1997 receptors interleukin 1 type i. Medical search. Frequent questions

The protein encoded by this gene is a decoy receptor for certain cytokines that belongs to the interleukin-1 receptor family. (wikipedia.org)
Recently, cytokines and their receptors have been located in many other tissues, including the peripheral and central nervous systems ( Hopkins and Rothwell, 1995 ). (jneurosci.org)
Fig. 4: Specific combinations of cytokines and corticosterone act together to induce PD-1 expression on NK cells. (nature.com)
1 ) IL-17A binds to its receptors -IL-17 receptor A/IL-17 receptor C- on synoviocytes, endothelial cells, fibroblasts and osteoblasts and stimulates production of pro-inflammatory cytokines, chemokines and other inflammatory mediators, and also, interacts synergistically with other pro- inflammatory cytokines such as IL-1, IL-6, and tumor necrosis factor alpha. (archivesofrheumatology.org)
These are strongly turned on by growth elements serum phorbol esters also to a lesser level by ligands of heterotrimeric G protein-coupled receptors cytokines osmotic tension and microtubule disorganization (Lewis 1998). (healthandwellnesssource.org)
On the other hand the p38 pathway is normally strongly turned on by most environmental strains pro-inflammatory cytokines such as for example interleukin 1 (IL-1) and tumour necrosis aspect α (TNF-α) both playing a significant function in the legislation from the inflammatory response. (healthandwellnesssource.org)
Transcripts levels of the pro-inflammatory cytokines IL-1β ( P = 0.003 at month-1 and P = 0.045 at month-2) and TNF-α ( P = 0.005 at month-1) and the anti-inflammatory cytokine IL-10 ( P = 0.005 at month-2) were higher in peripheral blood after anti-TB treatment in TB-DM compared to TB patients. (biomedcentral.com)
Compared with controls, the detectable proportion of HIV-1 particles derived from CD14 macrophages and CD26 lymphocytes was increased in persons with acute malaria coinfection and correlated with markedly increased plasma concentrations of both proinflammatory cytokines and soluble markers of macrophage and lymphocyte activation. (lww.com)
IL-11 belongs to the interleukin-6 (IL-6)-type subfamily of long-chain helical cytokines, including IL-6, ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M, and cardiotrophin-1, which all share the glycoprotein gp130 as a signal transducing receptor component. (cellsignal.com)
Interleukin (IL)-12 and IL-23, cytokines induced during early stages of IBD, play important roles in differentiation of interferon (IFN)-γ/tumor necrosis factor (TNF)-producing Th1 cells as well as IL-17-producing Th17 cells. (frontiersin.org)
12. Sparrelid E, Emanuel D, Fehniger T, Andersson U, Andersson J. Interstitial pneumonitis in bone marrow transplant recipients is associated with local production of TH2-type cytokines and lack of T cell-mediated cytotoxicity. (southernbiotech.com)
Combined stimulation with the T helper cell type 2 cytokines interleukin (IL)-4 and IL-10 induces mouse mast cell apoptosis. (southernbiotech.com)
Its biological activities are shared by IL-6-family of cytokines such as leukemia inhibitory factor and oncostatin M. IL-6 exerts its biological activities through interaction with specific receptors expressed on the surface of target cells. (sbhsciences.com)
3 In CML, several pro-inflammatory cytokines, such as IL-6, 5 4 IL-1β, 6 and TNF-α, 4 have been shown to be up-regulated in patient serum. (haematologica.org)
It is well established that inflammatory cytokines such as interleukin-1β (IL-1β) play a major regulatory role in the selective destruction of insulin-producing β-cells, resulting in the onset of type 1 diabetes ( 1 - 3 ). (diabetesjournals.org)
Another mechanism whereby injured pancreatic acinar cells trigger the inflammatory response is through synthesis and release of cytokines (36) and chemokines (11), and upregulation of adhesion molecules such as the intercellular adhesion molecule-1 (ICAM-1) (136), which together promote neutrophil and monocyte infiltration (27, 71) and exacerbate tissue injury (10, 27, 37). (pancreapedia.org)
Chemokines (chemotactic cytokines) are positively charged polypeptides with highly conserved cysteine (C) residues within the N-terminal sequence, classifying them as 'C', 'CC', 'CXC' or 'CX3C' types (102, 143). (pancreapedia.org)
and producing cytokines, such as aging procedures such as endoscopic with ~750 000 new cases every year interleukin (IL)-10, that modulate the ultrasonography, which can lead to ( 1 ). (who.int)
The integration of pathogen-associated molecular patterns (PAMPs) from microorganisms with their surface receptors in the immune cells, induces the production of several cytokines and chemokines that presents either a pro- and/or anti-inflammatory role by stimulating the secretion of a great variety of antibody subtypes and the activation of mechanisms of controlling the disease, such as the regulatory T cells. (bvsalud.org)

Human synovial fibroblasts coexpress IL-1 receptor type I and type II mRNA. (wikipedia.org)
4 ) found that uPA mRNA seems to be up-regulated in endometriotic glands and endometrial stroma as well as PAI-1 mRNA in endometriotic and endometrial stroma from women with endometriosis. (ispub.com)
We have established by differential display polymerase chain reaction of mRNA that interleukin (IL)-18 is expressed by osteoblastic stromal cells. (ox.ac.uk)

The TNFalpha-induced 111In-eosinophil accumulation was not affected after pretreatment of rats with the platelet-activating factor (PAF) receptor antagonist UK-74,505 or the antihuman interleukin-8 monoclonal antibody (MoAb) DM/C7. (ox.ac.uk)
Antigen binds to IgE (bound to tissue mast cells and blood basophils), trigger the release of mediators (histamine, chemotactic factors, etc.), and synthesize other mediators (prostaglandins, leukotrienes, platelet-activating factor, interleukins). (ceufast.com)

Using immunocytochemistry and ELISA, we investigated the production of interleukin (IL)-1β in the rat hippocampus after focal application of kainic acid inducing electroencephalographic (EEG) seizures and CA3 neuronal cell loss. (jneurosci.org)

Coadministration of TNFalpha with the soluble TNFalpha receptor (p55)-IgG fusion protein (TNFR-IgG) totally inhibited the 111In-eosinophil accumulation induced by the cytokine. (ox.ac.uk)
OPG (osteoprotegerin) is a soluble TNF receptor-like molecule and the natural inhibitor of osteoclastogenesis [3]. (oatext.com)

This protein binds interleukin-1α (IL1A), interleukin-1β (IL1B), and interleukin 1 receptor antagonist (IL1Ra), preventing them from binding to their regular receptors and thereby inhibiting the transduction of their signaling. (wikipedia.org)
CCL2 acts predominantly via the CC-receptor CCR2, although it also binds to CCR4 (138), whereas CXCL1 and CXCL2 both act via CXCR2 (125). (pancreapedia.org)

Diabetes mellitus type 2 (DM) may impede immune responses in tuberculosis (TB) and thus contribute to enhanced disease severity. (biomedcentral.com)
Immune activation and induction of HIV-1 replication within. (lww.com)
To determine the impact of Plasmodium falciparum malaria coinfection and its treatment on cellular reservoirs of viral replication in HIV-1-infected persons and to relate this to changes in systemic immune activation. (lww.com)
Immunomagnetic HIV-1 capture analysis was used to determine the cellular origin of cell-free virus particles present in all 30 plasma samples and indices of immune activation were measured using enzyme-linked immunosorbent assays. (lww.com)
Parasite clearance following treatment with antimalarial drugs resulted in decreased detection of HIV-1 particles derived from the CD14 macrophage cell subset and correlated with a marked diminution in systemic immune activation. (lww.com)
Acute P. falciparum malaria coinfection impacts virus-host dynamics in HIV-1-infected persons at the cellular level, notably showing a reversible induction of HIV-1 replication in CD14 macrophages that is associated with changes in immune activation. (lww.com)
Interleukin-11 (IL-11) was initially cloned as a mediator of plasmacytoma cell proliferation and was later found to exhibit a wide variety of biological effects in neural cells as well as in the hematopoietic and immune systems (1). (cellsignal.com)
Inflammatory bowel disease is a complex set of diseases that includes Crohn's disease (CD) and ulcerative colitis (UC), each with multiple bacterial, immune, and non-immune cell types contributing to inflammation. (frontiersin.org)
Tumor necrosis factor (TNF) receptor shedding controls thresholds of innate immune activation that balance opposing TNF functions in infectious and inflammatory diseases. (southernbiotech.com)
An allergy is "an acquired, abnormal immune response to a substance (allergen) that does not normally cause a reaction" (Thomas, 1997, pp. 66-67). (ceufast.com)
Interleukin-6 (IL-6) is a multifunctional cytokine that regulates pleiotropic roles in immune regulation, inflammation, hematopoiesis, and oncogenesis. (sbhsciences.com)
This type of activation, called "trans-signalling", renders virtually all cells capable of responding to IL-6/sIL-6R alpha complexes, making for a large new spectrum of IL-6 activities, ranging from the control of the immune response to involvement in pathological states. (sbhsciences.com)
The present results suggest that the CNS innate immune system can respond to an acute stressor as if it were cellular damage, thereby releasing the danger signal HMGB-1 in the brain to prime microglia by acting on the NLRP3 inflammasome, in preparation for a later immune challenge. (jneurosci.org)
The concept has developed that innate immune receptors discriminate between danger and non-danger rather than self and non-self ( Matzinger, 2002 ). (jneurosci.org)
Banchereau J, Ueno H, Dhodapkar M, Connolly J, Finholt JP, Klechevsky E, Blanck JP, Johnston DA, Palucka AK, Fay J. Immune and clinical outcomes in patients with stage IV melanoma vaccinated with peptide-pulsed dendritic cells derived from CD34+ progenitors and activated with type I interferon. (nwbio.com)

This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. (wikipedia.org)
We have recently identified a hematopoietic cell-specific immediate-early gene, DUB-1, that encodes a growth-regulatory deubiquitinating enzyme. (ox.ac.uk)
The DUB-1 gene contains a 112-bp enhancer element that is specifically induced by the beta c subunit of the interleukin-3 (IL-3) receptor. (ox.ac.uk)
Disruption of lipid rafts (e.g., with cyclodextrin) markedly reduced IL-1β−induced gene expression of inducible NO synthase (iNOS) and NO release from β-cells. (diabetesjournals.org)
Overexpression of an inactive mutant of Cav-1 lacking the tyrosine phosphorylation site (Y14F) or an siRNA-mediated Cav-1 knock down also resulted in marked attenuation of IL-1β-induced iNOS gene expression and NO release from these cells, thus further implicating Cav-1 in this signaling cascade. (diabetesjournals.org)
A novel single-nucleotide substitution, Leu 467 Pro, in the interferon-gamma receptor 1 gene associated with allergic diseases. (lu.se)

We hypothesize that IL-3 activates a JAK2/Raf-1 signaling pathway that is required for DUB-1 induction and is independent of STAT5. (ox.ac.uk)
Here we provide the first evidence to suggest that tyrosine phosphorylation of Cav-1 and subsequent interaction among members of the Ras signaling pathway within the membrane lipid microdomains represent early signaling mechanisms of IL-1β in β-cells. (diabetesjournals.org)

Glutamic acid decarboxylase (GAD) sequence 206-220 (designated GAD2) represents a late-stage epitope, but GAD2-specific T cell receptor transgenic T cells producing interferon γ (IFNγ) protect against passive TID. (rupress.org)
Interleukin-18 (interferon-gamma-inducing factor) is produced by osteoblasts and acts via granulocyte/macrophage colony-stimulating factor and not via interferon-gamma to inhibit osteoclast formation. (ox.ac.uk)
Chinese patients with defective IL-12/23-interferon-gamma circuit in Taiwan: partial dominant interferon-gamma receptor 1 mutation presenting as cutaneous granuloma and IL-12 receptor beta1 mutation as pneumatocele. (lu.se)
Two patients with complete defects in interferon gamma receptor-dependent signaling. (lu.se)
The novel IFNGR1 mutation 774del4 produces a truncated form of interferon-gamma receptor 1 and has a dominant-negative effect on interferon-gamma signal transduction. (lu.se)
Disseminated Mycobacterium peregrinum infection in a child with complete interferon-gamma receptor-1 deficiency. (lu.se)
Genetic basis of patients with bacille Calmette-Gu rin osteomyelitis in Japan: identification of dominant partial interferon-gamma receptor 1 deficiency as a predominant type. (lu.se)
561del4 defines a novel small deletion hotspot in the interferon-gamma receptor 1 chain. (lu.se)
Multifocal osteomyelitis caused by nontuberculous mycobacteria in patients with a genetic defect of the interferon-gamma receptor. (lu.se)
A point mutation in a domain of gamma interferon receptor 1 provokes severe immunodeficiency. (lu.se)
Recurrent Mycobacterium avium osteomyelitis associated with a novel dominant interferon gamma receptor mutation. (lu.se)
Interferon-gamma and interleukin-12 pathway defects and human disease. (lu.se)
Listeria monocytogenes and recurrent mycobacterial infections in a child with complete interferon-gamma-receptor (IFNgammaR1) deficiency: mutational analysis and evaluation of therapeutic options. (lu.se)

Here we found that the regulation of natural killer (NK) cell function by the glucocorticoid receptor (GR) was required for host survival after infection with mouse cytomegalovirus (MCMV). (nature.com)

Intrahippocampal application of 0.77 nmol of bicuculline methiodide, which induces EEG seizures but not cell loss, enhanced IL-1β immunoreactivity and microglia, although to a less extent and for a shorter time compared with kainate. (jneurosci.org)
Fig. 3: Infection with MCMV induces glucocorticoid-dependent PD-1 expression in spleen NK cells. (nature.com)
Figure 1: CD3/CD46 stimulation induces IL-10 production in human peripheral blood CD4 + T lymphocytes. (nature.com)

Note: Certain human cell lines or cell types (e.g., neutrophils, monocytes) can first be treated with reagents that block receptors for the Fc regions of immunoglobulin to avoid nonspecific immunofluorescent staining mediated by Fc receptors (for example see Browning et al). (bdbiosciences.com)
In contrast, on monocytes and, indeed, more-differentiated macrophages, TNF is a much more potent activator than IL-1. (biomedcentral.com)
Clearly, this difference reflects receptor distribution, as monocytes have very few IL-1 receptors [ 8 ] but relatively abundant p55 and p75 TNF receptors. (biomedcentral.com)

One of the major and most studied mediators of neuroinflammation is interleukin-1β (IL-1β). (biomedcentral.com)

As summarized elsewhere (1), the combination of a declining birth rate and an increased average life span is expected to increase the proportion of the population aged 65 years and older in the United States from 12.4% in 2000 to 19.6% in 2030. (cdc.gov)
Globally, the number of older adults (aged 65 years and older) is projected to increase even more dramatically - more than doubling from 420 million in 2000 to 973 million in 2030 (1). (cdc.gov)
2000 Oct 1. (medscape.com)

Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain. (sagepub.com)
The molecular basis of X-linked severe combined immunodeficiency: defective cytokine receptor signaling. (sagepub.com)

However, limitations apart, it is of interest that in these huTNF transgenic mice, a neutralizing monoclonal antibody to the murine type I IL-1 receptor completely prevented the development of arthritis, suggesting that IL-1 acts downstream of TNF in the pathogenesis of chronic arthritis [ 6 ]. (biomedcentral.com)

In the same animals, immunostaining of immunoglobulin G and SJC-positive extravasated neutrophils was used to confirm the pro-inflammatory effects of interleukin-1β (IL-1β). (biomedcentral.com)

Also, proteolysis is found in pathological conditions such as tumor growth, metastasis, arthritis and autoimmune diseases ( 1 ). (ispub.com)
Interleukin (IL)-9-producing subset called Th9 cell, Th22 cells which primarily secrete IL-22, IL-13 and tumor necrosis factor- and Th25 cells via producing IL-25 are believed to be important for initiating allergic reactions and developing airway inflammation. (cdc.gov)
Tumor necrosis factor alpha-induced eosinophil accumulation in rat skin is dependent on alpha4 integrin/vascular cell adhesion molecule-1 adhesion pathways. (ox.ac.uk)

uPA, PAI-1 and interleukin-6 were determined by enzyme linked immunosorbent assay (ELISA) in non oncological diseases (n=34) and in healthy individuals (n=20) and correlated with vitamin E treatment after operations. (ispub.com)

10 , 11 ) One of the effects of IL-17A on the bone structure is the disturbance of the receptor activator relationship between nuclear factor kappa beta ligand and osteoprotegerin. (archivesofrheumatology.org)
On the one hand, IL-17A increases the expression of receptor activator of nuclear factor kappa beta ligand, which has a central role in the stimulation of osteoclastogenesis, and on the other, it inhibits the expression of osteoprotegerin, which reduces the production of osteoclasts. (archivesofrheumatology.org)
Urokinase plasminogen activator (uPA) and urokinase plasminogen activator receptor (uPAR) are the central molecules for uPA/uPAR/plasmin-dependent proteolysis, which is thought to play a significant role in the development of pregnancy, as well as its many complications during pregnancy. (ispub.com)
Interleukin (IL)-12, which is secreted by antigen-presenting cells, acts via signal transducer and activator of transcription (STAT)4 to promote the differentiation of naïve T cells into Th1 cells ( 9 - 11 ). (frontiersin.org)
Osteoclasts and odontoclasts are multinucleated cells derived from hematogenous bone marrow, from the monocyte/macrophage cell lineage, and are formed by the fusion of these cells under the action of colony stimulating factor 1 (CSF-1), macrophage colony stimulating factor (M-CSF), monocyte chemotactic protein-1 (MCP-1) and RANKL (receptor activator of nuclear factor kappa-B ligand), which also have a role in chemotaxis and cell differentiation [1]. (oatext.com)
The differentiation of the osteoclast precursor into a mature osteoclast requires RANKL binding to its receptor RANK (receptor activator of nuclear factor kappa-B). However, OPG binding to RANKL will block RANKL binding to RANK, which will result in inhibition of osteoclastogenesis (Figure 1) [3]. (oatext.com)

Clin Immunol 2002(1): 25-7 [ PubMed abstract ]. (lu.se)

Endotoxin levels are less than or equal to 1 EU / 1 μg mIL-11. (cellsignal.com)
Relation between house-dust endotoxin exposure, type 1 T-cell development, and allergen sensitisation in infants at high risk of asthma. (southernbiotech.com)
Endotoxin-induced activation of cerebral catecholamine and serotonin metabolism: contrast with interleukin-1. (wgc2010.sk)

Over the past several years, a number of studies have been conducted which point to the role of interleukin-17A (IL-17A) in the development of chronic arthritis. (archivesofrheumatology.org)
The high prevalence of recurrent malaria, tuberculosis, chronic helminth infections, and water-borne pathogens in developing countries may play an important role in the pathogenesis of HIV-1 infection in persons living in such regions [ 1,2 ]. (lww.com)
10 8 By contrast, chronic exposure to IL-1 leads to exhaustion of normal HSC. (haematologica.org)

IL-11 acts on cells expressing gp130 and the IL-11 receptor (IL-11R) α subunit. (cellsignal.com)
IL-6 Receptor (IL-6R, gp80) is 80 kDa alpha subunit, transmembrane glycoprotein that is 449 aa long. (sbhsciences.com)
Upon binding of IL-6 to the receptor (alpha subunit), gp130 is homodimerized and is subsequently involved in down-stream signal processes binding tyrosine kinases and activating STAT1 and STAT3 transcriptional factors. (sbhsciences.com)

1% after 6 hours of exposure, while absorption through scratched and abraded skin was 57% over the same time period (Ilyin et al. (cdc.gov)
These types of interactions would be expected for all routes of exposure. (cdc.gov)
6 ) suggest that low-density lipoprotein (LDL) regulates PAI-1, uPA, and tPA in biphasic patterns in HMC, and the up regulation of PAI-1, uPA, and tPA after long-term LDL exposure seems to be mediated by a delayed protein kinase C (PKC) activation associated with an increased PA inhibitory activity. (ispub.com)
Early childhood exposure to bacterial/viral infection can shift the T-helper 2 cell responses to the more specific T-helper 1 responses. (ceufast.com)
Exposure to 100 inescapable tail shocks (ISs) increased HMGB-1 and NLRP3 protein in the hippocampus and led isolated microglia to release HMGB-1 ex vivo . (jneurosci.org)
Ionizing radiation injures tissues variably, depending on factors such as radiation dose, rate of exposure, type of radiation, and part of the body exposed. (msdmanuals.com)

[ 16 ] Expression of protease-activated receptor 1 and 2 occurs in orofacial granulomatosis. (medscape.com)

98%) is thought to be derived from short-lived lymphocytes ordinarily [ 11,12 ], HIV-1 replication within the macrophage reservoir is increased during mycobacterial and Pneumocystis carinii coinfections [ 13-15 ]. (lww.com)
In the context of AP, the most extensively investigated chemokines are CC-ligand 2 (CCL2, also known as monocyte chemoattractant protein-1 or MCP-1), CXC-ligand 1 (CXCL1, also known as cytokine-induced neutrophil chemoattractant or CINC in rat and keratinocyte cytokine or KC in mouse), and CXC-ligand 2 (CXCL2, also known as macrophage inflammatory protein 2-alpha or MIP2a). (pancreapedia.org)

Host resistance to endotoxic shock requires the neuroendocrine regulation of group 1 innate lymphoid cells. (nature.com)

Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. (wikipedia.org)
CD123 + and BDCA2 + pDCs were detected by immunohistochemistry in RA synovial tissue in which expression of the IFN-α-inducible protein MxA was also found, suggesting production of type I IFN by maturing pDCs. (aai.org)
Mechanistically, endogenous glucocorticoids produced shortly after infection induced selective and tissue-specific expression of the checkpoint receptor PD-1 on NK cells. (nature.com)
STAT4 also signals activation of the TF T-bet, a lineage-defining factor for Th1 differentiation, which upregulates the IL-12 receptor, IFN-γ expression, and causes further expansion of Th1 cells (Figure 1 ) ( 12 ). (frontiersin.org)
Differential expression of the chemokine receptors by the Th1- and Th2-type effector populations within circulating CD4 + T cells. (southernbiotech.com)
Bonzo/CXCR6 expression defines type 1-polarized T-cell subsets with extralymphoid tissue homing potential. (southernbiotech.com)
Intracerebral disulfide HMGB-1 mimicked the effect of the stressor, because microglia isolated from HMGB-1-treated rats expressed exaggerated NLRP3 and proinflammatory cytokine expression after LPS treatment, whereas fully reduced HMGB-1 had no effect. (jneurosci.org)

Globally, respiratory infections in childhood are a lead- Hospital and Pamela Youde Nethersole Eastern Hospital, ing cause of disease, contributing to absenteeism and provide 90% of all acute pediatric hospital care (admission economic strain through use of healthcare resources (1). (cdc.gov)
This study aims to determine the serum levels of interleukin-17A (IL-17A) in children with juvenile idiopathic arthritis (JIA) and analyze the correlation between IL-17A values and disease activity, certain clinical features, and laboratory markers of inflammation. (archivesofrheumatology.org)
range 1 to 18 years), who had been diagnosed with JIA (18 children were diagnosed during the study period and 12 children were diagnosed before the start of the study) and had active disease during the study period. (archivesofrheumatology.org)
The inflammatory cytokine interleukin-6 (IL-6) is a powerful inducer of the hepatic acute-phase response, and it has been proposed to be a central mediator in the pathogenesis of coronary heart disease through a combination of autocrine, paracrine, and endocrine mechanisms ( 8 ). (ispub.com)
In these studies, CD4 + T cell-depleting and blocking antibodies caused remission from disease in a number of CD and UC patients examined, suggesting a prominent role of CD4 + T cells in propagating disease ( 1 , 2 ). (frontiersin.org)
Metal allergy is an inflammatory disease categorized as a delayed-type hypersensitivity (DTH) reaction. (mdpi.com)
disease duration was 7.0 (1-16) and 7.8 (2-27) years, respectively. (bmj.com)
More broadly, it discusses the biology of TNF-α and IL-1 and suggests explanations of why TNF-α is a pivotal cytokine in this disease. (biomedcentral.com)
This issue has been extensively debated and even in the best-defined models, such as collagen-induced arthritis in DBA/1 mice, the aggressive, acute nature of the disease makes it unlike human RA. (biomedcentral.com)
1 The BCR-ABL1 fusion protein is a constitutively active tyrosine kinase and triggers a cascade of aberrant downstream signaling pathways leading to clonal outgrowth of CML cells and subsequent disease manifestation. (haematologica.org)
genetic and environmental factors seem to increase the susceptibility of some individuals in developing this severe inflammatory disease (1) ( Fig. 1 ). (bvsalud.org)

IL-1R2 protein also interacts non-productively with the second component of the signaling IL-1 receptor, namely IL-1RAcP, and a complex of the IL-1R2 and IL-1RAcP extracellular domains with interleukin-1 beta has been solved by X-ray crystallography. (wikipedia.org)
The lower affinity IL-13 binding protein, previously designated IL-13 R alpha, IL-13 R alpha ' or NR4, is now referred to as IL-13 R alpha 1. (rndsystems.com)
The IL-13 R alpha 1 cDNA encodes a 427 amino acid (aa) residue precursor protein with a putative 21 aa residue signal peptide, a 324 aa residue extracellular domain, a 23 aa residue transmembrane region, and a 59 aa residue cytoplasmic tail. (rndsystems.com)
The purity of Mouse IL-11 Recombinant Protein was determined by SDS-PAGE of 1 µg reduced (+) and non-reduced (-) recombinant mIL-11 and staining with Coomassie Blue. (cellsignal.com)
Here, high mobility group box-1 (HMGB-1) protein was explored as a potential mediator of stress-induced microglial priming and whether HMGB-1 does so via the nucleotide-binding domain, leucine-rich repeat, pyrin domain containing protein 3 (NLRP3) inflammasome. (jneurosci.org)
High mobility group box-1 protein (HMGB-1) is perhaps the most studied alarmin. (jneurosci.org)
Immunologic and confocal microscopic evidence also suggested a transient but significant stimulation of tyrosine phosphorylation of Cav-1 in β-cells briefly (for 15 min) exposed to IL-1β that was markedly attenuated by three structurally distinct inhibitors of protein tyrosine phosphorylation. (diabetesjournals.org)
Members of a subfamily of these enzymes share a specific domain that was first identified in the yeast Sac1 protein [1]. (embl.de)

Indeed, antigen-presenting cells are important reservoirs of HIV-1 [ 16,17 ] and induction of HIV-1 replication within these cells may contribute significantly to the cofactor effect of confections on HIV-1 pathogenesis. (lww.com)
T helper cells recognize antigen presented in the context of major histocompatibility complex II on antigen-presenting cells in a T cell receptor-dependent fashion (not shown). (frontiersin.org)

Fig. 1: Organ-specific glucocorticoid regulation of the production of IFN-γ by NCR1 + ILCs in the spleen and liver after infection with MCMV. (nature.com)
Fig. 6: The glucocorticoid-PD-1 regulatory pathway is required for protection against infection with MCMV. (nature.com)
Type 2 DM patients are estimated to have a 3-fold higher risk of developing active TB infection compared to non-diabetic individuals [ 1 ]. (biomedcentral.com)
Bordetella pertussis infection in 2-month-old infants promotes type 1 T cell responses. (southernbiotech.com)

Two important pathways were examined in the current study: (1) a basic pathway of exocytosis that brings new proteins to the cell surface and permits the cell to grow, and (2) synaptic transmission, a specialized form of exocytosis, regulated by Ca 2+ entry, in which vesicles already present at synapses fuse with the membrane and recycle locally (Murthy, 2003). (sdbonline.org)

Human growth hormone and extracellular domain of its receptor: crystal structure of the complex. (sagepub.com)
The extracellular domain of IL-13 R alpha 1 is also closely related to that of IL‑13 R alpha 2. (rndsystems.com)

The purpose of this study was to determine whether there is a stimulation of production of uPA, PAI-1 and interleukin-6 before and after operation in plasma patients with gynecological diseases, and whether vitamin E could inhibit this process. (ispub.com)
The requirement for JAK2 in the stimulation of the DUB-1 enhancer was further supported by the suppression of DUB-1 induction in Ba/F3 cells stably expressing the dominant-negative JAK2 polypeptide. (ox.ac.uk)
In this study, we set out to investigate if increased cerebral levels of IL-1 have a negative effect on the neurovascular coupling in the cortex in response to sensory stimulation. (biomedcentral.com)
We used two approaches to measure the neuronal activity and haemodynamic changes in the anaesthetised rat barrel somatosensory cortex in response to mechanical whisker stimulation, before and for 6 h after intra-striatal injection of interleukin-1β or vehicle. (biomedcentral.com)
2D-OIS data revealed that the size of the haemodynamic response to mechanical whisker stimulation declined over the 6 h following IL-1β injection whereas the vehicle group remained stable, significant differences being seen after 5 h. (biomedcentral.com)
Moreover, the size of the transient increases of neuronal LFP activity in response to whisker stimulation decreased after IL-1β injection, significant changes compared to vehicle being seen for gamma-band activity after 1 h and beta-band activity after 3 h. (biomedcentral.com)
The amplitude of the functional pO 2 response similarly decreased after 3 h post-IL-1β injection, whereas IL-1β had no significant effect on the peak of whisker-stimulation-induced MUA. (biomedcentral.com)
The stimulation-evoked increases in gamma power and pO 2 correlated significantly throughout the 6 h in the vehicle group, but such a correlation was not observed in the IL-1β-injected group. (biomedcentral.com)

Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin‐induced cell proliferation and Stat5 activation. (sagepub.com)
Our findings identify an endogenous receptor-mediated event that drives Tr1 differentiation and suggest that the complement system has a previously unappreciated role in T-cell-mediated immunity and tolerance. (nature.com)
In the present study, we have characterized the ability of TNFalpha in inducing eosinophil accumulation in rat skin and have shown the inhibitory effects of anti-alpha4 integrin and anti-vascular cell adhesion molecule-1 (VCAM-1) antibodies on this response. (ox.ac.uk)
The "hygiene hypothesis" suggests that in more developed countries where there are fewer children per family, cleaner indoor environments, and early vaccination and antibiotic usage, children may be deprived of the ability to develop this natural "shifting" towards the T-helper 1 cell response. (ceufast.com)
The number of cell types expressing IL-6 R does not reflect the spectrum of cell types that can respond to IL-6. (sbhsciences.com)
We recently reported that the activation of H-Ras represents one of the signaling steps underlying the interleukin-1β (IL-1β)−mediated metabolic dysfunction of the islet β-cell. (diabetesjournals.org)
In the present study, we examined potential contributory roles of membrane-associated, cholesterol-enriched lipid rafts/caveolae and their constituent proteins (e.g., caveolin-1 [Cav-1]) as potential sites for IL-1β−induced nitric oxide (NO) release in the isolated β-cell. (diabetesjournals.org)
Three distinct cell types are recognized in uveal melanomas: spindle A, spindle B, and epithelioid. (medscape.com)
In a novel form of IFN-gamma receptor 1 deficiency, cell surface receptors fail to bind IFN-gamma. (lu.se)

Thus, convulsant and/or excitotoxic stimuli increase the production of IL-1β in microglia-like cells in the hippocampus. (jneurosci.org)
This glucocorticoid-PD-1 pathway limited production of the cytokine IFN-γ by spleen NK cells, which prevented immunopathology. (nature.com)
Fig. 5: MCMV-induced IFN-γ production by spleen NK cells is regulated by a glucocorticoid-PD-1 axis. (nature.com)
8. Iwasaki M, Nagata K, Takano S, Takahashi K, Ishii N, Ikezawa Z. Association of a new-type prostaglandin D2 receptor CRTH2 with circulating T helper 2 cells in patients with atopic dermatitis. (southernbiotech.com)
In Ba/F3 cells, IL-3 induced a dose-dependent activation of DUB-1-luciferase (luc) and GAS-luc reporter constructs. (ox.ac.uk)
The role of Th17 cells in type I diabetes (TID) remains largely unknown. (rupress.org)
The potent chondrogenic effects of IL-1 are well recognised, and it is clear that IL-1 activates chondrocytes and fibroblasts more potently than TNF does, a difference that may reflect the relative abundance of IL-1 receptors on these cells. (biomedcentral.com)
2 1 There is growing evidence to suggest that primitive CML cells affect the bone marrow (BM) niche, contributing to deregulated cytokine levels. (haematologica.org)
In cocultures with osteoblasts and spleen cells from IFN-gamma receptor type II-deficient mice, IL-18 was found to inhibit OCL formation, indicating that IL-18 acted independently of IFN-gamma production: IFN-gamma had no effect in these cocultures. (ox.ac.uk)
Additionally, in cocultures in which spleen cells were derived from receptor-deficient mice and osteoblasts were from wild-type mice and vice versa, we identified that the target cells for IFN-gamma inhibition of OCL formation were the hemopoietic cells. (ox.ac.uk)

[ 12 ] In contrast, multiple bone lesions, alone or in association with a nonrisk site, may, although nonfatal, require 1 year of therapy with combination treatments such as prednisone plus vincristine. (medscape.com)
In contrast, the intravenous administration of an anti-alpha4 integrin MoAb, HP2/1 (3.5 mg/kg), or an anti-VCAM-1 MoAb, 5F10 (2 mg/kg), greatly inhibited the 111In-eosinophil accumulation induced by TNFalpha (the responses detected at 10(-11) mol/site were inhibited by 78% and 50%, respectively). (ox.ac.uk)

Interleukin-17A stimulates the release of degradation enzymes from the matrix metalloproteinases family, which cause cartilage destruction. (archivesofrheumatology.org)

This effect was blocked by coinjection of 1 μg (hr)IL-1β receptor antagonist or 0.1 ng of 3-((+)-2-carboxypiperazin-4-yl)-propyl-1-phosphonate, selective antagonists of IL-1β and NMDA receptors, respectively. (jneurosci.org)

Detects human IL-13 R alpha 1 in ELISAs and Western blots. (rndsystems.com)
The human IL-13 R alpha 1 was originally cloned based on sequence homology to the mouse IL-13 R alpha 1. (rndsystems.com)

The T-helper 1 responses are more specific, and the body develops antibodies to these allergens when the T-helper 1 system is activated. (ceufast.com)
In fact, T-helper 1 responses actually suppress the T-helper 2 response. (ceufast.com)
These reactions are local or systemic anaphylactic inflammatory responses which are IgE-mediated and underlie all atopic diseases (Thomas, 1997). (ceufast.com)

In his review article, Professor Wim van den Berg argues that both TNF-α and IL-1 must be blocked in RA and that although TNF is clearly a potent inflammatory molecule, the dominant cytokine in the subsequent degradation of the joint tissue is IL-1. (biomedcentral.com)

IL-18 inhibited OCL formation in the presence of osteoclastogenic agents including 1alpha,25-dihydroxyvitamin D3, prostaglandin E2, parathyroid hormone, IL-1, and IL-11. (ox.ac.uk)

Phase I evaluation of thrice-daily intravenous bolus interleukin-4 in patients with refractory malignancy. (nwbio.com)

Interleukin-13 mucosal production in Helicobacter pylori-related gastric diseases. (southernbiotech.com)

To determine whether HMGB-1 signaling is necessary for stress-induced sensitization of microglia, the HMGB-1 antagonist BoxA was injected into the cisterna magna before IS. (jneurosci.org)

Examine the medical history in support of risk factors, such as Hispanic channel, preceding chemotherapy, and genetic abnormalities such as Down syndrome, Fanconi anemia, neurofibromatosis type I, Shwachman syndrome, Bloom syndrome, and familial monosomy 7. (wgc2010.sk)
The traditional Lancefield classification system, which is based on serotyping, has been replaced by emm typing, which has been used to characterize and measure the genetic diversity among isolates of S pyogenes . (medscape.com)

Detection of IL‑13 R alpha 1 in Human Granulocytes by Flow Cytometry. (rndsystems.com)

Similarly, inhibition of the PI3K-mTOR pathway by addition of the PI3K inhibitor 2-[4-morpholinyl]-8-phenyl-4H-1-benzopyran-4-one (LY294002) or the mTOR inhibitor rapamycin, although reducing several parameters of transformation, also failed to block transformation. (embl.de)

Chondrocytes from OA patients were used in primary culture and stimulated with 10 ng/ml interleukin(IL)-1β in the presence or absence of AD-MSC microvesicles, exosomes or conditioned medium. (karger.com)

Anatomy39

Organisms12

Diseases9

Chemicals and Drugs134

Analytical, Diagnostic and Therapeutic Techniques and Equipment22

Phenomena and Processes39

Disciplines and Occupations1

Information Science3

Health Care2

Cytokines19

MRNA3

Platelet-activa2

Production of interleukin1

Soluble2

Binds2

Immune15

Gene6

Signaling pathway2

Interferon13

Glucocorticoid receptor1

Induces3

Monocytes3

Mediators1

20003

Cytokine receptor2

Monoclonal antibody1

Neutrophils1

Tumor3

Enzyme-linke1

Activator6

Abstract1

Endotoxin3

Chronic3

Subunit3

Exposure6

Orofacial granulomatosis1

Macrophage2

Innate1

Expression7

Disease11

Protein8

Antigen2

Infection4

Synaptic1

Extracellular domain2

Stimulation8

Cell9

Cells10

Contrast2

Stimulates1

Selective1

Human IL-132

Responses3

Molecule1

Prostaglandin1

Intravenous1

Diseases1

Stress-induced1

Genetic2

Flow Cytometry1

Inhibitor1

Presence or absence1