• genes
  • Stem cell markers are genes and their protein products used by scientists to isolate and identify stem cells. (wikipedia.org)
  • Below is a list of genes/protein products that can be used to identify various types of stem cells, or functional assays that do the same. (wikipedia.org)
  • Testing this hypothesis, we detected changes in the expression of the genes encoding bone morphogenetic proteins 2 and 7 ( Bmp2, Bmp7 ) in the interdigital and distal joint tissues, suggesting that HOXA13 may directly regulate their expression in these discrete regions. (biologists.org)
  • A multifunctional DNA-binding protein that promotes the formation of serum response factor/homeodomain complexes: identity to TFII-I". Genes Dev. (wikipedia.org)
  • In the normal mouse embryo, Bmp4 is expressed in mesenchymal cells surrounding the Wolffian duct (WD) and ureter stalk, whereas bone morphogenetic protein (BMP) type I receptor genes are transcribed either ubiquitously ( Alk3 ) or exclusively in the WD and ureter epithelium ( Alk6 ). (jci.org)
  • SKI has been shown to interfere with normal cellular functioning by both directly impeding expression of certain genes inside the nucleus of the cell as well as disrupting signaling proteins that activate genes. (wikipedia.org)
  • 2000
  • Studies on nerve cell affinity of chitosan-derived materials," Journal of Biomedical Materials Research A , vol. 52, no. 2, pp. 285-295, 2000. (hindawi.com)
  • A. Lahiji, A. Sohrabi, D. S. Hungerford, and C. G. Frondoza, "Chitosan supports the expression of extracellular matrix proteins in human osteoblasts and chondrocytes," Journal of Biomedical Materials Research A , vol. 51, no. 4, pp. 586-595, 2000. (hindawi.com)
  • 1992
  • http://www.ucdmc.ucdavis.edu/publish/facultybio/orthopaedics/faculty/54 http://www.jhu.edu/gazette/aprjun96/apr1596/chairs.html Scientists Succeed In Growing Bone, The New York Times, Oct. 22, 1996 Hopkins grows its own bone orchard, The Baltimore Sun, Jan. 24, 1992 Khouri R, Koudsi B, Reddi H. Tissue Transformation Into Bone In Vivo: A Potential Practical Application. (wikipedia.org)
  • Mutations
  • Mutations resulting in loss of consensus donor splice site at exon 2-intron 2 junctions result in significant diffuse calcification of soft tissue cartilage. (wikipedia.org)
  • 1998). "Mutations of the alpha2(V) chain of type V collagen impair matrix assembly and produce ehlers-danlos syndrome type I". Hum. (wikipedia.org)
  • Molecular
  • Work with BMP material isolated from rabbit dentin matrix protein fraction, using polyacrylamide gel electrophoresis (PAGE) has been assigned a molecular weight of about 23,000. (google.ca)
  • tissue
  • The proteins may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair. (google.com)
  • These proteins may be used to induce bone and/or cartilage formation and in wound healing and tissue repair. (google.com)
  • 1 Toward this end, tissue engineering approaches have received great deal of attention as promising alternatives to conventional autologous bone grafts that are considered the golden standard for repairing critical-sized bone defects. (pubmedcentralcanada.ca)
  • 2 , 3 Numerous biomaterials have been developed for bone tissue engineering applications ranging from naturally derived materials to synthetic biopolymers. (pubmedcentralcanada.ca)
  • 4 - 8 In the past decades, significant progress has been made to fabricate three-dimensional (3D) porous polymeric scaffolds with controlled morphology and micro-architecture for bone tissue engineering. (pubmedcentralcanada.ca)
  • In the copending application and patent there are disclosed and claimed a process, (and the product of that process), for separating bone morphogenetic protein (BMP) from bone tissue. (google.ca)
  • Radiation impairs bone healing due to a complex cascade of cellular and tissue events. (biomedcentral.com)
  • 2. The method of claim 1 ,wherein said first or second portion of adipose tissue that is removed from said patient is lipoaspirate. (google.es)
  • Connective Tissue, 29: 285-290, 1998. (kyoto-u.ac.jp)
  • for example, it ranges from the soft ECM of brain tissue to that of rigid bone or the stiff cell wall of plant cells. (wikipedia.org)
  • collagen
  • Though the ECM is composed of many intracellularly-synthesized components - including a number of glycosaminoglycans (GAGs) and fibrous proteins such as fibronectin, laminin, collagen, and elastin - it is the latter two fibers that are most influential in defining the mechanical properties of the ECM. (wikipedia.org)
  • Collagen is the fibrous protein that gives the ECM its tensile strength, or rigidity. (wikipedia.org)
  • Immunolocalization
  • Temporal and spatial immunolocalization of TGF-βs, bone morphogenetic protein (BMP) and their receptors in the intervertebral disk of senescence-accelerated mice (SAM) were examined to determine the biological roles in the process of the degeneration in intervertebral disks. (nii.ac.jp)
  • Immunolocalization of bone morphogenetic protein and its receptors in degeneration of interneutehral disc'Spine. (nii.ac.jp)
  • Publications] Reiko Takae, Shinji Matsunaga, Nobuhiko Origuchi, Takuya Yamamoto, Norio Morimoto, Shusaku Suzuki, Takashi Sakou: 'Immunolocalization of bone morphogenetic protein and its receptors in degeneration of intervertebral disc'Spine. (nii.ac.jp)
  • defects
  • T he clinical needs for bone regeneration are diverse, and there are roughly one million patients who have skeletal defects each year in the United States alone, which require bone graft procedures to achieve union. (pubmedcentralcanada.ca)
  • A freeze dried coprecipitate of BMP with calcium phosphate, made by the aforementioned process of said patent may be implanted in a bone defect caused by injury, old infection, malignancy, and congenital defects. (google.ca)
  • The reconstruction of bone defects is often impaired by radiotherapy since bone quality is compromised by radiation. (biomedcentral.com)
  • Micro-CT and histological analysis were used to test the healing of bone defects 4 and 8 weeks after transplantation. (biomedcentral.com)
  • osteogenesis
  • Furthermore, the continuous tension on the bone produced by the distractor may facilitate stimulation of osteogenesis around the implant. (google.com)
  • In subcutaneous osteogenesis test, EPCs-BMSC sheets formed larger areas of new bone and blood vessels. (biomedcentral.com)
  • human
  • Human BMP-2 proteins are produced by culturing a cell transformed with a cDNA substantially as shown in Table II or Table III and recovering from the culture medium a protein containing the 97 amino acid sequence #299 to #396 of Table II or amino acid #311 to #408 of Table III, respectively. (google.com)
  • BMP compositions including the human factor and bovine factor thereof, the process of isolating BMP compositions and factors, and the use of such factors and compositions to induce bone formation in animals. (google.ca)
  • 1998). "Bone morphogenetic protein-6 production in human osteoblastic cell lines. (wikipedia.org)
  • A 2008 bioinformatics study identified about 45 examples of such proteins, containing up to three three-finger domains, represented in the human genome. (wikipedia.org)
  • formation
  • Members of the BMP-2A protein family may be further characterized by the ability to demonstrate cartilage and/or bone formation activity in the rat bone formation assay described below. (google.com)
  • In preferred embodiments, the proteins of the invention demonstrate activity in this rat bone formation assay at a concentration of 0.5 μg -100 μg/gram of bone. (google.com)
  • Periodontitis may cause the inflammation of the periodontal supporting tissues, formation of periodontal pocket, progressive attachment loss and alveolar bone absorption, which finally result in loose and loss of teeth. (medsci.org)
  • Publications] Nobuo Origuchi, Yasuhiro Ishidou, Tomonori Nagamine, Toshiyuki Onishi, Shinji Matsunaga, Hiroki Yoshida, Takashi Sakou: 'The spatial and temporal immuolocalization of TGF-β1 and bone morlphogenetic protein-2/-4 in phalic bone formation in Inbred Sprague Dawley male rats. (nii.ac.jp)
  • BMP1 protein and procollagen C proteinase (PCP), a secreted metalloprotease requiring calcium and needed for cartilage and bone formation, are identical. (wikipedia.org)
  • TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. (wikipedia.org)
  • GDF6 has been shown to play an important role in the patterning of the epidermis and bone and joint formation. (wikipedia.org)
  • Currently it is thought that the SKI protein prevents response to TFG- β levels, causing tumor formation. (wikipedia.org)
  • 2002
  • For example, the bHLH proteins neurogenin (Ngn) 1 and Ngn2 are essential for neurogenesis in the neocortex ( Schuurmans and Guillemot, 2002 ). (biologists.org)
  • Identification
  • Identification of transforming growth factor β family members present in bone-inductive protein purified from bovine bone," Proceedings of the National Academy of Sciences of the United States of America , vol. 87, no. 24, pp. 9843-9847, 1990. (hindawi.com)
  • cytokine
  • Transforming growth factor-beta 2 (TGF-β2) is a secreted protein known as a cytokine that performs many cellular functions and has a vital role during embryonic development (alternative names: Glioblastoma-derived T-cell suppressor factor, G-TSF, BSC-1 cell growth inhibitor, Polyergin, Cetermin). (wikipedia.org)
  • wherein
  • 8. The composition of claim 7 wherein said protein is a dimer. (google.com)
  • 9. The composition of claim 8 wherein each subunit is characterized by amino acid #283 to #396 of FIG. 2. (google.com)
  • 2. The distractor of claim 1 , wherein said first member and said second member are made of bioabsorbable material. (google.com)
  • 3. The process of claim 1 wherein said BMP composition consists essentially of about 7 parts 22-kDa and about 1 part 14-kDa BMP associated proteins, and about 2 parts 18.5 0.5-kDa bBMP factor. (google.ca)