• The systematic name of this enzyme class is 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide:quinone oxidoreductase. (wikipedia.org)
  • Other names in common use include NRH:quinone oxidoreductase 2, NQO2, NQO2, NAD(P)H:quinone oxidoreductase-2 (misleading), QR2, quinone reductase 2, N-ribosyldihydronicotinamide dehydrogenase (quinone), and NAD(P)H:quinone oxidoreductase2 (misleading). (wikipedia.org)
  • For example, polymorphisms of NAD(P)H:quinone oxidoreductase (NQO1), an enzyme that metabolizes benzene derivatives, are associated with an increased risk of AML. (medscape.com)
  • NAD(P)H:quinone reductase (NQO1) and other antioxidant enzymes, whose gene expression are commonly under the regulation of the transcription factor Nrf2, can serve as target proteins utilized toward development of disease-modifying therapy for PD. (en-journal.org)
  • In enzymology, a ribosyldihydronicotinamide dehydrogenase (quinone) (EC 1.10.99.2) is an enzyme that catalyzes the chemical reaction 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone ⇌ {\displaystyle \rightleftharpoons } 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone Thus, the two substrates of this enzyme are 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide and quinone, whereas its two products are 1-(beta-D-ribofuranosyl)nicotinamide and hydroquinone. (wikipedia.org)
  • As oxy prescriptions for chronic pain rose from 670,000 in 1997 to 6.2 million in 2002, rates of prescription abuse skyrocketed. (cfgnh.org)
  • The following two industrial case studies, conducted in 1997, illustrate essential considerations in building a team environment, including identification of skills needed by team members, new hiring process approaches, training and development approaches, and an incentives approach. (vt.edu)
  • NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. (ecmdb.ca)
  • A simple and efficient protocol has been developed to access thioethers by reacting indoles with p-quinone methides using thiourea as the sulfur source. (bvsalud.org)
  • DEP are complicated particles consisting of carbonaceous nuclei and a vast number of organic chemical compounds such as polyaromatic hydrocarbons, aliphatic hydrocarbons, heterocycles, and quinones. (ersjournals.com)
  • These studies suggest that quinones may be key compounds in the enhancing effects of DEP on allergic airway diseases. (ersjournals.com)
  • As described by Salas and Cannon-Bowers ( 1997 ), contemporary technical management methods often reflect change in culture more than technology. (vt.edu)
  • Quinones themselves have toxicological properties, serving as alkylating agents and interacting with, for example, flavoproteins to generate reactive oxygen species (ROS) which can induce biological injury 20 - 23 . (ersjournals.com)
  • Finally, this study addressed recent developments on synthetic MEK inhibitors (from their discovery in 1997 to 2022), their unique properties, and their relevance to MEK mutant inhibition. (bvsalud.org)
  • In 1997, a lung cancer cell line was first found to have a MEK mutation (encoding MEK2P298L). (bvsalud.org)
  • In our experiments, the reaction apparently proceeded through an S-(3-indolyl)isothiuronium iodide intermediate and subsequent generation of indolethiol that attacked the 1,6 position of p-quinone methides to give desired thioethers in good to excellent yields. (bvsalud.org)
  • Alfredo Quinones-Hinojosa, M.D. (mayoclinic.org)
  • Alfredo Quinones-Hinojosa, M.D., is a consultant and serves as chair of the Department of Neurologic Surgery at Mayo Clinic's campus in Florida, and he is recognized with the distinction of a named professorship, the William J. and Charles H. Mayo Professorship. (mayoclinic.org)
  • He was awarded with a channel system program to complete his Ph.D. program under the supervision of Professor Dr. Henning Hopf, in the field of cyclophane chemistry for two years at TU-Brauschweig, Germany and was awarded with a scientific grant to be a scientific visitor to TU-Braunschweig, Germany from 28 November 1997 until 31 January 1999. (webmedcentral.com)
  • During this period I spent with Prof. Dr. Henning Hopf in the period from 28-11-1997 until 31-1-1999. (webmedcentral.com)
  • 2. Awarded a scientific grant to be a scientific visitor to Braunschweig, Germany, Prof Dr H. Hopf to do research during the period from 28-11-1997 until 31-1-1999. (webmedcentral.com)
  • In enzymology, a ribosyldihydronicotinamide dehydrogenase (quinone) (EC 1.10.99.2) is an enzyme that catalyzes the chemical reaction 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone ⇌ {\displaystyle \rightleftharpoons } 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone Thus, the two substrates of this enzyme are 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide and quinone, whereas its two products are 1-(beta-D-ribofuranosyl)nicotinamide and hydroquinone. (wikipedia.org)
  • August 14, 2009 - The US Food and Drug Administration (FDA) has notified healthcare professionals of the potential for falsely elevated blood glucose results with the use of glucose dehydrogenase pyrroloquinoline quinone (GDH-PQQ) glucose test strips in patients receiving products containing certain nonglucose sugars. (medscape.com)
  • Unopposed estrogens can break down into quinone estrogens that react with and damage the DNA in breast cells. (johnleemd.com)
  • Identification of fatty acid hydroperoxide cofactors in the cytochrome P450-mediated oxidation of estrogens to quinone metabolites. (medecinesciences.org)
  • Microsomemediated 8-hydroxylation of guanine bases of DNA by steroid estrogens: correlation of DNA damage by free radicals with metabolic activation to quinones. (medecinesciences.org)
  • Genetic evidence for quinone requirement was also obtained using Arabidopsis mutants accumulating phytoene (Norris et al. (tam-receptor.com)
  • Mayo Clinic se esfuerza en publicar nuevos materiales traducidos con frecuencia. (mayoclinic.org)
  • soy el Profesor de Neurocirugía de Mayo en Mayo Clinic, en Florida. (mayoclinic.org)
  • In addition to his clinical activities, Dr. Quinones-Hinojosa leads NIH-funded research to find a cure for brain cancer. (mayoclinic.org)
  • Dr. Quinones-Hinojosa's research team has found that when human mesenchymal stem cells (hMSCs) are packed with the bone morphogenetic protein 4 (BMP4) protein - either through the lab's novel nanoparticle formulation or via viral reengineering - brain tumor initiating cells (BTICs) are rendered extremely sensitive to chemotherapy and radiation, with significant shrinkage in tumor volume. (mayo.edu)
  • Sengstacke remained publisher of the paper until his death in 1997. (blogspot.com)
  • Wagner and Moore, 1997), suggesting that it may function as a terminal oxidase located within plastids (Carol et al. (tam-receptor.com)
  • Molecular origin of cancer: catechol estrogen-3,4-quinones as endogenous tumor initiators. (medecinesciences.org)
  • Dr. Quinones-Hinojosa's team believes that its new approach could offer patients a significantly better option. (mayo.edu)
  • The only local therapy for glioblastoma today is Gliadel, approved by the Food and Drug Administration in 1997. (mayo.edu)