• PMID
  • Two types of IL-1 receptor, each with three extracellular immunoglobulin (Ig)-like domains, limited sequence similarity (28%) and different pharmacological characteristics have been cloned from mouse and human cell lines: these have been termed type I and type II receptors [ PMID: 8702856 ]. (ebi.ac.uk)
  • Both IL-1 receptors appear to be well conserved in evolution, and map to the same chromosomal location [ PMID: 1833184 ]. (ebi.ac.uk)
  • The crystal structures of IL1A and IL1B [ PMID: 2602367 ] have been solved, showing them to share the same 12-stranded beta-sheet structure as both the heparin binding growth factors and the Kunitz-type soybean trypsin inhibitors [ PMID: 1738162 ]. (ebi.ac.uk)
  • A similar gene product from Cowpox virus (CPV) has also been shown to specifically bind murine IL-1 beta [ PMID: 1339315 ]. (ebi.ac.uk)
  • This entry represents Interleukin-1 receptor type 1 (IL1R1), the crystal structure of the soluble extracellular part of type-I IL1R complexed with IL1RA has been determined to 2.7A resolution [ PMID: 9062194 ]. (ebi.ac.uk)
  • Immunol
  • Publications] T.Doi, T.watanabe, et al: 'The death signals from B cell antigen receptor target mitochondria, activating necrotic and apoptotic death cascades in murine B-cell line, WEHI-231' J.Immunol. (nii.ac.jp)
  • mRNA
  • Human synovial fibroblasts coexpress IL-1 receptor type I and type II mRNA. (wikipedia.org)
  • Further, in rats subjected to lipopolysaccharide-induced neuroinflammation, the pro-inflammatory cytokine interleukin-1β protein and mRNA levels were increased by 1.3- and 10-fold, respectively, and acetate supplementation reduced this expression to control levels. (biomedcentral.com)
  • Myeloid differentiation primary response gene 88 (MyD88) was originally discovered and cloned by Liebermann and Hoffman in 1990 as one of the 12 different mRNA transcripts that were induced in M1 myeloblastic leukemia cells upon activation with lung-conditioned medium or recombinant interleukin (IL)-6 (Lord et al. (springer.com)
  • Only intracellular IL-1ra type I mRNA was detected in human umbilical vein ECs (HUVECs) and human coronary artery ECs (HCAECs) when they were stimulated with bacterial lipopolysaccharide/phorbol myristate acetate and transforming growth factor-β. (ahajournals.org)
  • These isoforms can either result from alternative splicing of the mRNA encoding for the receptor or by shedding of the extra cellular domain of the receptor protein. (wikipedia.org)
  • functional
  • Soluble foreign antigen usually leads to a transient clonal expansion of antigen-specific T cells, followed by the deletion and/or functional inactivation of the cells (for review see references 1 and 2). (rupress.org)
  • To identify novel effectors downstream of the TCR, we designed a retroviral-based functional genetic screen to select for proteins that inhibit receptor-mediated T cell activation. (jimmunol.org)
  • pathway
  • IRAKs are essential components of the Interleukin-1 receptor signaling pathway and some Toll-like receptor signaling pathways. (wikipedia.org)
  • One signaling pathway in particular nerve growth factor (NGF) may be dependent on the function of IRAK-1 in its signaling pathway for its activation and cell survival. (wikipedia.org)
  • Furthermore, the data suggest that CCK activates a central pathway involving NMDA receptors to produce inhibition of RVLM presympathetic neuronal discharge. (physiology.org)
  • 4) We showed the first direct evidence of a cross-talk between G-protein mediated signal pathway and antigen-receptor mediated signal transduction pathway in T and B cells. (nii.ac.jp)
  • The IL-1 receptor signaling pathway" (abstract page). (wikipedia.org)
  • affinity
  • This gene, IL8RB, a gene encoding another high affinity IL8 receptor, and IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. (wikipedia.org)
  • An experiment with transient gene expression demonstrated that this receptor was incapable of binding to interleukin 1 alpha and interleukin 1 beta with high affinity. (wikipedia.org)
  • We have recently described an additional high affinity receptor for IL-13, IL-13Rα2, whose function in IL-13 signaling is unknown. (rupress.org)
  • Coexpression of IL-13Rα1 with IL-4Rα results in the formation of a high affinity receptor signaling complex ( 8 , 9 , 11 ). (rupress.org)
  • We shows that the affinity of Abs produced was comparable to that in wild type mice. (nii.ac.jp)
  • This may be due to effects of the respective alpha chains, which are unique to each receptor, the kinetics and affinity of cytokine-cytokine receptor binding, or due to the availability and concentration of each cytokine. (wikipedia.org)
  • responses
  • 1997) Antiinflammatory cytokine responses during clinical sepsis and experimental endotoxemia: sequential measurements of plasma soluble interleukin (IL)-1 receptor type II, IL-10, and IL-13. (sinobiological.com)
  • Stimulation and activation of ECs by the proinflammatory cytokine interleukin (IL)-1 causes multiple responses within the endothelium but most notably induces the expression of adhesion molecules, which promote monocyte recruitment and infiltration into the arterial wall. (ahajournals.org)
  • These results show that inhibition of T1/ST2 has a specific effect on virally induced Th2 responses and suggests that therapy targeted at this receptor might be of value in treating Th2-driven illness. (pubmedcentralcanada.ca)
  • These results are consistent with a phenotype of enhanced IL-13 responsiveness and demonstrate a role for endogenous IL-13 and IL-13Rα2 in regulating immune responses in wild-type mice. (rupress.org)
  • Publications] Y.Banu and T.Watanabe: 'Augumentation of antigen receptor-mediated responses by histamine H1 receptor signaling. (nii.ac.jp)
  • murine
  • T1/ST2 is an IL-1 receptor family member originally identified in murine fibroblasts 19 20 . (pubmedcentralcanada.ca)
  • 3) The death signals from B cell antigen receptor target mitochondria, activating necrotic and apoptotic death cascade in a murine B-cell line, WEHI-23I cell. (nii.ac.jp)
  • kinases
  • 1997 ). The first exon encodes the N-terminal DD, which mediates downstream interactions with the IRAK family of kinases. (springer.com)
  • Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. (wikipedia.org)
  • interferon
  • This protein is structurally related to interferon receptors. (wikipedia.org)
  • Serum immunoglobulin E levels were increased in IL-13Rα2 −/− mice despite the fact that serum IL-13 was absent and immune interferon γ production increased compared with wild-type mice. (rupress.org)
  • tumor
  • The N-terminal DD is related to a motif that was originally defined as the region of similarity between the cytoplasmic tails of the FAS/Apol/CD95 and TNF (tumor necrosis factor) receptors that is required for cytotoxic signaling by the so-called death receptors (Tartaglia et al. (springer.com)
  • Interleukin (IL)-13 has recently been shown to play important and unique roles in asthma, parasite immunity, and tumor recurrence. (rupress.org)
  • Both type 1 and type 2 IL-13R are shown to be expressed on various tumor cell types ( 11 , 13 , 15 -17 , 23 -25 ). (aacrjournals.org)
  • 2002
  • It is estimated that in the year 2002 alone, 205,000 new patients (including 1,500 male) were diagnosed in the United States and about 40,000 patients died from this disease ( 1 ). (aacrjournals.org)
  • proinflammatory
  • Increased activation of the IL-1 proinflammatory axis has been reported in diabetes, and IL-1 is also involved in atherogenesis by a multitude of mechanisms. (diabetesjournals.org)
  • IRAK
  • Some special/significant features of each IRAK family member: There is some evidence that IRAK-1 functions in regulating other signaling cascades leading to NF-kB activation. (wikipedia.org)
  • IRAK-M negatively regulates TLR signaling by inhibiting the IRAK-4/IRAK-1 complex The newest described IRAK family member, IRAK-4, has been found to be critical for the recruitment of IRAK-1 and for its activation/degradation. (wikipedia.org)
  • Subsequent studies associated IRAKs with multiple signalling pathways triggered by interleukin, and specified multiple IRAK types. (wikipedia.org)
  • expression
  • In this study, we examined the effect of a 28-day-dosing regimen of glyceryl triacetate, to induce acetate supplementation, on brain histone acetylation and interleukin-1β expression in a rat model of lipopolysaccharide-induced neuroinflammation. (biomedcentral.com)
  • To date, the Th1 phenotype is associated with chemokine receptor 1, 3, and 5 (references 4 and 5 ) and IL-18 receptor expression 6 . (pubmedcentralcanada.ca)
  • Expression of IL-13Rα2 transcripts are restricted to spleen and brain and in contrast to IL-13Rα1, a soluble form of this receptor has been detected in mouse serum ( 13 ). (rupress.org)
  • This receptor is reported to enhance cell proliferation and expression of apoptosis inhibitor BCL2L1/BCL2-XL and BCL2. (wikipedia.org)
  • human
  • Mizutani H, Rapid and specific conversion of precursor interleukin 1 beta (IL-1 beta) to an active IL-1 species by human mast cell chymase . (proteopedia.org)
  • When psychologically stressed, the human body produces stress hormones like cortisol, which are able to trigger interleukin-6 release into the circulation. (wikipedia.org)
  • 1994
  • From 1994-1997 he had an Assistant Professorship at the Department for Internal Medicine at the University of Leipzig with Prof. Werner Scherbaum. (wikipedia.org)