• Adoptive cell therapy using tumor-infiltrating lymphocytes (TILs) has shown activity in melanoma, but has not been previously evaluated in metastatic non-small cell lung cancer. (nature.com)
  • Kv1.3 Channels Mark Functionally Competent CD8+ Tumor-Infiltrating Lymphocytes in Head and Neck Cancer. (uc.edu)
  • Without mature B lymphocytes, antibody-producing plasma cells are also absent. (medscape.com)
  • The diagnosis is confirmed by abnormally low or absent numbers of mature B lymphocytes, as well as low or absent expression of the µ heavy chain on the surface of the lymphocyte. (medscape.com)
  • PD1 blockade enhances K+ channel activity, Ca2+ signaling, and migratory ability in cytotoxic T lymphocytes of patients with head and neck cancer. (uc.edu)
  • Reliable predictions of Cytotoxic T lymphocyte (CTL) epitopes are essential for rational vaccine design. (biomedcentral.com)
  • γ interferon expression in CD8+ T cells is a marker for circulating cytotoxic T lymphocytes that recognize an HLA A2-restricted epitope of human cytomegalovirus phosphoprotein pp65. (bdbiosciences.com)
  • BTK is necessary for the proliferation and the differentiation of B lymphocytes. (medscape.com)
  • The results were analyzed using a newly developed mathematical model to determine fractional rates of lymphocyte proliferation and death. (qxmd.com)
  • The lymphocyte proliferation and death rates in both CD4(+) and CD8(+) cell populations were substantially reduced by 5-11 weeks and nearly normal by one year. (qxmd.com)
  • These molecular defects interfere with lymphocyte development and function, blocking the differentiation and proliferation of T cells and, in some types, of B cells and NK cells. (medscape.com)
  • In X-linked SCID, loss of IL-2 receptor (IL-2R) function leads to the loss of a lymphocyte proliferation signal. (medscape.com)
  • The aim of our research was to determine how immunotherapy changes the proportion of lymphocyte subsets in dog peripheral blood and the levels of cytokines secreted by these cells during therapy. (mdpi.com)
  • This study was taken up to evaluate the antigenotoxic potential of ginger in human peripheral blood lymphocytes. (scialert.net)
  • In vitro treatment of peripheral blood lymphocytes with TSO induced significant number of micronuclei in all samples. (scialert.net)
  • Clinical studies are also underway to evaluate TIL in earlier stage cancers in combination with currently approved treatments, and to investigate Iovance peripheral blood lymphocyte (PBL) T cell therapy for blood cancers. (biospace.com)
  • The present prospective study, carried out over fifteen years, describes the pattern of natural course of disease progression in a group of ART naive male professional blood donors with asymptomatic HIV-1 infection in relation to serum iron status, viral load, peripheral CD4 + T lymphocyte count, serum levels of cytokines and immune activation markers viz. (scirp.org)
  • and (iii) the dramatic reductions to lymphocyte numbers and function 1-2 h after exercise reflects a transient and time-dependent redistribution of immune cells to peripheral tissues, resulting in a heightened state of immune surveillance and immune regulation, as opposed to immune suppression. (frontiersin.org)
  • In colorectal biopsies and peripheral blood lymphocytes of patients with IBD, polyps and CRC, we evaluated 1) genomic instability using the γH2AX assay as marker of DSB and micronuclei in mononuclear lymphocytes kept under cytodieresis inhibition, and 2) cellular stress through expression and cellular localization of glutathione-S-transferase omega 1 (GSTO1). (oncotarget.com)
  • Cord blood was analyzed using a FACSort flow cytometer to determine proportions of T lymphocytes (CD3 + cells and their subsets, CD4 + and CD8 + ), B lymphocytes (CD19 + ) and natural killer (NK) cells. (biomedcentral.com)
  • CD4+ T-cells and other lymphocyte subsets in persons infected with human immunodeficiency virus (HIV). (cdc.gov)
  • The guidelines describe single-platform technology (SPT), a process in which absolute counts of lymphocyte subsets are measured from a single tube by a single instrument. (cdc.gov)
  • With CD45 gating, the relative numbers of beads and lymphocyte subsets are enumerated, and their absolute numbers and percentage values are calculated. (cdc.gov)
  • The antibodies from lymphocyte secretion (ALS) assay was earlier used to detect specific antibody response after oral vaccination with a killed cholera vaccine in healthy adults without any requirement for in vitro antigen stimulation. (wikipedia.org)
  • Physiologic dsDNA breaks are generated in a variety of normal cellular functions, including the RAG endonuclease-mediated rearrangement of antigen receptor genes during the normal development of lymphocytes. (biomedcentral.com)
  • These breaks are necessary to create the vast diversity seen in lymphocyte antigen receptors. (biomedcentral.com)
  • The BD FastImmune™ CD8 Intracellular Cytokine Detection Kit is designed for the detection of intracellular cytokines and the activation marker CD69 in antigen-activated CD8 + T lymphocytes in whole blood. (bdbiosciences.com)
  • The development of lymphomas in families with autoimmune lymphoproliferative syndrome with germline Fas mutations and defective lymphocyte apoptosis. (cdc.gov)
  • The antibodies from lymphocyte secretions (ALS) assay is an immunological assay to detect active diseases like tuberculosis, cholera, typhoid etc. (wikipedia.org)
  • 2003. Rapid diagnosis of active tuberculosis by detecting antibodies from lymphocyte secretions. (wikipedia.org)
  • B-lymphocytes undergo isotype switching, and IgM, IgG, and IgA antibodies are found in the neuropil adjacent to the lesion. (jneurosci.org)
  • 2 The interaction of IVIG with a large number of components of the immune system including Fc receptors, complement molecules, cytokines, B and T lymphocytes, neutrophils and NK cells, may explain at least in part their anti-inflammatory effects. (academie-medecine.fr)
  • A lymphocyte is a type of white blood cell (leukocyte) in the vertebrate immune system . (newworldencyclopedia.org)
  • The two main types of lymphocytes are T cells and B cells , which function in the adaptive immune system . (newworldencyclopedia.org)
  • Other lymphocyte-like cells are commonly known as natural killer cells, or NK cells, and are part of the innate immune system . (newworldencyclopedia.org)
  • The two main categories of lymphocytes are the B lymphocytes ( B cells ) and T lymphocytes ( T cell ), both of which are involved in the adaptive immune system (Alberts 1989). (newworldencyclopedia.org)
  • In addition, lymphocyte-like cells called natural killer (NK) cells are involved in the immune system, albeit part of the innate immune system . (newworldencyclopedia.org)
  • The adaptive immune system is based on dedicated lymphocytes. (newworldencyclopedia.org)
  • The aim of this study was to investigate whether DAbR1 can be expressed on lymphocytes and used as a reporter gene as well as a suicide gene for therapy of immune-related adverse effects. (snmjournals.org)
  • PAHs and PM 2.5 in ambient air may influence fetal immune development via shifts in cord blood lymphocytes distributions. (biomedcentral.com)
  • Given that lymphocyte production, including T and B cell development, starts early in gestation [ 7 ] and that critical stages in development of the immune system may also reflect temporal variation in susceptibility to immunotoxicants, this study investigated the association between maternal exposure to air pollution during each month of gestation and cord blood lymphocyte proportions. (biomedcentral.com)
  • Tumor infiltrating lymphocyte (TIL) therapy uses a patient's own immune cells to attack cancer. (biospace.com)
  • High serum iron was associated with elevated levels of Th 2 category of cytokines, heightened immune activation, faster decline in CD4 + T lymphocyte count and higher viral set point. (scirp.org)
  • In the absence of similar research, we endeavored to investigate the prognostic usefulness of posttreatment neutrophil-to-lymphocyte ratio (NLR) in patients treated with definitive concurrent chemoradiotherapy (CCRT) for locally advanced pancreatic adenocarcinoma (LAPAC). (hindawi.com)
  • This study aimed to evaluate the prognostic significance of CD3, CD8 and CD20 positive lymphocytes in pancreatic ductal adenocarcinoma. (biomedcentral.com)
  • This study evaluated the prognostic significance of CD3, CD8 and CD20 positive lymphocytes in pancreatic ductal adenocarcinoma. (biomedcentral.com)
  • HIV infection is characterized by a decrease and, eventually, a depletion of CD4+ T-lymphocytes (helper T cells). (cdc.gov)
  • Taken together, these new findings strongly indicate that CD4(+) lymphocyte depletion seen in AIDS is primarily a consequence of increased cellular destruction, not decreased cellular production. (qxmd.com)
  • The data suggest that diabetic mice present impaired immunological response to Pb18 infection and insulin modulates inflammation by reducing IL-6 levels in lung and CINC-1 levels in spleen and liver homogenates, restoring leukocyte concentrations in PeLF and also restoring populations of dendritic cells and B lymphocytes in lungs of diabetic mice, permitting the host to better control the infection. (hindawi.com)
  • Development of a novel in vitro assay (ALS assay) for evaluation of vaccine-induced antibody secretion from circulating mucosal lymphocytes. (wikipedia.org)
  • Expression of (cac)n/(gtg)n simple repetitive sequences in mRNA of human lymphocytes. (nih.gov)
  • Lymphocytes did not change GSTO1 expression and localization until CRC formation, where enzyme expression was increased. (oncotarget.com)
  • A scanning electron microscope (SEM) image of a single human lymphocyte. (newworldencyclopedia.org)
  • 1984. Alloantibodies to PHA-activated lymphocytes detect human Qa-like antigens. . (oregonstate.edu)
  • Single-platform technology (SPT) is designed to enable de- system and managing the health care of persons infected with terminations of both absolute and percentage lymphocyte sub- human immunodeficiency virus (HIV) ( 1-4 ). (cdc.gov)
  • We discovered that, in mouse models, activated B-lymphocytes infiltrate infarcted tissue in the weeks after stroke. (jneurosci.org)
  • T. Twellmann, T.W. Nattkemper, W. Schubert, H. Ritter, Cell detection in micrographs of tissue sections using support vector machines, in: Proceedings of the ICANN: workshop on Kernel & Subspace Methods for Computer Vision, Vienna, Austria, 2001, pp. 79–88. (crossref.org)
  • While it is known that genotoxic agents, such as IR, activate transcriptional programs involved in maintaining the integrity of the genome, we also want to investigate whether or not the genotoxic breaks could affect lymphocyte-specific maturation transcriptional responses similar to those we observed following RAG-induced physiological DSBs. (biomedcentral.com)
  • HIV-1-specific mucosol CD8+ lymphocyte responses in the cervix of HIV-1-resistant prostitues in Nairobi. (bdbiosciences.com)
  • 2001. Potent antimutagenic activity of white tea in comparison with green tea in the Salmonella assay. . (oregonstate.edu)
  • Micronuclei frequency began to rise in lymphocytes of subjects with polyps, suggesting a systemic genomic instability condition. (oncotarget.com)
  • Increase of bone marrow lymphocytes in systemic mastocytosis: reactive lymphocytosis or malignant lymphoma? (bmj.com)
  • To clarify the nature (reactive or neoplastic) of lesional, perifocally aggregated lymphocytes in bone marrow infiltrates of systemic mastocytosis (SM), the histopathology of which can resemble malignant lymphoma with focal bone marrow involvement, particularly low grade malignant B cell lymphoma of lymphoplasmacytic immunocytoma subtype, which frequently exhibits increased mast cell (MC) numbers. (bmj.com)
  • Targeted knockdown of Kv1.3 channels in T lymphocytes corrects the disease manifestations associated with systemic lupus erythematosus. (uc.edu)
  • Using immunophenotyping, HIV-positive blood samples and age-matched controls were tested for the proportion of lymphocytes that are T cells, B cells, natural killer (NK) cells, CD4+ T cells (helper T cells), and CD8+ T cells (suppressor/inducer T cells). (cdc.gov)
  • The NK cells are sometimes labeled "large granular lymphocytes," while the T cells and B cells are labeled as "small lymphocytes. (newworldencyclopedia.org)
  • While offering protection against millions of possible invaders, including viruses , bacteria , are cancer cells, lymphocytes allow normal body cells and helpful, symbiotic bacteria to flourish at the same time. (newworldencyclopedia.org)
  • A stained lymphocyte surrounded by red blood cells viewed using a light microscope. (newworldencyclopedia.org)
  • 2001). They were named "natural killer" because of the initial notion that they do not require prior activation in order to kill cells which are missing MHC class I. (newworldencyclopedia.org)
  • 50%), compact MC infiltrates are accompanied by perifocal clusters of lymphocytes containing a mixture of B and T cells. (bmj.com)
  • In addition, diabetic mice presented a reduced influx of TCD4+ cells, TCD8+ cells, B lymphocytes, NK cells, and dendritic cells compared to control infected groups. (hindawi.com)
  • Insulin treatment restored the leukocyte number in PeLF and restored the presence of B lymphocytes, dendritic cells, and NK cells in lungs of diabetic animals. (hindawi.com)
  • An accumulation of lymphocytes, especially CD4 + T cells, in TPE has been well documented ( 2 ). (atsjournals.org)
  • My laboratory is interested in ion channels and the membrane mechanisms that regulate the activation and function of T lymphocytes. (uc.edu)
  • et 20 témoins en bonne santé ne présentant pas d'infection par le virus de l'hépatite C. Une réduction importante de la fréquence des cellules tueuses naturelles totales dans le groupe des patients porteurs d'une infection chronique a été observée par rapport au groupe des témoins ( P = 0,001) ou au groupe des patients dont l'infection a connu une résolution spontanée ( P = 0,01). (who.int)
  • Increased turnover of T lymphocytes in HIV-1 infection and its reduction by antiretroviral therapy. (qxmd.com)
  • 2001. beta-Catenin mutation in rat colon tumors initiated by 1,2-dimethylhydrazine and 2-amino-3-methylimidazo[4,5-f]quinoline, and the effect of post-initiation treatment with chlorophyllin and indole-3-carbinol. . (oregonstate.edu)
  • There are reports of oligoclonal bands in the CSF of stroke patients, suggesting that in some people a B-lymphocyte response to stroke may occur in the CNS. (jneurosci.org)
  • X-tile software (Yale School of Medicine, CT, USA) was used to stratify patients into 'high' and 'low' for each of the lymphocytes stained and their association with survival. (biomedcentral.com)
  • This study investigates the association between cord blood lymphocyte proportions and maternal exposure to air pollution during each gestational month. (biomedcentral.com)
  • There was no significant association between alterations in lymphocyte distribution and air pollution exposure during the mid gestation. (biomedcentral.com)
  • 2001. An exploratory analysis of the effect of pesticide exposure on the risk of spontaneous abortion in an Ontario farm population. (cdc.gov)
  • From 1975-2001, a rapid and steady increase occurred in the incidence of ocular NHL, with annual increases of 6.2% and 6.5% among White males and White females, respectively. (medscape.com)
  • Beyond this basic grouping, SCID may be categorized according to phenotypic lymphocyte profiles that include both B-cell status (B + or B - ) and NK-cell status (NK + or NK - ) in addition to T-cell status (T - , because there is always a T-cell deficiency in SCID). (medscape.com)
  • Conversely, T-lymphocyte levels are elevated. (medscape.com)
  • When CD20 positive lymphocyte levels were high, survival improved (p = 0.029) and similar results were seen for CD20 in combination with intratumoural CD3 (p = 0.001) and stromal CD8 (p = 0.013). (biomedcentral.com)
  • Multivariable linear regression models were fitted to estimate associations between monthly PAH or PM 2.5 and cord blood lymphocytes, adjusting for year of birth and district of residence and, in further models, gestational season and number of prior live births. (biomedcentral.com)
  • The adjusted models show significant associations between PAHs or PM 2.5 during early gestation and increases in CD3 + and CD4 + lymphocytes percentages and decreases in CD19 + and NK cell percentages in cord blood. (biomedcentral.com)
  • Blood 2001 Jul 98 (1): 194-200. (cdc.gov)
  • Therefore, we tested the hypothesis that a B-lymphocyte response to stroke could contribute to the onset of dementia. (jneurosci.org)
  • We identified a central lymphocyte-specific transcriptional response common to both physiologic and genotoxic breaks, which includes many lymphocyte developmental processes. (biomedcentral.com)
  • We previously showed that physiologic breaks initiate lymphocyte development-specific transcriptional programs. (biomedcentral.com)
  • Lymphocytes play an important and integral role in the body's defenses, and are part of a system of extraordinary complexity and coordination. (newworldencyclopedia.org)