• 1996
  • Various factors that contribute to such environmental cues have been identified and shown to influence differentially the generation of the three major cell types of the central nervous system (CNS): neurons, oligodendrocytes, and astrocytes ( Johe et al , 1996 ). (embopress.org)
  • MEF2 transcription factors, although not specific to muscle lineage, are necessary co-factors of the MRFs to initiate myogenesis ( Molkentin and Olson, 1996 ). (biologists.org)
  • Hand2
  • In conjunction with HAND2 (a fellow bHLH transcription factor), complementary and overlapping expression patterns are thought to play a role in interpreting asymmetrical signals in the developing heart which leads to the characteristic looping. (wikipedia.org)
  • The induction of Hand2 by progesterone-dependent mechanisms in uterine stromal tissue suppresses fibroblast growth factors (FGFs) that would otherwise stimulate estrogen producing pathways and impair embryo implantation. (wikipedia.org)
  • Hand2, in addition to its other functions in the developing heart and limbs, has been found to be an important transcription factor seen in the endometrial stroma. (wikipedia.org)
  • molecular
  • In this paper I present molecular evidence that the transcription- translation- based feedback loop mechanism of the circadian oscillator is conserved in these higher plant species and suggest that this mechanism can also be observed in other higher plants. (ufl.edu)
  • Other pro-survival factors interacting with class III β-tubulin enabling cellular adaptation to oxidative stress include the molecular chaperone HSP70/GRP75. (wikipedia.org)
  • dorsal
  • The most dorsal spinal progenitor pool fails to express the bHLH neuralizing TF Atoh1 , which results in a lack of Lhx2- positive and Barhl2- positive dI1 interneurons. (biologists.org)
  • Hand1
  • Mutation of HAND1 has been shown to hinder the effect of GATA4, another vital cardiac transcription factor, and is associated with congenital heart disease. (wikipedia.org)
  • Arising from cells derived from the primary heart field in the cardiac crescent, HAND1 goes from being expressed on both sides of the heart tube to the ventral surface of the caudal heart segment and the aortic sac, then being restricted to the outer curvature of the left ventricle in the looped heart. (wikipedia.org)
  • ATOH1
  • We identified transcripts unique to the Atoh1-derived lineage using microarray analyses of specific bHLH-sorted populations from mouse. (jneurosci.org)
  • We identified transcripts enriched in Atoh1 lineage cells and biased against identifying common bHLH targets. (jneurosci.org)
  • Genetic
  • Each stage has various associated genetic factors lack of which will result in muscular defects. (wikipedia.org)
  • Associated Genetic Factors: c-Met/HGF and LBX1 Mutations in these genetic factors causes a lack of migration. (wikipedia.org)
  • Associated Genetic Factors: PAX3, c-Met, Mox2, MSX1, Six, Myf5, and MyoD Mox2 (also referred to as MEOX-2) plays an important role in the induction of mesoderm and regional specification. (wikipedia.org)
  • These consequences further reveal the complexity of myogenesis and the importance of each genetic factor in proper muscle development. (wikipedia.org)
  • essential
  • The paired homeodomain factor Phox2b, known to be essential for survival of SNS precursors, is downregulated, suggesting that Phox2b is a target of BMP signaling. (biologists.org)
  • Enhancer
  • They include: Myocyte enhancer factors (MEFs), which promote myogenesis. (wikipedia.org)
  • Three human mRNA coding sequences designated RSRF (Related to Serum Response Factor) were cloned and shown to dimerize, bind a consensus sequence similar to the one present in the MCK enhancer region, and drive transcription. (wikipedia.org)
  • cysteine
  • Proteomic analysis has revealed that many factors bound to these cysteine residues are involved in the oxidative stress and glucose deprivation response. (wikipedia.org)
  • myogenic
  • Also known in the medical literature as MRF4 and herculin), MYF6 is a myogenic regulatory factor (MRF) in the process known as myogenesis. (wikipedia.org)