OrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and Processes
ItraconazoleAntifungal AgentsTriazolesAmphotericin BAspergillosisKetoconazoleFluconazoleMycosesDrug Resistance, FungalAzolesCandidaAspergillus fumigatusMicrobial Sensitivity TestsAspergillusOnychomycosisLung Diseases, FungalHistoplasmosisCandidiasisPyrimidinesFlucytosineDrug Resistance, Multiple, FungalDermatomycosesSporotrichosisChromoblastomycosisMeningitis, FungalDrug InteractionsFungiCandidiasis, OralAspergillosis, Allergic BronchopulmonaryEchinocandinsClotrimazoleSporothrixBlastomycosisAdministration, OralCandida albicansCryptococcus neoformansNaphthalenesCandidiasis, VulvovaginalTerfenadinePseudallescheriaPaecilomycesFoot DermatosesDrug IncompatibilityCapsulesStomatitis, DentureErgosterolFungemiaGonadal DisordersAbsidiaPenicillium14-alpha Demethylase InhibitorsAIDS-Related Opportunistic InfectionsMiconazoleGriseofulvinMycological Typing TechniquesMycetomaMadurellaDermatitis, SeborrheicOpportunistic InfectionsSterol 14-DemethylaseMalasseziaHistoplasmaTrichophytonPharmaceutical SolutionsBlastomycesExophialaCryptococcosisHematologic NeoplasmsZygomycosis
Sporanox2017FluconazolePosaconazoleAntifungal medicationSystemicCapsulesFormulationAzolesColorectal cancerPharmacokineticsMiceAmphotericinFexofenadineSporotrichosisCitationRifampinHedgehogInhibitorsAntacidDormancyAntiviralTacrolimusPatientsAbsorptionTumorTreatmentAssaysPatientLungOral solutionTrialDailyStudyFull-yearFound
Sporanox3
20171
  • Cash, cash equivalents and marketable securities as of September 30, 2018 were approximately $3.1 billion, an increase of approximately $1.0 billion compared to $2.1 billion as of December 31, 2017. (biospace.com)
Fluconazole4
  • Itraconazole has a broader spectrum of activity than fluconazole (but not as broad as voriconazole or posaconazole). (wikipedia.org)
  • citation needed] Itraconazole is a relatively well-tolerated drug (although not as well tolerated as fluconazole or voriconazole) and the range of adverse effects it produces is similar to the other azole antifungals: elevated alanine aminotransferase levels are found in 4% of people taking itraconazole "small but real risk" of developing congestive heart failure liver failure, sometimes fatal The cyclodextrin used to make the syrup preparation can cause diarrhea. (wikipedia.org)
  • Short report: the absorption of fluconazole and itraconazole under conditions of low intragastric acidity. (webmd.com)
  • Although an optimal regimen has not yet been established for the treatment of recurrent vulvovaginal candidiasis, therapies include ketoconazole (400 mg/day), itraconazole (50-100 mg/day), fluconazole (100 mg/wk) for 6 weeks, and clotrimazole (500-mg vaginal suppositories once per wk). (medscape.com)
Posaconazole1
  • Rhoden E, Nix WA, Weldon WC, Selvarangan R. Antifungal azoles itraconazole and posaconazole exhibit potent in vitro antiviral activity against clinical isolates of parechovirus A3 (Picornaviridae). (childrensmercy.org)
Antifungal medication1
  • Itraconazole, sometimes abbreviated ITZ, is an antifungal medication used to treat a number of fungal infections. (wikipedia.org)
Systemic2
  • Tolsura is a new formulation of itraconazole indicated for the treatment of certain systemic fungal infections in adult patients. (med-chemist.com)
  • Systemic exposure (area under the plasma concentration-time curve) to single-dose apalutamide increased 68% with gemfibrozil but was relatively unchanged with itraconazole (study A). Apalutamide reduced systemic exposure to midazolam ↓92%, omeprazole ↓85%, S-warfarin ↓46%, fexofenadine ↓30%, rosuvastatin ↓41%, and pioglitazone ↓18% (study B). After a single dose, apalutamide is predominantly metabolized by CYP2C8, and less by CYP3A4. (springer.com)
Capsules6
  • Itraconazole is produced as blue 22 mm (0.87 in) capsules with tiny 1.5 mm (0.059 in) blue pellets inside. (wikipedia.org)
  • citation needed] The three-layer structure of these blue capsules is complex because itraconazole is insoluble and is sensitive to pH. (wikipedia.org)
  • Itraconazole oral solution should be taken an hour before food, or two hours after food (and likewise if a combination of capsules and oral solution are used). (wikipedia.org)
  • Mayne Pharma Group Limited (ASX: MYX) announced, that the US Food and Drug Administration (FDA) has approved the New Drug Application (NDA) for Tolsura™ (SUBA®-itraconazole) 65mg capsules. (med-chemist.com)
  • We believe physicians will appreciate having access to Tolsura, which has been shown in clinical studies to have increased bioavailability and significantly reduced variability when compared to conventional oral itraconazole capsules. (med-chemist.com)
  • A patient-specific, clinically significant reason why itraconazole 100mg oral capsules cannot be used in place of Onmel® 200mg tablets. (oklahoma.gov)
Formulation2
  • Mayne Pharma's CEO, Mr Scott Richards said, "We are very pleased to have received FDA approval of this patented formulation of itraconazole which incorporates Mayne Pharma's proprietary SUBA technology to improve the bioavailability of poorly soluble drugs. (med-chemist.com)
  • 2018. Recent Advances in Formulation Strategies for Vitamin D. AAPS PharmSciTech. (vitamindwiki.com)
Azoles1
Colorectal cancer2
  • Itraconazole perturbs colorectal cancer dormancy through SUFU-mediated WNT inhibition. (ox.ac.uk)
  • Itraconazole targets cell cycle heterogeneity in colorectal cancer. (ox.ac.uk)
Pharmacokinetics2
  • 5.Jaruratanasirikul S, Sriwiriyajan S. Effect of omeprazole on the pharmacokinetics of itraconazole. (webmd.com)
  • Shimizu M, Uno T, Sugawara K, Tateishi T. Effects of single and multiple doses of itraconazole on the pharmacokinetics of fexofenadine, a substrate of P-glycoprotein. (springer.com)
Mice1
  • Researchers at the Cancer Research UK Cambridge Institute have shown in laboratory studies in mice that itraconazole effectively halts the growth and progression of certain types of bowel cancer. (manufacturingchemist.com)
Amphotericin1
  • In general, mild to moderate disease is typically treated with oral itraconazole-except in pregnant women and those with CNS disease, all of whom should always receive amphotericin B. Patients with moderately severe to severe disseminated disease should receive amphotericin B followed by a long-term oral azole when they clinically improve. (medscape.com)
Fexofenadine1
Sporotrichosis2
Citation1
  • citation needed] In the past decade, itraconazole has been explored as an anticancer agent for patients with basal cell carcinoma, non-small cell lung cancer, and prostate cancer. (wikipedia.org)
Rifampin1
Hedgehog4
  • Recent research works suggest itraconazole (ITZ) could also be used in the treatment of cancer by inhibiting the hedgehog pathway in a similar way to sonidegib. (wikipedia.org)
  • Organoid drug screening identified itraconazole perturbs dormancy through non-canonical hedgehog signalling effects on the WNT pathway. (ox.ac.uk)
  • Human CRC cell dormancy and tumor growth can also be perturbed by itraconazole, which is found to inhibit Wnt signaling through noncanonical hedgehog signaling. (ox.ac.uk)
  • Recently, two separate high-throughput screens (HTS) identified itraconazole (ITZ), a well-known antifungal agent, as both an inhibitor of the hedgehog (Hh) pathway and angiogenesis (IC 50 = 690 nM and 160 nM, respectively). (uconn.edu)
Inhibitors1
  • Study A randomized 45 healthy men to single-dose apalutamide 240 mg alone or with strong inhibitors of cytochrome P450 (CYP)3A4 (itraconazole) or CYP2C8 (gemfibrozil). (springer.com)
Antacid2
  • Absorption of itraconazole is impaired when taken with an antacid, H2 blocker or proton pump inhibitor. (wikipedia.org)
  • 15.Lohitnavy M, Lohitnavy O, Thangkeattiyanon O, Srichai W. Reduced oral itraconazole bioavailability by antacid suspension. (webmd.com)
Dormancy1
  • Mouse organoid drug screening identifies that itraconazole generates spheroid collapse and loss of dormancy. (ox.ac.uk)
Antiviral1
Tacrolimus2
Patients1
Absorption1
  • Itraconazole may be taken with orange juice or cola, as absorption is also improved by acid. (wikipedia.org)
Tumor1
  • For example, in a phase II study involving men with advanced prostate cancer, high-dose itraconazole (600 mg/day) was associated with significant PSA responses and a delay in tumor progression. (wikipedia.org)
Treatment2
  • In January 2018, an otherwise healthy 22-year-old man came to an established otorhinolaryngology practice with therapy-refractory otitis externa in both ears that had persisted for almost 4 years despite antimicrobial drug treatment. (cdc.gov)
  • In addition, we started itraconazole treatment 100 mg twice daily for 6 months, which led to rapid clinical improvement without relapse. (medihelp.life)
Assays2
  • Preclinical validation shows itraconazole to be effective in multiple assays through Wnt inhibition, causing both cycling and dormant cells to switch to global senescence. (ox.ac.uk)
  • Furthermore, in these assays, we have shown CE and itraconazole (a P450 inhibitor) can act synergistically to further improve potency. (rcsb.org)
Patient1
Lung1
  • Itraconazole also showed activity in a phase II trial in men with non-small cell lung cancer when it was combined with the chemotherapy agent, pemetrexed. (wikipedia.org)
Oral solution1
  • 6.Johnson MD, Hamilton CD, Drew RH, Sanders LL, Pennick GJ, Perfect JR. A randomized comparative study to determine the effect of omeprazole on the peak serum concentration of itraconazole oral solution. (webmd.com)
Trial2
  • Phase I/II trial assessing hydroxychloroquine and itraconazole in women with advanced platinum-resistant epithelial ovarian cancer (EOC)(HYDRA-01). (google.ca)
  • These data provide preclinical evidence to support an early phase trial of itraconazole in CRC. (ox.ac.uk)
Daily1
Study1
  • Haryana and on Mathura Road in New Delhi 5 billion in October 2018,' to maximise effective bladder deficit bears no structural relationship arthralgia is more common and degenerated discs of 11 high tibial osteotomy comprised the study group received intraarticular. (beltstl.com)
Full-year1
  • Vertex also reiterated its guidance for full-year 2018 total CF product revenues and guidance for combined GAAP and non-GAAP R&D and SG&A expenses. (biospace.com)
Found1
  • They found, for the first time that itraconazole blocked signals from a pathway called Wnt, which is implicated in the growth and spread of many different cancers. (manufacturingchemist.com)