• Activation of transforming growth factor beta receptors causes the phosphorylation and nuclear translocation of Smad proteins, which then participate in the regulation of expression of target genes. (nih.gov)
  • Prediction of the coding sequences of unidentified human genes. (wikipedia.org)
  • In addition, Rep.3 carries 2 genes encoding the histone-like nucleoid-structuring protein. (cdc.gov)
  • His section, which moved to the Laboratory of Immunogenetics in 2012, currently works to understand how genome-wide, CTCF/BORIS-binding sequences regulate different functions, including inter- and intra-chromosomal 3D DNA-looping interactions, mono-allelic expression of imprinted and non-imprinted genes, X-chromosome inactivation, and regulation of stem/germ cell-specific promoters associated with targeted DNA demethylation. (nih.gov)
  • Bioinformatics programs usually allow for alternate start codons when searching for protein coding genes. (wikiversity.org)
  • RNA polymerase II is recruited to the promoters of protein-coding genes in living cells. (wikiversity.org)
  • The activation process, involving transcription factors, along with histones and cofactors, displaces or remodels chromatin, and opens up regions of the DNA and the core promoters of genes, for the binding of regulatory proteins to the core promoter, and the recruitment of RNA polymerase. (ukessays.com)
  • Proteins which maintain the transcriptional quiescence of specific GENES or OPERONS . (nih.gov)
  • Employing this strategy, we discovered four candidate structured RNAs including a new riboswitch class as well as three additional likely cis -regulatory elements that precede genes encoding ribosomal proteins S2 and S12, and the cytoplasmic protein component of the signal recognition particle. (biomedcentral.com)
  • Given its numeric advantage, genes from members of the SAR11 clade are well-represented in marine metagenomic libraries with nearly 20% of sequence reads from the Global Oceanographic Survey (GOS) matching most closely to genes present in the ' Cand . (biomedcentral.com)
  • If the proteins candidates are really physically interacting with each other, this event will starts the transcription of downstream reporter genes, e. g. (igem.org)
  • CAAT box (also CAT box) A conserved sequence found within the promoter region of the protein-encoding genes of many eukaryotic organisms. (fao.org)
  • candidate-gene strategy An experimental approach in which knowledge of the biochemistry and/or physiology of a trait is used to draw up a list of genes whose protein products could be involved in the trait. (fao.org)
  • Wnt proteins trigger a wide variety of responses, ranging from cell fate specification through the activation of specific target genes to the control of cell polarity and migration through pathways that directly modulate the cytoskeleton ( Angers and Moon, 2009 ). (wormbook.org)
  • Expression or transient expression of cell cycle arresting genes is described for "metabolic engineering", i.e. regulating expression of desirable proteins, and it is mentioned that a transcriptional "squelching" effect by the VP16 transactivator domain may be lethal for the host cell, even at moderate expression levels (Berger et al. (allindianpatents.com)
  • A recent study using chromatin immunoprecipitation sequencing (ChIP-seq) analysis identified 2470 potential Nrf1 targets in human neuroblastoma cells, indicating roles for Nrf1 in regulating genes for mitochondrial biogenesis and cell growth and in the pathogenesis of neurodegenerative diseases [ 16 ]. (biomedcentral.com)
  • Polycomb response elements (PREs) are cis-regulatory sequences required for Polycomb repression of Hox genes in Drosophila . (silverchair.com)
  • After the decay of segmentation gene products, transcriptional ON and OFF states of Hox genes are heritably maintained by Polycomb group (PcG) and trithorax group (trxG)proteins which, however, are present in all cells. (silverchair.com)
  • PcG repressors keep Hox genes inactive in cells in which these genes must remain inactive whereas trxG regulators are needed to maintain the active state of Hox genes in appropriate cells. (silverchair.com)
  • None of these proteins has been shown to directly regulate transcription of genes in monocyte/macrophage except TRIM33 that we have recently shown to be a macrophage specific transcriptional inhibitor of Ifnb1 . (oncotarget.com)
  • When located near the same genes, TRIM33 is bound to different sequences in the two cell lines suggesting a role of TRIM33 in both immature and mature myeloid cells. (oncotarget.com)
  • [8] DUX4 protein is a modulator of hundreds of other genes, many of which are involved in muscle function. (mdwiki.org)
  • Burkholderia species have environmental, industrial and medical significance, and are important opportunistic pathogens in individuals with cystic fibrosis (CF). Using a combination of existing and newly determined genome sequences, this study investigated prophage carriage across the species B. vietnamiensis , and also isolated spontaneously inducible prophages from a reference strain, G4. (mdpi.com)
  • The whole-genome sequence of TSY216 was completed and deposited in GenBank (accession nos. (cdc.gov)
  • In total, 4,579 coding sequences were detected and annotated by using the National Center for Biotechnology Information Prokaryotic Genome Annotation Pipeline ( http://www.ncbi.nlm.nih.gov/genome/annotation_prok/ ). (cdc.gov)
  • 5. Cellular cap-binding protein, eIF4E, promotes picornavirus genome restructuring and translation. (nih.gov)
  • Pandiyan A, Ray MK (2013) Draft genome sequence of the Antarctic psychrophilic bacterium Pseudomonas syringae strain Lz4W. (springer.com)
  • The genome of ' Candidatus Pelagibacter ubique' HTCC 1062 is the closest match for approximately 20% of marine metagenomic sequence reads. (biomedcentral.com)
  • To circumvent many of the challenges associated with analyzing metagenomic sequence data, we have used the genome of ' Cand . (biomedcentral.com)
  • Sequence determination of the entire genome and assignment of potential protein-coding regions JOURNAL DNA Res. (lifesciencedb.jp)
  • I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome JOURNAL DNA Res. (lifesciencedb.jp)
  • In the absence of helper virus co-infection, the Rep protein represses AAV gene expression and the AAV DNA integrates into the cellular genome. (nih.gov)
  • Genome-wide TFBS identification, a crucial step in deciphering transcription regulatory networks and annotating genomic sequences, remain a key challenge in post-genomics research. (biomedcentral.com)
  • The 23S rRNA gene encodes a component of the 50S ribosome, where bacterial protein synthesis occurs. (medscape.com)
  • [ 4 ] The mtrR gene encodes a repressor of a bacterial efflux pump that exports antibiotics, including macrolides, out of the bacteria. (medscape.com)
  • Rep.3 encodes 999 coding sequences and 66 transfer RNAs, among which 39 have been assigned putative functions and 960 encode hypothetical proteins and proteins of unknown function. (cdc.gov)
  • In this regard, a 165-kb plasmid, pSf-R27, in Shigella flexneri encodes a histone-like nucleoid-structuring protein that was claimed to be a transcriptional repressor of the plasmid ( 9 ). (cdc.gov)
  • KirrelL is an essential downstream effector gene in this network and encodes an Ig-superfamily protein required for the fusion of skeletogenic cells and the formation of the skeleton. (elifesciences.org)
  • GdhR is a transcriptional repressor of the virulence factor gene lctP, which encodes a unique l-lactate permease that has been linked to pathogenesis of Neisseria gonorrhoeae, and loss of gdhR can confer increased fitness of gonococci in a female mouse model of lower genital tract infection. (cdc.gov)
  • By analyzing a panel of U.S. (from 2017 to 2018) and Danish (1928 to 2013) clinical isolates, we observed a statistical association between gdhR6 and the previously described adenine deletion in the promoter of mtrR (mtrR-P A-del), encoding the repressor (MtrR) of the mtrCDE operon that encodes the MtrCDE multidrug efflux pump that can export antibiotics, host antimicrobials, and biocides. (cdc.gov)
  • Salmonella Pathogenicity Island 1 (SPI-1) encodes a type three secretion system (T3SS), effector proteins, and associated transcription factors that together enable invasion of epithelial cells in animal intestines. (mdpi.com)
  • The SnoN gene, a member of the Ski family of proto-oncogenes that was originally identified based on sequence homology with v-Ski, encodes an oncoprotein that can induce anchorage-independent growth of chicken and quail embryo fibroblasts when overexpressed [ 9 - 12 ]. (biomedcentral.com)
  • Consistent with the critical role previously reported for Sin3 proteins in the histone acetylation process, we found that the growth of the strain with the pst1-1 allele was supersensitive to the specific histone deacetylase inhibitor trichostatin A. However, our analysis of strains with the pst1-1 mutation was unable to detect any changes in the acetylation of specific lysines of histones H3 and H4 as measured in bulk chromatin. (tamu.edu)
  • Chromosomes are very long molecules of DNA which are wrapped around histone proteins to form nucleosomes. (ukessays.com)
  • MeCP2 is also shown to interact with Sin3/Histone deacetylase co-repressor complex. (ukessays.com)
  • NOC2 like nucleolar associated transcriptional repressor (NOC2L) was recently identified as a novel inhibitor of histone acetyltransferase (INHAT). (biomedcentral.com)
  • They are olfactory cell at the direction phase and widely, can view Activated into 19 complexes( Subfamily A1-19) spliced on a pleiotropic protein( Joost entry and Methner A, 2002). (familie-vos.de)
  • The results of immunofluorescence microscopy showed that the nuclear localization of the Tf1 capsid protein was disrupted in the strain with the pst1-1 mutation, indicating an important role of pst1(+) in modulating the nuclear import of Tf1 virus-like particles. (tamu.edu)
  • This mutation (gdhR6) was found to reduce GdhR transcriptional repression at lctP in gonococcal strains containing the mutant protein compared to wild-type GdhR. (cdc.gov)
  • Interestingly, gdhR6 was found in clinical gonococcal strains isolated in the United States and Denmark at a high frequency and was frequently associated with a mutation in the promoter of the gene encoding a repressor (MtrR) of both the mtrCDE antimicrobial efflux pump operon and gdhR. (cdc.gov)
  • Uses for the reaction include disease diagnosis, detection of difficult-to-isolate pathogens, mutation analysis, genetic testing, DNA sequencing, and analyzing evolutionary relationships. (lookformedical.com)
  • In the mtrR gene, deletions in the promoter region, observed in one sequenced isolate, and missense mutations in the coding region, identified in all four sequenced isolates, can lead to decreased efflux pump repression, increased export of macrolides, and ultimately, decreased ability of azithromycin to inhibit bacterial protein synthesis. (medscape.com)
  • The RNA-binding catabolite repression control (Crc) protein acts as a global post-transcriptional regulator of CCR in Pseudomonas species. (springer.com)
  • Milojevic T, Grishkovskaya I, Sonnleitner E, Djinovic-Carugo K, Bläsi U (2013) The Pseudomonas aeruginosa catabolite repression control Protein, Crc, is devoid of RNA binding activity. (springer.com)
  • Together, these results suggest that PREs function as general silencer elements through which PcG proteins mediate transcriptional repression. (silverchair.com)
  • [7] In humans RNAP II consists of seventeen protein molecules (gene products encoded by POLR2A-L, where the proteins synthesized from 2C-, E-, and F-form homodimers). (wikiversity.org)
  • The different cell types in multicellular organisms arise due to the synthesis and accumulation of different sets or RNA and protein molecules. (ukessays.com)
  • The essential steps include thermal denaturation of the double-stranded target molecules, annealing of the primers to their complementary sequences, and extension of the annealed primers by enzymatic synthesis with DNA polymerase. (lookformedical.com)
  • Interestingly, the pst1-1 mutant strain produced wild-type levels of Tf1-encoded proteins and cDNA, indicating that the defect in transposition occurred after reverse transcription. (tamu.edu)
  • This analysis identified three hypothetical proteins (Ent638_0594, Ent638_3274 , and Ent638_3824), an lpp repeatcontaining protein, and an entericidin B membrane. (lbl.gov)
  • In addition to a constitutively occupied E2F1-Sp1 site immediately upstream of the cyclin E transcription start region, there is downstream a cell cycle-regulated site (termed CERM) that may function as a cyclin E-repressor module. (nih.gov)
  • High concentrations of Rep appear to be cytotoxic to the cell, and it is not possible to produce a cell line that constitutively expresses Rep proteins. (nih.gov)
  • SYT_ECOLI ] ThrS is also a translational repressor protein, it controls the translation of its own gene by binding to its mRNA. (proteopedia.org)
  • NOC2L protein is 84,919 Da and contains 749 amino acids in human, and its orthologs range from worms to mammals (NCBI Reference Sequence: NP_056473.3). (biomedcentral.com)
  • Fu, L., Li, C., Na, W., and Shi, Y.-B. (2019) Liganded thyroid hormone receptor activates methyl-CpG binding domain protein 3 (MBD3) through binding to an intronic TRE during Xenopus metamorphosis. (nih.gov)
  • In vitro method for producing large amounts of specific DNA or RNA fragments of defined length and sequence from small amounts of short oligonucleotide flanking sequences (primers). (lookformedical.com)
  • For those circumstances in which the holoenzyme is built onto the euchromatin, it is necessary to consider the holoenzyme components and the likely sequence of binding, RNA polymerase II entrance upon the scene and subsequent action. (wikiversity.org)
  • We show here that, although the PPT sequence is relatively resistant to RNase H cleavage, it can be cleaved internally by the polymerase-independent RNase H activity of Ty1 RT. (cnrs.fr)
  • Like deltaEF1, SIP1 binds to 5'-CACCT sequences in different promoters, including the Xenopus brachyury promoter. (nih.gov)
  • B3 Ku binds to the C-terminal region of DNA-PK (amino acids 3002-3850) near the protein kinase domain (Jin et al. (nih.gov)
  • Moreno R, Marzi S, Romby P, Rojo F (2009) The Crc global regulator binds to an unpaired A-rich motif at the Pseudomonas putida alkS mRNA coding sequence and inhibits translation initiation. (springer.com)
  • 19. Binding of cellular repressor protein or the IE2 protein to a cis-acting negative regulatory element upstream of a human cytomegalovirus early promoter. (nih.gov)
  • Single-fluorophore fluorescent protein-based indicators have been engineered to respond to various cellular parameters including pH, halides, free Ca 2+ and redox potentials. (nature.com)
  • Genetically-encoded reporter constructs that are derived from fluorescent proteins are leading a revolution in the real-time visualization and tracking of various cellular events. (nature.com)
  • Recent advances include the continued development of 'passive' markers for the measurement of biomolecule expression and localization in live cells, and 'active' indicators for monitoring more complex cellular processes such as small-molecule-messenger dynamics, enzyme activation and protein-protein interactions. (nature.com)
  • Dr. Lobanenkov's team characterized the novel CTCF & BORIS proteins as being universally involved in the epigenetic regulation of mammalian cellular and viral genomes. (nih.gov)
  • 18. Eukaryotic translation initiation factor 4GI and p97 promote cellular internal ribosome entry sequence-driven translation. (nih.gov)
  • Interaction between the cellular protein eEF1A and the 3′-terminal stem-loop of West Nile virus genomic RNA facilitates viral minus-strand RNA synthesis. (microbiologyresearch.org)
  • The discovery of many RNA sequences that do not encode proteins (non-coding RNAs or ncRNA) and have biological functions beyond those of tRNA and rRNA, has significantly expanded the known role of RNA in diverse cellular processes. (biomedcentral.com)
  • 2. Eukaryotic initiation factor 4G-poly(A) binding protein interaction is required for poly(A) tail-mediated stimulation of picornavirus internal ribosome entry segment-driven translation but not for X-mediated stimulation of hepatitis C virus translation. (nih.gov)
  • 12. The C-terminal domain of eukaryotic protein synthesis initiation factor (eIF) 4G is sufficient to support cap-independent translation in the absence of eIF4E. (nih.gov)
  • 1647 nucleotide sequences were obtained. (scirp.org)
  • Our recent survey showed that the DNA structures of different cognate binding sequences of a transcription factor generally conserve well with smaller root mean squared deviations (RMSDs), suggesting that the interaction modes are conserved between the transcription factor and its specific binding sequences even though there are variations at certain positions of the binding motif [ 3 ]. (biomedcentral.com)
  • Pumilio family members are characterised by the presence of eight tandem copies of an imperfectly repeated 36 amino acids sequence motif, the Pumilio repeat, surrounded by a short N- and C-terminal conserved region. (embl-heidelberg.de)
  • Neri D, Szyperski T, Otting G, Senn H, Wüthrich K (1989) Stereospecific nuclear magnetic resonance assignments of the methyl groups of valine and leucine in the DNA-binding domain of the 434 repressor by biosynthetically directed fractional 13 C labeling. (springer.com)
  • Gardner KH, Kornat DR, Rosen MK, Kay LE (1996) An (H)C(CO)NH-TOCSY pulse scheme for sequential assignment of protonated methyl groups in an otherwise deuterated 15 N, 13 C-labeled proteins. (springer.com)
  • We describe a novel Smad-interacting protein, SIP1, which was identified using the yeast two-hybrid system. (nih.gov)
  • 20. Repressor binding to a dorsal regulatory site traps human eIF4E in a high cap-affinity state. (nih.gov)
  • They establish a putative direct link between a developmental gene regulatory network driving cell fate commitment and an effector protein enabling a key behavior of the specified cell type, thereby strengthening the explanatory power of a well-established GRN model. (elifesciences.org)
  • in an attempt to find novel INHAT by conducting low-stringency iterative analyses of the Basic Local Alignment Search Tool (BLAST) to screen databases for proteins containing putative INHAT regions. (biomedcentral.com)
  • 0.0085 6.10 KPN_01977 Lysozyme inhibitor 9.57 12.45 0.0007 7.34 KPN_02742 Hypothetical 8.95 11.38 0.0057 5.40 KPN_03160 Hypothetical 11.17 13.82 0.0028 6.30 KPN_04221 Periplasmic repressor CpxP 10.08 12.49 0.0044 5.32 KPN_04433 Putative stress-response protein 9.46 11.81 0.0083 5.09 KPN_04512 a N-glycosyl-transferase PgaC 6.40 9.74 0.0003 10.13 KPN_04513. (lbl.gov)
  • 19150 L (IM or OM) unkn 7180 37 LSAC 21 T 2 putative lipoprotein YgdI Z4126 (ygdI) 8342 L (IM or OM) unkn 5912 1112 LSAC 21 S 3 putative Bor protein of bacteriophage BP-933W Z1474 (borW) 10477 L (hydr LS) unkn 5666 0 ITGC 17. (lbl.gov)
  • The barrel-like structures of Aequorea fluorescent proteins (AFPs), which effectively shield the chromophore from the external environment, make them well suited to more 'passive' applications such as monitoring the spatio-temporal (location, translocation, accumulation and degradation) dynamics of appropriate fusion proteins. (nature.com)
  • One issue in structure-based TFBS prediction concerns the potential divergence of DNA structures of different sequences for a transcription factor since only one TF-DNA complex model is used for evaluating different sequences. (biomedcentral.com)
  • Recent advances in fluorescent proteins include the engineering or discovery of variants that have enhanced brightness, improved pH resistance, the ability to undergo photochemical colour conversion, or red fluorescent emission. (nature.com)
  • Among the alternatives to fluorescent proteins, the tetracysteine-biarsenical labelling system is one of the most promising owing to its minimal steric bulk, fast rate of labelling, the availability of several colours and its ability to provide staining that is suitable for electron microscopy. (nature.com)
  • In the more 'active' applications of fluorescent proteins, biochemical parameters such as metabolite concentration, enzyme activity, or protein-protein interactions can be detected by their effects on the fluorescence properties of the designed indicators. (nature.com)
  • The current favourites are the fluorescent proteins, such as GFP, DsRed and their mutant derivatives. (allindianpatents.com)
  • Advances in fluorescence microscopy and the engi-neering of the green fluorescent protein (GFP) from Aequorea victoria into mutants with improved properties and altered colours have provided the basic tools that allow the investigation of complex processes in live cells. (nature.com)
  • The structure of threonyl-tRNA synthetase-tRNA(Thr) complex enlightens its repressor activity and reveals an essential zinc ion in the active site. (proteopedia.org)
  • Sankaranarayanan R, Dock-Bregeon AC, Romby P, Caillet J, Springer M, Rees B, Ehresmann C, Ehresmann B, Moras D. The structure of threonyl-tRNA synthetase-tRNA(Thr) complex enlightens its repressor activity and reveals an essential zinc ion in the active site. (proteopedia.org)
  • In vitro and in vivo stability of the epsilon2zeta2 protein complex of the broad host-range Streptococcus pyogenes pSM19035 addiction system. (mdc-berlin.de)
  • A typical structure-based TFBS prediction method evaluates each candidate DNA sequence by "threading" it onto the DNA structure of a known TF-DNA complex and the binding affinity or binding energy is then calculated using energy functions [ 3 ]. (biomedcentral.com)
  • In the absence of Wnt signaling, β-catenin is targeted for degradation by a destruction complex that consists of the scaffold protein Axin, the tumor suppressor gene product APC, and the kinases CK1 and GSK3β. (wormbook.org)
  • No complex found for this protein. (yeastrc.org)
  • Where there is download An American Soldier in World War I (Studies in War, Society, and ", either by severe destabilization or a complex in IL1 transporter, proteins required rafts explain. (familie-vos.de)
  • as, cobalamin( Cbl, hexokinase ligand) other regulators are mediated below( Chapter 155 in The Metabolic and Molecular Bases of Inherited Disease, complex sequence, Scriver et al. (familie-vos.de)
  • Depending on whether transcription is activated or repressed, the co-regulator can be TIF2 (transcriptional intermediary factor 2) or NCoR (nuclear receptor co-repressor). (iucr.org)
  • Nuclear hormone receptors, their ligands, and relevant accessory proteins play important roles in development and aging, metabolism, and disease, and comprise a large superfamily of receptors for a multitude of hormones, xenobiotics, lipids, and other known and unknown ligands. (nih.gov)
  • Thus, further understanding of receptor specificity, ligand selectivity, interaction with cytoplasmic and/or nuclear accessory proteins, chromatin, and the transcriptional machinery, will require development of a unique database to collect and integrate this information. (nih.gov)
  • The PABP-specific translation inhibitor PABP-interacting protein 2 (Paip2) interferes with the DENV 3′UTR-PABP interaction, and in vitro translation of DENV reporter RNAs in baby hamster kidney cell extracts is inhibited by Paip2 in a dose-dependent manner. (microbiologyresearch.org)
  • By using purified recombinant proteins and in vitro DNA-binding and cross-linking experiments, we found that gdhR6 impairs the DNA-binding activity of GdhR at lctP without an apparent effect on protein oligomerization. (cdc.gov)
  • Sequencing of the 23S rRNA and mtrR coding regions of the four sequenced isolates, which demonstrated identical mutations, further supports the isolates' relatedness. (medscape.com)
  • entering of branches at mRNA properties in sequence sites. (erik-mill.de)
  • Poly(A)-binding protein (PABP) is a key player in mRNA circularization and translation initiation of polyadenylated mRNAs. (microbiologyresearch.org)
  • mRNA polyadenylate-binding protein: gene isolation and sequencing and identification of a ribonucleoprotein consensus sequence. (microbiologyresearch.org)
  • The multiple RNA-binding domains of the mRNA poly(A)-binding protein have different RNA-binding activities. (microbiologyresearch.org)
  • The 4qA allele stabilizes this DUX4 mRNA, allowing it to be used for production of DUX4 protein . (mdwiki.org)
  • 18. Human thyroxine-binding globulin gene: complete sequence and transcriptional regulation. (nih.gov)
  • CTCF is a ubiquitous, 11-zinc-finger DNA-binding protein involved in transcriptional regulation, reading of imprinted sites, X-chromosome inactivation, and enhancer blocking/insulator function. (nih.gov)
  • examine the transcriptional regulation of kirrelL, a gene whose protein product is required for cell-cell fusion during the morphogenesis of the sea urchin larval skeleton. (elifesciences.org)
  • Binding of Wnt to the receptors Frizzled and LRP6 leads to inhibition of β-catenin degradation through a mechanism that involves the cytoplasmic protein Dishevelled and recruitment of Axin to LRP6 at the plasma membrane. (wormbook.org)
  • Zinc finger E-box-binding homeobox 2 is a protein that in humans is encoded by the ZEB2 gene. (wikipedia.org)
  • In this paper, we investigate the function of Smicl, a zinc-finger Smad-interacting protein that is expressed maternally in the Xenopus embryo. (biologists.com)
  • These include an amino-terminal domain containing a novel protein fold that makes minor groove contacts with the tRNA acceptor stem. (proteopedia.org)
  • The Mu Ner protein is a small (74 amino acids), basic, DNA-binding protein found in phage Mu. (nih.gov)
  • A small domain consisting of 60-65 amino acid residues was detected in the ribosomal protein S4, two families of pseudouridine synthases, a novel family of predicted RNA methylases, a yeast protein containing a pseudouridine synthetase and a deaminase domain, bacterial tyrosyl-tRNA synthetases, and a number of uncharacterized, small proteins that may be involved in translation regulation. (embl-heidelberg.de)
  • The resulting amino acid change in the GdhR protein resulted in enhanced expression of a virulence gene (lctP) that has been suggested to promote gonococcal survival during infection. (cdc.gov)
  • Molecular dissection of the interaction between amyloid precursor protein and its neuronal trafficking receptor SorLA/LR11. (mdc-berlin.de)
  • One candidate of a potential protein-interaction pair is fused to the DNA-binding domain of a transcription factor and the other candidate to the activation domain of a transcription factor. (igem.org)
  • A DNA binding sequence is split into overlapping pentamers (5 base pairs) for calculating transcription factor-pentamer interaction energy. (biomedcentral.com)
  • 17. Structural roles for human translation factor eIF3 in initiation of protein synthesis. (nih.gov)
  • Together with the increasing diversity of structural elements in the Protein Data Bank the results from TIF2 confirm the potential of fragment-based molecular replacement to significantly accelerate the phasing step for native diffraction data at around 2 Å resolution. (iucr.org)
  • AAV is a deceptively simple virus with only two open reading frames one encoding the structural proteins and the other the nonstructural, or Rep, proteins. (nih.gov)
  • REFERENCE 1 (bases 1 to 3573470) AUTHORS Thelwell,C., Robinson,N.J. and Turner-Cavet,J.S. TITLE An SmtB-like repressor from Synechocystis PCC 6803 regulates a zinc exporter JOURNAL Proc. (lifesciencedb.jp)
  • Yet analysis of this data to identify functional RNAs lags behind efforts to characterize protein diversity. (biomedcentral.com)
  • Therefore, SIP1, like deltaEF1, is likely to be a transcriptional repressor, which may be involved in the regulation of at least one immediate response gene for activin-dependent signal transduction pathways. (nih.gov)
  • In order to delineate the biological function of NOC2L, further studies were conducted to investigate NOC2L-targeted proteins and the underlying regulation mechanisms. (biomedcentral.com)
  • Due to its importance in EPEC virulence, regulation of the LEE has been of high priority and its investigation has elucidated many virulence regulators, including master regulator of the LEE Ler, H-NS, other nucleoid-associated proteins, GrlA, and PerC. (frontiersin.org)
  • post-translationally, DAISY reducing areas are proteins for 3rd many products of inhibitors and minimize formin-like information to single mechanisms of Canadian second studies. (erik-mill.de)
  • Mechanistically, Id proteins specify cardiac cell fate by repressing two inhibitors of cardiogenic mesoderm formation- Tcf3 and Foxa2 -and activating inducers Evx1 , Grrp1, and Mesp1 . (xenbase.org)
  • The structures of the protein-DNA complexes reveal a relatively unperturbed global conformation regardless of the identity of the base-pair at position 8 or residue 55. (rcsb.org)
  • As the tertiary structures of Mu Ner and these two related proteins are unknown, it is clear that a three-dimensional (3D) structure of Mu Ner is essential in order to gain insight into its mode of DNA binding. (nih.gov)
  • These approaches are not dependent on the identification of conserved RNA sequences or secondary structures, and therefore are well-suited for the discovery of unstructured or poorly-conserved ncRNAs. (biomedcentral.com)
  • 1. Characterization of a repressor element and a juxtaposed tissue-restricted activator element located on the distal neu gene promoter. (nih.gov)
  • 16. Characterization of a corticotropin-releasing hormone-responsive element in the rat proopiomelanocortin gene promoter and molecular cloning of its binding protein. (nih.gov)
  • Recent progress towards understanding the PcG/trxG system has come from the biochemical characterization of PcG and trxG protein complexes. (silverchair.com)
  • Matrix absence depends also characterized to enter health of involvement proteins and disorder pathway through acids on animal antigens, The kinase into the dCMP has VDAC1, VDAC2, and VDAC3 in the transcriptional pathway and the intracellular V support( MCU) ion in the similar miR-449C. (familie-vos.de)
  • However, such methods usually cannot be used to identify RNA motifs that may not have conserved secondary structure, are small with few base-pairing elements, or are not well-represented in genomic sequence databases. (biomedcentral.com)
  • The ZEB2 protein is a transcription factor that plays a role in the transforming growth factor β (TGFβ) signaling pathways that are essential during early fetal development. (wikipedia.org)
  • In this paper, we present an efficient pentamer algorithm by splitting DNA binding sequences into overlapping fragments along with a simplified integrative energy function for transcription factor binding site prediction. (biomedcentral.com)
  • It has been shown that lysine 55 of PurR makes a direct contact with the adenine base (Ade8) directly 5' to the central CpG base-pair step in the high-affinity purF operator sequence. (rcsb.org)
  • Mutations of the gene can cause the gene to produce nonfunctional ZEB2 proteins or inactivate the function gene as a whole. (wikipedia.org)
  • Wnt proteins are also important regulators of C. elegans development, with functions in processes as diverse as cell fate specification, asymmetric cell division, cell migration and synapse formation. (wormbook.org)
  • 3. Binding of an ETS-related protein within the DNase I hypersensitive site of the HER2/neu promoter in human breast cancer cells. (nih.gov)
  • 12. Activation of gastrin transcription in pancreatic insulinoma cells by a CACC promoter element and a 70-kDa sequence-specific DNA-binding protein. (nih.gov)
  • To determine why this is the case, we used confocal microscopy to image intercalating cells labeled using transplantation and a transgenic approach that labels CCPs with green fluorescent protein (GFP). (silverchair.com)
  • Cells expressing Rep proteins display aberrant growth rates and phenotype. (nih.gov)
  • Using systematic and unbiased functional screening approaches, we discovered that the Id family of helix-loop-helix proteins is both necessary and sufficient to direct cardiac mesoderm formation in frog embryos and human embryonic stem cells. (xenbase.org)