• vascular
  • 10. The method of claim 1 wherein the vascular graft, synthetic prosthesis, heterograft tissue or medical device comprises a porous conduit having an exterior surface and a lumenal surface and wherein the antithrombotic membrane mimetic surface is produced on a lumenal surface of the conduit. (google.com)
  • We have previously shown that part of the heparin-binding domain of the vascular endothelial growth factor (VEGF), designated HBDt, localizes very selectively to surfaces of the endothelial cells of i.t blood vessels. (aacrjournals.org)
  • We previously showed that the rather novel vascular endothelial growth factor (VEGF) heparin-binding domain substructure (HBDt), when expressed on the surface of a modified M13 phage, selectively enabled accumulation in vivo on the vascular surface of the CD31-positive endothelium of tumor vasculature ( 1 ). (aacrjournals.org)
  • LRP1 is a member of the LDLR family and ubiquitously expressed in multiple tissues, though it is most abundant in vascular smooth muscle cells (SMCs), hepatocytes, and neurons. (wikipedia.org)
  • bind
  • Factor Xa inhibitors generally bind in an L-shaped conformation, where one group of the ligand occupies the anionic S1 pocket lined by residues Asp189, Ser195, and Tyr228, and another group of the ligand occupies the aromatic S4 pocket lined by residues Tyr99, Phe174, and Trp215. (wikipedia.org)
  • Both Factor Xa and Va bind to the membrane independently of each other, but they both bind to mutually exclusive binding sites. (wikipedia.org)
  • platelet
  • In cirrhosis, the rebalanced state can be disrupted by several factors including stasis, portal hypertension, dysfibrinogenemia, production of endogenous heparinoids, platelet and endothelial dysfunction, renal failure and infection. (springer.com)
  • Elevated levels of von Willebrand Factor in cirrhosis support platelet adhesion despite reduced functional capacity. (springer.com)
  • FIP1L1 gene fusions between it and either the platelet-derived growth factor receptor, alpha (PGDFRA) or Retinoic acid receptor alpha (RARA) genes are causes of certain human diseases associated with pathologically increased levels of blood eosinophils and/or Leukemias. (wikipedia.org)
  • tumor
  • We fused the HBDt structure to the extracellular domain of human tissue factor (TFt) through a linker to explore the feasibility of targeting the truncated extracellular domain of TFt to the tumor microvessel plasmalemma in a mode to locally initiate the thrombogenic cascade. (aacrjournals.org)
  • For example, TF is released in response to exposure to cytokines (particularly interleukin 1), tumor necrosis factor, and endotoxin. (wikipedia.org)
  • TFPI
  • Methods and Results- Transcardiac (aorta/coronary sinus) free and total TFPI (free + lipoprotein-bound form) levels, as well as TFPI/factor Xa (FXa) complex levels, were measured in plasma samples obtained from patients with acute myocardial infarction undergoing primary PTCA and patients with unstable angina undergoing urgent PTCA. (ahajournals.org)
  • thromboplastin
  • In particular, the invention is concerned with the therapy of antihemophilic factor or plasma thromboplastin component inhibitors. (google.com)
  • atherosclerotic
  • Background −Tissue factor, which is required for the initiation of the extrinsic coagulation cascade, is known to be upregulated in cells within atherosclerotic lesions, including smooth muscle cells. (ahajournals.org)
  • Interest in the role that tissue factor expressed by smooth muscle cells (SMC) may play in atherosclerotic lesion growth, restenosis after angioplasty, and acute coronary syndrome has been heightened by multiple observations. (ahajournals.org)
  • gene
  • The gene for factor IX is located on the X chromosome (Xq27.1-q27.2) and is therefore X-linked recessive: mutations in this gene affect males much more frequently than females. (wikipedia.org)
  • Polly, a transgenic cloned Poll Dorset sheep carrying the gene for factor IX, was produced by Dr Ian Wilmut at the Roslin Institute in 1997. (wikipedia.org)
  • The human factor X gene is located on the thirteenth chromosome (13q34). (wikipedia.org)
  • rFVIIa
  • The aim of the recent Factor Seven for Acute Hemorrhagic Stroke (FAST) trial 12 was to confirm the findings of an earlier Phase 2b study in which rFVIIa reduced hematoma growth and improved both survival and functional outcome in patients with ICH. (ahajournals.org)
  • epidermal
  • The light chain contains an N-terminal γ-carboxyglutamic acid domain (Gla domain) and two epidermal growth factor-like domains (EGF1 and EGF2). (wikipedia.org)
  • conjunction
  • The dissociation of subunits VIIa and III in conjunction with the removal of cardiolipin results in total loss of enzyme activity. (wikipedia.org)
  • cleavage
  • Following cleavage, Factor Va contains a heavy chain, composed of the A1 and A2 domains and a light chain, consisting of the A3, C1, and C2 domains. (wikipedia.org)
  • human
  • The kinetic model consisting of 76 ordinary differential equations (76 species, 57 reactions, 105 kinetic parameters) predicted the clotting of resting and convulxin-activated human blood as well as predicted T i of human blood under 50 different initial conditions that titrated increasing levels of TF, Xa, Va, XIa, IXa, and VIIa. (pubmedcentralcanada.ca)
  • The first crystal structure of human factor Xa was deposited in May 1993. (wikipedia.org)
  • membrane
  • A cell's ability to dynamically form microfilaments provides the scaffolding that allows it to rapidly remodel itself in response to its environment or to the organism's internal signals, for example, to increase cell membrane absorption or increase cell adhesion in order to form cell tissue. (wikipedia.org)
  • Factor Xa and Factor Va interact tightly with each other when associated on the plasma membrane. (wikipedia.org)
  • activity
  • 8 9 10 In epidemiological studies, the coagulation activity of factor VII (FVII c ) is positively correlated to serum triglycerides 11 (less consistently to serum cholesterol) and is found to predict coronary heart disease (CHD). (ahajournals.org)
  • Tissue factor (TF) encryption is the post-translational suppression of TF procoagulant activity (PCA) on the cell surface. (ahajournals.org)
  • Formulations include: nonacog alfa (trade name BeneFix) albutrepenonacog alfa (trade name Idelvion) eftrenonacog alfa (trade name Alprolix) Some rare mutations of factor IX result in elevated clotting activity, and can result in clotting diseases, such as deep vein thrombosis. (wikipedia.org)
  • deficiency
  • Factor IX deficiency is treated by injection of purified factor IX produced through cloning in various animal or animal cell vectors. (wikipedia.org)
  • Tranexamic acid may be of value in patients undergoing surgery who have inherited factor IX deficiency in order to reduce the perioperative risk of bleeding. (wikipedia.org)
  • Inborn deficiency of factor X is very rare (1:1,000,000), and may present with epistaxis (nosebleeds), hemarthrosis (bleeding into joints) and gastrointestinal blood loss. (wikipedia.org)
  • Apart from congenital deficiency, low factor X levels may occur occasionally in a number of disease states. (wikipedia.org)
  • Deficiency of vitamin K or antagonism by warfarin (or similar medication) leads to the production of an inactive factor X. In warfarin therapy, this is desirable to prevent thrombosis. (wikipedia.org)
  • inhibitors
  • The invention generally deals with novel methods for preparing new compositions useful in the management of hemorrhagic episodes in patients with inhibitors of blood clotting factors. (google.com)