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  • proteins
  • The majority of FGF family members are glycosaminoglycan binding proteins which possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. (wikipedia.org)
  • The heparin-binding (fibroblast) growth factor family of proteins. (ebi.ac.uk)
  • Chemical stimulation of angiogenesis is performed by various angiogenic proteins, including several growth factors. (wikipedia.org)
  • Matrix molecules, growth factors, and enzymes) Chondroitin sulfate chain Transmembrane domain - self-association C1 domain - actin-association cytoskeleton Variable domain - syndecan-specific C2 domain - attach to PDZ proteins Syndecans normally form homodimers or multimers. (wikipedia.org)
  • Mutations in this gene can develop dysfunctional proteins "impede cartilage growth and development and affect chondrocyte proliferation and calcification" which can lead to craniosynostosis and multiple types of skeletal dysplasia (Osteochondrodysplasia). (wikipedia.org)
  • angiogenesis
  • For several years there has been considerable interest in stimulating angiogenesis by a variety of growth factors, including the family of fibroblast growth factors (FGF). (ahajournals.org)
  • 3 The most commonly cited effect of FGF-5 in the heart is to promote angiogenesis. (ahajournals.org)
  • Re- various bio-factors to facilitate the angiogenesis and search on skin cell transplantation for wound healing granulation of wound bed for further surgery, they could was first reported by Billingham and Reynolds in 1952 never replace the skin autograft delivering the essential [5]. (deepdyve.com)
  • The first vessels in the developing embryo form through vasculogenesis, after which angiogenesis is responsible for most, if not all, blood vessel growth during development and in disease. (wikipedia.org)
  • Angiogenesis is a normal and vital process in growth and development, as well as in wound healing and in the formation of granulation tissue. (wikipedia.org)
  • The essential role of angiogenesis in tumor growth was first proposed in 1971 by Judah Folkman, who described tumors as "hot and bloody," illustrating that, at least for many tumor types, flush perfusion and even hyperemia are characteristic. (wikipedia.org)
  • mRNA
  • The mRNA expressions of Cbfa1 (an osteoblast-specific transcription factor), type I collagen, alkaline phosphatase (ALP), osteocalcin and integrin β1 (a mechanotransducer) were increased by cyclic stretch in OPLL cells, whereas no change was observed in non-OPLL cells. (springer.com)
  • differential
  • In fact, different organs in the body -even between different species - are known to utilize a similar sets of paracrine factors in differential development. (wikipedia.org)
  • bFGF
  • Treatment of basic fibroblast growth factor (bFGF) with organic disulfides, preferably glutathione disulfide, or with inorganic compounds of similar function results in a bFGF composition of enhanced stability and resistance to multimerization. (google.com)
  • 5. The method of claim 1 which further includes the step of subjecting the treated bFGF to chromatographic purification. (google.com)
  • 7. Stabilizied basic FGF prepared by the method of claim 5, with the proviso that when bFGF includes the amino acid sequence shown as residues 24-155 of the overplaced numbers shown in FIG. 8 or 9, the protective agent is not glutathione disulfide. (google.com)
  • binds
  • Syndecan-4 also binds to phosphatidylinositol (4,5)-bisphosphate (PIP2) through the variable domain and increases PKC activity ten-fold. (wikipedia.org)
  • Keratinocytes
  • Keratinocytes produce various bio-factors and worldwide research activities on cell therapy in burn re- cytokines including interleukin (IL)-1, IL-6, IL-7, IL-8, search. (deepdyve.com)
  • autocrine
  • In addition, FGF-5 can function as an autocrine/paracrine mechanism of cardiac cell growth and as a cytoprotective mechanism against irreversible ischemic damage. (ahajournals.org)
  • Signaling molecules known as paracrine factors diffuse over a relatively short distance (local action), as opposed to endocrine factors (hormones which travel considerably longer distances via the circulatory system), juxtacrine interactions, and autocrine signaling. (wikipedia.org)
  • family
  • The fibroblast growth factors (FGF) are a family of at least eighteen structurally related polypeptides (named FGF-1 to FGF-18) that are characterized by a high degree of affinity for proteoglycans, such as heparin. (google.com)
  • FGFRs
  • Although these factors possess remarkably similar sequence homology, they do not bind FGFRs and are involved in intracellular processes unrelated to the FGFs. (wikipedia.org)
  • signals
  • In the forelimb initiation and limb growth in mice, axial (lengthwise) cues from the intermediate mesoderm produces Tbx5, which subsequently signals to the same mesoderm to produce Fgf10. (wikipedia.org)
  • cells
  • 14 For experiments, HASMCs (P5 to P10) were seeded (3×10 4 cells/cm 2 ) on silicone membranes (0.005-in thickness, Specialty Manufacturing) coated with 5 μg/cm 2 human plasma fibronectin (Collaborative). (ahajournals.org)
  • Factors then travel to nearby cells in which the gradient of factor received determines the outcome. (wikipedia.org)
  • Paracrine signaling of growth factors between nearby cells has been shown to exacerbate carcinogenesis. (wikipedia.org)
  • Within 4 days of the injury, the distal end of the portion of the nerve fiber proximal to the lesion sends out sprouts towards those tubes and these sprouts are attracted by growth factors produced by Schwann cells in the tubes. (wikipedia.org)