• encodes
  • Zebrafish homozygous for the lockjaw ( low ) mutation show defects in all of these derivatives and we show that low (allelic with montblanc ) encodes a zebrafish tfap2a , one of a small family of transcription factors implicated in epidermal and neural crest development. (biologists.org)
  • Cross-hybridization of the mouse cDNA to a human thymus library yielded the human homolog, which encodes a protein 83% identical to the mouse ectodomain. (jax.org)
  • This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. (wikipedia.org)
  • MTA2 is acetylated at lysine 152 within the BAH domain This gene encodes a protein that has been identified as a component of NuRD, a nucleosome remodeling deacetylase complex identified in the nucleus of human cells. (wikipedia.org)
  • pathways
  • Professor Utz is an expert in the study of human and murine autoantibodies and autoantigens, apoptosis signaling pathways, animal models of autoimmunity, proteomics and multiplexed assay development for biomarker discovery. (stanford.edu)
  • cDNA
  • MTA2 was initially recognized as an MTA1 like 1 gene, named MTA1-L1, from a large scale sequencing of randomly selected clones from human cDNA libraries in 1999. (wikipedia.org)
  • Bcl2
  • Antiapoptotic protein BCL2-associated athanogene 4 (BAG4/SODD) and adaptor proteins TRADD and TRAF2 have been shown to interact with this receptor, and thus play regulatory roles in the signal transduction mediated by the receptor. (wikipedia.org)
  • We also showed transcriptional up-regulation of Bcl2 using the luciferase assay with Bcl2 reporter containing P1 full promoter, quantitative reverse transcription-PCR, and t-Darpp small interfering RNA. (aacrjournals.org)
  • The Bcl2 promoter contains binding sites for cyclic AMP-responsive element binding protein CREB/ATF1 transcription factors and using the electrophoretic mobility shift assay with a CREB response element, we detected a stronger binding in t-Darpp-expressing cells. (aacrjournals.org)
  • Indeed, knockdown of Akt, CREB, or ATF1 in t-Darpp-expressing cells reduced Bcl2 protein levels. (aacrjournals.org)
  • constitutive
  • Between different donors, a high variability of both constitutive expression levels and TNF␣ -induced changes in 52-kd Ro/SSA mRNA and protein expression was observed. (docme.ru)
  • It also facilitates the interaction of SR proteins with RNA polymerase II and is required for processing of weak constitutive splice sites, having also strong implications in cancer and other human diseases. (wikipedia.org)
  • endogenous
  • Insults resulting from exposure to a variety of neurotoxins, both exogenous and endogenous, constitute the main triggering event of pathological apoptosis in the adult nervous system ( Yuan and Yankner, 2000 ). (jneurosci.org)
  • HSV-1 ICP0 and several of its homologs in other herpes viruses bind to SUMO-1 in a manner similar to endogenous proteins, causing depletion of SUMO-1, and disruption of nuclear bodies. (wikipedia.org)
  • antibody
  • These molecules are fusion proteins that are made up of an antibody raised against the knob domain of the adenovirus coat protein, fused to a natural ligand for a cell-surface receptor. (wikipedia.org)
  • Jurkat cells and peripheral blood mononuclear cells (PBMC) incubated with the monoclonal antibody Ad22 results in apoptosis within 3 hours. (wikipedia.org)
  • mediates
  • The F-box protein is one of the four components of the SCF (SKp1, Cullin, F-box protein) complex, which mediates ubiquitination of proteins targeted for degradation by the proteasome, playing an essential role in many cellular processes. (mdpi.com)
  • Cell
  • Among them, D-type G1 cyclins and a Cdk inhibitor, p27Kip1, function as the target of growth factors to integrate extracellular signals into cell cycle regulators. (biomedsearch.com)
  • The proteins are found on mitochondrial, microsomal, and NUCLEAR MEMBRANE sites within many cell types. (labome.org)
  • Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. (wikipedia.org)
  • For adenovirus replication to occur, the host cell must be induced into S phase by viral proteins interfering with cell cycle proteins. (wikipedia.org)
  • This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. (wikipedia.org)
  • NFAT transcription factors are implicated in breast cancer, more specifically in the process of cell motility at the basis of metastasis formation. (wikipedia.org)
  • Antinuclear antibodies (ANAs, also known as antinuclear factor or ANF) are autoantibodies that bind to contents of the cell nucleus. (wikipedia.org)
  • SON is the name that has been given to a large Ser/Arg (SR)-related protein, which is a splicing co-factor that contributes to an efficient splicing within cell cycle progression. (wikipedia.org)
  • page needed] Although there is a lack of knowledge about its exact splicing control in the progression of the cell cycle and it has remained largely unexplored, it's certain that this splicing-associated protein is necessary for the maintenance of the embryonic stem cells because it influences the splicing of pluripotency regulators. (wikipedia.org)
  • Binding of TSP-1 to CD47 influences several fundamental cellular functions including cell migration and adhesion, cell proliferation or apoptosis, and plays a role in the regulation of angiogenesis and inflammation. (wikipedia.org)
  • CD47 ligation leads to cell death in many normal and tumor cell lines via apoptosis or autophagy. (wikipedia.org)
  • Human Herpes Virus (HHV) Infected Cell Polypeptide 0 (ICP0) is a protein, encoded by the DNA of herpes viruses. (wikipedia.org)
  • During these early stages of infection, ICP0 protein is synthesized and transported to the nucleus of the infected host cell. (wikipedia.org)
  • Another regulatory T cell subset is Treg17 cells. (wikipedia.org)
  • Additional regulatory T cell populations include Tr1, Th3, CD8+CD28-, and Qa-1 restricted T cells. (wikipedia.org)
  • If a T cell receives an intermediate signal, then it will become a regulatory cell. (wikipedia.org)
  • regulates
  • It has been shown that the extreme C-terminus of IRF-1 regulates its ability to activate transcription, nanobodies targeting this domain (MF1) are able to increase IRF-1 activity. (wikipedia.org)
  • But as we could read in the article called "SON protein regulates GATA-2 through transcriptional control of the microRNA 23a-27-24-a clúster", SON protein has even more functions in the organism. (wikipedia.org)
  • Similar to the founding family member MTA1, MTA2 functions as a chromatin remodeling factor and regulates gene expression. (wikipedia.org)
  • nucleus
  • SON protein is essential for maintaining the subnuclear organization of the factors that are processed in the nucleus highlighting its direct role in pre-mRNA splicing. (wikipedia.org)
  • MTA2 protein localizes in the nucleus and is a component of the nucleosome remodeling and the deacetylation complex (NuRD). (wikipedia.org)
  • interaction
  • Such an intimate cellular relationship involves regulatory crosstalk between partners that allows the interaction to persist. (biologists.org)
  • At the DP (double-positive) stage, they are selected by their interaction with the cells within the thymus, begin the transcription of Foxp3, and become Treg cells, although they may not begin to express Foxp3 until the single-positive stage, at which point they are functional Tregs. (wikipedia.org)
  • regulation
  • To maintain the pluripotency of the embryonic stem cells, transcription factors and epigenetic modifiers play an important role despite the fact that little is known about the regulation of pluripotency throughout the process of splicing. (wikipedia.org)
  • antibodies
  • The up-regulatory effect of TNF␣ on 52-kd Ro/SSA mRNA and protein expression was inhibited by anti-TNFRI antibodies but enhanced by antiTNFRII antibodies. (docme.ru)
  • These cells coordinate an immune response upon the detection of foreign proteins (antigens), producing antibodies that bind to these antigens. (wikipedia.org)
  • The ENAs consist of ribonucleoproteins and non-histone proteins, named by either the name of the donor who provided the prototype serum (Sm, Ro, La, Jo), or the name of the disease setting in which the antibodies were found (SS-A, SS-B, Scl-70). (wikipedia.org)
  • However, apoptosis was not observed following culture with other anti-CD47 antibodies. (wikipedia.org)
  • cytochrome
  • The MitoCapture mitochondrial apoptosis and cytochrome c release assays indicated that t-Darpp expression enforces the mitochondrial transmembrane potential and protects against ceramide-induced apoptosis. (aacrjournals.org)
  • In intrinsic activation, cytochrome c from the mitochondria works in combination with caspase-9, apoptosis-activating factor 1 (Apaf-1), and ATP to process procaspase-3. (wikipedia.org)
  • viral
  • Adapter molecules Bi-specific adapter molecules can be administered along with the virus to redirect viral coat protein tropism. (wikipedia.org)
  • Coat-protein modification This method involves genetically modifying the fiber knob domain of the viral coat protein to alter its specificity. (wikipedia.org)
  • Short peptides added to the C-terminal end of the coat protein successfully altered viral tropism. (wikipedia.org)
  • It acts synergistically with HSV-1 immediate early (IE) protein, ICP4, and is essential for reactivation of latent herpes virus and viral replication. (wikipedia.org)
  • immune system
  • This is because the protein IAP produced by CD-47 acts as a don't eat me signal to the immune system and drives organ fibrosis. (wikipedia.org)
  • Programmed death-ligand 1 (PD-L1) is a 40kDa type 1 transmembrane protein that has been speculated to play a major role in suppressing the immune system during particular events such as pregnancy, tissue allografts, autoimmune disease and other disease states such as hepatitis. (wikipedia.org)
  • The regulatory T cells (Tregs /ˈtiːrɛɡ/), formerly known as suppressor T cells, are a subpopulation of T cells that modulate the immune system, maintain tolerance to self-antigens, and prevent autoimmune disease. (wikipedia.org)
  • T regulatory cells are a component of the immune system that suppress immune responses of other cells. (wikipedia.org)
  • translocation
  • Overexpression of bcl-2 proteins, due to a translocation of the gene, is associated with follicular lymphoma. (labome.org)
  • The translocation breakpoint led to the loss of the controlling elements of the NFATc2 protein and the fusion of the N terminal region of the EWSR1 gene conferred constant activation of the protein. (wikipedia.org)
  • mRNA
  • It may also be involved in protecting cells from apoptosis and in pre-mRNA splicing. (wikipedia.org)
  • Not only the SON protein interferes in the splicing but also makes complex mechanisms such as the RNA post-transcriptional to cooperate with the splicing-mRNA processing. (wikipedia.org)
  • Resting human cholangiocytes express PD-L1 mRNA, but not the protein, due to translational suppression by microRNA miR-513. (wikipedia.org)