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  • mediate
  • The effect of PRL-3 on integrin β1, ERK1/2, and MMPs that mediate motility, invasion, and metastasis were measured by Western blot, immunofluorencence, co-immunoprecipitation and zymographic assays. (biomedcentral.com)
  • interacts
  • Each 180 kD a-chain contains a globular intracellular domain of approximately 70 kDa, which interacts with beta4-integrin, plectin, and BP230 and is necessary for the stable attachment of hemidesmosomes to keratin intermediate filaments. (wikipedia.org)
  • vitro
  • Depletion of integrin β1 with siRNA, not only abrogated the activation of ERK1/2 stimulated by PRL-3, but also abolished PRL-3-induced motility and invasion of LoVo cells in vitro. (biomedcentral.com)
  • cell
  • Herein we aim to explore the association of PRL-3 with integrin β1 signaling and its functional implications in motility, invasion, and metastasis of colon cancer cell LoVo. (biomedcentral.com)
  • critical
  • Previous studies have demonstrated that integrin is critical for glial wrapping in both vertebrates and Drosophila. (ubc.ca)
  • decrease
  • however, the presence of a reconstituted basement membrane in combination with lactogenic hormones partially prevented this decrease. (biologists.org)
  • In our previous study, we observed that PRL-3 could decrease tyrosine phosphorylation of integrin β1 and enhance activation of ERK1/2 in HEK293 cells. (biomedcentral.com)
  • expression
  • Moreover, PRL-3-stimulated lung metastasis of LoVo cells in a nude mouse model was inhibited when integrin β1 expression was interfered with shRNA. (biomedcentral.com)
  • cells
  • In 1979, a large, non - collagenous glycoprotein was isolated from both an Engelbreth-Holm-Swarm (EHS) sarcoma and basement membrane producing cells . (edu.au)
  • complex
  • We show that basigin is specifically expressed in perineurial glia where it is present in a complex with integrin. (ubc.ca)
  • blood
  • The collagenous structure that divides the upper chambers of the heart from the lower chambers is an impermeable membrane that excludes both blood and electrical impulses through typical physiological means. (wikipedia.org)
  • structure
  • The collagenous structure that divides the upper chambers of the heart from the lower chambers is an impermeable membrane that excludes both blood and electrical impulses through typical physiological means. (wikipedia.org)