Semaphorins, a family of about 20 secreted, transmembrane and GPI-linked glycoproteins, and their cognate receptors (plexins and neuropilins) play a pivotal role in the crosstalk between cancer and stromal cells present in the tumor microenvironment. (biomedcentral.com)
Semaphorins were originally identified in the nervous system for their ability to regulate axon guidance through the interaction with their receptors, plexins and neuropilins [ 1 ]. (biomedcentral.com)
Consistently, increased Sema 3A levels have been detected in brain of patients with schizophrenia and many polymorphisms in Sema 3A or in the Sema 3A receptors, Neuropilins (Npn 1 and 2) and Plexin As (Plxn As), have been associated to autism. (biomedcentral.com)
Indeed, the increased transmissibility of SARS-CoV-2 compared with SARS-CoV could potentially be explained by an increased number of cellular receptors allowing the virus to penetrate host cells. (abcam.com)
20193
The novel coronavirus, SARS-CoV-2, is thought to have emerged in China in 2019 and has since spread across the globe, causing a global pandemic. (abcam.com)
METHODS: Available internal records from 1998 to 2019 were used to identify presenters and projects. (bvsalud.org)
RESULTS: One hundred forty-five students, residents, and fellows presented 276 projects at Resident Research Day from 1998 to 2019. (bvsalud.org)
Endothelial3
Neuropilin 1 (NP1) is a part of essential receptor complexes mediating both semaphorin3A (SEMA3A) and vascular endothelial growth factor (VEGF) which is one of important mediators involved in the pathogenesis. (koreamed.org)
We are investigating the effects and the molecular mechanisms of several cardiovascular risk factors, including HIV protease inhibitors, the adipokine resistin, soluble CD40L, and uric acid, on biochemical pathways associated with endothelial cell functions. (bcm.edu)
During angiogenesis, actin-rich filopodia protrusions have been proposed to drive endothelial tip cell functions by translating guidance cues into directional migration and mediating new contacts during anastomosis. (biologists.com)
Receptor5
This gene encodes a member of the neuropilin family of receptor proteins. (wikipedia.org)
To address the efficacy of the SELT-FALI technique, we used Neuropilin-2 (Nrp2), a receptor for a repulsive axon guidance molecule of Semaphorin-3F (Sema3F) as a test target molecule. (esmed.org)
It consists at least of a catalytic light chain and a multidomain heavy chain which has 2 LDL receptor class A domains, a MAM domain, a SRCR domain and a CUB domain. (embl.de)
SARS-CoV-2 S protein binds to the ACE2 receptor at the surface of host cells, initially through the S1 RBD. (abcam.com)
Within the trimeric S protein, only one of the three RBD heads is present in the accessible conformation to bind the human Angiotensin 2 (hACE2) host cell receptor 10 . (abcam.com)
NRP21
Neuropilin 2 (NRP2) is a protein that in humans is encoded by the NRP2 gene. (wikipedia.org)
Semaphorin1
Palmitoylation regulates neuropilin-2 localization and function in cortical neurons and conveys specificity to semaphorin signaling via palmitoyl acyltransferases. (harvard.edu)
Proteins5
9) Sano Y, Watanabe W, Matsunaga S. Choromophore-assisted laser inactivation-towards a spatiotemporal-functional analysis of proteins, and the ablation of chromatin, organelle and cell function. (esmed.org)
In particular, Class 3 Sema (Sema 3) is among the best characterized Sema family members and the only produced as secreted proteins in mammals, thereby exerting both autocrine and paracrine functions. (biomedcentral.com)
HLA-G differs from the other MHC class I genes by its low polymorphism and alternative splicing that generates seven HLA-G proteins, whose tissue-distribution is restricted to normal fetal and adult tissues that display a tolerogeneic function toward both innate and acquired immune cells. (biovendor.com)
The SARS-CoV-2 genome encodes four major structural proteins: the spike (S) protein, nucleocapsid (N) protein, membrane (M) protein and the envelope (E) protein, each of which is essential to compose the viral particle 3 . (abcam.com)
In addition to binding ACE2, increasing evidence suggests that SARS-CoV-2 can also bind other surface proteins to gain cell entry. (abcam.com)
Tumor2
Tumor hypoxia is a consequence of inadequate oxygen supply caused by extensive abnormalities in the vascular network [ 2 ]. (biomedcentral.com)
To search for mechanisms for the development of hypoxia, the morphology and function of the tumor vascular networks were studied with intravital microscopy and immunohistochemistry, and the expression of several angiogenesis-related genes was measured with quantitative PCR. (biomedcentral.com)
Sympathetic2
They concluded that '….relations of the sympathetic nerve … to the course of inflammation, … are due to some nervous functions of the sympathetic nerve other than… vasoconstriction and vasodilatation' [ 1 ]. (biomedcentral.com)
Already in 1936, Reilly speculated that endotoxin concentrates in sympathetic tissue and irritates sympathetic nerve fibers, which results in a systemic reaction that resembles symptoms of typhoid fever [ 2 ]. (biomedcentral.com)
Genomic1
Early genomic analysis of SARS-CoV-2 revealed that it belongs to the betacoronavirus genus, lineage B, alongside SARS-CoV-2 1 , 2 . (abcam.com)
Interactions2
This indicates that these domain-domain interactions are critical for structure and function of the enzyme. (embl.de)
In the developing lung, the specific temporal-spatial interactions between mesenchymal and epithelial cells are carefully orchestrated to permit the gradual establishment of an effective blood-gas barrier (BGB) [ 1 , 2 ]. (biomedcentral.com)
Vascular5
The vascular system is built by 2 processes, vasculogenesis and angiogenesis. (medscape.com)
The development of hypoxic regions was not caused by low vessel density, but was rather a result of inadequate vascular function. (biomedcentral.com)
Inadequate vascular function was not caused by low vessel diameters or long vessel segments, but was associated with poor vascular pericyte coverage. (biomedcentral.com)
Two of the four investigated melanoma models developed hypoxic regions in microscopic tumors, and the development of hypoxia was associated with poor vascular pericyte coverage and inadequate vascular function. (biomedcentral.com)
These morphological abnormalities collectively increase the geometric resistance to blood flow and impair vascular function [ 7 ]. (biomedcentral.com)
Targets2
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
A cell culture model for investigation of synapse influence-ability: epigenetics, expression and function of gene targets important for synapse formation and preservation in SH-SY5Y neuroblastoma cells differentiated by retinoic acid. (mhh.de)
Gene1
Many of the mutations found in SARS-CoV-2 variants of concern (VoCs) are found in the S gene - most commonly within the S1/RBD regions. (abcam.com)
2001) [ 8 ] showed convincingly that a reduction in p53 expression or function in LNCaP confers the ability to form tumors in castrated male nude mice (parental LNCaP cells do not have this ability). (oncotarget.com)
Mutations2
p53 likely also plays a role given that p53 mutations are commonly found in advanced PC, and loss of wild-type protein function contributes to the phenotype of castration-resistant prostate cancer (CRPC). (oncotarget.com)
Loss‑of‑function NOTCH1 mutations are early events during esophageal tumorigenesis, whereas gain‑of‑function NOTCH1 mutations are late events during T‑cell leukemogenesis and B‑cell lymphomagenesis. (spandidos-publications.com)
Tumour1
The Mackenzie Cancer Research Group has been investigating the contribution of stromal cells and the tumour microenvironment to human tumour biology since the inception of our research group in 1998. (otago.ac.nz)
Understanding the structure and function of SARS-CoV-2 and its variants is essential in developing vaccines and therapies to tackle the COVID-19 disease. (abcam.com)
Metastatic3
However, most patients with metastatic carcinomas progress to a state of disease insensitive to androgen ablation, called castration resistant prostate cancer (CRPC) [ 1 , 2 ]. (oncotarget.com)
Metastatic disease is highly lethal, and less than 20% of the affected patients survive over a 5 year interval [ 2 , 3 ]. (biomedcentral.com)
Metastatic progression of EOC is very unique, as metastases that cause death spread locoregionally, in the peritoneal cavity [ 2 ]. (biomedcentral.com)
We hypothesized that the donor heart preservation with hypoxic conditioned medium derived from BMSCs (CM-BMSCs) would improve post-transplant graft function. (researchsquare.com)
Normoxic CM and hypoxic CM were isolated from rat BMSCs cultured under normoxic (20% O 2 ) or hypoxic (1% O 2 ) condition. (researchsquare.com)
R-18 and U-25 tumors developed hypoxic regions before they reached a size of 2-3 mm in diameter, whereas A-07 and D-12 tumors of similar size did not show hypoxic regions. (biomedcentral.com)
Most tumors are heterogeneous in oxygen tension and develop regions with hypoxic cells during growth [ 1 , 2 ]. (biomedcentral.com)
Protein function1
Selective destrcution of protein function by choromophore-sdisted laser inactivation. (esmed.org)
Enzyme1
Angiotensin Converting Enzyme 2 is an enzyme that is part of the renin-angiotensin-aldosterone system, or RAAS. (waynekirkwood.com)
Cells2
We have previously demonstrated that chondroitin sulfate glycosaminoglycans (CS-GAGs) on breast cancer cells function as P-selectin ligands. (biomedcentral.com)
These cells, among other functions, provide a protective barrier against invading pathogens and secrete surfactant molecules to provide a non-adhesive surface. (biomedcentral.com)
Human1
These grants will specifically identify genes that cause human developmental brain disorders, and investigate their function. (edu.au)
Cell4
Neuropilin (A5 antigen), a calcium-independent cell adhesion molecule that function during the formation of certain neuronal circuits. (embl.de)
Like all coronaviruses, SARS-CoV-2 utilizes the S glycoprotein to mediate entry into the host cell. (abcam.com)
TMPRSS2 cleavage of the SARS-CoV-2 S protein is believed to enable the fusion of the viral capsid with the host cell to permit viral entry 5 , 6 . (abcam.com)
Both Neuropilin-1 and Neuropilin-2 have been shown to bind the cleaved form of the SARS-CoV-2 S protein to mediate host cell entry 13, 14 . (abcam.com)
Structural1
Various kinds of glycosaminoglycans (GAGs) and proteoglycans (PGs) have been known to be involved in structural and space-filling functions, as well as many physiological regulations in skin. (koreamed.org)
Role1
We have several projects focusing on the role and on the mechanisms of several genes, such as microRNA 196a (miR-196a), X-inactive specific transcript (XIST), and Jude-2 in pancreatic cancer. (bcm.edu)
Acute2
To analyze the biological function of the molecule, acute and temporally restricted inactivation of the targeted molecule is critical. (esmed.org)
The disease course is usually complicated by extra-articular manifestations (EAMs), such as psoriasis, inflammatory bowel disease (IBD), and acute anterior uveitis (AAU) [ 2 ]. (hindawi.com)
Viral1
A recombinant modified vaccinia Ankara (MVA) virus expressing mature viral protein 2 (VP2) of the infectious bursal disease virus (IBDV) was constructed to develop MVA-based vaccines for poultry. (koreamed.org)
Tissues1
These organs and tissues were fixed en block in 10% formalin and cut coronally into four to six slices of 3-mm thickness, depending on the age of the rat, and embedded together in one block for each rat. (shengsci.com)
Laboratory1
DE-AC02-05CH11231, Lawrence Livermore National Laboratory under Contract No. DE-AC52-07NA27344, and Los Alamos National Laboratory under contract No. DE-AC02-06NA25396, UT-Battelle and Oak Ridge National Laboratory under contract DE-AC05-00OR22725, as well as German Research Foundation (DFG) INST 599/1-2. (jakenzyme.com)
Mice1
Rescue of synaptic and cognitive functions in polysialic acid-deficient mice and dementia models by short polysialic acid fragments. (mhh.de)
Reveals1
Genomewide analysis of the Drosophila tetraspanins reveals a subset with similar function in the formation of the embryonic synapse. (neurotree.org)
Development1
The chromatographic conditions included ascending separation technique, twin trough chamber for plate development, chamber saturation time 4 min and migration distance 10 cm at a temperature of 25 �� 2��C. Detection was done in UV�Cvisible range. (jakenzyme.com)
Large1
Their study of EV71 began in 1998, when a large EV71 outbreak occurred in Taiwan. (cgu.edu.tw)
Regulatory1
However, the SNS is not active just in these extreme situations, but is part of constant regulatory machinery that keeps body functions in a steady-state equilibrium. (biomedcentral.com)
Brain1
The consortium will also collect brain MRI data and neuropsychological data to try to understand the relationship between specific patterns of brain wiring and brain function. (edu.au)
Network1
Later, as alveolarization progresses, secondary septa develop and the microvascular network matures from a double to a single capillary network [ 2 , 5 , 6 ]. (biomedcentral.com)