• 1984
  • He has co-authored/edited 2 books: The Antibody Enigma (1984) and Immunobiology 4th Edition (1999), co-edited seven volumes on The Antibodies with Maurizio Zanetti (1995-2002) and has served on the review and editorial boards of many journals. (wikipedia.org)
  • soluble
  • Lower level of BAFF transcripts (or a higher level of soluble BAFF) show a higher risk of producing donor-specific antibodies in the investigated patients. (wikipedia.org)
  • Most are soluble intracellular proteins, but a subset associate with membranes via a membrane-targeting posttranslational modification, such as an N-terminal myristoyl group, and can act as the catalytic subunit for receptors that lack their own catalytic domain. (wikipedia.org)
  • In vivo, triggering the HLA-DR-TIRC7 pathway in lipopolysaccaride (LPS) activated lymphocytes using soluble HLA-DRα2 leads to inhibition of proinflammatory as well as inflammatory cytokines and induction of apoptosis. (wikipedia.org)
  • cytomegalovirus
  • Neutralizing antibodies were isolated against SARS, cytomegalovirus, avian influenza and dengue virus. (wikipedia.org)
  • Unusually potent antibodies that neutralize human cytomegalovirus (HCMV) were isolated and their epitopes mapped to a pentameric glycoprotein complex, which is currently tested as a candidate vaccine. (wikipedia.org)
  • vaccination
  • From a cohort of 656 singleton births formed in the Faroe Islands during 1999-2001, children were invited for examination with assessment of serum antibody concentrations at 5 years (before and after a booster vaccination) and at 7 years of age. (nih.gov)
  • At age 5 years, before the booster vaccination, the antidiphtheria antibody concentration was inversely associated with PCB concentrations in milk and 18-month serum. (nih.gov)
  • cell
  • Cell-mediated autoimmunity in paraneoplastic neurological syndromes with anti-Hu antibodies. (medscape.com)
  • Detailed protocols are now available that can be used to label lymphocytes (and other cell types) with a high degree of reliability and precision. (wikipedia.org)
  • Pillars Article: Islet-cell Antibodies in Diabetes Mellitus with Autoimmune Polyendocrine Deficiencies. (jimmunol.org)
  • Dichotomous view of the T-lymphocyte system, showing the major T-cell populations. (asmscience.org)
  • The important clinical application of the flow cytometry is the CD34 + quantification to hematopoietic reconstitution after stem cell transplant and lymphocyte subsets to evaluate the immune reply to tissue or organ transplant and animals diseases. (scielo.br)
  • Scientific assays about flow cytometry evaluation of the stem cell and lymphocyte subsets of dogs have been performed successfully by veterinary hematology scientists in the Universidade Estadual Paulista (UNESP), Campus Jaboticabal. (scielo.br)
  • Many of the activated genes in stimulated T lymphocytes were known to be involved in the G0/G1 cell cycle transition or encoding for chemokines, signaling molecules involved in inflammatory response. (wikipedia.org)
  • The two isoforms are: long isoform a, also named OC116 short isoform b, also named TIRC7 (N-terminus truncated, lacks amino acid residues 1-216 of the long isoform) TIRC7 is expressed in T lymphocytes and is essential for normal T cell activation. (wikipedia.org)
  • influenza
  • The most striking examples are antibodies with exceptional breadth, being able to neutralize all influenza A viruses and even four different paramyxoviruses (18,19). (wikipedia.org)
  • physiological
  • the common lymphoid progenitors (CLPs) can differentiate into all types of lymphocytes but lack the myeloid potential under physiological conditions, although some myeloid-related genes can be detected in CLPs depending on experimental conditions [ 1 , 2 ]. (intechopen.com)
  • dependence
  • The main objective was to assess the possible dependence of antibody concentrations against diphtheria and tetanus toxoids in children with regard to prenatal and postnatal PCB exposures. (nih.gov)
  • activation
  • Sera of HCV antibody positive and cold activation positive showed a high incidence of elevation of RF during storage at low temperature (4) but the elevation was suppressed by addition of guinea pig serum as a complement source or in a buffer with a higher ionic strength. (nii.ac.jp)
  • Discovery
  • Ferrara N, Hillan KJ, Gerber HP, Novotny W (2004) Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. (springer.com)
  • Belimumab (Benlysta) is a monoclonal antibody developed by Human Genome Sciences and GlaxoSmithKline, with significant discovery input by Cambridge Antibody Technology, which specifically recognizes and inhibits the biological activity of B-Lymphocyte stimulator (BLyS) and is in clinical trials for treatment of Systemic lupus erythematosus and other autoimmune diseases. (wikipedia.org)
  • decrease
  • The strongest associations suggested a decrease in the antibody concentration by about 20% for each doubling in PCB exposure. (nih.gov)
  • Childhood
  • In this study we applied serum concentrations of specific antibodies against childhood vaccines as sentinels of immunotoxicity. (nih.gov)
  • response
  • While most patients with HIV show an antibody response after six weeks, window periods vary and may occasionally be as long as three months. (wikipedia.org)
  • protective
  • At age 5 years, the odds of an antidiphtheria antibody concentration below a clinically protective level of 0.1 IU/L increased by about 30% for a doubling in PCB in milk and 18-month serum. (nih.gov)