• PMID
  • Two types of IL-1 receptor, each with three extracellular immunoglobulin (Ig)-like domains, limited sequence similarity (28%) and different pharmacological characteristics have been cloned from mouse and human cell lines: these have been termed type I and type II receptors [ PMID: 8702856 ]. (ebi.ac.uk)
  • Both IL-1 receptors appear to be well conserved in evolution, and map to the same chromosomal location [ PMID: 1833184 ]. (ebi.ac.uk)
  • The crystal structures of IL1A and IL1B [ PMID: 2602367 ] have been solved, showing them to share the same 12-stranded beta-sheet structure as both the heparin binding growth factors and the Kunitz-type soybean trypsin inhibitors [ PMID: 1738162 ]. (ebi.ac.uk)
  • A similar gene product from Cowpox virus (CPV) has also been shown to specifically bind murine IL-1 beta [ PMID: 1339315 ]. (ebi.ac.uk)
  • This entry represents Interleukin-1 receptor type 1 (IL1R1), the crystal structure of the soluble extracellular part of type-I IL1R complexed with IL1RA has been determined to 2.7A resolution [ PMID: 9062194 ]. (ebi.ac.uk)
  • Immunol
  • Publications] T.Doi, T.watanabe, et al: 'The death signals from B cell antigen receptor target mitochondria, activating necrotic and apoptotic death cascades in murine B-cell line, WEHI-231' J.Immunol. (nii.ac.jp)
  • pathway
  • Furthermore, the data suggest that CCK activates a central pathway involving NMDA receptors to produce inhibition of RVLM presympathetic neuronal discharge. (physiology.org)
  • IRAKs are essential components of the Interleukin-1 receptor signaling pathway and some Toll-like receptor signaling pathways. (wikipedia.org)
  • One signaling pathway in particular nerve growth factor (NGF) may be dependent on the function of IRAK-1 in its signaling pathway for its activation and cell survival. (wikipedia.org)
  • 4) We showed the first direct evidence of a cross-talk between G-protein mediated signal pathway and antigen-receptor mediated signal transduction pathway in T and B cells. (nii.ac.jp)
  • The IL-1 receptor signaling pathway" (abstract page). (wikipedia.org)
  • affinity
  • We have recently described an additional high affinity receptor for IL-13, IL-13Rα2, whose function in IL-13 signaling is unknown. (rupress.org)
  • Coexpression of IL-13Rα1 with IL-4Rα results in the formation of a high affinity receptor signaling complex ( 8 , 9 , 11 ). (rupress.org)
  • This gene, IL8RB, a gene encoding another high affinity IL8 receptor, and IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. (wikipedia.org)
  • An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. (wikipedia.org)
  • We shows that the affinity of Abs produced was comparable to that in wild type mice. (nii.ac.jp)
  • This may be due to effects of the respective alpha chains, which are unique to each receptor, the kinetics and affinity of cytokine-cytokine receptor binding, or due to the availability and concentration of each cytokine. (wikipedia.org)
  • responses
  • 1997) Antiinflammatory cytokine responses during clinical sepsis and experimental endotoxemia: sequential measurements of plasma soluble interleukin (IL)-1 receptor type II, IL-10, and IL-13. (sinobiological.com)
  • These results show that inhibition of T1/ST2 has a specific effect on virally induced Th2 responses and suggests that therapy targeted at this receptor might be of value in treating Th2-driven illness. (pubmedcentralcanada.ca)
  • Stimulation and activation of ECs by the proinflammatory cytokine interleukin (IL)-1 causes multiple responses within the endothelium but most notably induces the expression of adhesion molecules, which promote monocyte recruitment and infiltration into the arterial wall. (ahajournals.org)
  • These results are consistent with a phenotype of enhanced IL-13 responsiveness and demonstrate a role for endogenous IL-13 and IL-13Rα2 in regulating immune responses in wild-type mice. (rupress.org)
  • Publications] Y.Banu and T.Watanabe: 'Augumentation of antigen receptor-mediated responses by histamine H1 receptor signaling. (nii.ac.jp)
  • 1994
  • 1994). "Expression cloning of a human IL-12 receptor component. (wikipedia.org)
  • From 1994-1997 he had an Assistant Professorship at the Department for Internal Medicine at the University of Leipzig with Prof. Werner Scherbaum. (wikipedia.org)
  • murine
  • T1/ST2 is an IL-1 receptor family member originally identified in murine fibroblasts 19 20 . (pubmedcentralcanada.ca)
  • 3) The death signals from B cell antigen receptor target mitochondria, activating necrotic and apoptotic death cascade in a murine B-cell line, WEHI-23I cell. (nii.ac.jp)
  • kinases
  • 1997 ). The first exon encodes the N-terminal DD, which mediates downstream interactions with the IRAK family of kinases. (springer.com)
  • Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. (wikipedia.org)
  • complex
  • IL-1R2 protein also interacts non-productively with the second component of the signalling IL-1 receptor, namely IL-1RAcP, and a complex of the IL-1R2 and IL-1RAcP extracellular domains with interleukin-1 beta has been solved by X-ray crystallography. (wikipedia.org)
  • Ribbon diagram of s-IL 1R complex to IL-1β. (proteopedia.org)
  • The complex has approximate dimensions of 97Å×52 Å ×35 Å with one s-IL1R molecule wrapping around the IL-1β molecule with 1:1 ratio. (proteopedia.org)
  • The overall ternary architecture of the IL-1β-IL-1RI-IL-1RAcP signaling complex has the cytoplasmic TIR domain necessary for signal transduction. (proteopedia.org)
  • IRAK-M negatively regulates TLR signaling by inhibiting the IRAK-4/IRAK-1 complex The newest described IRAK family member, IRAK-4, has been found to be critical for the recruitment of IRAK-1 and for its activation/degradation. (wikipedia.org)
  • Trypsin 2-α 1 antitrypsin complex displayed a better diagnostic performance than trypsinogen 2 and CRP in differentiating acute pancreatitis from extrapancreatic disease [ 9 ], and myeloid-related protein 8/14 complex is a sensitive indicator of disease activity [ 10 ]. (medsci.org)
  • IL-1 action is complex and is regulated at multiple stages. (ahajournals.org)
  • This receptor complex is widely expressed on both lymphoid and nonlymphoid cells and can also be activated by IL-4, thus accounting for the significant overlap in IL-4 and IL-13 activities ( 12 ). (rupress.org)
  • The receptor of IL20 is a heterodimeric receptor complex consisting of this protein and interleukin 20 receptor beta (IL20B). (wikipedia.org)
  • tumor
  • The N-terminal DD is related to a motif that was originally defined as the region of similarity between the cytoplasmic tails of the FAS/Apol/CD95 and TNF (tumor necrosis factor) receptors that is required for cytotoxic signaling by the so-called death receptors (Tartaglia et al. (springer.com)
  • Interleukin (IL)-13 has recently been shown to play important and unique roles in asthma, parasite immunity, and tumor recurrence. (rupress.org)
  • interferon
  • Serum immunoglobulin E levels were increased in IL-13Rα2 −/− mice despite the fact that serum IL-13 was absent and immune interferon γ production increased compared with wild-type mice. (rupress.org)
  • This protein is structurally related to interferon receptors. (wikipedia.org)
  • proinflammatory
  • Increased activation of the IL-1 proinflammatory axis has been reported in diabetes, and IL-1 is also involved in atherogenesis by a multitude of mechanisms. (diabetesjournals.org)
  • human
  • Flow cytometric analysis of cytokine receptors on human Langerhans' cells. (wikipedia.org)
  • The mechanism of CD4 + T-cell depletion during chronic human immunodeficiency virus type 1 (HIV-1) infection remains unknown. (pubmedcentralcanada.ca)
  • Human immunodeficiency virus type 1 (HIV-1) is the etiologic agent of AIDS, which is a manifestation of the progressive CD4 + T-cell depletion that occurs in the setting of HIV-1 infection ( 19 , 59 ). (pubmedcentralcanada.ca)
  • When psychologically stressed, the human body produces stress hormones like cortisol, which are able to trigger interleukin-6 release into the circulation. (wikipedia.org)
  • IRAK
  • Some special/significant features of each IRAK family member: There is some evidence that IRAK-1 functions in regulating other signaling cascades leading to NF-kB activation. (wikipedia.org)
  • Subsequent studies associated IRAKs with multiple signalling pathways triggered by interleukin, and specified multiple IRAK types. (wikipedia.org)
  • soluble form
  • Type II IL-1R and a soluble form of AcP are involved in additional layers of IL-1 regulation ( 5 , 6 ). (rupress.org)
  • Expression of IL-13Rα2 transcripts are restricted to spleen and brain and in contrast to IL-13Rα1, a soluble form of this receptor has been detected in mouse serum ( 13 ). (rupress.org)