• dementia
  • They include multiple system atrophy, progressive supranuclear palsy, corticobasal degeneration, and dementia with Lewy bodies (DLB). (wikipedia.org)
  • Dementia with Lewy bodies is another synucleinopathy and it has close pathological similarities with PD, especially with the subset of PD cases with dementia. (wikipedia.org)
  • Similar assemblies are found in related disorders, including progressive supranuclear palsy, dementia with Lewy bodies, multiple system atrophy, corticobasal degeneration and Pick's disease. (cam.ac.uk)
  • Coming, as it did, with ups and downs along the way, this search for a fluid test is guiding researchers who are working to develop similar markers for α-synuclein and progranulin, two major proteins involved in many of the overlapping forms of dementia at issue in earlier parts of this news series. (alzforum.org)
  • The 9th International Conference AD/PD, held last March in the Czech capital city of Prague, as well as an immediately preceding workshop on dementia with Lewy bodies (DLB) and Parkinson disease dementia (PDD) in Germany, showcased a rapidly growing field of groups who are racing to broaden the field. (alzforum.org)
  • MSA is characterized by a combination of the following, which can be present in any combination: autonomic dysfunction parkinsonism (muscle rigidity +/ tremor and slow movement) ataxia (Poor coordination / unsteady walking) A variant with combined features of MSA and Lewy body dementia may also exist. (wikipedia.org)
  • Similar plaques appear in some variants of Lewy body dementia and in inclusion body myositis (a muscle disease), while Aβ can also form the aggregates that coat cerebral blood vessels in cerebral amyloid angiopathy. (wikipedia.org)
  • fibrils
  • Seeding of preformed α‐synuclein fibrils causes similar alterations in dendritic spine density and morphology as well as dendritic swellings. (cloudfront.net)
  • presynaptic terminals
  • Although the function of alpha-synuclein is not well understood, studies suggest that it plays a role in maintaining a supply of synaptic vesicles in presynaptic terminals by clustering synaptic vesicles. (wikipedia.org)
  • Alpha-synuclein is specifically upregulated in a discrete population of presynaptic terminals of the brain during a period of acquisition-related synaptic rearrangement. (wikipedia.org)
  • human
  • Long‐term in vivo imaging of apical dendrites was performed in mice overexpressing wild‐type human α‐synuclein. (cloudfront.net)
  • role
  • Although misfolded and aggregated α‐synuclein (α‐syn) is recognized in the disease progression of synucleinopathies, its role in the impairment of cortical circuitries and synaptic plasticity remains incompletely understood. (cloudfront.net)