Accommodation of an N-(deoxyguanosin-8-yl)-2-acetylaminofluorene adduct in the active site of human DNA polymerase iota: Hoogsteen or Watson-Crick base pairing? (neb.com)
A new anti conformation for N-(deoxyguanosin-8-yl)-2-acetylaminofluorene (AAF-dG) allows Watson-Crick pairing in the Sulfolobus solfataricus P2 DNA polymerase IV (Dpo4). (neb.com)
Rats4
In this work, we studied progenitor/oval cell surface markers in the liver of rats subjected to 2-acetylaminofluorene treatment followed by partial hepatectomy (2-AAF/PH) by using rat genome 230 2.0 Array chips and subsequent RT-PCR, immunofluorescent (IF), immunohistochemical (IHC) and in situ hybridization (ISH) analyses. (elsevierpure.com)
Catechol estrogen formation in liver microsomes from female ACI and Sprague-Dawley rats: comparison of 2- and 4-hydroxylation revisited. (kyoto-u.ac.jp)
J Nutr 2001 Nov;131:3087S-91S Hosaka S, Kawa S, Aoki Y, Tanaka E, Yoshizawa K, Karasawa Y, Hosaka N, Kiyosawa K. Hepatocarcinogenesis inhibition by caffeine in ACI rats treated with 2-acetylaminofluorene. (kyoto-u.ac.jp)
Acetaldehyde1
WARNING: This product can expose you to chemicals including Acetaldehyde / 2-Acetylaminofluorene, Bracken fern, which is [are] known to the State of California to cause cancer. (campingworld.com)
Mutagenic1
2-Acetylaminofluorene (AAF, 2-AAF) is a carcinogenic and mutagenic derivative of fluorene. (wikipedia.org)
Receptors1
TGF beta 1, TGF beta 2, and TGF beta 1.2 appear to have equivalent biological activity, although there appear to be differences in binding to certain types of receptors. (caslab.com)
19991
2, 1999, recollected samples for Dr. Cassady in 2003 and again in 2005. (worldbotanical.com)
analyze the expression of miR-451 in 2 pairs of matched NSCLC and noncancerous tissue samples. (pi3k-inhibitors.com)
Mouse1
These antibodies target TGF beta-2 in human, mouse and rat samples. (caslab.com)
Rabbits1
Our polyclonal, recombinant polyclonal and monoclonal TGF beta-2 antibodies are developed in rabbits and mice. (caslab.com)
Reactive1
The reactive nitrenium, carbonium and arylamidonium ion metabolites of 2-AAF react with the nucleophilic groups in DNA, proteins and endogenous thiols like glutathione. (wikipedia.org)
Enzyme3
2-AAF is a substrate for cytochrome P-450 (CYP) enzyme, which is a part of a super family found in almost all organisms. (wikipedia.org)
In addition, the cytosolic N,O-aryl hydroxamic acid acyltransferase enzyme catalyzes the transfer of the acetyl group from the N atom of the N-OH-2-AAF to the O atom of the N-OH group to produce N-acetoxy-2-aminofluorene (N-OH-2-AF). (wikipedia.org)
The interconversion of amide and amine metabolites of 2-AAF can further occur via the microsomal enzyme deacetylase producing the N-hydroxy metabolite of the amine derivative. (wikipedia.org)
Figure 2 Detection of miR-451 expression in mock or stably transfected A549 cells. (pi3k-inhibitors.com)
Beta7
Antibodies that detect TGF beta-2 can be used in several scientific applications, including Western Blot, immunohistochemistry (paraffin), ELISA, immunocytochemistry, and immunohistochemistry (frozen). (caslab.com)
These antibodies were checked by Knockdown to confirm specificity to TGF beta-2. (caslab.com)
Find the TGF beta-2 antibody that fits your needs. (caslab.com)
Choose from 1 of 15 TGF beta-2 antibodies, which have been validated in experiments with 10 publications and 36 images featured in our data gallery. (caslab.com)
TGF beta 1, TGF beta 2, and TGF beta 3 are each synthesized as very similar precursor proteins in that each is cleaved to yield a 112 amino acid polypeptide which remains associated with the latent part of the molecule. (caslab.com)
TGF beta 2 is produced by many cell types and has been found at the highest concentration in porcine platelets and mammalian bone. (caslab.com)
Latent TGF beta 2 is the predominant isoform found in bodily fluids such as amniotic fluid, breast milk, and the aqueous and vitreous humor of the eye. (caslab.com)
Animals1
Concentrations for 20 substances were listed under the headings: (1) Rapidly fatal to man and animals, (2) Dangerous in 0.51 h, (3) 0.51 h without serious disturbances, and (4) Only minimal symptoms observed (3). (cdc.gov)
Surface1
fruit (camara) shaped somewhat like a dolphin with a short to long curved beak, 7 10 mm long, with many conspicuous wart-like oil glands on the surface, indehiscent, 2-seeded. (worldbotanical.com)
Cell1
NSCLC mainly includes the histologic types of adenocarcinoma (ADC) and squamous cell carcinoma (SCC) [ 2 ]. (jcancer.org)
Aminofluorene3
In addition, the cytosolic N,O-aryl hydroxamic acid acyltransferase enzyme catalyzes the transfer of the acetyl group from the N atom of the N-OH-2-AAF to the O atom of the N-OH group to produce N-acetoxy-2-aminofluorene (N-OH-2-AF). (wikipedia.org)
2-Aminofluorene metabolism and DNA adduct formation by mononuclear leukocytes from rapid and slow acetylator mouse strains. (cdc.gov)
We reacted uracil-containing M13mp2 DNA with N-hydroxy-2-aminofluorene to produce a template with N-(deoxyguanosin-8-yl)-2-aminofluorene adducts. (neb.com)
Adducts1
We did not observe an increase in mutations when synthesis was attempted on a template reacted with N-acetoxy-2-(acetylamino)fluorene to give N-(deoxyguanosin-8-yl)-2-(acetylamino)fluorene adducts. (neb.com)
Derivative5
2-Acetylaminofluorene (AAF, 2-AAF) is a carcinogenic and mutagenic derivative of fluorene. (wikipedia.org)
The interconversion of amide and amine metabolites of 2-AAF can further occur via the microsomal enzyme deacetylase producing the N-hydroxy metabolite of the amine derivative. (wikipedia.org)
Foci of transformed NIH3T3 cells were observed after transfection of plasmids containing the c-Ha-ras-1 protooncogene modified in vitro either with the 3-N,N-acetoxyacetyl derivative (N-AcO-AGlu-P-3) of the mutagenic L-glutamic acid pyrolysis product 3-amino-4, 6-dimethyldipyrido-[1,2-a:3′,2′-d]imidazole (Glu-P-3) or with 1′-acetoxysafrole (AcO-S), a reactive derivative of the carcinogen safrole. (uea.ac.uk)
You can always visit its website for the last version.This invention relates to production of the 2-acetylaminofluorene derivative represented by the general formula: ##STR2## wherein R is a carboxy group, for example, an esterified carboxylic acid, for example, a methylcarboxyl group, an amide group or an aliphatic carboxyl group, more particularly to a method for producing said derivative represented by said formula without the use of toxic reagents. (tueventoenvivo.com)
The efficient production of said 2-acetylaminofluorene derivative, however, requires use of highly toxic reagents such as nitrosodimethylamine, ethyl isocyanate and the like. (tueventoenvivo.com)
Liver7
2. Efficacy of caffeic acid in preventing nickel induced oxidative damage in liver of rats. (nih.gov)
Relative Sensitivity of (32)P-postlabelling of DNA and the Autoradiographic UDS Assay in the Liver of Mice Exposed to 2-acetylaminofluorene (2AAF). (epa.gov)
[2] The liver converts glucose into glycogen, a form of sugar that can be stored, and then later released as glucose when the body needs a burst of energy. (bonasanahealth.com)
Hepatology 2013;58:1569-1579) Hepatitis C virus (HCV) infection is a leading cause of liver disease, with at least 2%-3% of the world's population chronically infected. (smadpathway.com)
Hepatocytes were isolated by liver perfusion either 2-4hr or 12-16hr after treatment and cultured in medium containing [methyl- 3 H]thymidine for 4hr and assessed for UDS by grain counting of autoradiographs. (tno.nl)
The most frequent types of primary liver cancer in adults are hepatocellular carcinoma (HCC) and cholangiocarcinoma (CCA), constituting HCC the 70-85% of cases and CCA the 30-15%, depending on the country [ 2 ] . (encyclopedia.pub)
Liver cancer also appears in children and adolescents, accounting hepatoblastoma (HB) and HCC for 67-80% and 20-33% of cases, respectively [ 2 ] [ 3 ] . (encyclopedia.pub)
Benzo1
Further studies were carried out on transformed foci induced in a previous study by reactive derivatives of benzo[a]pyrene and 2-acetylaminoflu-orene and by depurination. (uea.ac.uk)
Rats4
Rats were euthanized 2 weeks after the last AAF injection. (nih.gov)
Astereacea) against 2-acetylaminofluorene-induced hepatotoxicity in rats. (nih.gov)
Toxicology and Carcinogenesis Studies of 2,3-Dibromo-1-Propanol (CAS No. 96-13-9) in F344/N Rats and B6C3F1 Mice (Dermal Studies). (nih.gov)
Rats were also treated with 20mg/kg body weight dimethylnitrosamine (DMN) or 50mg/kg body weight 2-acetylaminofluorene (2-AAF) as positive controls for the 2-4hr and 12-16hr expression of UDS, respectively. (tno.nl)
Fluorene1
Shows activity towards p-nitrophenol and N-hydroxy-2-acetylamino-fluorene (N-OH-2AAF). (nih.gov)
Hepatocytes2
Coumarin treatment at doses of 32-320mg/kg body weight had no statistically significant or dose-related effect on UDS in rat hepatocytes either 2-4hr or 12-16hr after dosing. (tno.nl)
Treatment with coumarin, DMN and 2-AAF had no statistically significant effect on the proportion of rat hepatocytes undergoing replicative DNA synthesis. (tno.nl)
Acid2
His research interest is focused on the application of electron spin resonance (ESR) to: 1) Study the dynamics of nucleic acids and nucleic acid - protein complexes, and 2) Detect genes by PCR/ESR. (uc.edu)
A) Application of electron paramagnetic resonance (EPR) spectroscopy: 1) to study dynamic features of nucleic acids and nucleic acid - protein complexes, and 2) to detect free radical damage in biological systems. (uc.edu)
Toxicity1
1) 1.Ethylene dichlorides - toxicity 2.Ethylene dichlorides - administration and dosage 3.Dose-response relationship, Drug 4.Environmental exposure I.International Programme for Chemical Safety II.Series ISBN 92 4 153001 4 (NLM Classification: QV 633) ISSN 1020-6167 The World Health Organization welcomes requests for permission to reproduce or translate its publications, in part or in full. (inchem.org)
Glucose1
Objective To investigate the effects of high glucose on expression of angiopoietin 2 (Ang2) and tyrosine kinase receptor (Tie2) in human umbilical vascular endothelial cells （HUVECs）cultured in vitro , and explore the possible mechanism of peritoneal angiogenesis in patients with peritoneal dialysis. (shsmu.edu.cn)
Protein1
that mutations in cathepsin B may cause inept localization of cathepsin B protein in zymogen granules that could lead to premature activation of trypsinogen.43 Type 2 diabetes (T2D)-associated polymorphisms in selleck chemical transcription factor 7 like protein 2 (TCF7L2, OMIM 602228) were screened in TCP and fibro calculus pancreatic diabetes (FCPD) patients. (smadpathway.com)
Form1
Mononuclear leukocytes (MNL) metabolized AF to its acetylated form 2-acetylaminofluorene (53963) (AAF). (cdc.gov)
Activity1
Comparative genetic activity of cis- and trans- 1,2-dichloroethylene in yeast. (unibo.it)
Publication1
WHO Library Cataloguing in Publication Data 1,2-Dichloroethane. (inchem.org)
Carbon1
All initiated animals were treated at the same age (11 weeks) with the following selection agents: three daily doses of 2-acetylaminofluorene (AAF) (30 mg/kg), followed by a single dose of carbon tetrachloride (2 ml/kg), followed by three additional daily treatments of AAF (30 mg/kg). (nih.gov)
Increases1
In contrast, both DMN 2-4hr after dosing and 2-AAF 12-16hr after dosing produced significant increases in UDS assessed as the net nuclear grain count. (tno.nl)
Repair1
The responsiveness of the animals used in this study to genotoxic agents was demonstrated by the clear induction of DNA repair after treatment with DMN and 2-AAF. (tno.nl)
Source1
INTERNATIONAL CHEMICAL SAFETY CARD REFERENCES APPENDIX 1 - SOURCE DOCUMENTS APPENDIX 2 - CICAD FINAL REVIEW BOARD R SUM D'ORIENTATION RESUMEN DE ORIENTACION FOREWORD Concise International Chemical Assessment Documents (CICADs) are the latest in a family of publications from the International Programme on Chemical Safety (IPCS) - a cooperative programme of the World Health Organization (WHO), the International Labour Organisation (ILO), and the United Nations Environment Programme (UNEP). (inchem.org)
Subject1
Nationwide, short-beaked common dolphins tend to be subject to bycatch fatality in 2 fisheries: your purse-seine fishery with regard to sardines away central To the south Sydney and the gillnet fishery with regard to gummy sharks away from the southern area of Sydney. (fakpathway.com)
Main1
Bayesian and traditional examines associated with populace anatomical framework uncovered the use of at the very least Six supervision models of frequent dolphins, of which at the least 3 are usually possibly influenced by the 2 main fisheries. (fakpathway.com)
Control1
0.05) MN and sperm morphology compared to control 2. (scialert.net)
High1
Sixty-four +/- 18 ml/min/1.Seventy-three m(2)) inside sufferers with out high blood pressure levels when compared to those that have high blood pressure levels. (fakpathway.com)