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  • mammal
  • He is best known as the leader of the research group that in 1996 first cloned a mammal from an adult somatic cell, a Finnish Dorset lamb named Dolly. (wikipedia.org)
  • Wilmut was the leader of the research group that in 1996 first cloned a mammal, a lamb named Dolly. (wikipedia.org)
  • Keith Henry Stockman Campbell (23 May 1954 - 5 October 2012), Professor of Animal Development at the University of Nottingham, was a British biologist who was a member of the team that in 1996 first cloned a mammal, a Finnish Dorset lamb named Dolly, from fully differentiated adult mammary cells. (wikipedia.org)
  • Scotland
  • Furthermore, the PPL teams based in Roslin, Scotland and Blacksburg (USA) used the technique to produce the first gene targeted domestic animals as well as a range of animals producing human therapeutic proteins in their milk. (wikipedia.org)
  • cryopreservation
  • In 1966, Wilmut spent 8 weeks working in the laboratory of Christopher Polge, who is credited with developing the technique of cryopreservation in 1949. (wikipedia.org)
  • The following year, Wilmut joined Polge's laboratory to undertake a Doctor of Philosophy degree at the University of Cambridge from which he graduated in 1971 with a thesis on the semen cryopreservation. (wikipedia.org)
  • However, in addition to in situ conservation, methods or techniques to maintain live animals outside their production or natural environment (ex situ live) or through cryopreservation of germplasm (ex situ) are set up to preserve (germplasm of) rare breeds as well as the more widely used commercial breeds. (fao.org)
  • oocytes
  • Recently, I was involved with a scientific group in Yonago, Japan in the development of ROSNI during which immature spermatozoa (spermatids) were harvested from the testes of infertile men and their nuclei were transferred into nucleated oocytes and electrofusion was applied and pregnancies were achieved. (zavos.org)
  • clone
  • She was born on 5 July 1996 and died from a progressive lung disease five months before her seventh birthday (the disease was not considered related to her being a clone). (wikipedia.org)
  • genome
  • 1 The technique, which is commonly referred to as "cloning", produced a paradigm shift in developmental biology and paved the way for genome reprogramming for reproductive gains. (ahajournals.org)
  • 4. Bowles EJ, Campbell KH, St John JC (2007) Nuclear transfer: preservation of a nuclear genome at the expense of its associated mtDNA genome(s). (warwick.ac.uk)
  • stem cell res
  • In February 2011, Hwang visited Libya as part of a $133 million project in the North African country to build a stem cell research center and transfer relevant technology. (wikipedia.org)
  • Agriculture
  • As a school boy, Wilmut worked as a farm hand on weekends, which inspired him to study Agriculture at the University of Nottingham. (wikipedia.org)
  • researchers
  • The first cloned cat was developed by researchers at Texas A&M University, again using the nuclear transfer technique. (ucsd.edu)
  • MRIs showed a greater level of fetal detail than ultrasound images, and researchers recognized the relevance of this technique as a means to gather information about fetal development and growth. (asu.edu)
  • processes
  • English inventions and discoveries are objects, processes or techniques invented, innovated or discovered, partially or entirely, in England by a person from England (that is, someone born in England - including to non-English parents - or born abroad with at least one English parent and who had the majority of their education or career in England). (wikipedia.org)
  • eggs
  • The technique used in swapping the genetic material was not immaculate: Some mutant DNA remained in the fertilized eggs and the ensuing replicating stem cell lines. (christogenea.org)
  • lung
  • She was born on 5 July 1996 and died from a progressive lung disease five months before her seventh birthday. (wikipedia.org)
  • method
  • Wilmut believes that this method holds greater potential for the treatment of degenerative conditions such as Parkinson's disease and to treat stroke and heart attack patients. (wikipedia.org)
  • Gurdon's advanced method of using differentiated nuclear transfer laid the groundwork for future animal cloning. (ucsd.edu)
  • cells
  • A number of alternative techniques are available, such as chemical sensitivation of cells, electroporation, optical injection and biolistics. (wikipedia.org)
  • potential
  • The gene transfer approaches using retroviral and lentiviral vectors have the potential for insertional mutagenesis and induction of an immune response. (ahajournals.org)
  • traditional
  • Additionally, the media can not be easily exchanged within the traditional hanging drop format, necessitating the transfer of hanging drops into bulk suspension cultures after 2-3 days of formation, whereby individual EBs tend to agglomerate. (wikipedia.org)

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  • laboratory
  • In 1966, Wilmut spent 8 weeks working in the laboratory of Christopher Polge, who is credited with developing the technique of cryopreservation in 1949. (wikipedia.org)
  • The following year, Wilmut joined Polge's laboratory to undertake a Doctor of Philosophy degree at the University of Cambridge from which he graduated in 1971 with a thesis on the semen cryopreservation. (wikipedia.org)
  • vitro
  • Follicle size-dependent effects of sow follicular fluid on in vitro cumulus expansion, nuclear maturation and blastocyst formation of sow cumulus oocytes complexes. (publish.csiro.au)
  • nucleus
  • Then in 1902, embryologist Hans Spemann used a hair from his infant son as a noose to constrict the egg of a salamander into a dumb-bell shape, with the nucleus in one half and only cytoplasm and other cellular material in the other, pioneering the process of nuclear transfer. (scienceinmyfiction.com)
  • It is a technique for cloning in which the nucleus of a somatic cell is transferred to the cytoplasm of an enucleated egg. (wikipedia.org)
  • Format
  • Additionally, the media can not be easily exchanged within the traditional hanging drop format, necessitating the transfer of hanging drops into bulk suspension cultures after 2-3 days of formation, whereby individual EBs tend to agglomerate. (wikipedia.org)
  • University
  • Sir Ian Wilmut, OBE FRS FMedSci FRSE (born 7 July 1944) is a British embryologist and Chair of the Scottish Centre for Regenerative Medicine at the University of Edinburgh. (wikipedia.org)
  • As a school boy, Wilmut worked as a farm hand on weekends, which inspired him to study Agriculture at the University of Nottingham. (wikipedia.org)
  • Wilmut is an Emeritus Professor at the Scottish Centre for Regenerative Medicine at the University of Edinburgh and in 2008 was knighted in the New Year Honours for services to science. (wikipedia.org)
  • years
  • Wilmut's father, Leonard Wilmut, was a mathematics teacher who suffered from diabetes for fifty years, which eventually caused him to become blind. (wikipedia.org)