• induce apoptosis
  • Excessive ROS, however, can exert cytotoxic effects, cause oxidative damage to proteins, and DNA, can interfere with cell growth and cell cycle progression, and induce apoptosis of gingival fibroblasts. (frontiersin.org)
  • The binding of PD-L1 to PD-1 or B7.1 transmits an inhibitory signal that reduces the proliferation of these T cells and can also induce apoptosis, which is further mediated by a lower regulation of the gene Bcl-2. (wikipedia.org)
  • pathways
  • Professor Utz is an expert in the study of human and murine autoantibodies and autoantigens, apoptosis signaling pathways, animal models of autoimmunity, proteomics and multiplexed assay development for biomarker discovery. (stanford.edu)
  • The present study aimed to characterize the effect of TNF␣ on messenger RNA (mRNA) and protein expression of the intracellular 52-kd Ro/SSA autoantigen in primary human keratinocytes and to elucidate the TNF␣ receptor (TNFR) signaling pathways mediating this effect. (docme.ru)
  • cDNA
  • Cross-hybridization of the mouse cDNA to a human thymus library yielded the human homolog, which encodes a protein 83% identical to the mouse ectodomain. (jax.org)
  • MTA2 was initially recognized as an MTA1 like 1 gene, named MTA1-L1, from a large scale sequencing of randomly selected clones from human cDNA libraries in 1999. (wikipedia.org)
  • constitutive
  • Between different donors, a high variability of both constitutive expression levels and TNF␣ -induced changes in 52-kd Ro/SSA mRNA and protein expression was observed. (docme.ru)
  • It also facilitates the interaction of SR proteins with RNA polymerase II and is required for processing of weak constitutive splice sites, having also strong implications in cancer and other human diseases. (wikipedia.org)
  • endogenous
  • Insults resulting from exposure to a variety of neurotoxins, both exogenous and endogenous, constitute the main triggering event of pathological apoptosis in the adult nervous system ( Yuan and Yankner, 2000 ). (jneurosci.org)
  • HSV-1 ICP0 and several of its homologs in other herpes viruses bind to SUMO-1 in a manner similar to endogenous proteins, causing depletion of SUMO-1, and disruption of nuclear bodies. (wikipedia.org)
  • antibody
  • These molecules are fusion proteins that are made up of an antibody raised against the knob domain of the adenovirus coat protein, fused to a natural ligand for a cell-surface receptor. (wikipedia.org)
  • Jurkat cells and peripheral blood mononuclear cells (PBMC) incubated with the monoclonal antibody Ad22 results in apoptosis within 3 hours. (wikipedia.org)
  • intracellular
  • Potential factors for MDR includes enhanced drug detoxification, decreased drug uptake, increased intracellular nucleophiles levels, enhanced repair of drug induced DNA damage, overexpression of drug transporter such as P-glycoprotein(P-gp), multidrug resistance-associated proteins (MRP1, MRP2), and breast cancer resistance protein (BCRP). (frontiersin.org)
  • TNF␣-induced up-regulation of 52-kd Ro/SSA mRNA expression peaked at 4 hours, followed by up-regulation of intracellular 52-kd Ro/SSA protein expression at 24 hours, independently of apoptosis. (docme.ru)
  • NOR1 is a member of the nuclear receptor family of intracellular transcription factors. (wikipedia.org)
  • In a mouse model of intracellular infection, L. monocytogenes induced PD-L1 protein expression in T cells, NK cells, and macrophages. (wikipedia.org)
  • regulates
  • It has been shown that the extreme C-terminus of IRF-1 regulates its ability to activate transcription, nanobodies targeting this domain (MF1) are able to increase IRF-1 activity. (wikipedia.org)
  • Similar to the founding family member MTA1, MTA2 functions as a chromatin remodeling factor and regulates gene expression. (wikipedia.org)
  • nucleus
  • This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. (wikipedia.org)
  • MTA2 protein localizes in the nucleus and is a component of the nucleosome remodeling and the deacetylation complex (NuRD). (wikipedia.org)
  • Antinuclear antibodies (ANAs, also known as antinuclear factor or ANF) are autoantibodies that bind to contents of the cell nucleus. (wikipedia.org)
  • SON protein is essential for maintaining the subnuclear organization of the factors that are processed in the nucleus highlighting its direct role in pre-mRNA splicing. (wikipedia.org)
  • During these early stages of infection, ICP0 protein is synthesized and transported to the nucleus of the infected host cell. (wikipedia.org)
  • membrane
  • HspB1 was also detected as a surface membrane protein in some cancer cell types (Shin et al. (atlasgeneticsoncology.org)
  • Comparison of the major outer-membrane protein (MOMP) gene of mouse pneumonitis (MoPn) and hamster SFPD strains of Chlamydia trachomatis with other Chlamydia strains. (wikipedia.org)
  • Latent membrane protein 1 (LMP1) is a major oncogene encoded by Epstein-Barr virus (EBV) and is essential for immortalization of B cells by the virus. (frontiersin.org)
  • interaction
  • Such an intimate cellular relationship involves regulatory crosstalk between partners that allows the interaction to persist. (biologists.org)
  • At the DP (double-positive) stage, they are selected by their interaction with the cells within the thymus, begin the transcription of Foxp3, and become Treg cells, although they may not begin to express Foxp3 until the single-positive stage, at which point they are functional Tregs. (wikipedia.org)
  • regulation
  • Binding of TSP-1 to CD47 influences several fundamental cellular functions including cell migration and adhesion, cell proliferation or apoptosis, and plays a role in the regulation of angiogenesis and inflammation. (wikipedia.org)
  • To maintain the pluripotency of the embryonic stem cells, transcription factors and epigenetic modifiers play an important role despite the fact that little is known about the regulation of pluripotency throughout the process of splicing. (wikipedia.org)
  • antibodies
  • The up-regulatory effect of TNF␣ on 52-kd Ro/SSA mRNA and protein expression was inhibited by anti-TNFRI antibodies but enhanced by antiTNFRII antibodies. (docme.ru)
  • However, apoptosis was not observed following culture with other anti-CD47 antibodies. (wikipedia.org)
  • These cells coordinate an immune response upon the detection of foreign proteins (antigens), producing antibodies that bind to these antigens. (wikipedia.org)
  • The ENAs consist of ribonucleoproteins and non-histone proteins, named by either the name of the donor who provided the prototype serum (Sm, Ro, La, Jo), or the name of the disease setting in which the antibodies were found (SS-A, SS-B, Scl-70). (wikipedia.org)
  • viral
  • For adenovirus replication to occur, the host cell must be induced into S phase by viral proteins interfering with cell cycle proteins. (wikipedia.org)
  • Adapter molecules Bi-specific adapter molecules can be administered along with the virus to redirect viral coat protein tropism. (wikipedia.org)
  • Coat-protein modification This method involves genetically modifying the fiber knob domain of the viral coat protein to alter its specificity. (wikipedia.org)
  • Short peptides added to the C-terminal end of the coat protein successfully altered viral tropism. (wikipedia.org)
  • It acts synergistically with HSV-1 immediate early (IE) protein, ICP4, and is essential for reactivation of latent herpes virus and viral replication. (wikipedia.org)
  • immune system
  • This is because the protein IAP produced by CD-47 acts as a don't eat me signal to the immune system and drives organ fibrosis. (wikipedia.org)
  • Programmed death-ligand 1 (PD-L1) is a 40kDa type 1 transmembrane protein that has been speculated to play a major role in suppressing the immune system during particular events such as pregnancy, tissue allografts, autoimmune disease and other disease states such as hepatitis. (wikipedia.org)
  • The regulatory T cells (Tregs /ˈtiːrɛɡ/), formerly known as suppressor T cells, are a subpopulation of T cells that modulate the immune system, maintain tolerance to self-antigens, and prevent autoimmune disease. (wikipedia.org)
  • T regulatory cells are a component of the immune system that suppress immune responses of other cells. (wikipedia.org)
  • Cell Cycle
  • Among them, D-type G1 cyclins and a Cdk inhibitor, p27Kip1, function as the target of growth factors to integrate extracellular signals into cell cycle regulators. (biomedsearch.com)
  • SON is the name that has been given to a large Ser/Arg (SR)-related protein, which is a splicing co-factor that contributes to an efficient splicing within cell cycle progression. (wikipedia.org)
  • page needed] Although there is a lack of knowledge about its exact splicing control in the progression of the cell cycle and it has remained largely unexplored, it's certain that this splicing-associated protein is necessary for the maintenance of the embryonic stem cells because it influences the splicing of pluripotency regulators. (wikipedia.org)
  • ubiquitination
  • The SCF E3 ubiquitin-ligase complex participates in the recognition and recruitment of target proteins for ubiquitination and degradation by the ubiquitin 26S proteasome system (UPS). (mdpi.com)
  • human
  • Infection with high-risk human papillomaviruses (HPVs) represents a major risk factor for the development of cervical cancer. (aacrjournals.org)
  • Human Herpes Virus (HHV) Infected Cell Polypeptide 0 (ICP0) is a protein, encoded by the DNA of herpes viruses. (wikipedia.org)
  • Small ubiquitin-related modifier 1 (SUMO-1) is a protein produced by human cells that is involved in the modification of many proteins, including human PML protein. (wikipedia.org)