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  • 1996
  • Various factors that contribute to such environmental cues have been identified and shown to influence differentially the generation of the three major cell types of the central nervous system (CNS): neurons, oligodendrocytes, and astrocytes ( Johe et al , 1996 ). (embopress.org)
  • Hand1
  • Mutation of HAND1 has been shown to hinder the effect of GATA4, another vital cardiac transcription factor, and is associated with congenital heart disease. (wikipedia.org)
  • Arising from cells derived from the primary heart field in the cardiac crescent, HAND1 goes from being expressed on both sides of the heart tube to the ventral surface of the caudal heart segment and the aortic sac, then being restricted to the outer curvature of the left ventricle in the looped heart. (wikipedia.org)
  • binds
  • The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box promoter region rather than the canonical enhancer box (E-box). (wikipedia.org)
  • molecular
  • In this paper I present molecular evidence that the transcription- translation- based feedback loop mechanism of the circadian oscillator is conserved in these higher plant species and suggest that this mechanism can also be observed in other higher plants. (ufl.edu)
  • Other pro-survival factors interacting with class III β-tubulin enabling cellular adaptation to oxidative stress include the molecular chaperone HSP70/GRP75. (wikipedia.org)
  • Math1
  • To address this question, we focused on Atoh1 (Math1), a bHLH transcription factor that specifies distinct neuronal subtypes of the proprioceptive pathway in mammals including the dI1 (dorsal interneuron 1) population of the developing spinal cord. (jneurosci.org)
  • HAND2
  • The induction of Hand2 by progesterone-dependent mechanisms in uterine stromal tissue suppresses fibroblast growth factors (FGFs) that would otherwise stimulate estrogen producing pathways and impair embryo implantation. (wikipedia.org)
  • Hand2, in addition to its other functions in the developing heart and limbs, has been found to be an important transcription factor seen in the endometrial stroma. (wikipedia.org)
  • enhancer
  • Three human mRNA coding sequences designated RSRF (Related to Serum Response Factor) were cloned and shown to dimerize, bind a consensus sequence similar to the one present in the MCK enhancer region, and drive transcription. (wikipedia.org)
  • They include: Myocyte enhancer factors (MEFs), which promote myogenesis. (wikipedia.org)
  • cysteine
  • Proteomic analysis has revealed that many factors bound to these cysteine residues are involved in the oxidative stress and glucose deprivation response. (wikipedia.org)
  • 2000
  • Later on Mitf and Chx10 continue to be expressed in adjacent regions of the eye, suggesting a reciprocal regulation between these two factors ( Nguyen and Arnheiter, 2000 ). (biologists.org)
  • regulatory
  • General transcription factors (GTFs) bind to a core promoter usually close to the transcription initiation site, together with the assembly of the pre-initiation complex, while sequence-specific TFs bind regulatory DNA elements at varying distances away from the transcription start site. (stembook.org)
  • Also known in the medical literature as MRF4 and herculin), MYF6 is a myogenic regulatory factor (MRF) in the process known as myogenesis. (wikipedia.org)
  • Myogenic regulatory factors (MRFs): MyoD, Myf5, Myf6 and Myogenin. (wikipedia.org)
  • Genetic
  • Each stage has various associated genetic factors lack of which will result in muscular defects. (wikipedia.org)
  • Associated Genetic Factors: c-Met/HGF and LBX1 Mutations in these genetic factors causes a lack of migration. (wikipedia.org)
  • Associated Genetic Factors: PAX3, c-Met, Mox2, MSX1, Six, Myf5, and MyoD Mox2 (also referred to as MEOX-2) plays an important role in the induction of mesoderm and regional specification. (wikipedia.org)
  • These consequences further reveal the complexity of myogenesis and the importance of each genetic factor in proper muscle development. (wikipedia.org)
  • suggests
  • Recent evidence suggests that, besides diffusible factors, cell-cell interactions mediated by membrane-bound receptors and ligand interactions, exemplified by Notch signaling, may play a critical role in retinal neurogenesis (Dorsky et al. (jneurosci.org)
  • Additionally, evidence based on coculture studies suggests that the epigenetic cues work under the constraints of competence dictated by intrinsic factors. (jneurosci.org)
  • Development
  • The COE (Collier/Olf/EBF) transcription factors have been implicated in the development of many cell types, including neurons. (biologists.org)
  • Knock-out experimentation on mice caused death and severe cardiac malformations such as failed cardiac looping, impaired ventricular development and defective chamber septation. (wikipedia.org)
  • In the third week of fetal development the rudimentary heart (bilaterally symmetrical cardiac tube) undergoes a characteristic dextral looping, forming an asymmetrical structure with bulges that represent the incipient ventricular and atrial chambers of the heart. (wikipedia.org)
  • In addition, this transcription factor plays an important role in limb and branchial arch development. (wikipedia.org)
  • fibroblast
  • If placed in cell culture, most myoblasts will proliferate if enough fibroblast growth factor (FGF) or another growth factor is present in the medium surrounding the cells. (wikipedia.org)