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  • gene
  • Certain variants of this gene increase the risk for decreased histocompatibility characteristic of type 1. (wikipedia.org)
  • It is classified by gene structure and coding sequence as a type III IF protein because of its homology with vimentin, GFAP and desmin. (wikipedia.org)
  • Glutamate decarboxylase 1 (brain, 67kDa) (GAD67), also known as GAD1, is a human gene. (wikipedia.org)
  • This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. (wikipedia.org)
  • antigen
  • Moreover, the prospect of implanting artificial cells with similar chemical composition in several patients irrespective of their leukocyte antigen could again allow reduction in costs. (wikipedia.org)
  • citation needed
  • medical citation needed] This may be deduced logically from the huge increase in the occurrence of type 2 diabetes that has correlated with the significant change in western lifestyle and diet. (wikipedia.org)
  • diabetics
  • About 50% of diabetics with diabetic cardiomyopathy show pathologic evidence for microangiopathy such as sub-endothelial and endothelial fibrosis, compared to only 21% of non-diabetic heart failure patients. (wikipedia.org)
  • intensive
  • Recently, the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study demonstrated that intensive diabetes therapy in T1D during the DCCT yielded a 33% reduction in the risk of mortality, versus conventional diabetes therapy, over a 27-year period of follow-up ( 14 ). (diabetesjournals.org)
  • During 1983-1989, the DCCT enrolled 1,441 patients with T1D between the ages of 13 and 39 years who were randomly assigned to receive either intensive or conventional therapy. (diabetesjournals.org)
  • The DCCT ended in 1993, at which time all patients were referred to their private health care providers with the recommendation that they follow an intensive regimen ( 16 ). (diabetesjournals.org)
  • In most healthcare organizations patient education is a labor-intensive, highly somewhat punishing activity for the provider or patient educator and the patients. (wikipedia.org)
  • thus
  • Due to the specific and unique needs and interests of the client/patient, the goal of exercise prescription should be focused on motivation and customization, thus making achieving goals more likely to become successful. (wikipedia.org)
  • Thus, reports on the isolation of P. penneri from infected patients is limited. (wikipedia.org)
  • insulin independence
  • This procedure is safe and relatively simple with rare complications, but, up to recently, only moderate success rates have been achieved at 1 year posttransplantation (with 41% graft survival, as defined by C-peptide ≥0.5 ng/ml, and 11% insulin independence) ( 1 ). (diabetesjournals.org)
  • 2001
  • Money's general views on gender identity as something learned during childhood were later directly contradicted by a biography published in 2001 by one of his former patients, David Reimer. (wikipedia.org)
  • symptomatic
  • Recognizing this, nearly 10 years ago the American Diabetes Association published a consensus recommendation that clinicians consider a risk factor-guided screening approach to early diagnosis of CAD in both symptomatic and asymptomatic patients. (diabetesjournals.org)
  • Tissue
  • Microencapsulation is a valuable technique for local, regional and oral delivery of therapeutic products as it can be implanted into numerous tissue types and organs. (wikipedia.org)
  • DRB1
  • DRB1*0301:DQA1*05:DQB1*0201 is associated with diabetes mellitus type 1, ovarian cancer, non-thymomic myasthenia gravis, idiopathic inflammatory myopathies, non-cancer associated Lambert-Eaton myasthenic syndrome and sarcoidosis The DRB1*0301/DRB1*1501 heterozygote is linked to primary Sjögren's syndrome HLA-DR17 is genetically linked to DR52 and HLA-DQ2 serotypes. (wikipedia.org)
  • patient's
  • It is important to inquire about the type and duration of the patient's diabetes and about the care the patient is receiving for diabetes. (medscape.com)
  • Since behavior is common to everyone, TBM shows providers and patient educators how to most effectively influence their patient's behavior regardless of their level of education or understanding of their disease. (wikipedia.org)
  • A significant portion of patient care is based on the provider's judgment and memory of the individual patient's efforts. (wikipedia.org)
  • The islets are infused into the patient's portal vein, and are then kept from being destroyed by the recipient's immune system through the use of two immunosuppressants, sirolimus and tacrolimus as well as a monoclonal antibody drug used in transplant patients called daclizumab. (wikipedia.org)
  • findings
  • 1, 2 However, the documentation of these early morphological findings in vivo is limited and their pathogenic importance is controversial. (bmj.com)
  • Somogyi showed that excessive insulin makes diabetes unstable and first published his findings in 1938. (wikipedia.org)
  • care
  • Safety and viability of microencapsulated human islets transplanted into diabetic humans," Diabetes Care , vol. 32, no. 10, pp. 1887-1889, 2009. (hindawi.com)
  • Standard T1DM patients' care strategies are based on the ongoing monitoring of food intake and continuous insulin prophylaxis. (omicsonline.org)
  • Thereafter, 1,394 participants (representing 97% of the entire cohort) joined the EDIC observational study (1994 to present), with ongoing diabetes care provided by their local providers ( 16 ). (diabetesjournals.org)
  • The Affordable Care Act (2010) will continue to unfold and patient behavior will have a significant impact of the bottom line of care. (wikipedia.org)
  • First, compliance depends on the ability of providers to be fair and objective and to apply the standards of care to all patients. (wikipedia.org)
  • Providers are required to pay close attention to what the patients do say and then record the observations in the plan of care. (wikipedia.org)
  • high
  • Patients using a pump or a multiple-injection regimen have a basal insulin (taken through the pump or with the injection of a long-acting insulin analogue) and a premeal rapid-acting insulin, the dose of which may be determined as a function of the carbohydrate count plus the correction (to adjust for how high the premeal glucose level is). (medscape.com)
  • Ischaemia, reduced protein synthesis, depleted myoinositol, and high sorbitol levels have been demonstrated in patients with diabetes and may result in nerve fibre loss in peripheral nerves. (bmj.com)
  • After discussing the potential value of early diagnosis, the types and frequency of testing, and most critically, which patients are particularly appropriate to be tested, the consensus panel recommended specialized CAD screening for patients thought to be at high risk. (diabetesjournals.org)
  • Though purity has improved steadily since the 1920s ultimately reaching purity of 99% by the mid-1970s thanks to high-pressure liquid chromatography (HPLC) methods, minor allergic reactions still occur occasionally, although the same types of allergic reactions have also been known to occur in response to synthetic "human" insulin varieties. (wikipedia.org)
  • Prediabetes is the precursor stage before diabetes mellitus in which not all of the symptoms required to diagnose diabetes are present, but blood sugar is abnormally high. (wikipedia.org)
  • Impaired fasting glycaemia or impaired fasting glucose (IFG) refers to a condition in which the fasting blood glucose or the 3-month average blood glucose (A1C) is elevated above what is considered normal levels but is not high enough to be classified as diabetes mellitus. (wikipedia.org)
  • Impaired fasting glucose is defined as a fasting glucose that is higher than the upper limit of normal, but not high enough to be classified as diabetes mellitus. (wikipedia.org)