Mammalian PLD1 has several domains for activators, inhibitors, and catalysis, which it shares with PLD2. (wikipedia.org)
Interestingly, DAG to which PKD1 is recruited in this pathway is formed downstream of phospholipase D1 (PLD1) and a lipase-inactive PLD1 or inhibition of PLD1 by pharmacological inhibitors blocked PKD1 activation under oxidative stress. (biologists.com)
Lipid1
Using tobacco pollen tubes as a model, we addressed the signaling effects of PA by probing the functions of three most relevant enzymes that regulate the production and degradation of PA, namely, phospholipases D (PLD), diacylglycerol kinases (DGKs), and lipid phosphate phosphatases (LPPs). (frontiersin.org)
Pathway1
Although the mechanisms of gene activation are still unclear, ceramide's role as a messenger of cytotoxic response to chemotherapy might be linked to the MDR pathway. (sphingolipidclub.com)
Humans1
Phospholipase D1 (PLD1) is an enzyme that in humans is encoded by the PLD1 gene, though analogues are found in plants, fungi, prokaryotes, and even viruses. (wikipedia.org)
Mechanisms1
Significant efforts have gone into understanding the mechanisms underlying the genes tied to FAD as the clinicopathological features are indistinguishable from regular onset AD. (biomedcentral.com)
Role3
One experiment with PLD1 knockout showed a significant reduction in the number of exocytotic fusion events, implying a strong role in exocytosis. (wikipedia.org)
PLD1 may play a role in some cells in the endocytosis of signaling receptors or exocytosis of signaling molecules. (wikipedia.org)
However, our data describe a role for PLD1-induced DAG as a competent second messenger at the mitochondria that relays ROS to PKD1-mediated mitochondria-to-nucleus signaling. (biologists.com)
Function1
To date it has been viewed that monosaturated and saturated DAG formed via PLD1 have no signaling function. (biologists.com)
Expression3
In silico transcriptomic survey revealed increased levels of expression of all three PA-regulatory genes in pollen development (particularly the DGKs). (frontiersin.org)
In the present study we examined the relationship between ceramide, ceramide metabolites and expression of the MDR1 gene in human breast cancer cell lines. (sphingolipidclub.com)
The impact of sphingolipids on MDR1 gene expression in cancer appears to reflect the myriad intracellular signaling pathways of ceramide and its metabolites. (sphingolipidclub.com)
Cell2
PLD was first cloned from HeLa cell cDNA in 1995, while mammalian PLD1 was first cloned from a rat in 1997. (wikipedia.org)
For example, one experiment in B cells showed that limiting PLD1 led to significantly reduced endocytosis of the B cell receptor. (wikipedia.org)
Cytosolic1
10. Rat pancreatic acinar cells express a cytosolic phospholipase D1b isoform that is not regulated by cholecystokinin. (nih.gov)
Selective2
Calphostin-c, an inhibitor VU-0359595: 1,700-fold selective versus phospholipase D2, IC50 = 3.7nM. (wikipedia.org)
2. Autoregulation of phospholipase D activity is coupled to selective induction of phospholipase D1 expression to promote invasion of breast cancer cells. (nih.gov)
Experiment3
One experiment with PLD1 knockout showed a significant reduction in the number of exocytotic fusion events, implying a strong role in exocytosis. (wikipedia.org)
For example, one experiment in B cells showed that limiting PLD1 led to significantly reduced endocytosis of the B cell receptor. (wikipedia.org)
Another experiment showed that knocking out PLD1 may hinder the ability of mice to secrete catecholamines, molecules that are essential for vesicular communication across the body. (wikipedia.org)
Human2
12. The progesterone receptor as a transcription factor regulates phospholipase D1 expression through independent activation of protein kinase A and Ras during 8-Br-cAMP-induced decidualization in human endometrial stromal cells. (nih.gov)
Type II Diabetes: the protein PED/PEA15 is often elevated in type II diabetic patients, thus enhancing PLD1 activity, and in turn impairing insulin. (wikipedia.org)
6. Phosphorylation-dependent regulation of phospholipase D2 by protein kinase C delta in rat Pheochromocytoma PC12 cells. (nih.gov)
8. Participation of phospholipase D and alpha/beta-protein kinase C in growth factor-induced signalling in C3H10T1/2 fibroblasts. (nih.gov)
14. Phosphorylation and activation of phospholipase D1 by protein kinase C in vivo: determination of multiple phosphorylation sites. (nih.gov)
with Pubmed ID, gene symbol/accession number and parasite interacting protein. (polygenicpathways.co.uk)
Patients1
Mutation analysis of the RSK2 gene in Coffin-Lowry patients: extensive allelic heterogeneity and a high rate of de novo mutations. (nih.gov)