1998 adenylate cyclase. Medical search. Frequent questions

Adenylyl cyclases V and VI are the particular adenylyl cyclases present in beta cells of the human pancreas. (reactome.org)
The G-protein beta-gamma complex interacts with adenylyl cyclases via protein-protein interactions with the C1 and C2 cytoplasmic loops of adenylyl cyclase. (reactome.org)
In the case of adenylyl cyclases V and VI the interaction inhibits cyclase activity. (reactome.org)
The best known class of adenylyl cyclases is class III or AC-III (Roman numerals are used for classes). (wikipedia.org)
These adenylyl cyclases are toxins secreted by pathogenic bacteria such as Bacillus anthracis, Bordetella pertussis, Pseudomonas aeruginosa, and Vibrio vulnificus during infections. (wikipedia.org)
These adenylyl cyclases are the most familiar based on extensive study due to their important roles in human health. (wikipedia.org)
Adenylyl cyclases are often activated or inhibited by G proteins, which are coupled to membrane receptors and thus can respond to hormonal or other stimuli. (wikipedia.org)

Isobe K., Pituitary adenylate cyclase-activating polypeptide induces gene expression of the catecholamine synthesizing enzymes, tyrosine hydroxylase and dopamine beta hydroxylase, through 3',5'-cyclic adenosine monophosphate- and protein kinase C-dependent mechanisms in cultured porcine adrenal medullary chromaffin cells. (riken.jp)
Pituitary adenylate cyclase-activating polypeptide (PACAP), a member of the vasoactive intestinal peptide/secretin/glucagon family , has an amino acid sequence identity of 68% with vasoactive intestinal polypeptide (VIP). (eurogentec.com)
Pituitary adenylate-cyclase-activating polypeptide expression in the immune system. (nih.gov)

It shows considerable homology with VIP but stimulates adenylate cyclase much more potently than VIP. (eurogentec.com)
Forskolin stimulates adenylate cyclase and iodine metabolism in thyroid. (yourhormones.com)

Stimulation of postsynaptic GABA B receptors generally triggers inhibition of adenylate cyclase and activation of G protein-gated inwardly rectifying K + (GIRK/Kir3) channels, leading to cell hyperpolarisation (Kaupmann et al. (springer.com)
[1] Adenylate cyclase is activated by a range of signaling molecules through the activation of adenylate cyclase stimulatory G ( G s )-protein-coupled receptors. (wikipedia.org)
Adenylate cyclase is inhibited by agonists of adenylate cyclase inhibitory G ( G i )-protein-coupled receptors. (wikipedia.org)

Multiple modes of insulin regulation of lipolysis and regulation of insulin responses by adenylate cyclase regulators. (nature.com)
Our study demonstrates a circadian rhythm of contrast sensitivity that peaks during the daytime, and that its regulation involves interactions of D4Rs, the clock gene Npas2 , and the clock-controlled gene adenylyl cyclase 1 ( Adcy1 ) in a subset of retinal ganglion cells (RGCs). (jneurosci.org)

The enterotoxin works by activating adenylate cyclase in the epithelial cells. (ppdictionary.com)

The outside signal (in this case, adrenaline) binds to a receptor, which transmits a signal to the G protein, which transmits a signal to adenylyl cyclase, which transmits a signal by converting adenosine triphosphate to cyclic adenosine monophosphate (cAMP). (wikipedia.org)
Following activation of adenylyl cyclase, the resulting cAMP acts as a second messenger by interacting with and regulating other proteins such as protein kinase A and cyclic nucleotide-gated ion channels. (wikipedia.org)
Depending on which family the G protein is, it goes on to activate (G αs protein subunit) or inhibit (G αi protein subunit) the membrane-bound cyclase. (pancreapedia.org)
The activated G protein goes on to activate adenylyl cyclase, producing large amounts of another chemical compound called cAMP. (ppdictionary.com)
As a result, if the G protein is constantly active, there is persistent activation of adenylyl cyclase and, in turn, a nonregulated rise of intracellular cAMP. (ppdictionary.com)

B. bronchiseptica" also produces many toxins such as bifunctional adenylate cyclase and dermonecrotic toxins. (kenyon.edu)

The interaction may produce either stimulation or inhibition of the adenylyl cyclase depending on the particular adenylyl cyclase. (reactome.org)

Liver adenylate cyclase responds more strongly to glucagon, and muscle adenylate cyclase responds more strongly to adrenaline. (wikipedia.org)

All classes of adenylyl cyclase catalyse the conversion of adenosine triphosphate (ATP) to 3',5'-cyclic AMP (cAMP) and pyrophosphate. (wikipedia.org)

A cyclase enzyme (lyase) catalyzes the formation of the cyclic nucleotide from its nucleotide triphosphate precursor ( Figure 1 ). (pancreapedia.org)

Cyclic AMP is synthesized from ATP by adenylate cyclase located on the inner side of the plasma membrane and anchored at various locations in the interior of the cell. (wikipedia.org)

Potential effect of forskolin on TSH-mediated adenylate cyclase stimulation. (yourhormones.com)

In 1998 a family of cAMP-sensitive proteins with guanine nucleotide exchange factor (GEF) activity was discovered. (wikipedia.org)

16] Hiraiwa M. Adenylate cyclase system responsive to thyroid stimulating hormone (TSH) of porcine thyroid cells in primary monolayer cultures. (yourhormones.com)

Two aspartic acid residues in the active site of the cyclase (AC or GC) promotes the binding of ATP. (pancreapedia.org)
Tests on pure mesembrine hydrochloride substantiated that sunlight and aqueous conditions are required to facilitate this transformation and obtain the active alkaloids.Patnala 2009 This traditional fermentation removes harmful oxalates while retaining the active alkaloids.Smith 1998 In extracts, the alkaloids are more bioavailable across the intestinal, buccal, and mucosal tissues. (proessencekanna.com)

Mesembrine, a phenylethylamine alkaloid, was first extracted from S. tortuosum in 1898.Smith 1998 It is the major alkaloid found in S. tortuosum, occurring at levels of 0.3% in the leaves and 0.86% in the stems. (proessencekanna.com)