• 1984
  • He has co-authored/edited 2 books: The Antibody Enigma (1984) and Immunobiology 4th Edition (1999), co-edited seven volumes on The Antibodies with Maurizio Zanetti (1995-2002) and has served on the review and editorial boards of many journals. (wikipedia.org)
  • cells
  • In addition to the formed antibodies in the body there remains a small number of memory T and B cells that make up the cellular component of the immunological memory. (wikipedia.org)
  • Memory B cells are plasma cells that are able to produce antibodies for a long time. (wikipedia.org)
  • The white pulp of the spleen contains germinal centers, with lymphocytes, plasma cells, and macrophages that help coordinate the immune response and play roles in both innate and adaptive immunity. (medscape.com)
  • Lymphocytes belong to the lymphoid lineage and are considered as divergent from other blood cells lineages as those from the myeloid or erythroid lineage. (intechopen.com)
  • In particular, many intermediates between established subsets have been reported, for example Th1/Th17 cells expressing both IFNγ (interferon‐gamma) and IL (interleukin)‐17. (els.net)
  • There have been some reports of Thy1 monoclonal antibodies cross reacting with some cytoskeletal elements: anti Thy-1.2 with actin in marsupial, murine, and human cells and anti Thy-1.1 with vimentin, and were suggested to be due to sequence homology by studies done more than 20 years back. (wikipedia.org)
  • Although predominantly presents on neutrophils, it is also expressed on a subset of eosinophils, differentiating pre-monocytes and plasmacytoid dendritic cells. (acris-antibodies.com)
  • If undiagnosed or left untreated, HIV usually progresses to AIDS, defined as possessing a CD4+ lymphocyte count under 200 cells/μl or HIV infection plus co-infection with an AIDS-defining opportunistic infection. (wikipedia.org)
  • Human monoclonal antibodies and vaccine design: Taking advantage of his studies on human memory B cells (16), Lanazvecchia developed novel and robust methods to immortalize human memory B cells and to preserve single plasma cells in culture (17, 18). (wikipedia.org)
  • This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. (wikipedia.org)
  • However, CIK cells have the ability to recognize infected or even malignant cells in the absence of antibodies and MHC, allowing for a fast and unbiased immune reaction. (wikipedia.org)
  • This is of particular importance as harmful cells that are missing MHC markers cannot be tracked and attacked by other immune cells, such as T-lymphocytes. (wikipedia.org)
  • Others propose to classify CIK cells as subset of NKT cells. (wikipedia.org)
  • It has been shown that lymphocytes, when exposed to interferon-gamma, anti-CD3 antibody, interleukin-1 and interleukin 2, are capable of lysing fresh, non-cultured cancer cells, both primary and metastatic. (wikipedia.org)
  • Extracted cells are ex-vivo exposed to interferon-gamma, anti-CD3 antibody, interleukin-1 and interleukin-2 in a time-sensitive schedule. (wikipedia.org)
  • Gene-transfected CIK cells were first applied in 1999 for the treatment of ten patients in metastatic state of disease. (wikipedia.org)
  • New, proteomic approaches, including T-cell and B-cells-epitope mapping, can also accelerate the pace at which scientists discover antibody-antigen relationships. (wikipedia.org)
  • Upon lymphocyte activation TIRC7 is upregulated to engage HLA-DRα2 and induce apoptotic signals in human CD4+ and CD8+ T-cells. (wikipedia.org)
  • B cells, also known as B lymphocytes, are a type of white blood cell of the lymphocyte subtype. (wikipedia.org)
  • B cells, unlike the other two classes of lymphocytes, T cells and natural killer cells, express B cell receptors (BCRs) on their cell membrane. (wikipedia.org)
  • Of the three B cell subsets, FO B cells preferentially undergo T cell-dependent activation while MZ B cells and B1 B cells preferentially undergo T cell-independent activation. (wikipedia.org)
  • lymphoid
  • the common lymphoid progenitors (CLPs) can differentiate into all types of lymphocytes but lack the myeloid potential under physiological conditions, although some myeloid-related genes can be detected in CLPs depending on experimental conditions [ 1 , 2 ]. (intechopen.com)
  • malignancies
  • Radiolabeled monoclonal antibodies have been studied as a possible treatment for human malignancies. (aacrjournals.org)
  • Monoclonal antibodies have shown potential to act as therapeutic agents and have shown efficacy especially with hematologic malignancies as evidenced by the approval of rituximab and more recently of yttrium-90-labeled ibritumomab tiuxetan for low-grade non-Hodgkin's lymphoma ( 1 - 3 ). (aacrjournals.org)
  • Capra was an early leader in using human monoclonal antibodies from patients with lymphocytic malignancies helping to drive the field towards biopharmaceutical therapeutics, which now represents one of the largest segments of the pharmaceutical, diagnostic and research-based industries. (wikipedia.org)
  • Patients
  • To determine the maximum tolerated dose of combined therapy using an yttrium-90-labeled anti-carcinoembryonic antigen (CEA) antibody with gemcitabine in patients with advanced CEA-producing solid tumors. (aacrjournals.org)
  • Patients were treated with escalating doses of gemcitabine given i.v. over 30 minutes on day 1 and 3 after the infusion of the yttrium-90-labeled antibody. (aacrjournals.org)
  • Human antichimeric antibody responses were the primary reason for stopping treatment in 12 patients. (aacrjournals.org)
  • Wells TJ, Davison J, Sheehan E, Kanagasundaram S, Spickett G, MacLennan CA, Stockley RA, Cunningham AF, Henderson IR, De Soyza A. The Use of Plasmapheresis in Patients with Bronchiectasis with Pseudomonas aeruginosa Infection and Inhibitory Antibodies . (ncl.ac.uk)
  • While most patients with HIV show an antibody response after six weeks, window periods vary and may occasionally be as long as three months. (wikipedia.org)
  • Lower level of BAFF transcripts (or a higher level of soluble BAFF) show a higher risk of producing donor-specific antibodies in the investigated patients. (wikipedia.org)
  • soluble
  • Most are soluble intracellular proteins, but a subset associate with membranes via a membrane-targeting posttranslational modification, such as an N-terminal myristoyl group, and can act as the catalytic subunit for receptors that lack their own catalytic domain. (wikipedia.org)
  • In vivo, triggering the HLA-DR-TIRC7 pathway in lipopolysaccaride (LPS) activated lymphocytes using soluble HLA-DRα2 leads to inhibition of proinflammatory as well as inflammatory cytokines and induction of apoptosis. (wikipedia.org)
  • cytomegalovirus
  • Neutralizing antibodies were isolated against SARS, cytomegalovirus, avian influenza and dengue virus. (wikipedia.org)
  • Unusually potent antibodies that neutralize human cytomegalovirus (HCMV) were isolated and their epitopes mapped to a pentameric glycoprotein complex, which is currently tested as a candidate vaccine. (wikipedia.org)
  • cell
  • In contrast, the naive plasma cell is fully differentiated and can not be further stimulated by antigen to divide or increase antibody production. (wikipedia.org)
  • These studies led to a single cell FACS-sorting based technology for the generation of monoclonal antibodies. (wikipedia.org)
  • Initial models of highly stable T‐cell subsets were useful but underestimated diversity. (els.net)
  • Cell-mediated autoimmunity in paraneoplastic neurological syndromes with anti-Hu antibodies. (medscape.com)
  • Detailed protocols are now available that can be used to label lymphocytes (and other cell types) with a high degree of reliability and precision. (wikipedia.org)
  • Many of the activated genes in stimulated T lymphocytes were known to be involved in the G0/G1 cell cycle transition or encoding for chemokines, signaling molecules involved in inflammatory response. (wikipedia.org)
  • The two isoforms are: long isoform a, also named OC116 short isoform b, also named TIRC7 (N-terminus truncated, lacks amino acid residues 1-216 of the long isoform) TIRC7 is expressed in T lymphocytes and is essential for normal T cell activation. (wikipedia.org)
  • BCRs allow the B cell to bind to a specific antigen, against which it will initiate an antibody response. (wikipedia.org)
  • vaccination
  • From a cohort of 656 singleton births formed in the Faroe Islands during 1999-2001, children were invited for examination with assessment of serum antibody concentrations at 5 years (before and after a booster vaccination) and at 7 years of age. (nih.gov)
  • At age 5 years, before the booster vaccination, the antidiphtheria antibody concentration was inversely associated with PCB concentrations in milk and 18-month serum. (nih.gov)
  • influenza
  • He also co-authored a series of papers which utilized human plasmablasts after immunization to define the human immune response to influenza vaccine and generated human monoclonal antibodies from the blood. (wikipedia.org)
  • The most striking examples are antibodies with exceptional breadth, being able to neutralize all influenza A viruses and even four different paramyxoviruses (18,19). (wikipedia.org)
  • dependence
  • The main objective was to assess the possible dependence of antibody concentrations against diphtheria and tetanus toxoids in children with regard to prenatal and postnatal PCB exposures. (nih.gov)
  • serum
  • In this study we applied serum concentrations of specific antibodies against childhood vaccines as sentinels of immunotoxicity. (nih.gov)
  • At age 5 years, the odds of an antidiphtheria antibody concentration below a clinically protective level of 0.1 IU/L increased by about 30% for a doubling in PCB in milk and 18-month serum. (nih.gov)
  • Developmental PCB exposure is associated with immunotoxic effects on serum concentrations of specific antibodies against diphtheria and tetanus vaccinations. (nih.gov)
  • The testing of groups B Moreover, Gulf War Veterans have an increase and D occurred over an extended period from chronic fatigue, fibromyalgia, neurocognitive in serum RNAs with segments homologous to 1995 through 1999. (onlinepdfcatalog.com)
  • decrease
  • The strongest associations suggested a decrease in the antibody concentration by about 20% for each doubling in PCB exposure. (nih.gov)