• The disease can easily be missed if the diagnosis is based solely on immunocytochemistry, because pancreatic endocrine tumors frequently synthesize multiple peptides. (medscape.com)
  • By virtue of these pharmacological actions, octreotide acetate has been used to treat the symptoms associated with metastatic carcinoid tumors (flushing and diarrhea), and Vasoactive Intestinal Peptide (VIP) secreting adenomas (watery diarrhea). (nih.gov)
  • Octreotide is also used to reduce flushing episodes and watery diarrhea caused by cancerous tumors (carcinoid syndrome) or tumors called vasoactive intestinal peptide tumors (VIP adenomas). (canpharm.com)
  • Neuroendocrine tumors are neoplasms of the neuroendocrine cells, located in the intestinal tract and pancreas. (news-medical.net)
  • Pancreatic neuroendocrine tumors can overproduce hormones such as insulin (insulinoma), gastrin (gastrinoma), glucagon (glucagonoma), or vasoactive peptide protein (VIPoma). (news-medical.net)
  • Although not exclusive, several areas have potential for further investigation including the hypothalamic-pituitary-adrenal axis, opioid peptides, the renin-angiotensin system, plus the group of peptides regulating food intake and energy balance, exemplified by leptin and neuropeptide Y. Evidence indicates that hormones regulating food intake (such as leptin and neuropeptide Y) may act upon the same neural circuitry in the brain that controls alcohol consumption. (nih.gov)
  • PURPOSE The National Institute on Alcohol Abuse and Alcoholism (NIAAA) invites applications to identify peptides and their receptors that regulate alcohol consumption, ultimately leading to an understanding of their mechanism(s) of action. (nih.gov)
  • The functional similarity between human and bacterial DPP4 was confirmed using 124 potential peptide substrates. (inra.fr)
  • Multiple-labelling immunocytochemical studies indicated that these cells did not express either of the preprotachykinin peptides, and that they generally lacked protein kinase Cγ, which is expressed by a subset of the excitatory interneurons in this region. (biomedcentral.com)
  • Aviptadil, a synthetic form of human vasoactive intestinal peptide, might be beneficial for COVID-19 patients at high risk of developing ARDS because of its ability to influence the regulation of exaggerated pro-inflammatory proteins and orchestrate the lung homeostasis. (biomedcentral.com)
  • Vasoactive intestinal peptide (VIP) expressing cells comprise a major class of inhibitory neurons and are well-positioned to mediate top-down and neuromodulatory influences on local circuits in sensory cortex. (elifesciences.org)
  • Discovered in non-human animals around 1930 by Oscar Riddle [8] and confirmed in humans in 1970 by Henry Friesen , [9] prolactin is a peptide hormone , encoded by the PRL gene . (wikipedia.org)
  • Cloning and sequence analysis of cDNA encoding the precursor of a human endothelin-derived vasoconstrictor peptide, endothelin: identity of human and porcine endothelin. (jamanetwork.com)
  • They also suggest that the GRP immunoreactivity seen in primary afferents in previous studies may have resulted from cross-reaction of the GRP antibody with substance P or the closely related peptide neurokinin A. (biomedcentral.com)
  • Onuoha GNAlpar EKGowar J Plasma levels of atrial natriuretic peptide in severe burn injury. (jamanetwork.com)
  • The current review aims to highlight the structural and functional features as well as the production and immunological regulation of mucins and the impact these key elements have within the context of barrier function and host defense in intestinal inflammation. (frontiersin.org)
  • Goblet cells dispersed among the intestinal epithelial cells are chiefly responsible for the synthesis and secretion of mucins within the gut and are heavily influenced by interactions with the immune system. (frontiersin.org)
  • The intestinal mucosal thickness, crypt cell area, and interstitial cells of Cajal area were significantly higher in the Lop-Pro/Pre group compared to the Lop group by 16.4%, 20.6%, and 42.3%, respectively. (pubmed.pro)
  • Potential applicants may obtain a copy of "Healthy People 2000" at http://www.crisny.org/health/us/health7.html . (nih.gov)
  • In comparison, GH stimulating peptides such as Mod GRF (1-29) and Ipamorelin may become an inexpensive therapy with the potential to improve bone health with an excellent safety profile. (biotechpeptides.com)
  • The intestinal mucus layer is principally comprised of a subset of high molecular weight glycoproteins called mucins, which play a crucial role in physical protection as well as in regulating the concentration and passage of water, ions, and other immune mediators such as antimicrobial peptides (AMPs) and immunoglobulin-A (IgA) within the gut ( 2 , 3 , 7 ). (frontiersin.org)
  • Therefore, studying the role of these peptides in the regulation of alcohol consumption is warranted. (nih.gov)
  • The goal of this initiative is to elucidate the role of peptides in pathological alcohol consumption, suggesting novel pharmacotherapeutic approaches for alcoholism. (nih.gov)
  • HEALTHY PEOPLE 2000 The Public Health Service (PHS) is committed to achieving the health promotion and disease prevention objectives of "Healthy People 2000," a PHS-led activity for setting priority areas. (nih.gov)
  • Research in animal models suggests that GH-stimulating peptides such as Ipamorelin may completely halt the bone loss triggered by steroids. (biotechpeptides.com)