• gene
  • Certain variants of this gene increase the risk for decreased histocompatibility characteristic of type 1. (wikipedia.org)
  • Glutamate decarboxylase 1 (brain, 67kDa) (GAD67), also known as GAD1, is a human gene. (wikipedia.org)
  • This gene encodes one of several forms of glutamic acid decarboxylase, identified as a major autoantigen in insulin-dependent diabetes. (wikipedia.org)
  • It is classified by gene structure and coding sequence as a type III IF protein because of its homology with vimentin, GFAP and desmin. (wikipedia.org)
  • 2001
  • Money's general views on gender identity as something learned during childhood were later directly contradicted by a biography published in 2001 by one of his former patients, David Reimer. (wikipedia.org)
  • diabetics
  • We aimed to compare heart rate variability in 29 HIV-infected patients using highly active antiretroviral therapy (HAART), 28 naïve-treatment HIV patients, and diabetics with controls. (hindawi.com)
  • The normalized power of the low-frequency component (LF) in naïve patients of 39.9 (interquartile interval (IQ), 28.5-65.7) and diabetics of 42.9 (IQ, 14.5-57.7) were decreased compared with controls (67.5, IQ, 37.9-75.4). (hindawi.com)
  • Many type 1 diabetics are diagnosed when they present with diabetic ketoacidosis. (wikipedia.org)
  • About 50% of diabetics with diabetic cardiomyopathy show pathologic evidence for microangiopathy such as sub-endothelial and endothelial fibrosis, compared to only 21% of non-diabetic heart failure patients. (wikipedia.org)
  • antigen
  • Islet cell autoantibodies, insulinoma-antigen 2 autoantibodies, residual C-peptide and the type 1 diabetes associated haplotypes DQ2, DQ8 and DQ6 were not associated with DR. (pubmedcentralcanada.ca)
  • Moreover, the prospect of implanting artificial cells with similar chemical composition in several patients irrespective of their leukocyte antigen could again allow reduction in costs. (wikipedia.org)
  • coronary
  • Coronary artery disease (CAD) accounts for a large fraction of the morbidity, mortality, and cost of diabetes. (diabetesjournals.org)
  • However, over this same time interval, there has been recognition of diabetes as a cardiovascular disease (CVD) equivalent, clear demonstration that medical interventions should provide primary and secondary CVD risk reduction in diabetic populations, and suggestive evidence that percutaneous coronary revascularization may not provide additive survival benefit to intensive medical management in patients with stable CAD. (diabetesjournals.org)
  • As coronary artery disease (CAD) is the major cause of morbidity, mortality, and medical cost of diabetes ( 1 ), early diagnosis of CAD to prevent progression and clinical events has intuitive appeal. (diabetesjournals.org)
  • In February 1998, the American Diabetes Association (ADA) convened an expert panel to develop consensus positions addressing a series of questions related to coronary heart disease in both symptomatic and asymptomatic patients with diabetes ( 2 ). (diabetesjournals.org)
  • In addition, the mortality rate in various clinical settings of ischemia-reperfusion (IR) injury, including acute myocardial infarction [ 2 , 3 ], and coronary artery bypass grafting [ 4 , 5 ], is higher in patients with diabetes mellitus, both in type 1 and in type 2 diabetic patients. (biomedcentral.com)
  • OBJECTIVE -Mortality in type 1 diabetic patients with end-stage renal failure is high and dominated by coronary atherosclerotic events. (diabetesjournals.org)
  • Most heart failure in people with diabetes results from coronary artery disease, and diabetic cardiomyopathy is only said to exist if there is no coronary artery disease to explain the heart muscle disorder. (wikipedia.org)
  • treatment
  • Their immunomodulatory and proangiogenic roles can be used to help arrest β-cell destruction, preserve residual β-cell mass, facilitate endogenous β-cell regeneration and prevent disease recurrence, thereby making them ideal candidates for the comprehensive treatment of diabetic patients. (omicsonline.org)
  • Were it not for this potential side effect, diabetes treatment would be considerably easier. (diabetesjournals.org)
  • In the preintensive treatment era, relative mortality in type 1 diabetes (T1D) exceeded that in the population without diabetes ( 1 , 2 ). (diabetesjournals.org)
  • Few studies evaluated the effect of treatment on heart rate variability in HIV-infected patients. (hindawi.com)
  • The results showed no alterations in heart rate variability in HAART patients compared with naïve patients [ 26 ], suggesting that treatment prevents alterations in heart rate variability. (hindawi.com)
  • The results showed evidence of substantial autonomic dysfunction in AIDS patients not using HAART compared with controls, but only mild abnormalities in HIV-infected patients [ 18 ], suggesting that the duration and severity of the disease but not the treatment were associated with autonomic dysfunction. (hindawi.com)
  • All these data showed that there is a lot of conflicting results about the effect of treatment with HAART on the heart rate variability of HIV-infected patients and that more studies comparing HAART and naïve patients are still necessary. (hindawi.com)
  • Before treatment, patients who went on to develop secondary autoimmunity had more than 2-fold greater levels of serum IL-21 than the nonautoimmune group. (jci.org)
  • It is an experimental treatment for type 1 diabetes mellitus. (wikipedia.org)
  • This theoretical phenomenon was named after Michael Somogyi, a Hungarian-born professor of biochemistry at the Washington University and Jewish Hospital of St. Louis, who prepared the first insulin treatment given to a child with diabetes in the USA in October 1922. (wikipedia.org)
  • thus
  • Due to the specific and unique needs and interests of the client/patient, the goal of exercise prescription should be focused on motivation and customization, thus making achieving goals more likely to become successful. (wikipedia.org)
  • findings
  • 1, 2 However, the documentation of these early morphological findings in vivo is limited and their pathogenic importance is controversial. (bmj.com)
  • Recently, studies have evaluated heart rate variability in HIV-infected patients [ 17 - 19 , 22 , 24 , 26 ], with most showing decreased heart rate variability similar to findings observed in patients with cardiomyopathy [ 17 , 19 , 22 , 24 ]. (hindawi.com)
  • Somogyi showed that excessive insulin makes diabetes unstable and first published his findings in 1938. (wikipedia.org)
  • symptomatic
  • Recognizing this, nearly 10 years ago the American Diabetes Association published a consensus recommendation that clinicians consider a risk factor-guided screening approach to early diagnosis of CAD in both symptomatic and asymptomatic patients. (diabetesjournals.org)
  • progression
  • Baker IDI's teams comprising medical specialists, scientists and public health experts are focussed on bringing their knowledge and expertise to bear on these areas: Metabolism and Inflammation: What is the role of inflammation in the initiation and progression of heart disease, diabetes, chronic kidney disease and heart failure? (wikipedia.org)