• novel
  • 7. MONTGOMERY, R., WARNER, M., LUM, B. AND SPEAR, P. Herpes simplex virus-1 entry into cells mediated by a novel member of the TNF/NGF receptor family. (130.88.97)
  • In addition, novel apoptotic players such as miRNAs and sphingolipid family members in various kind of cancer are discussed. (springer.com)
  • macrophage
  • After activation, NK cells also secrete several cytokines such as interferon-γ (IFN-γ), tumor necrosis factor-α (TNF-α), granulocyte macrophage colony-stimulating factor (GM-CSF), and chemokines (CCL1, CCL2, CCL3, CCL4, CCL5, and CXCL8) that can modulate the function of other innate and adaptive immune cells. (frontiersin.org)
  • family
  • Members of the tumor necrosis factor (TNF) family govern many diverse physiological and cellular responses including cellular proliferation, differentiation, and apoptosis. (springer.com)
  • RANK interacts with five members of the TNF receptor-associated factor (TRAF) family, of which TRAF6 is indispensable for its signaling capability. (springer.com)
  • Differential requirements for tumor necrosis factor receptor-associated factor family proteins in CD40-mediated induction of NF-kappaB and Jun N-terminal kinase activation. (nih.gov)
  • TNF receptor family member BCMA (B cell maturation) associates with TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-kappa B, elk-1, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinase. (nih.gov)
  • CD28 also promotes survival of activated T cells through a pathway, which up-regulates the apoptosis inhibitory Bcl-2 family member Bcl-x L ( 3 , 4 ). (rupress.org)
  • These molecules link to members of the TNF receptor-associated factor (TRAF) family of signaling adaptors via small, ill-conserved motifs in their cytoplasmic tails. (rupress.org)
  • 5. GRAVESTEIN, L. AND BORST, J. Tumor necrosis factor receptor family members in the immune system. (130.88.97)
  • Family members are defined based on similarity in their extracellular domain - a region that contains many cysteine residues arranged in a specific repetitive pattern . (130.88.97)
  • RT "Dense Alu clustering and a potential new member of the NF kappa B RT family within a 90 kilobase HLA class III segment. (genome.jp)
  • LIGHT was initially discovered in 1998 by former La Jolla Institute scientist Carl Ware, Ph.D. The TNF family of molecules has proven to be important players in inflammation-driven autoimmune diseases and is a particular focus of the La Jolla Institute. (innovations-report.com)
  • Members of the very wide interleukin-1 receptor (IL-1R) family are characterized by extracellular immunoglobulin-like domains and intracellular Toll/Interleukin-1R (TIR) domain. (wikipedia.org)
  • There are differences in number of Ig-like domains between members of IL-1R family. (wikipedia.org)
  • The cytoplasmic region of this receptor was found to bind to several TRAF family members, which may mediate the signal transduction pathways that activate the immune response. (wikipedia.org)
  • These cells are dubbed Type 1 cells and are characterized by the inability of anti-apoptotic members of the Bcl-2 family (namely Bcl-2 and Bcl-xL) to protect from Fas-mediated apoptosis. (wikipedia.org)
  • CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker. (wikipedia.org)
  • TL1A
  • Over the past decade significant progress has been made in defining the characteristics of this receptor, including the identification of its ligand, TNFSF15 (TL1A). (springer.com)
  • nuclear
  • TRAF6 stimulates the activation of the c-jun N-terminal kinase (JNK) and nuclear factor kappa-b (NF-kB) pathways which trigger differentiation and activation of osteoclasts. (wikipedia.org)
  • vascular
  • These uterine NK cells secrete IL-8, vascular endothelial growth factor (VEGF), stromal cell-derived factor-1, and interferon gamma-inducible protein-10 (IP-10) which help in tissue building, remodeling, and angiogenesis ( 4 ). (frontiersin.org)