcium absorption and parathyroid hormone levels that occur with changes in vitamin D levels. (medscape.com)
In healthy postmenopausal women with serum 25(OH)D levels averaging 34.4 ng/mL (86.5 nmol/L), intestinal calcium absorption increased from 45% to 65% compared to those with mean 25(OH)D levels of 20 ng/mL (50.1 nmol/L). (medscape.com)
Chapuy et al reported an inverse correlation between serum intact parathyroid hormone (iPTH) and serum 25(OH)D. Serum iPTH held a stable plateau level when serum 25(OH)D values exceeded 31 ng/mL (78 nmol/L) but started to rise when the serum 25(OH)D values fell below this level. (medscape.com)
Vitamin D sufficiency has been defined as serum 25(OH)D levels of 30 ng/mL (75 nmol/L) and above based on analysis of observational studies of vitamin D and various health outcomes. (medscape.com)
Their conclusion based on all endpoints was that 25(OH)D levels of 30 ng/mL (75 nmol/L) or greater are more effective in achieving positive outcomes than lower levels. (medscape.com)
The best outcomes were seen with 25(OH)D levels from 36-40 ng/mL (90-100 nmol/L). (medscape.com)
Vitamin D toxicity is observed when serum 25(OH)D levels are greater than 150 ng/mL (374 nmol/L). (medscape.com)
Canadians have mean serum 25(OH)D levels averaging 67 nmol/L. The journal literature was searched for papers reporting dose-response relationships for vitamin D indices and disease outcomes. (nih.gov)
The estimated benefits in disease reduction were based on increasing the mean serum 25(OH)D level to 105 nmol/L. It is estimated that the death rate could fall by 37,000 deaths (22,300-52,300 deaths), representing 16.1% (9.7-22.7%) of annuals deaths and the economic burden by 6.9% (3.8-10.0%) or $14.4 billion ($8.0 billion-$20.1 billion) less the cost of the program. (nih.gov)
Normal plasma levels of 25OHD are 25 to 250 nanomoles (nmol)/L (10 to 100 mcg/L) (SACN 2016). (e-lactancia.org)
Due to these variables it is ideal to know your vitamin D status by measuring your blood level of 25-hydroxyvitamin D. The level you're shooting for is 75 nmol/l. (patrickholford.com)
We investigated the dose-response effects of supplementation with calcifediol compared to vitamin D3 and assessed the dose which results in mean serum 25(OH)D3 concentrations between 75 and 100 nmol/L. (hva.nl)
RESULTS: Supplementation with 20 μg vitamin D3 increased 25(OH)D3 concentrations towards 70 nmol/L within 16 weeks. (hva.nl)
Steady state was achieved from week 12 onwards with serum 25(OH)D3 levels stabilizing between 84 and 89 nmol/L in the 10 μg calcifediol group. (hva.nl)
A daily dose of 10 μg calcifediol allows serum 25(OH)D3 concentrations to be maintained between 75 and 100 nmol/L. (hva.nl)
Serum 25-(OH)D levels more than 50 nmol/L (20 ng/mL) is generally considered adequate for bone and overall health. (infantrisk.com)
Vitamin D levels less than 30 nmol/L (2 ng/mL) are associated with vitamin D deficiency, which may cause bones to become thin or brittle and can cause rickets in children. (infantrisk.com)

During Phase 1, blood will be drawn and assayed for 25-hydroxyvitamin D (25OHD). (nih.gov)
2. in the liver it is hydroxylated to calcifediol, also called calcidiol or 25-hydroxyvitamin D (25OHD). (e-lactancia.org)
25-hydroxyvitamin D (25OHD), as the circulating form of vitamin D in human blood, has an inverse relationship with parathyroid hormone (PTH) [ 7 ]. (hindawi.com)
Background: Vitamin D deficiency is common in patients with cystic fibrosis (CF), and guidelines recommend 25-hydroxyvitamin D (25OHD) levels ≥ 30 ng/mL. (johnshopkins.edu)

Median serum ascorbic acid and 25-hydroxyvitamin D [‎25-OHD]‎ concentrations were low in mothers and infants. (who.int)
Weighted estimating equations related plasma klotho and serum 25(OH)D concentrations measured at one visit to SPPB measured longitudinally at multiple visits. (nih.gov)
CONCLUSIONS: Calcifediol supplementation rapidly and safely elevates serum 25(OH)D3 concentrations to improve vitamin D status in older adults. (hva.nl)
Changes in lymphocyte subset proportions during stimulation of their peripheral blood mononuclear cells (PBMCs) with the active form of vitamin D, 1,25-dihydroxyvitamin D 3 (1,25(OH) 2 D 3 ), and correlations with serum concentrations of the vitamin D precursor 25-hydroxyvitamin D 3 (serum 25(OH)D 3 ) were explored. (breathinglabs.com)

25-Hydroxyvitamin D and parathyroid hormone are not associated with carotid intima-media thickness or plaque in the Multi-Ethnic Study of Atherosclerosis. (cdc.gov)
Objective: Observational evidence supports independent associations of 25-hydroxyvitamin D (25-OHD) and parathyroid hormone (PTH) with cardiovascular risk. (cdc.gov)
Patients in the calcitriol group received a dose of 0.25 µg once daily to start that was later adjusted in response to 25(OH)D, calcium, phosphorus, and intact parathyroid hormone (iPTH). (renalandurologynews.com)

The enzyme catalyzes the hydroxylation of calcifediol to calcitriol (the bioactive form of Vitamin D): calcidiol + 2 reduced adrenodoxin + 2 H+ + O2 ⇌ calcitriol + 2 oxidized adrenodoxin + H2O The enzyme is also able to oxidize ercalcidiol (25-OH D2) to ercalcitriol, secalciferol to calcitetrol, and 25-hydroxy-24-oxocalciol to (1S)-1,25-dihydroxy-24-oxocalciol. (wikipedia.org)

maternal supplementation with 1,200 IU per day did assure maternal levels of 25 OHD, but not those of infants (Czech 2014). (e-lactancia.org)
Males fed I3C exhibited higher serum levels of 25-hydroxy-vitamin D3 (25OH-D3). (nih.gov)
8 , 9 Studies in CYP2R1 null mice, indicating significantly reduced levels of 25(OH)D 3 in these mice, have confirmed the role of CYP2R1 in the hydroxylation of vitamin D at C-25. (nature.com)
10 However, synthesis of low levels of 25(OH)D 3 in these mice suggests that other 25-hydroxylases, yet to be identified, are also involved in the conversion of vitamin D to 25(OH)D 3 . (nature.com)
In this study, we further analyzed the association between sun exposure, serum 25(OH)D, and pterygium in varied age groups, occupations, geographical latitudes, and blepharoptosis status (which may affect ocular UVB exposure), to provide more clues on the association between the blood levels of 25(OH)D and pterygium in a large representative sample of the Korean general population. (biomedcentral.com)
Blood levels of 25-Hydroxyvitamin D (written "25-(OH)D") give the best indication of the body's vitamin D status. (infantrisk.com)

If their level is less than 20 ng/ml (deficiency), they will be invited to participate in Phase 2. (nih.gov)
17. Severe 25-hydroxyvitamin D deficiency identifies a poor prognosis in patients with hepatocellular carcinoma - a prospective cohort study. (nih.gov)
Researchers at Massey were the first to conduct such a trial and demonstrate a role for vitamin D deficiency in the development of insulin resistance, a condition which can lead to type 2 diabetes. (massey.ac.nz)
In conclusion, a low 25(OH)D concentration is an independent risk factor for MetS in elderly people without vitamin D deficiency. (vitamindwiki.com)
Cincinnati, Ohio, USA), 30 minutes/week (diaper only) or 2 hours/week (fully clothed without a hat) of sunlight exposure appeared sufficient to prevent deficiency (5). (sacredbirthing.com)

To investigate the relationship between serum 25 (OH) D level, liver function, and liver fibrosis in infants with in biliary atresia (BA) infants one year after Kasai procedure. (researchsquare.com)
Serum 25 (OH)D level can reflect the degree of liver fibrosis and liver function in biliary atresia infants living with the native liver at 12 months after the Kasai procedure. (researchsquare.com)
Research has shown that without postnatal sunlight exposure, vitamin D stores of fetal origin were depleted by eight weeks in exclusively breastfed infants (Tampere, Finland [61°N] in winter)(2). (sacredbirthing.com)
Yet administration of 1,000 IU to lactating mothers (Tampere, Finland [61°N] in winter) did not normalize the 25-hydroxyvitamin D levels of their infants (15). (sacredbirthing.com)
The recommended daily allowance is 400 IU/day for infants and 600 IU/day for all other populations.2 The American Academy of Pediatrics recommends that all children, especially breastfeeding infants, receive a 400 IU/day supplement starting soon after birth. (infantrisk.com)

One exception is that 25(OH)D levels do not indicate clinical vitamin D status in patients with chronic renal failure or type 1 vitamin D-dependent rickets or when calcitriol (1,25-dihydroxyvitamin D) is used as a supplement. (medscape.com)

We conclude that monthly maternal or daily infant supplementation with vitamin D along with sun exposure is superior to sun exposure alone in maintaining normal infant 25(OH)D at 3·5 months, and provide protection from elevated alkaline phosphatase and infectious morbidity. (cambridge.org)
The serum 25(OH) D level was significantly lower in patients without vitamin D supplements at 3 months after surgery (t=-2.974，P＜0.05), and the aspartate aminotransferase to platelet ratio index (APRI) was higher in patients with vitamin D supplementation. (researchsquare.com)
During Phase 2, deficient women will receive a blinded dose of 50,000 IU of vitamin D supplementation per week. (nih.gov)
Individuals may be offered prophylactic magnesium and 25-hydroxyvitamin D 3 supplementation. (biochemjournal.com)
BACKGROUND & AIMS: Oral supplementation with vitamin D is recommended for older adults to maintain a sufficient 25-hydroxyvitamin D (25(OH)D) status throughout the year. (hva.nl)
While supplementation with vitamin D2 or D3 is most common, alternative treatment regimens exist which require further investigation with respect to increasing 25(OH)D concentration. (hva.nl)

Plasma 25. (bmj.com)
Exposure Plasma concentration of 25-hydroxyvitamin D measured by enzyme immunoassay. (bmj.com)
Results Plasma 25-hydroxyvitamin D concentration was inversely associated with the risk of total cancer, with multivariable adjusted hazard ratios for the second to fourth quarters compared with the lowest quarter of 0.81 (95% confidence interval 0.70 to 0.94), 0.75 (0.65 to 0.87), and 0.78 (0.67 to 0.91), respectively (P for trend=0.001). (bmj.com)
2012. "Determinants of Plasma 25-Hydroxyvitamin D and Development of Prediction Models in Three US Cohorts. (harvard.edu)
The assay measures total true 25-hydroxy vitamin D levels (D2 + D3 levels) in both serum and plasma samples and fully automates removal of non-specific protein binding and cross reactivity to ensure accuracy. (aacc.org)

Metabolism of 25-hydroxyvitamin D3 to 24,25-dihydroxyvitamin D3 by blood derived macrophages from a patient with alveolar rhabdomyosarcoma during short-term culture and 1 alpha,25-dihydroxyvitamin D3 after long-term culture. (manchester.ac.uk)

Approach and Results: We evaluated cross-sectional and longitudinal associations of 25-OHD and PTH with carotid intima-media thickness (IMT) and carotid plaques among 3251 participants free of cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis. (cdc.gov)

Zhang Dongliang, MD, of Peking University International Hospital in China, and colleagues directly compared oral preparations of natural vitamin D 2 with active vitamin D 3 sterol in a randomized trial of 204 patients with CKD stages 3 to 5 not on renal replacement therapy. (renalandurologynews.com)
Renal outcomes were also similar, including renal replacement therapy initiation, more than 25% decline in estimated glomerular filtration rate, doubling of serum creatinine levels, and hospitalization. (renalandurologynews.com)
Serum 1 alpha,25(OH)2D3 in the patient was markedly suppressed at 5 pg/ml (normal 20-50 pg/ml) indicating that raised 1 alpha,25(OH)2D3 was not the cause of the hypercalcaemia, but rather, that raised calcium may have suppressed renal 1 alpha,25(OH)2D3 synthesis. (manchester.ac.uk)

Vitamin D, whether produced in the skin upon sun exposure or ingested from various dietary sources, is converted in the liver to 25-hydroxyvitamin D [25(OH)D]. The latter is the major circulating form of vitamin D and is thus used for evaluating the vitamin D status of patients (1,2). (who.int)
Ultraviolet-B (UVB) light exposure is the major risk factor for developing a pterygium, and serum 25-hydroxyvitamin D (25(OH)D) level is an objective measure of UVB light exposure. (biomedcentral.com)
In this study, we investigated the association between pterygium, sun exposure, and serum 25(OH)D. (biomedcentral.com)
The present study provides epidemiological evidence of an association of daily sun exposure and serum 25(OH)D levels with pterygium in a representative Korean population. (biomedcentral.com)
Considering the fact that vitamin D production is primarily and fundamentally influenced by UVB exposure [ 19 ], we postulated that serum 25-hydroxyvitamin D (25(OH)D) levels might represent a surrogate marker for the exposure to UVB light, and could therefore be used for analysis of the association between UVB exposure and pterygium. (biomedcentral.com)
In a further experiment synthesis of 1 alpha,25(OH)2D3 by long-term cultured macrophages fell from 2.25 to 0.04 pmol/h/incubation following exposure to 10 nM 1 alpha,25(OH)2D3 for 7 days, whereas 24,25(OH)2D3 synthesis was induced (0.46 pmol/h/incubation). (manchester.ac.uk)

The investigators observed no statistically significant difference between the 2 treatments in controlling calcium, phosphorus, and iPTH. (renalandurologynews.com)
In addition, mechanisms involved in age-related dysregulation of 1,25(OH) 2 D 3 action, recommended daily doses of vitamin D and calcium, and the use of vitamin D analogs for the treatment of osteoporosis (which remains controversial) are reviewed. (nature.com)
We also evaluated the relation of calcium intake with serum 25-hydroxy-vitamin D [25(OH)D] and 1,25-dihydroxy-vitamin D [1,25(OH) 2 D], in a Prostate, Lung, Colorectal, and Ovarian Trial substudy ( n = 275). (aacrjournals.org)

In the second study, researchers assessed the relationship between vitamin D levels and malignant melanoma [2]. (drbriffa.com)

25-Hydroxyvitamin D 1-alpha-hydroxylase (VD 1A hydroxylase) also known as calcidiol 1-monooxygenase or cytochrome p450 27B1 (CYP27B1) or simply 1-alpha-hydroxylase is a cytochrome P450 enzyme that in humans is encoded by the CYP27B1 gene. (wikipedia.org)

Epub 2021 Feb 2. (cdc.gov)
Epub 2021 Feb 25. (cdc.gov)

Epub 2014 Mar 25. (nih.gov)

Among the patients with malignant melanoma, significantly reduced serum 25(OH)D levels were found in the stage IV patients as compared to stage I patients, and those with low 25(OH)D serum levels (20 ng/ml). (drbriffa.com)

This retrospective study was conducted using the clinical data of children with BA confirmed by cholangiography and/or surgery admitted to Children Hospital of Shanxi Province between October 2018 and October 2020, as well as the follow-up data at 1, 3, 6, and 12 months after Kasai Portoenterotomy so as to analyze the relationship between serum 25(OH) D level, liver function, and liver fibrosis. (researchsquare.com)
Nonetheless, about 40-50% of children still need liver transplantation within two years after surgery [ 2 , 3 ] . (researchsquare.com)
The current studies have shown that the level of serum 25(OH) VD is closely related to liver fibrosis and related complications caused by chronic liver disease in adults [ 4,5] . (researchsquare.com)
The purpose of this study was to analyze preoperative and postoperative 25(OH) D levels from 3 to 12 months after the Kasai procedure and their relationship with liver function and liver fibrosis. (researchsquare.com)
Sex, age, serum 25-hydroxyvitamin D (25(OH) VD) level, liver function, and liver fibrosis indicators were collected. (researchsquare.com)
10. Clinical Effect of Preoperative 25-OH-Vitamin D3 Level in Liver Transplant Recipients. (nih.gov)
In the liver, it is converted by one or more enzymes into 25-hydroxyvitamin D3 [25(OH)D3]. (thepaleodiet.com)
25-Hydroxylation of vitamin D in the liver results in the formation of 25-hydroxyvitamin D [25(OH)D 3 ], the major circulating form of vitamin D and the most reliable index of vitamin D status. (nature.com)
After its synthesis in the liver, 25(OH)D 3 is transported by DBP to the kidney where it is internalized by megalin, a transmembrane protein that acts as a surface receptor for DBP. (nature.com)

25-Hydroxycholecalciferol-1-hydroxylase. (wikipedia.org)

Serum 25(OH)D was negatively associated with osteocalcin, the homeostatic model assessment insulin resistance (HOMA-IR) index, body mass index (BMI), and glycated hemoglobin A1c. (vitamindwiki.com)
Binary logistic regression models showed that 25(OH)D, physical activity, and osteocalcin were negatively independent MetS factors, but that the HOMA-IR index, BMI, and being female were positively independent factors. (vitamindwiki.com)
The ratio of CD19 + CD27 + memory B cells (Bmem) to all B cells after stimulation with 1,25(OH) 2 D 3 was negatively correlated with serum 25(OH)D 3 in MS (Spearman's ρ =-0.594, p =0.042), but positively correlated in NMOSD (Pearson's r = 0.739, p =0.006). (breathinglabs.com)
In addition, the level of 1,25(OH) 2 D 3 -induced CYP24A1 mRNA expression in PBMCs was significantly and negatively correlated with serum 25(OH)D 3 (for ΔC T , r =0.744, p =0.014) in MS. (breathinglabs.com)

D is a natural component of breast milk where it is found primarily as cholecalciferol, but also as ergocalciferol and its respective 25-hydroxylated metabolites. (e-lactancia.org)
The vitamin D3 metabolites were identified by co-chromatography with authentic 24,25(OH)2D3 or 1 alpha,25(OH)2D3 in three different high-performance liquid chromatography systems. (manchester.ac.uk)

thus, the total serum 25(OH)D level is currently considered the best indicator of vitamin D supply to the body from cutaneous synthesis and nutritional intake. (medscape.com)

15 ng/mL) before hospital admission was a significant predictor of sepsis in the critically ill, and patients with sepsis whose 25-hydroxyvitamin D level before admission was less than 30 ng/mL had increased risk for mortality after the ICU admission. (medscape.com)
The reference range of the total 25(OH)D level is 25-80 ng/mL. (medscape.com)
Over 33 months, the 25-hydroxyvitamin D level of ergocalciferol recipients increased significantly from 15.14 to 37.32 ng/mL. (renalandurologynews.com)
The dosing strategy for ergocalciferol was 50,000 units once weekly for the first 3 months, then 50,000 units once monthly, toward a target blood level of 25-hydroxyvitamin D [25(OH)D] of 30 ng/mL. (renalandurologynews.com)
Results showed that the 25(OH)D level in the ergocalciferol group increased significantly from 15.14 to 37.32 ng/mL over 33 months. (renalandurologynews.com)
Aiming to maintain 25-OHD levels ≥ 35 ng/mL in individuals with CF decreases the risk of having a PTH level associated with secondary hyperparathyroidism and bone loss. (johnshopkins.edu)

Reduced serum 25-hydroxyvitamin D levels in stage IV melanoma patients. (drbriffa.com)

1 2 In vitro studies have shown that vitamin D exerts antiproliferative and pro-differentiating effects on malignant cells through the regulation of multiple signalling pathways involved in cell cycle arrest, apoptosis, angiogenesis, and inflammation. (bmj.com)

This study used a retrospective, observational analysis of deidentified tests performed at a national clinical laboratory to determine if circulating 25-hydroxyvitamin D (25(OH)D) levels are associated with severe acute respiratory disease coronavirus 2 (SARS-CoV-2) positivity rates. (nih.gov)
Methods In a retrospective cohort study at a large, tertiary, urban, academic medical center, records of patients who had 25-hydroxyvitamin D levels measured within 30 days of admission for severe sepsis or septic shock from June 2006 to April 2011 were examined. (medscape.com)

is has to convert into 25-hydroxyvitamin D, which acts more like a hormone than a vitamin. (patrickholford.com)
There is good evidence that various cells in other tissues besides the kidney can convert 25OHD3 into 1α,25(OH)2D3. (thepaleodiet.com)

Multivariable linear and logistic regressions were used to test associations of 25-OHD and PTH with the extent and progression of IMT and the prevalence and incidence of carotid plaque. (cdc.gov)

[ 3 ] When vitamin D is converted to its active form, 1,25-dihydroxyvitamin D, within these cells, it induces modulation of both innate and adaptive immune responses. (medscape.com)

Over 190,000 patients from all 50 states with SARS-CoV-2 results performed mid-March through mid-June, 2020 and matching 25(OH)D results from the preceding 12 months were included. (nih.gov)
Co-evaluation of magnesium and 25-hydroxyvitamin D 3 may be useful in predicting the severity of the disease in patients with COVID-19. (biochemjournal.com)
Low magnesium and 25-hydroxyvitamin D 3 levels can be considered a risk factor in patients with COVID-19. (biochemjournal.com)
1984. Antibodies to HTLV-1 and HTLV-3 in from Two Japanese Patients: One possible Pre-A.I.D.S. Lancet 2:936. (gmushrooms.com)

[ 11 ] In general, these assays depend on an antibody that recognizes 25(OH)D2 and 25(OH)D3 in equimolar proportions and the competitive displacement of tracer 25(OH)D (25(OH)D that has been tagged with a radioactive isotope such as 125-I or a chemiluminescent ligand) by acetonitrile extracted samples. (medscape.com)

This assay used vitamin D-binding protein (DBP) obtained from rat serum as the binding agent and exploited the capacity of vitamin D in test samples to displace bound [ 3 H]25(OH)D 3 from DBP. (medscape.com)
Diazyme's new 25-Hydroxy Vitamin D assay received FDA 510(k) clearance. (aacc.org)

AKI is conventionally defined by an increase in serum creatinine ≥0.3 mg/dL within 48 h or ≥1.5 times from baseline within 7 days and/or a decrease in urine output [ 2 ]. (karger.com)
25-OHD and PTH were measured at baseline by mass spectrometry and immunoassay, respectively. (cdc.gov)
Baseline serum 1,25(OH) 2 D was determined by RIA. (aacrjournals.org)

Serum 25(OH)D was significantly lower in the wheezing group, and its decrease was a risk factor for wheezing. (who.int)

We have examined the ability of blood-derived monocytes and macrophages isolated from a patient with alveolar rhabdomyosarcoma and hypercalcaemia, to form 24,25-dihydroxyvitamin D3 (24,25(OH)2D3) or 1 alpha,25-dihydroxyvitamin D3 (1 alpha,25(OH)2D3) from 25-hydroxyvitamin D3 (25(OH)D3). (manchester.ac.uk)
The results of this study show for the first time that immature blood derived monocyte-macrophage cells can synthesize 24,25(OH)2D3 before they mature into macrophages able to synthesize 1 alpha,25(OH)2D3. (manchester.ac.uk)

2, 4 It can then reach the kidneys, where it will be further metabolized into the "active" form of vitamin D: 1α,25-dihydroxyvitamin D3 [1α,25(OH)2D3]. (thepaleodiet.com)
The binding of 1α,25(OH)2D3 (either from the kidneys or derived from local production) to the VDR will affect the expression of approximately 2,000 genes and regulate many cellular processes. (thepaleodiet.com)

Participants were divided into quarters based on the sex and season specific distribution of 25-hydroxyvitamin D among subcohorts. (bmj.com)
Methods: Klotho and 25-hydroxyvitamin D [25(OH)D] were measured in 860 participants aged ≥ 55 years in InCHIANTI, a prospective cohort study comprising Italian adults. (nih.gov)
Participants with more MetS features have lower serum 25(OH)D and osteocalcin. (vitamindwiki.com)

Able to provide results in less than 2 hours, labs can run the assays manually or on fully-automated microtiter plate readers. (aacc.org)
It also automates the steps of bacterial DNA extraction, amplification, hybridization, and target detection, allowing clinicians to obtain results in 2 hours. (aacc.org)
RESULTS: In both MS and NMOSD, stimulation of PBMCs with 1,25(OH) 2 D 3 followed by steroid suppressed the proliferation of total lymphocytes and T cells. (breathinglabs.com)

Bischoff-Ferrari et al reviewed evidence from studies that evaluated the thresholds of serum 25(OH)D levels and their relation to bone mineral density (BMD), lower-extremity function, dental health, and the risk of falls, fractures, and colorectal cancer. (medscape.com)
2012 . 25-Hydroxyvitamin D levels and risk of ischemic heart disease, myocardial infarction, and early death: population-based study and meta-analyses of 18 and 17 studies. (nih.gov)
People with magnesium and 25-hydroxyvitamin D 3 deficiencies may be considered at risk for COVID-19 disease. (biochemjournal.com)
Apart from these known risk factors, inadequate vitamin D status as assessed by serum 25-hydroxyvitamin D (25(OH)D) concentration has also been identified as a potential risk factor in the pathogenesis of CRC. (biomedcentral.com)
The risk of MetS was progressively lower along with the increased 25(OH)D concentration, even above 60 ng/mL. (vitamindwiki.com)
As a result, individuals living on this diet are at greater risk of heart attack, stroke, type 2 diabetes and even death 4 , with dietary factors estimated to be associated with a substantial proportion of mortalities 5 . (dsm.com)

It included 244 Kuwaiti pre-school children (age 2 to 5 years) who presented at the outpatient clinic for vitamin D status evaluation, and were recruited after obtaining consents from the parents or care givers. (who.int)

Currently, there are several assays for measuring serum 25(OH)D. Each of them has its strengths and weaknesses. (medscape.com)

Six single nucleotide polymorphisms (SNPs) associated with serum 25(OH)D concentration in genome-wide association studies were identified and genotyped in 3,418 individuals, of whom 929 had type 2 diabetes. (nih.gov)

A series of hydroxylations, the first one at the 25th carbon (C-25) and the second at carbon 1 (C-1), are needed to produce the active form of vitamin D, 1,25(OH) 2 D 3 . (nature.com)

The findings of studies investigating whether or not low serum 25-hydroxyvitamin D [25(OH)D] concentration promotes development of atherosclerosis have been contradictory. (nih.gov)

The model r(2) for each cohort ranged from 0.25 to 0.33. (harvard.edu)

Anatomy19

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