1998 prostate. Medical search. Frequent questions

Prostate-specific antigen (PSA), also known as gamma-seminoprotein or kallikrein-3 (KLK3), P-30 antigen, is a glycoprotein enzyme encoded in humans by the KLK3 gene. (wikipedia.org)
Approximately 20-30% of men with 1 or more positive margins experience relapse, depending on the site of the positive margin, preoperative prostate-specific antigen (PSA) level, Gleason score, and presence of seminal vesical invasion. (medscape.com)
Screening for prostate-specific antigen (PSA) has led to earlier detection of prostate cancer 3 , but elevated serum PSA levels may be present in non-malignant conditions such as benign prostatic hyperlasia (BPH). (nature.com)
Barry, M. J. Prostate-specific-antigen testing for early diagnosis of prostate cancer. (nature.com)
Secondary endpoints included toxic effects, time to prostate-specific-antigen (PSA) progression, and overall survival. (researchgate.net)
Prostate-specific antigen testing increased during this period. (annfammed.org)
11 , 12 The prevailing view was that clinicians will likely forgo shared decision making and paternalistically order screening tests, such as the measurement of prostate-specific antigen (PSA), to avoid legal vulnerability. (annfammed.org)
Prostate-specific membrane antigen (PSMA)-ligand PET imaging provides unprecedented accuracy for whole-body staging of prostate cancer. (snmjournals.org)
Prostate-specific membrane antigen (PSMA)-ligand PET/CT or PET/MRI provides high sensitivity and specificity for prostate cancer staging ( 1 ). (snmjournals.org)
Hormonal treatment of advanced prostate cancer should be consideredfor patients who have stages C and D1 disease, a high risk of recurrenceafter local therapy, or prostate-specific antigen-measured recurrenceafter local treatment. (cancernetwork.com)
2010 who were aged at least 18 years, had a prostate-specific antigen (PSA) screening test done within 12 months prior to enrollment, and had no prior history of prostate cancer. (cdc.gov)
The finasteride trial enrolled men with a prostate-specific antigen (PSA) of less than 3 ng/mL, constituting the majority of U.S. men, but those with a lower risk of cancer. (cigna.com)
If there is any concern about potential prostate problems, the patient or healthcare practitioner may also request a blood draw for a PSA test, which measures a prostate-specific antigen (see box below). (womensinternational.com)
The intention of this study is to describe the impact and underlying potential basis of the prostate-specific antigen (PSA) flare-up phenomenon in patients with hormone-refractory prostate cancer (HRPC) treated with docetaxel-based chemotherapy. (springer.com)
Patients were evaluated based on modified criteria from the Prostate-Specific Antigen Working Group regarding survival and toxicity. (springer.com)
Olbert PJ, Hegele A, Kraeuter P et al (2006) Clinical significance of a prostate-specific antigen flare phenomenon in patients with hormone-refractory prostate cancer receiving docetaxel. (springer.com)
Bubley GJ, Carducci M, Dahut W et al (1999) Eligibility and response guidelines for phase II clinical trials in androgen-independent prostate cancer: recommendations from the prostate-specific antigen working group. (springer.com)
There was only a slight decrease in prostate-specific antigen (PSA) level and pelvic disease post treatment. (jpalliativecare.com)
Perhaps the greatest breakthrough in the detection and management of prostate cancer was the approval of the prostate-specific antigen (PSA) blood test in 1986 , but it was only approved for men already diagnosed with prostate cancer. (lifeextension.com)
1 Prostate-specific antigen is a protein produced by the cells of the prostate gland, including both cancerous cells as well as cells that are benign. (lifeextension.com)
Do general practitioners use prostate-specific antigen as a screening test for early prostate cancer? (mja.com.au)
These declines are due, at least in part, to the combination of prostate specific antigen (PSA)-based prostate cancer screening and better treatment of men diagnosed with prostate cancer and men who progress to metastatic disease (3-6). (cdc.gov)
On the basis of the high and consistent expression of prostate-specific membrane antigen (PSMA) in metastatic prostate cancer (PC), the goal of this study was the development, preclinical evaluation, and first proof-of-concept investigation of a PSMA inhibitor for imaging and therapy (PSMA I&T) for 68 Ga-based PET and 177 Lu-based endoradiotherapeutic treatment in patients with metastatic and castration-resistant disease. (snmjournals.org)
On prostate cancer (PC) cells, the cell surface enzyme prostate-specific membrane antigen (PSMA), also known as glutamate carboxypeptidase II or N -acetyl- l -aspartyl- l -glutamate peptidase, is highly upregulated, whereas it shows low or no expression in the normal prostate ( 3 ). (snmjournals.org)
Prostate-specific antigen (PSA) is a protein produced by normal prostate cells. (medscape.com)

Professor Iain McEwan from the University of Aberdeen has received £81,634 for a 3 year PhD study to identify new drugs for the treatment of advanced prostate cancer. (abdn.ac.uk)
He said: "Men with advanced prostate cancer have limited treatment options, further hampered by prostate cancer's ability to develop resistance to standard treatments. (abdn.ac.uk)
There is a clear need to invest in research to focus on new ways to control and treat advanced prostate cancer, and this funding from The Prostate Cancer Charity will allow us to focus our attention on testing a new approach for developing drugs to block the activity of a protein called the androgen receptor. (abdn.ac.uk)
Although hormonal therapy is an importanttreatment modality for advanced prostate cancer, long-termtreatment carries significant side effects that need to be considered. (cancernetwork.com)
Tannock IF, de Wit R, Berry WR et al (2004) Docetaxel plus prednisone or mitoxantrone plus prednisone for advanced prostate cancer. (springer.com)
Also, see the Advanced Prostate Cancer: Signs of Metastatic Disease slideshow for help identifying the signs of metastatic disease. (medscape.com)
however, most urologists would testify that they see far fewer patients with advanced prostate cancer since the PSA era began. (medscape.com)

He poignantly recalled his experience as a family medicine resident, when he was sued for letting a patient decide whether to be screened for prostate cancer after engaging him in shared decision making, as current guidelines recommend. (annfammed.org)
We used data from an ongoing case-control study of veterans screened for prostate cancer at the Durham Veterans Affairs Medical Center (DVAMC) in Durham, North Carolina. (cdc.gov)

We hypothesized that calcium would be positively associated with prostate cancer risk. (cdc.gov)
8 - 10 However, there is still limited number of modifiable risk factors identified for prostate cancer and more studies are needed to identify some modifiable risk factors associated with prostate cancer. (dovepress.com)
location of rovirus (XMRV) has been recently associated with prostate cancer and chronic fatigue syndrome. (cdc.gov)
Rising levels of PSA in serum are associated with prostate cancer. (medscape.com)

If indicated, prostate biopsy is performed to obtain a tissue sample for histopathological analysis. (wikipedia.org)
The study consisted of 108 biopsy-positive prostate cancer cases, 161 biopsy-negative controls, and 237 healthy controls. (cdc.gov)
3 ] Subsequent studies showed that diagnostic tests (PSA, prostate digital rectal exam, and prostate biopsy) had improved performance for detection of cancer and of high-grade cancer in men who received finasteride. (cigna.com)
Active surveillance includes periodic PSA testing, digital rectal examination (DRE), and prostate biopsy. (medscape.com)
PSA testing not only helps identify men in whom a prostate biopsy would be appropriate but also assists in assessing the response to therapy, determining tumor progression, and, in its most controversial role, screening for prostate cancer. (medscape.com)
Before the PSA era, an abnormality in the prostate had to be palpably evident before a biopsy would be performed, and nearly 70% of men diagnosed with prostate cancer already had extraprostatic or metastatic disease. (medscape.com)
ABSTRACT In recent years, greater numbers of prostate biopsy cores are being submitted for histopathological assessment, with a concomitant increase in workload for the pathologist. (who.int)

the others are the grade of prostate cancer (Gleason grading system) and the stage of cancer based on physical examination and imaging studies. (wikipedia.org)
20, Gleason score ≥ 8, OR clinical stage ≥ T3 Given the relative simplicity of the 1998 D'Amico criteria (above), other predictive models of risk stratification based on mathematical probability constructs exist or have been proposed to allow for better matching of treatment decisions with disease features. (wikipedia.org)
7) and high-grade prostate cancer (Gleason score ≥7). (cdc.gov)
The reduction in prostate cancer incidence occurred primarily in Gleason score 5 to 6 cancers. (cigna.com)
The Gleason score (grade rate of prostate cancer in Saudi Arabia 810 prostatic needle biopsies obtained of malignant cases) was not, however, ranked sixth among male patients with from 100 patients from 2005 until the recorded as this parameter was outside a crude annual incidence of 5.7 per end of 2011 were retrieved from the the scope of this retrospective study. (who.int)

PSA is a member of the kallikrein-related peptidase family and is secreted by the epithelial cells of the prostate gland. (wikipedia.org)
A healthy prostate gland is about the size of a walnut (see figure). (womensinternational.com)
Thus, a healthy prostate gland is required for the satisfactory performance of both sexual and urinary functions. (womensinternational.com)
The prostate gland is highly unusual in that it increases in size four different times in a man's life-at birth, puberty, young adulthood, and around age 50. (womensinternational.com)
The three primary health conditions that affect the prostate gland are prostatitis, enlarged prostate ( benign prostatic hyperplasi a, often shortened to BPH), and prostate cancer. (womensinternational.com)
This article succinctly describes conventional prostate gland diagnostic tests along with those that mainstream medicine often overlooks, to the detriment of their patients. (lifeextension.com)
1 Since very little PSA escapes into the bloodstream from a healthy prostate, an elevated PSA level in the blood indicates an abnormal condition of the prostate gland-which can be either benign or malignant. (lifeextension.com)
2 If PSA readings begin to elevate, there are interventions that can reduce or stabilize the production of PSA, shutting down a mechanism used by cancer cells to escape their confinement within the prostate gland. (lifeextension.com)
A normal prostate gland is approximately 20 g in volume, 3 cm in length, 4 cm wide, and 2 cm in depth. (medscape.com)
As men get older, the prostate gland is variable in size secondary to benign prostatic hyperplasia. (medscape.com)
The image below depicts the anatomy of the prostate gland. (medscape.com)
Prostate is small gland, about size and shape of walnut, that is part of male reproductive system. (medscape.com)
We would encourage other hospital pathologists to review periodically the uniformity of diagnoses in an attempt to improve their practices in prostate gland pathology. (who.int)

This project will use human prostate cancer samples to study the activity of the molecules Sprouty2 and PI3/AKT in prostate cancer. (abdn.ac.uk)
Saw palmetto extract suppresses insulin-like growth factor-I signaling and induces stress-activated protein kinase/c-Jun N-terminal kinase phosphorylation in human prostate epithelial cells. (nutrimedical.com)
Cadherin switching in human prostate cancer progression. (nature.com)
Administered alone, FBZ inhibited proliferation faster than VES in both mouse and human prostate cancer cell lines and a synergistic effect between both was also observed. (researchgate.net)
Reduced lysyl oxidase messenger RNA levels in experimental and human prostate cancer. (bvsalud.org)

Signature expression profiles of normal adjacent prostate (NAP), BPH, localized prostate cancer, and metastatic, hormone-refractory prostate cancer were determined. (nature.com)
The alpha-emitter radium-223 ((223)Ra) is a bone-seeking radionuclide studied as a new treatment for patients with bone metastases from hormone-refractory prostate cancer. (researchgate.net)
Patients with hormone-refractory prostate cancer and bone pain needing external-beam radiotherapy were assigned to four intravenous injections of (223)Ra (50 kBq/kg, 33 patients) or placebo (31 patients), given every 4 weeks. (researchgate.net)
Larger clinical trials are warranted to study (223)Ra on the prevention of SREs and on overall survival in patients with hormone-refractory prostate cancer. (researchgate.net)
patients with bone metastases from hormone-refractory prostate cancer. (researchgate.net)
Oudard S, Banu E, Beuzeboc P et al (2005) Multicenter randomized phase II study of two schedules of docetaxel, estramustine, and prednisone versus mitoxantrone plus prednisone in patients with metastatic hormone-refractory prostate cancer. (springer.com)
Despite continuous research efforts in the past decades, there are still cancers where no effective treatment is available, such as advanced kidney cancer or hormone-refractory prostate cancer. (karger.com)

Men with prostate cancer may be characterized as low, intermediate, or high risk for having/developing metastatic disease or dying of prostate cancer. (wikipedia.org)

Docetaxel is a chemotherapy agent for castrate-resistant prostate cancer (CRPC). (iiarjournals.org)
As a consequence, PSMA has attracted attention as a target for molecular imaging and for targeted radioligand therapy, especially in metastatic castrate-resistant prostate cancer (mCRPC). (snmjournals.org)

medical citation needed] Of those found to have prostate cancer, overtreatment is common because most cases of prostate cancer are not expected to cause any symptoms due to low rate of growth of the prostate tumor. (wikipedia.org)
With NADT prior to RP, the intent is to eradicate malignant androgen-dependent cells, in the hope that sufficient tumor regression will permit complete resection of residual prostate cancer, improving pathologic outcome and survival. (medscape.com)
However, owing to the inaccuracy of clinical staging, approximately 50% of men with clinical stage T1 or T2 prostate cancer have tumor extension outside of the prostate capsule, and 5-40% have positive surgical margins. (medscape.com)
The clinical staging of prostate cancer was devised from the American Joint Committee on Cancer (AJCC) tumor, node, metastasis (TNM) system. (medscape.com)

Transurethral resection of the prostate ( TURP ) was originally developed in the United States between 1920 and 1930 and was generally considered the criterion standard for surgical management of BPH. (medscape.com)

Those concerns regarding prostate cancer progression have led to a renewed interest in the use of NADT prior to RP. (medscape.com)
Shurbaji, M. S., Kalbfleisch, J. H. & Thurmond, T. S. Immunohistochemical detection of a fatty acid synthase (OA-519) as a predictor of progression of prostate cancer. (nature.com)
Environmental factors such as diet are thought to influence prostate cancer development and progression. (cdc.gov)
A potential mechanism for the role of calcium in prostate cancer development and progression is that intracellular calcium controls the growth of prostate cancer cells and the process of apoptosis (9). (cdc.gov)
Current cigarette smoking, rather than past or cumulative smoking, is a risk factor for prostate cancer with aggressive pathologic characteristics and increased risk of recurrence and progression among men who have prostate cancer, and for prostate cancer mortality (8). (cdc.gov)

In patients with clinically localized prostate cancer, the National Comprehensive Cancer Network (NCCN) strongly discourages the use of NADT before RP outside of a clinical trial. (medscape.com)
We assessed two of these genes-hepsin, a transmembrane serine protease, and pim-1, a serine/threonine kinase-at the protein level using tissue microarrays consisting of over 700 clinically stratified prostate-cancer specimens. (nature.com)
The Management of clinically localized prostate cancer. (upenn.edu)

METHODS As part of a randomized controlled trial conducted between January 2002 and November 2004, patients and physicians completed exit questionnaires about prostate cancer screening discussions after health maintenance examinations. (annfammed.org)
Between January 2002 and November 2004, Merenstein's former residency training site (a northern Virginia family practice center serving a suburban patient population) was the setting of a randomized trial of Web-based and paper-based decision aids for prostate cancer screening, the results of which are reported elsewhere. (annfammed.org)
Fossa SD, Vaage S, Letocha H et al (2002) Liposomal doxorubicin (Caelyx) in symptomatic androgen-independent prostate cancer (AIPC)-delayed response and flare phenomenon should be considered. (springer.com)

PSA is not uniquely an indicator of prostate cancer, but may also detect prostatitis or benign prostatic hyperplasia. (wikipedia.org)
By far the most common prostate illness is "enlarged prostate," or benign prostatic hyperplasia (BPH), which is the abnormal but non-cancerous growth of prostate cells. (womensinternational.com)
Transurethral needle ablation (TUNA) of the prostate is a procedure used to treat benign prostatic hyperplasia ( BPH ). (medscape.com)
[ 7 ] The PSA level also tends to rise in men with benign prostatic hyperplasia (BPH) and is a good marker for prostate volume. (medscape.com)

Thanks to an array of available diagnostic tools, more rational treatment of prostate cancer is within everyone's reach. (lifeextension.com)
The role of medications that suppress androgen production is controversial in the treatment of prostate cancer. (oncolink.org)
The ACS notes that PSA testing may reduce the likelihood of dying from prostate cancer but nevertheless poses serious risks, particularly those associated with the treatment of prostate cancer that would not have caused ill effects if left undetected. (medscape.com)

Chemoprevention with finasteride and dutasteride reduces the incidence of prostate cancer, but the evidence is inadequate to determine whether chemoprevention with finasteride or dutasteride reduces mortality from prostate cancer. (cigna.com)

1 In addition, the incidence of prostate cancer has increased significantly in most Asian populations. (dovepress.com)
The report finds that for 1999 to 2003, Latinos had lower incidence rates than non-Hispanic whites (NHW) for most cancers, but were less likely than the NHW population to be diagnosed with localized stage disease for cancers of the lung, colon and rectum, prostate, female breast, and cervix. (cdc.gov)

Prostate cancer risk stratification is based on groups defined by D'Amico et al in 1998. (medscape.com)

Noguchi K, Uemura H, Harada M et al (2001) Inhibition of PSA flare in prostate cancer patients by administration of flutamide for 2 weeks before initiation of treatment with slow-releasing LH-RH agonist. (springer.com)
RÉSUMÉ Nous décrivons les tendances de l'incidence des cancers courants dans les pays du Conseil de coopération du Golfe de 1998 à 2001. (who.int)

Fortunately, prostate cancer tends to be very slow-growing and, when diagnosed early, is one of the most curable cancers. (womensinternational.com)
The objective of the present study was to evaluate the risk of cancer (all, breast, prostate and colon cancers) in association with exposure to CCB. (bmj.com)
les cancers les plus répandus chez les hommes étaient les cancers du poumon et de la prostate et, chez les femmes, les cancers du sein et de la thyroïde. (who.int)
The top ranking cancers among males are obtained from accessible death certificates in liver, lung and prostate. (who.int)

The reference interval provided by most conventional laboratories for the PSA test is 0.00-4.00 nanograms per milliliter (ng/mL) . 4 Conventional reference ranges suggest that PSA levels under 4.0 ng/mL are normal, but any reading over 2.0 ng/mL can indicate unhealthy activity, such as prostatitis, benign prostate hypertrophy, or prostate cancer. (lifeextension.com)

False-positive test results can cause confusion and anxiety in men, and can lead to unnecessary prostate biopsies, a procedure which causes risk of pain, infection, and hemorrhage. (wikipedia.org)

For this reason, most physical exams for men age 50 and over now include a thorough digital rectal exam to check the prostate. (womensinternational.com)
Rectal volume (RV), cross-sectional area (CSA), and rectal volume from the seminal vesicles to the inferior prostate (SVP) were assessed on the planning CT. (urotoday.com)
Hudson was diagnosed with prostate cancer in 1998, and with rectal cancer in 2011. (globenewswire.com)

Molecular genetics and epidemiology of prostate carcinoma. (nature.com)
Boyle P, Severi G. Epidemiology of prostate cancer chemoprevention . (cancervic.org.au)

Nearly all of these studies were performed in populations made up predominantly of white men, even though associations between modifiable risk factors such as calcium intake and prostate cancer risk may differ by race. (cdc.gov)

9] In 2007, a critical review of this plant's efficacy examined a detailed series of in vitro and in vivo studies on prostate growth and bladder function. (nutrimedical.com)
Researchers identified molecular targets of Pygeum africanum extract affecting both growth factor-mediated prostate growth and specific parameters of bladder function. (nutrimedical.com)
Muscles in the prostate help move sperm through the ejaculatory duct and also help open the bladder to allow urine to pass through the urethra. (womensinternational.com)
The requesters listed several health effects, including respiratory conditions and skin, kidney, bladder, and prostate problems that they believed were related to exposure to the synthetic metal-working fluid (MWF) used in the machine shop. (cdc.gov)

Clinical practice guidelines for prostate cancer screening vary and are controversial, in part due to uncertainty as to whether the benefits of screening ultimately outweigh the risks of overdiagnosis and overtreatment. (wikipedia.org)
In the United States, the Food and Drug Administration (FDA) has approved the PSA test for annual screening of prostate cancer in men of age 50 and older. (wikipedia.org)
citation needed] While PSA testing may help 1 in 1,000 avoid death due to prostate cancer, 4 to 5 in 1,000 would die from prostate cancer after 10 years even with screening. (wikipedia.org)
PURPOSE In 2004, a commentary by Merenstein was published in JAMA describing how he was sued for engaging a patient in shared decision making for prostate cancer screening. (annfammed.org)
A natural experiment (a study assessing shared decision making under way at the practice that was sued) enabled us to evaluate whether physicians changed their prostate cancer screening behavior after the lawsuit. (annfammed.org)
The patient declined screening, was later found to have prostate cancer, and successfully sued the practice, in essence, for encouraging shared decision making. (annfammed.org)
Prostate cancer : new questions about screening and treatment : hearing before the Committee on Oversight and Government Reform, House of Representatives, One Hundred Eleventh Congress, second session, March 4, 2010. (upenn.edu)
Breast cancer (BC) and prostate cancer (PC) mortality rates in Lithuania remain comparatively high despite the ongoing BC and PC screening programmes established in 2006. (biomedcentral.com)
1 It wasn't until 1994 that the FDA approved the PSA test as a prostate cancer screening test for all men. (lifeextension.com)
PSA levels have been used in screening large populations of men for prostate cancer and have been shown to be useful. (medscape.com)
Despite the apparent survival advantage conferred by PSA screening, the US Preventive Services Task Force (USPSTF) recommends against screening for prostate cancer in men aged 75 years or older. (medscape.com)
The USPSTF also concludes that at present, the balance between the benefits and the drawbacks of prostate cancer screening in men younger than age 75 years cannot be assessed, because the available evidence is insufficient. (medscape.com)
Should mass screening for prostate cancer be introduced at the national level? (bvsalud.org)

failed verification] Since the expected harms relative to risk of death are perceived by patients as minimal, men found to have prostate cancer usually (up to 90% of cases) elect to receive treatment. (wikipedia.org)

Heidenreich A, Sommer F, Ohlmann CH et al (2004) Prospective randomized phase II trial of pegylated doxorubicin in the management of symptomatic hormone-refractory prostate carcinoma. (springer.com)
Kreis W, Budman DR, Fetten J et al (1999) Phase I trial of the combination of daily estramustine phosphate and intermittent docetaxel in patients with metastatic hormone refractory prostate carcinoma. (springer.com)

Between 1998 and 2006, 962 patients were treated with computed tomography (CT)-based offline adaptive IGRT. (urotoday.com)
A MEDLINE search was used to identify all English language articles published between January 1990 and September 1998 in which prostate cancer patients were treated with a combination of radiotherapy and androgen deprivation. (oncolink.org)

Since 1986, when tests for measuring PSA levels in serum were introduced into clinical practice, early diagnosis and management of prostate cancer has been revolutionized, and much has been learned about the strengths and weaknesses of these assays. (medscape.com)

Other potent herbs and nutrients in nutraMetrix MPC® Maximum Prostate Care help to maintain blood pressure, promote healthy cholesterol levels, maintain healthy sperm count, support male libido, support a healthy immune system and promote healthy prostate cells. (nutrametrix.com)

If surgical therapy (i.e., radical prostatectomy) is successful at removing all prostate tissue (and prostate cancer), PSA becomes undetectable within a few weeks. (wikipedia.org)
It promotes the normal absorption of the male hormones, testosterone and dihydrotestosterone, into the prostate tissue. (nutrametrix.com)
Although the traditional definitionof 'advanced' prostate cancerencompasses patients with widespreadosteoblastic or soft-tissue metastases,this nomenclature for advanced diseaseshould be challenged. (cancernetwork.com)
Detection of viral nucleic acid in tissue sections of cancer- of 161 BAL and tracheal secretion samples were collected ous prostate glands and cloning of the viral integration sites from patients with severe RTI and immunosuppression as a confi rmed XMRV as a bona fi de human infection with a result of solid organ or bone marrow transplantation. (cdc.gov)
The TUNA system produces thermal tissue ablation by applying low-level RF energy to prostate tissue. (medscape.com)

Market America has taken the time in creating nutraMetrix MPC® Maximum Prostate Care to ensure that the selected herbs and nutrients will maximize the health of the prostate and effectively optimize overall health. (nutrametrix.com)
Heston was a five-term president of the National Rifle Association of America (NRA), from 1998 to 2003. (wikipedia.org)

However, a recent review of the relevant medical literature, published in The New England Journal of Medicine , concluded that testosterone therapy is not associated with increases in the rate of prostate cancer or any other prostate illness. (womensinternational.com)

Professor Hing Leung from the Beatson Institute for Cancer Research, University of Glasgow and NHS Greater Glasgow and Clyde has received £150,812 for a 3 year project to identify how certain molecules promote the growth of prostate cancer. (abdn.ac.uk)
This project aims to identify and develop new drug targets to block the activity of a protein that interacts with the male hormone testosterone, known as the androgen receptor, which is known to drive the growth of prostate cancer in the presence of testosterone, but also in the absence of testosterone when the cancer is no longer responding to hormone therapy. (abdn.ac.uk)

This review of major publications relating to prostate cancer and sleep sought to gain an understanding of the methods used for sleep assessment and the magnitude of effect that ADT has on sleep. (mdpi.com)

Neoadjuvant androgen deprivation therapy (NADT) is systemic therapy administered after the diagnosis of prostate cancer but before locoregional therapy such as radical prostatectomy (RP) or radiation. (medscape.com)
The diagnosis of prostate cancer re- at King Khalid University Hospital, quires the estimation of prostate-specif- Riyadh. (who.int)

Figure 2: Hepsin is overexpressed in prostate cancer. (nature.com)
Figure 3: PIM1 is overexpressed in prostate cancer. (nature.com)

The 2010 update of the American Cancer Society (ACS) guideline for early detection of prostate cancer stresses the importance of involving men in the decision whether to test for prostate cancer. (medscape.com)

These drugs may deserve to be tested for their efficacy in the control of prostate cancer using in vivo models. (researchgate.net)
control of prostate ca ncer using in vivo m odels. (researchgate.net)

The annual regular budget for the biennium 1998-1999 will be approximately US$ 18 million. (who.int)

However, a meta-analysis of the sequencing of androgen deprivation therapy with radiation therapy in localized prostate cancer concluded that adjuvant androgen deprivation therapy results in superior outcomes, compared with neoadjuvant or concurrent androgen deprivation therapy. (medscape.com)
2]The premise of androgen ablationrelies on growth of most prostate carcinomacells being androgen-dependent.The androgen receptor expressedby these cells binds dihydrotestosterone,which is then transported intothe nucleus, leading to a cascade ofevents that induces cellular growth. (cancernetwork.com)
When medications deplete the body's androgen supply or when the testes are removed (the testes supply 97% of a man's androgen), prostate cancer cells die. (oncolink.org)
Unfortunately, androgen deprivation rarely results in cure, as not all prostate cancer cells are androgen-dependent. (oncolink.org)

Taking lycopene by mouth might slightly reduce the risk of developing prostate cancer. (medlineplus.gov)

Dr. Pienta is currently actively developing clinical trials and treating patients with newly diagnosed high risk and metastatic prostate cancer. (hopkinsmedicine.org)
Because four machinists had been newly diagnosed with asthma in 1998, medical evaluations focused on respiratory effects. (cdc.gov)

PSA is present in small quantities in the serum of men with healthy prostates, but is often elevated in the presence of prostate cancer or other prostate disorders. (wikipedia.org)
some PSA escapes the prostate and can be found in the serum. (medscape.com)

Prostatitis , or inflammation of the prostate, is the least common prostate condition. (womensinternational.com)
In his 2006 Guide to Prostate Health , Dr. Katz notes that holistic medicine is an important part of the treatment for chronic prostatitis, which often does not respond to conventional therapies. (womensinternational.com)

Anatomy15

Organisms4

Diseases26

Chemicals and Drugs72

Analytical, Diagnostic and Therapeutic Techniques and Equipment76

Psychiatry and Psychology1

Phenomena and Processes40

Disciplines and Occupations3

Anthropology, Education, Sociology and Social Phenomena1

Humanities1

Information Science10

Named Groups3

Health Care30

Geographicals1

Antigen25

Advanced prostate cancer7

Screened for prostate cancer2

Associated with prostate cancer4

Biopsy7

Gleason5

Gland13

Human prostate5

Hormone-refrac7

Metastatic disease1

Castrate-resistant prostate cancer2

Tumor4

Transurethral resectio1

Progression5

Clinically3

20023

Prostatic4

Treatment of prostate cancer3

Mortality from prostate cancer1

Incidence2

D'Amico1

20012

Cancers4

Benign1

Biopsies1

Rectal3

Epidemiology2

Modifiable risk factors1

Bladder4

Screening13

Found to have prostate cancer1

Carcinoma2

Patients were treated2

Practice1

Healthy prostate1

Tissue5

America2

Rate of prostate cancer1

Growth of prostate cancer2

Relating to prostate cancer1

Diagnosis of prostate cancer2

Overexpressed in prostate cancer2

Detection1

Vivo2

19991

Androgen4

Lycopene1

Newly diagnosed2

Serum2

Prostatitis2