2002 gene expression profiling. Medical search. Frequent questions

In this study, we tried to identify differentially expressed genes between largest (F1) and second-largest follicles (F2), and classify them by global gene expression profiling using a combination of microarray and quantitative real-time PCR (QPCR) analysis. (biomedcentral.com)
Five genes that were differentially expressed between invasive and either benign or normal tissues were validated by real time PCR in an independent panel of 46 serous tumors (4 benign, 7 LMP, 35 invasive). (biomedcentral.com)
Differentially expressed genes in the left atria of mitral regurgitation (MR) pigs have been linked to peroxisome proliferator-activated receptor (PPAR) signaling pathway in the KEGG pathway. (biomedcentral.com)
Gene expression profiling analysis through PCR assay identified 23 genes to be differentially expressed in the left atria of MR patients compared to normal controls. (biomedcentral.com)
Differentially expressed genes of the PPAR pathway have been identified in the left atria of MR patients compared with patients with aortic valve disease and normal controls. (biomedcentral.com)
Interestingly, gene ontology and pathway enrichment analysis of the differentially expressed genes in that study showed that peroxisome proliferator-activated receptor (PPAR) signaling pathway was identified in the KEGG pathway. (biomedcentral.com)
In this study, we aim to explore the key element genes of the PPAR signaling pathway that were differentially expressed in the left atrial myocardium of MR patients vs. normal controls. (biomedcentral.com)
The peroxisome proliferator- activated receptor gamma coactivator 1-alpha ( Ppargc1a ) gene was found to be involved in the networks generated using Ingenuity Pathway Studio (IPA) from the differentially expressed transcript cluster lists of week 2 versus 1, week 3 versus 2, week 6 versus 3, and week 8 versus 6. (molvis.org)

The purpose of this study was to develop a robust, standardized method for comparative expression profiling and molecular characterization of Leishmania donovani clinical isolates. (cambridge.org)
Intracellular amastigote protocols need further refinement, but we describe a first generation tool for high-throughput comparative molecular characterization of patients' isolates, based on the changing expression profiles of promastigotes during in vitro differentiation. (cambridge.org)
Gene expression profiling is a technique used in molecular biology to query the expression of thousands of genes simultaneously. (wikipedia.org)
The unique pattern of gene expression for a given cell or tissue is referred to as its molecular signature. (wikipedia.org)
BCR/ABL + gene expression pattern was more heterogeneous and was most similar to ALL without known molecular rearrangements. (aacrjournals.org)
We also identified a set of 83 genes that were highly expressed in leukemia blasts from patients without known molecular abnormalities who subsequently relapsed following therapy. (aacrjournals.org)
Supervised analysis of kinase genes revealed a high-level FLT3 expression in a subset of cases without molecular rearrangements. (aacrjournals.org)
Genomic profiling also identifies genes associated with poor outcome in cases without molecular aberrations and specific genes that may be new therapeutic targets in adult ALL. (aacrjournals.org)
Here we report molecular profiling of 230 resected lung adenocarcinomas using messenger RNA, microRNA and DNA sequencing integrated with copy number, methylation and proteomic analyses. (nature.com)
In order to clarify the molecular relationships among the spectrum of serous ovarian tumors, we compared gene expression profiles of 7 LMP and 28 invasive (moderate and poorly differentiated or Grade 2 and Grade 3) serous ovarian tumors with two different reference groups: 7 serous benign ovarian tumors and four normal whole ovary specimens. (biomedcentral.com)
The differences in the gene expression profiles reflect important aspects of biological variation within the clinically diagnosed arthritides that may help to understand the molecular pathology of and (sub-)classify rheumatic diseases. (biomedcentral.com)
we hypothesized that profiles of airway fluid cytokines that represent major effectors molecules of leukocytic inflammation could provide insights for developing a new molecular-based classification of asthma. (cdc.gov)
Molecular Screening of Nasopharyngeal Carcinoma: Detection of LMP-1, LMP-2 Gene Expression in Vietnamese Nasopharyngeal Swab Samples. (cdc.gov)

Bortoluzzi S, Alessi FD, Romualdi C, Danieli GA: The human adult skeletal muscle transcriptional profile reconstructed by a novel computational approach. (karger.com)
Microarray technology is a popular means of producing whole genome transcriptional profiles, however high cost and scarcity of mRNA has led many studies to be conducted based on the analysis of single samples. (biomedcentral.com)
Transcriptional analysis of a novel cluster of LY-6 family members in the human and mouse major histocompatibility complex: five genes with many splice forms. (nih.gov)

Techniques include DNA microarray technology or sequenced-based techniques such as serial analysis of gene expression (SAGE). (wikipedia.org)
In situ protein expression for NAPPA is typically carried out on flat microscope slides by flooding the entire microarray surface with IVTT reagent. (nature.com)
We take a look at the use of DNA microarray for gene expression or expression profiling and how DNA chips are used for drug discovery and development as a whole. (ddw-online.com)
DNA microarray technology has rapidly seduced scientists and clinicians with the ability to simultaneously measure the expression of tens of thousands of transcripts, enabling data-driven, holistic comparisons of groups or populations of cells, subtyping tissues, or predicting prognosis [ 1 , 2 ]. (biomedcentral.com)
A potentially powerful way to gain insight in the complex pathogenesis of rheumatoid arthritis (RA) and to classify arthritides has arisen from cDNA microarray technology, which provides the opportunity to determine differences in gene expression of a large portion of the genome in search of genes that are differently expressed between clinically diagnosed arthritides. (biomedcentral.com)
We produced a custom-made, 3-dimensional microarray system (3DMS), using previously identified ERGs, and analyzed expression of ERGs on breast cancer tissues. (iiarjournals.org)

He then joined Chinese Human Genome Centre at Shanghai (CHGCS) as a research fellow working on gene expression profiling of gastric cancer and hepatocellular carcinoma using patient samples (PNAS 2001, World J Gastroenterol. (ed.ac.uk)

Expression-profile analysis in Schwann cells identifies genes involved in myelination. (the-scientist.com)

Hypothalamic expression of huntingtin causes distinct metabolic changes in Huntington's disease mice. (lu.se)

This method was used to measure the number of copies of repeated genes such as rRNA genes (2) and to measure whether specific genes were under-replicated during the replication process used in forming polytene chromosomes (3). (ddw-online.com)
Expression of stage-specific genes in follicles may be closely associated with their growth or atresia. (biomedcentral.com)
However, specific genes of the PPAR signaling pathway in the left atria of MR patients have never been explored. (biomedcentral.com)
We used PCR assay (84 genes) for PPAR pathway and quantitative RT-PCR to study specific genes of the PPAR pathway in the left atria. (biomedcentral.com)
The results from this study may identify specific genes of the PPAR signaling pathway that might be responsible for the atrial structural remodeling associated with atrial enlargement and progression of heart failure in patients with MR. (biomedcentral.com)

Gene expression profiling is increasingly used in the field of infectious diseases for characterization of host, pathogen and the nature of their interaction. (cambridge.org)
These Unigenes represent a wide range of genes classified according to their characterization and function. (karger.com)
Stochastic models of gene transcription with upstream drives: exact solution and sample path characterization. (crossref.org)
Characterization of novel Bruton's tyrosine kinase gene mutations in Central European patients with agammaglobulinemia. (lu.se)

Disabling demyelinating neuropathies are associated with mutations in genes associated with regulating the process of myelination. (the-scientist.com)

Overall, our analyses provide novel opportunities for the normalisation of genome-wide expression profiling data. (biorxiv.org)

controlled for UV-induced mutational load by comparing mutated genes-of-interest against a baseline level of intronic mutation. (frontiersin.org)
Positional cloning of lymphopenia ( lyp ) in the BB rat revealed a frameshift mutation in Gimap5 , a member of at least seven related GTPase Immune Associated Protein genes located on rat chromosome 4q24. (hindawi.com)
Our data substantiates the Gimap5 frameshift mutation as the primary defect with only limited contributions to lymphopenia from the remaining Gimap genes. (hindawi.com)
Positional cloning of the lyp gene revealed a frame shift mutation in Gimap5 (previously known as Ian5 or Ian4L1 ). (hindawi.com)
Gimap5 was identified as the lyp gene in the BBDP rat through a frameshift mutation and premature truncation of the Gimap5 protein [ 2 , 6 ] and can be rescued in a P1-derived artificial chromosome (PAC) transgenic rat [ 7 ]. (hindawi.com)
This system has already been used successfully in several studies for gene expression and mutation analysis ( 8 , 9 ). (iiarjournals.org)
HD is a devastating disorder always caused by an expanded CAG triplet repeat mutation in the huntingtin gene. (lu.se)
Mutation of the BTK gene and clinical feature of X-linked agammaglobulinemia in mainland China. (lu.se)
De novo mutation in the BTK gene of atypical X-linked agammaglobulinemia in a patient with recurrent pyoderma. (lu.se)

Because of these selective properties, the majority of cells within a tumor will share a common profile of gene expression. (wikipedia.org)
DNA labeled with fluorophores (target) is prepared from a sample such as a tumor biopsy and is hybridized to the complementary DNA (cDNA) sequences on the gene chip. (wikipedia.org)
Of note, similar gene expression patterns associated with metastatic behaviour of breast cancer tumor cells have also been found in breast cancer of dog, the most common tumor of the female dog. (wikipedia.org)
Assessment of F-MuLV-induced tumorigenesis reveals new candidate tumor genes including Pecam1, St7, and Prim2. (rochester.edu)
The study identified 2 genes known to contribute to tumor progression and 8 known to be present in tumor cells but which have unknown functions. (frontiersin.org)
To identify genes associated with neoplastic progression in the serous subtype of ovarian tumors, we compared gene expression in tissues that exhibited the spectrum of tumor behavior, namely benign, low malignant potential (LMP) and invasive. (biomedcentral.com)
In some cases, ERG expressions were low even though the tumor was ER positive. (iiarjournals.org)
Because the expression of the estrogen receptor (ER) in patients with primary breast cancer is one of the most powerful indicators of response to adjuvant hormonal therapy, the effects of endocrine-therapeutic agents strongly depend on whether tumor cell growth remains estrogen responsive ( 3 ). (iiarjournals.org)
Expression Profiling of Circulating Tumor Cells in Pancreatic Ductal Adenocarcinoma Patients: Biomarkers Predicting Overall Survival. (cdc.gov)

These data revealed biological pathways and novel genes involved in disease. (biomedcentral.com)
The aim of this study was to identify the genes and pathways underlying the growth of the mouse sclera during postnatal development. (molvis.org)

Although analyses that give information on the expression of a few genes provide insight and have been responsible for a large proportion of the bacterial pathogenesis literature currently available, our ultimate goal is to understand expression changes across the whole genome. (cdc.gov)
The additional information generated by whole genome studies goes far beyond that derived by characterizing in isolation more genes and gene products, because analysis of the whole genome allows complete regulatory networks to be identified and characterized. (cdc.gov)
While whole exome sequencing (WES) remains popular and effective as a method of genetically profiling different cancers, advances in sequencing technology has enabled an increasing number of whole-genome based studies. (frontiersin.org)
Analysis of gene expression can include measuring expression levels of a small set of genes to whole genome expression monitoring. (ddw-online.com)

We analyse two comprehensive transcriptome datasets from human tissues and human-derived cell lines in terms of the expression profiles of the SLC and ABC families of membrane transporters. (biorxiv.org)
In today's research laboratory, two common ways that gene expression is assessed is by using quantitative polymerase chain reaction techniques (QTPCR) for monitoring expression of smaller numbers of genes, and by employing DNA microarrays for the highly parallel monitoring of thousands of genes (or the whole transcriptome). (ddw-online.com)
Smart-seq2 for sensitive full-length transcriptome profiling in single cells. (crossref.org)

However, we now have a number of methods that allow identification of genes critical for survival in a host as well as methods that allow direct measurement of gene expression during interaction with a host. (cdc.gov)

Proteins can also be expressed outside of living cells by subjecting gene DNA to 'cell-free' in vitro coupled transcription and translation (IVTT) reagent. (nature.com)
Bortoluzzi S, Alessi FD, Romualdi C, Danieli GA: Differential expression of genes coding for ribosomal proteins in different human tissues. (karger.com)
The fact that the Gimap genes are located together in a tight cluster on RNO4 (and in conserved synteny with many other species), combined with their sequence similarities, suggests the possibility that the proteins carry out similar function. (hindawi.com)
The expression pattern of these proteins in BMSC has not been well characterized. (sld.cu)
Comparative gene expression profiling of in vitro differentiated megakaryocytes and erythroblasts identifies novel activatory and inhibitory platelet membrane proteins. (nih.gov)
The association between caries experience/activity and the electrophoretic profiles of salivary proteins lactoferrin and lysozyme was evaluated. (bvsalud.org)

Two of these methods, signature-tagged mutagenesis and in vivo expression technology, do not directly measure gene expression and do not allow true genomic-scale analysis, but they have been devised to identify genes necessary for pathogens during real infections. (cdc.gov)
A second group of methods, which includes DNA microarrays and proteomics, have advantages that overcome the limitations implicit in signature-tagged mutagenesis and in vivo expression technology, namely, the ability to directly measure expression (gene or protein) levels on a true genome-wide scale, but their application to analysis of bacterial pathogens during real infections is still in its infancy. (cdc.gov)

Ileal mucosa in asthma exhibits a specific transcriptomic profile, which includes the overexpression of innate immune genes, mostly characteristic of Paneth and goblet cells, in addition to other changes that may resemble Crohn's disease. (biomedcentral.com)
Comprehensive transcriptomic profiling identifies breast cancer patients who may be spared adjuvant systemic therapy. (cdc.gov)

The level of fluorescence at a particular spot provides quantitative information about the expression of the particular gene corresponding to the spotted cDNA sequence. (wikipedia.org)
Our aim was to clone and sequence the cDNA of the BB diabetes prone (DP) and diabetes resistant (DR) alleles of all seven Gimap genes in the congenic DR. lyp rat line with 2 Mb of BB DP DNA introgressed onto the DR genetic background. (hindawi.com)
The resulting cDNA was fragmented, labeled with biotin, and hybridized to a Mouse Gene 1.0 ST Array. (molvis.org)

Previous data has reported similarity between human brain and testis gene expression patterns. (karger.com)
Hence, it means that human testis could also play a crucial role in human speciation if these two tissues exhibit similar gene expression patterns. (karger.com)
Determining the large scale anatomy of gene expression patterns of various human tissues could draw a more convincing conclusion, and better our understanding of the correlation/inter-correlation among different tissues. (karger.com)
Among the 17 tissues, the highest similarity in gene expression patterns was between human brain and testis, based on DDD and clustering analysis. (karger.com)
Present results provide evidence to support the proposal that human testis and brain share the highest similarity of gene expression patterns. (karger.com)
Given the uncertainty about the relationship between these different forms, we compared their patterns of gene expression. (biomedcentral.com)
To enhance risk assessments, expression patterns need to have demonstrated comparability across species for extrapolation purposes and be robust at different doses for dose-response predictions. (cdc.gov)

Activated ER binds to estrogen-responsive elements (EREs), which are located in the promoter regions of various target genes. (iiarjournals.org)
NF-κB activation by fluid flow, leading to expression of target genes such as E-selectin, ICAM-1, and VCAM-1, may regulate early monocyte recruitment and fatty streak formation. (rupress.org)

Additional mechanisms include generating reactive oxygen species and altering gene expression (ATSDR, 2007). (cdc.gov)

On the biological level, we demonstrate that gene expression levels fluctuate during in vitro development of both intracellular amastigotes and promastigotes. (cambridge.org)

The limitations and possibilities associated with expression profiling in intracellular amastigotes and promastigotes were assessed through a series of comparative experiments in which technical and biological parameters were scrutinized. (cambridge.org)

The sequence analysis of the 32-35,000 predicted genes indicates the there may be as many as 1,000 kinase or kinase-like genes. (ddw-online.com)

They showed that DF up-regulates genes regulating E 2 synthesis, anti-apoptosis, cell proliferation and gene transcription. (biomedcentral.com)

vated mRNA expression. (lu.se)
secretion or mRNA expression. (cdc.gov)

A Value of Information Analysis of Research on the 21-Gene Assay for Breast Cancer Management. (cdc.gov)

These results highlight several genes that may play an important role across the spectrum of serous ovarian tumorigenesis. (biomedcentral.com)

We chose to use expression-curves rather than single, specific, time-point measurements to capture this biological variation. (cambridge.org)

Attenuated huntingtin gene CAG nucleotide repeat size in individuals with Lynch syndrome. (lu.se)

Eighteen genes were statistically significantly mutated, including RIT1 activating mutations and newly described loss-of-function MGA mutations which are mutually exclusive with focal MYC amplification. (nature.com)
In particular, with some exceptions such as olfactory receptors and genes involved in keratin production, transporter genes are significantly more heterogeneously expressed than are most non-transporter genes. (biorxiv.org)
these often differ significantly from the 'housekeeping' genes commonly used for normalisation in transcriptomics and qPCR studies. (biorxiv.org)
6 ], the transforming growth factor beta 1 ( Tgfβ1 ) gene and several collagen genes were significantly downregulated in 8-week-old B6 mice scleras when compared with 3-week-old B6 mice scleras. (molvis.org)

Global gene expression profiles of F1 (10.7 +/- 0.7 mm) and F2 (7.8 +/- 0.2 mm) were analyzed by hierarchical cluster analysis and expression profiles of 16 representative genes were confirmed by QPCR analysis. (biomedcentral.com)
LY6G5C belongs to a cluster of leukocyte antigen-6 (LY6) genes located in the major histocompatibility complex (MHC) class III region on chromosome 6. (nih.gov)
Hierarchical cluster analysis revealed a remarkably ordered variation in gene expression profiles in the affected joint tissues of patients with RA and OA. (biomedcentral.com)

Gene expression profiling of ErbB receptor and ligand-dependent transcription. (rochester.edu)
It is well documented that increased expression of LH receptor (LHR) in granulosa cells (GC) and specific changes of intrafollicular factors such as the insulin-like growth factor (IGF) and inhibin-activin-follistatin systems play a critical role in E 2 production in the DF [ 6 , 7 ]. (biomedcentral.com)
Bexarotene (Bxt) is a retinoid-X receptor agonist used in the treatment of cutaneous lymphoma with a favorable safety profile whose effects have been recently investigated in other neurodegenerative diseases. (frontiersin.org)
As an agonist of the retinoic-X receptor (RXR) pathway, Bxt notably increased the nuclear expression of the RXRα throughout transcriptionally active euchromatin domains. (frontiersin.org)

Their analysis led to the identification of myelination-associated genes involved in lipid synthesis. (the-scientist.com)

Repression of Pumilio Protein Expression by Rbfox1 Promotes Germ Cell Differentiation. (tcd.ie)
The PPARs are ligand activated transcription factors that regulate genes important in cell differentiation, various metabolic processes, especially lipid and glucose homeostasis, insulin sensitivity, control of inflammatory processes and vascular integrity [ 6 ]. (biomedcentral.com)

The differences in gene expression profiles induced by the two predators suggest that there are functional differences between the altered tail tissues of the two groups of tadpoles. (biomedcentral.com)
The Gini index (coefficient) characterises inequalities of distributions, and is used in a novel way to describe the distribution of the expression of each transporter among the different tissues and cell lines. (biorxiv.org)
Similar trends hold true for the expression profiles of transporters in different cell lines, suggesting that cell lines exhibit largely similar transport behaviour to that of tissues. (biorxiv.org)
PCBP1 is both reasonably highly expressed and has a low Gini coefficient in both tissues and cell lines, and is an excellent novel housekeeping gene. (biorxiv.org)
Central to this investigation is an understanding of what gene products are required and expressed during a natural infection and how this expression changes over time (from initial colonization to causation of disease and spread of the pathogen to new hosts) and space (in different cells or tissues within the host). (cdc.gov)
Therefore, we studied the gene expression profile of synovial tissues from affected joints of patients with diagnosed RA (n = 21) in comparison to those of patients with osteoarthritis (OA) (n = 9), a degenerative joint disease. (biomedcentral.com)
One class revealed abundant expression of gene clusters indicative of the presence and activation of the adaptive immune response, and the other group resembled the expression pattern of the OA tissues, which is characterized by a low inflammatory gene expression signature and increased tissue remodeling. (biomedcentral.com)

These translocations most commonly involve the TFE3 gene on locus Xp11.2 and less commonly involve the TFEB gene on locus 6p21. (medscape.com)

Functional analyses indicated that some of the genes induced by dragonfly larvae caused an increase in laminins necessary for cell adhesion in the extracellular matrix. (biomedcentral.com)

Protein expression in living cells involves untethered intermediate molecules such as mRNA, enzymes, ribosomes, amino acids and polypeptides. (nature.com)
The presence of BDNF and GDNF mRNA was determined by RT-PCR and protein expression was evaluated by Western Blot. (sld.cu)

Current cancer research makes use primarily of DNA microarrays in which an arrayed series of microscopic spots of pre-defined DNA oligonucleotides known as probes are covalently attached to a solid surface such as glass, forming what is known as a gene chip. (wikipedia.org)
Gene expression profiles from 128 adult patients with newly diagnosed ALL were characterized using high-density oligonucleotide microarrays. (aacrjournals.org)
Two of the most common uses of the DNA microarrays are genetic analysis and the analysis of gene expression. (ddw-online.com)
This report will focus in using DNA microarrays for the analysis of gene expression or expression profiling, and how DNA chips are used for drug discovery and development. (ddw-online.com)
Expression profiling was carried out on samples of 7 benign, 7 LMP and 28 invasive (moderate and poorly differentiated) serous tumors and four whole normal ovaries using oligonucleotide microarrays representing over 21,000 genes. (biomedcentral.com)

In the context of cancer, gene expression profiling has been used to more accurately classify tumors. (wikipedia.org)
Presented below are ways that gene expression profiling has been used to more precisely classify tumors into subgroups, often with clinical effect. (wikipedia.org)

Four novel and three recurrent mutations of the BTK gene and pathogenic effects of putative splice mutations. (lu.se)

Because the environment encountered within a living host will be quite different from the external environment, pathogens must be able to regulate the necessary genes in coordination as they move from the environment to the host and from one host niche to another. (cdc.gov)

The higher expression of gremlin 1 and HIF1a genes after exposure to dragonfly larvae indicated an in vivo hypoxic reaction, while down-regulation of syndecan-2 may indicate impairment of angiogenesis. (biomedcentral.com)
Gene Expression Regulation, Developmental" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (jefferson.edu)
This graph shows the total number of publications written about "Gene Expression Regulation, Developmental" by people in this website by year, and whether "Gene Expression Regulation, Developmental" was a major or minor topic of these publications. (jefferson.edu)
Below are the most recent publications written about "Gene Expression Regulation, Developmental" by people in Profiles. (jefferson.edu)

To interpret their results they performed careful anchor gene correlation analysis (AGCA), using the expression of proliferative markers (Ki-67 antigen or PCNA ), inflammatory genes ( MCP -1 or interleukin 6) or myelination genes (such as PMP22 or MAG ), as anchor genes. (the-scientist.com)
Correlation between replicate UHRR samples improved by two orders of magnitude following batch-correction using ComBat (ranging from 0.9833-0.9991 to 0.9997-0.9999) and increased the consistency of the gene-lists from the duplicate clinical samples, from 11.6% in quantile normalised data to 66.4% in batch-corrected data. (biomedcentral.com)

Gene ontology implicated the immune system, including interleukins 4 and 13, as well as antimicrobial peptides in this overexpression. (biomedcentral.com)

While almost all cells in an organism contain the entire genome of the organism, only a small subset of those genes is expressed as messenger RNA (mRNA) at any given time, and their relative expression can be evaluated. (wikipedia.org)

Given that the basic genome of a differentiated organism is constant between cells (and we here ignore epigenomics), what mainly discriminates one cell type from another is its expression profile. (biorxiv.org)
Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism. (jefferson.edu)

We demonstrated that global gene expression profiling of F1 and F2 clearly reflected a difference in their follicular status. (biomedcentral.com)
The ability to group chemical with similar global gene expression profiles has the potential to provide an early earning system for suspect carcinogenic chemicals before they are introduced into commerce. (cdc.gov)

Genes contributing to the similarity include ribosomal protein (RP) genes as well as genes involved in transcription, translation and cell division. (karger.com)
At this time, there is a paucity of information as to the expression of the Gimap genes in specific cell types. (hindawi.com)
Over-expression of WNT7A in an ovarian cancer cell line led to increased migration and invasive capacity. (biomedcentral.com)
Significant differential expression was found in the ileum alone, and not in any other cell/tissue types. (biomedcentral.com)
Translocation carcinoma is a renal cell carcinoma (RCC) subtype that harbors a translocation involving a member of the microphthalmia transcription factor gene family. (medscape.com)

Currently around a million experiments are performed simultaneously for gene expression analysis 2 and around a billion for next generation DNA sequencing 3 . (nature.com)

Development and External Validation of a Novel 12-Gene Signature for Prediction of Overall Survival in Muscle-Invasive Bladder Cancer. (cdc.gov)

Specifically, the identified transcription factors Lrp, ArgP and Crp link transhydrogenase expression to particular amino acids and intracellular concentrations of cAMP. (microbiologyresearch.org)

Genes identified as involved in the main biologic processes during postnatal scleral development were further confirmed using qPCR. (molvis.org)

In a separate study, we showed that transformation of the immortalized urothelial cells with the environmental carcinogen arsenite (As 3+ ) results in an increase in expression of genes associated with the basal subtype of bladder cancer. (oncotarget.com)
The results of our study indicate that there is a decrease in expression of genes associated with keratinization and cornification and this gene signature includes the genes associated with the basal subtype of breast cancer. (oncotarget.com)

Anatomy24

Organisms12

Diseases27

Chemicals and Drugs53

Analytical, Diagnostic and Therapeutic Techniques and Equipment55

Phenomena and Processes82

Disciplines and Occupations6

Technology, Industry, Agriculture2

Information Science10

Health Care10

Differentially expressed8

Molecular13

Transcriptional3

Microarray6

20011

Identifies genes involved1

Changes in Huntington's disease1

Specific genes5

Characterization4

Mutations in genes1

Genome-wide expression1

Mutation9

Tumor9

Pathways2

Whole genome4

Transcriptome3

Identification of genes1

Proteins6

Methods2

Transcriptomic2

CDNA3

Patterns7

Target genes2

Mechanisms1

Vitro1

Comparative1

Kinase1

Proliferation1

MRNA expression2

Assay1

Tumorigenesis1

Biological1

Huntingtin gene1

Significantly4

Cluster3

Receptor4

Synthesis1

Differentiation2

Tissues7

Commonly1

Analyses1

Protein Expression2

Microarrays5

Tumors2

Splice1

Regulate1

Regulation4

Correlation2

Ontology1

Subset1

Organism2

Global gene expression2

Cell5

Simultaneously1

Survival1

Transcription factors1

QPCR1

Subtype2