• susceptibility
  • The diabetic patients' genome sequences differ from the controls' genome in specific loci along and around numerous genes, and these differences in the nucleotide sequences alter phenotypic traits that exhibit increased susceptibility to the diabetes. (wikipedia.org)
  • Most SNPs that increase the risk of diabetes reside in noncoding regions of the genes, making the SNP's mechanism for increasing susceptibility largely unknown. (wikipedia.org)
  • These SNPs in ORFs result in altering of the protein function, and the altered function and therefore compromise the performances of the protein product causes increased susceptibility to the type 2 diabetes. (wikipedia.org)
  • It is important to note that those discovered genes do not determine susceptibility to diabetes for all people or cases. (wikipedia.org)
  • TCF7L2 is one of the well-studied genes for diabetes susceptibility in most populations. (wikipedia.org)
  • However, SNPs in TCF7L2 that would normally increase the risk of diabetes does not affect the susceptibility for Pima Indians. (wikipedia.org)
  • antigen
  • Islet cell autoantibodies, insulinoma-antigen 2 autoantibodies, residual C-peptide and the type 1 diabetes associated haplotypes DQ2, DQ8 and DQ6 were not associated with DR. (pubmedcentralcanada.ca)
  • Moreover, the prospect of implanting artificial cells with similar chemical composition in several patients irrespective of their leukocyte antigen could again allow reduction in costs. (wikipedia.org)
  • thus
  • Due to the specific and unique needs and interests of the client/patient, the goal of exercise prescription should be focused on motivation and customization, thus making achieving goals more likely to become successful. (wikipedia.org)
  • Thus, reports on the isolation of P. penneri from infected patients is limited. (wikipedia.org)
  • insulin independence
  • This procedure is safe and relatively simple with rare complications, but, up to recently, only moderate success rates have been achieved at 1 year posttransplantation (with 41% graft survival, as defined by C-peptide ≥0.5 ng/ml, and 11% insulin independence) ( 1 ). (diabetesjournals.org)
  • findings
  • 1, 2 However, the documentation of these early morphological findings in vivo is limited and their pathogenic importance is controversial. (bmj.com)
  • Recently, studies have evaluated heart rate variability in HIV-infected patients [ 17 - 19 , 22 , 24 , 26 ], with most showing decreased heart rate variability similar to findings observed in patients with cardiomyopathy [ 17 , 19 , 22 , 24 ]. (hindawi.com)
  • Somogyi showed that excessive insulin makes diabetes unstable and first published his findings in 1938. (wikipedia.org)
  • polyuria
  • Play media The classical symptoms of type 1 diabetes include: polyuria (excessive urination), polydipsia (increased thirst), dry mouth, polyphagia (increased hunger), fatigue, and weight loss. (wikipedia.org)
  • symptomatic
  • Recognizing this, nearly 10 years ago the American Diabetes Association published a consensus recommendation that clinicians consider a risk factor-guided screening approach to early diagnosis of CAD in both symptomatic and asymptomatic patients. (diabetesjournals.org)
  • context
  • This chronic disease requires preventive efforts, early diagnosis, and collaborative care of the patient and family within the context of a medical home. (aappublications.org)
  • diabetics
  • We aimed to compare heart rate variability in 29 HIV-infected patients using highly active antiretroviral therapy (HAART), 28 naïve-treatment HIV patients, and diabetics with controls. (hindawi.com)
  • The normalized power of the low-frequency component (LF) in naïve patients of 39.9 (interquartile interval (IQ), 28.5-65.7) and diabetics of 42.9 (IQ, 14.5-57.7) were decreased compared with controls (67.5, IQ, 37.9-75.4). (hindawi.com)
  • About 50% of diabetics with diabetic cardiomyopathy show pathologic evidence for microangiopathy such as sub-endothelial and endothelial fibrosis, compared to only 21% of non-diabetic heart failure patients. (wikipedia.org)
  • risk
  • After discussing the potential value of early diagnosis, the types and frequency of testing, and most critically, which patients are particularly appropriate to be tested, the consensus panel recommended specialized CAD screening for patients thought to be at high risk. (diabetesjournals.org)
  • These results, if confirmed, could provide additional insights into the pathogenesis of the most common microvascular complication of diabetes and lead to better risk stratification for both patient screenings and DR treatment trials. (pubmedcentralcanada.ca)
  • The risk of a child developing type 1 diabetes is about 5% if the father has it, about 8% if a sibling has it, and about 3% if the mother has it. (wikipedia.org)
  • As of 2011 more than 36 genes have been found that contribute to the risk of type 2 diabetes. (wikipedia.org)
  • However, single nucleotide polymorphism (SNP) is one of many mechanisms that leads to increased risk for type 2 diabetes. (wikipedia.org)
  • As CDKN2A and B regulate the pancreatic beta-cell replication, and HNF1B is homeodomain containing transcription factor that regulates other genes, faulty regulations of those genes increase the risk of diabetes. (wikipedia.org)
  • islets
  • Safety and viability of microencapsulated human islets transplanted into diabetic humans," Diabetes Care , vol. 32, no. 10, pp. 1887-1889, 2009. (hindawi.com)
  • Subsequent studies showed that transplanted islets could reverse diabetes in both rodents and non-human primates. (wikipedia.org)
  • The islets are infused into the patient's portal vein, and are then kept from being destroyed by the recipient's immune system through the use of two immunosuppressants, sirolimus and tacrolimus as well as a monoclonal antibody drug used in transplant patients called daclizumab. (wikipedia.org)
  • Tissue
  • Microencapsulation is a valuable technique for local, regional and oral delivery of therapeutic products as it can be implanted into numerous tissue types and organs. (wikipedia.org)
  • DRB1
  • DRB1*0301:DQA1*05:DQB1*0201 is associated with diabetes mellitus type 1, ovarian cancer, non-thymomic myasthenia gravis, idiopathic inflammatory myopathies, non-cancer associated Lambert-Eaton myasthenic syndrome and sarcoidosis The DRB1*0301/DRB1*1501 heterozygote is linked to primary Sjögren's syndrome HLA-DR17 is genetically linked to DR52 and HLA-DQ2 serotypes. (wikipedia.org)
  • It is also associated with Membranous glomerularnephritis DRB1*0301 (see HLA-DR17) DRB1*0302 (See HLA-DR18) DRB1*0304 is associated with graves disease DR3 and/or DQ2 is associated with Moreen's ulceration, "bout onset" multiple sclerosis, Grave's disease and systemic lupus erythematosus DR3-DQ2 linkage is associated with coeliac disease, dermatitis herpetiformis, Diabetes mellitus type 1. (wikipedia.org)