• genes
  • Stem cell markers are genes and their protein products used by scientists to isolate and identify stem cells. (wikipedia.org)
  • Below is a list of genes/protein products that can be used to identify various types of stem cells, or functional assays that do the same. (wikipedia.org)
  • Testing this hypothesis, we detected changes in the expression of the genes encoding bone morphogenetic proteins 2 and 7 ( Bmp2, Bmp7 ) in the interdigital and distal joint tissues, suggesting that HOXA13 may directly regulate their expression in these discrete regions. (biologists.org)
  • A multifunctional DNA-binding protein that promotes the formation of serum response factor/homeodomain complexes: identity to TFII-I". Genes Dev. (wikipedia.org)
  • In the normal mouse embryo, Bmp4 is expressed in mesenchymal cells surrounding the Wolffian duct (WD) and ureter stalk, whereas bone morphogenetic protein (BMP) type I receptor genes are transcribed either ubiquitously ( Alk3 ) or exclusively in the WD and ureter epithelium ( Alk6 ). (jci.org)
  • 1992
  • http://www.ucdmc.ucdavis.edu/publish/facultybio/orthopaedics/faculty/54 http://www.jhu.edu/gazette/aprjun96/apr1596/chairs.html Scientists Succeed In Growing Bone, The New York Times, Oct. 22, 1996 Hopkins grows its own bone orchard, The Baltimore Sun, Jan. 24, 1992 Khouri R, Koudsi B, Reddi H. Tissue Transformation Into Bone In Vivo: A Potential Practical Application. (wikipedia.org)
  • osteogenic
  • The present invention relates to an osteogenic distractor suitable for indexed osteotomy following permanent implantation into bone. (google.com)
  • The osteogenic distractor may be a means for anchoring two or more sections of bone and a means for facilitating movement of one section of anchored bone relative to another. (google.com)
  • expression
  • In the chick embryo, we find that the expression pattern of MMP-2 varies spatially and temporally, suggesting that it is developmentally regulated. (wiley.com)
  • More recently, non-toxic 3FP proteins have been found to be widely expressed in many different tissues in snakes, prompting the alternative hypothesis that proteins of restricted expression in saliva were selectively recruited for toxic functionality. (wikipedia.org)
  • The ratio of PAX2 to AIB-1 protein expression may be predictive of the effectiveness of tamoxifen in breast cancer treatment. (wikipedia.org)
  • Molecular
  • Work with BMP material isolated from rabbit dentin matrix protein fraction, using polyacrylamide gel electrophoresis (PAGE) has been assigned a molecular weight of about 23,000. (google.ca)
  • collagen
  • Though the ECM is composed of many intracellularly-synthesized components - including a number of glycosaminoglycans (GAGs) and fibrous proteins such as fibronectin, laminin, collagen, and elastin - it is the latter two fibers that are most influential in defining the mechanical properties of the ECM. (wikipedia.org)
  • Collagen is the fibrous protein that gives the ECM its tensile strength, or rigidity. (wikipedia.org)
  • receptors
  • Temporal and spatial immunolocalization of TGF-βs, bone morphogenetic protein (BMP) and their receptors in the intervertebral disk of senescence-accelerated mice (SAM) were examined to determine the biological roles in the process of the degeneration in intervertebral disks. (nii.ac.jp)
  • Immunolocalization of bone morphogenetic protein and its receptors in degeneration of interneutehral disc'Spine. (nii.ac.jp)
  • Publications] Reiko Takae, Shinji Matsunaga, Nobuhiko Origuchi, Takuya Yamamoto, Norio Morimoto, Shusaku Suzuki, Takashi Sakou: 'Immunolocalization of bone morphogenetic protein and its receptors in degeneration of intervertebral disc'Spine. (nii.ac.jp)
  • 3FP domains occur in the extracellular domains of some cell-surface receptors as well as in GPI-anchored and secreted globular proteins, usually involved in signaling. (wikipedia.org)
  • common protein targets include those involved in cholinergic signaling, such as the nicotinic acetylcholine receptors, muscarinic acetylcholine receptors, and acetylcholinesterase. (wikipedia.org)
  • these are often known as LU domains and can be found in the extracellular domains of cell-surface receptors and in either GPI-anchored or secreted globular proteins. (wikipedia.org)
  • Many LU domain containing proteins are involved in cholinergic signaling and bind acetylcholine receptors, notably linking their function to a common mechanism of 3FTx toxicity. (wikipedia.org)
  • TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. (wikipedia.org)
  • mesenchymal
  • Osteosarcoma is defined as a malignant tumor of mesenchymal cells, characterized by the direct formation of malignant osteoid and/or woven bone by the tumor. (aacrjournals.org)
  • One morphogenetic event during development that is likely regulated in part by proteases is the epithelial-mesenchymal transformation (EMT). (wiley.com)
  • In vitro transformation of mesenchymal cells derived from embryonic muscle into cartilage in response to extracellular matrix components of bone. (wikipedia.org)
  • osteogenesis
  • Furthermore, the continuous tension on the bone produced by the distractor may facilitate stimulation of osteogenesis around the implant. (google.com)
  • Osteoprotegerin
  • This warrants exploration of new therapeutic options, and among them, osteoprotegerin (OPG), a naturally occurring protein that inhibits bone resorption, is very promising in blocking the vicious cycle between bone resorption and tumor proliferation that takes place during tumor development in bone site. (aacrjournals.org)
  • induce bone
  • BMP compositions including the human factor and bovine factor thereof, the process of isolating BMP compositions and factors, and the use of such factors and compositions to induce bone formation in animals. (google.ca)
  • human
  • Human BMP-2 proteins are produced by culturing a cell transformed with a cDNA substantially as shown in Table II or Table III and recovering from the culture medium a protein containing the 97 amino acid sequence #299 to #396 of Table II or amino acid #311 to #408 of Table III, respectively. (google.com)
  • 1998). "Bone morphogenetic protein-6 production in human osteoblastic cell lines. (wikipedia.org)
  • Human umbilical vein endothelial cells (HUVECs) (Clonetics, East Rutherford, NJ) were cultured in endothelial basal medium (EBM)-2 supplemented with EGM-2MV and studied at passages 4-7. (hmamedicalclinic.com)
  • A 2008 bioinformatics study identified about 45 examples of such proteins, containing up to three three-finger domains, represented in the human genome. (wikipedia.org)
  • In human embryonic development, Cerberus and the protein coded by GREM3 inhibit NODAL in the Wnt signaling pathway during the formation of the germ layers. (wikipedia.org)
  • cytokine
  • Transforming growth factor-beta 2 (TGF-β2) is a secreted protein known as a cytokine that performs many cellular functions and has a vital role during embryonic development (alternative names: Glioblastoma-derived T-cell suppressor factor, G-TSF, BSC-1 cell growth inhibitor, Polyergin, Cetermin). (wikipedia.org)
  • wherein
  • 8. The composition of claim 7 wherein said protein is a dimer. (google.com)
  • 9. The composition of claim 8 wherein each subunit is characterized by amino acid #283 to #396 of FIG. 2. (google.com)
  • 2. The distractor of claim 1 , wherein said first member and said second member are made of bioabsorbable material. (google.com)
  • 3. The process of claim 1 wherein said BMP composition consists essentially of about 7 parts 22-kDa and about 1 part 14-kDa BMP associated proteins, and about 2 parts 18.5 0.5-kDa bBMP factor. (google.ca)
  • formation
  • Members of the BMP-2A protein family may be further characterized by the ability to demonstrate cartilage and/or bone formation activity in the rat bone formation assay described below. (google.com)
  • In preferred embodiments, the proteins of the invention demonstrate activity in this rat bone formation assay at a concentration of 0.5 μg -100 μg/gram of bone. (google.com)
  • Publications] Nobuo Origuchi, Yasuhiro Ishidou, Tomonori Nagamine, Toshiyuki Onishi, Shinji Matsunaga, Hiroki Yoshida, Takashi Sakou: 'The spatial and temporal immuolocalization of TGF-β1 and bone morlphogenetic protein-2/-4 in phalic bone formation in Inbred Sprague Dawley male rats. (nii.ac.jp)
  • GDF6 has been shown to play an important role in the patterning of the epidermis and bone and joint formation. (wikipedia.org)
  • Bmp7
  • In addition, the fact that this BMP is closely related to BMP5 and BMP7 has led to speculation of possible bone inductive activity. (wikipedia.org)
  • 2002
  • For example, the bHLH proteins neurogenin (Ngn) 1 and Ngn2 are essential for neurogenesis in the neocortex ( Schuurmans and Guillemot, 2002 ). (biologists.org)