• expression
  • J:82773 Dichmann DS, Miller CP, Jensen J, Scott Heller R, Serup P, Expression and misexpression of members of the FGF and TGFbeta families of growth factors in the developing mouse pancreas. (jax.org)
  • It has been hypothesised that, in an alternate type of mutation, positive selection for increased expression of the FGF5 protein was one of the contributing factors in the evolutionary loss of hair in cetaceans as they transitioned from the terrestrial to the aquatic environment. (wikipedia.org)
  • The core protein mRNA levels of proteoglycans were not affected, thus the decrease in GAG chains was as a result of some other factor, which in this case turned out to be a decrease in expression of sulfate transferase enzymes, which play a key role in GAG biosynthesis. (wikipedia.org)
  • Recent studies indicate that cyclic strain plays an important role in growth and gene expression in VSMCs under both normal and pathological conditions. (ahajournals.org)
  • Each pathway leads to the activation of transcription factors which enter the nucleus to alter gene expression. (wikipedia.org)
  • 15 17 Moreover, the upregulation of decorin expression in nongrowing confluent arterial smooth muscle cells (ASMCs) 18 suggests a relationship between the expression of decorin and growth quiescence in ASMCs. (ahajournals.org)
  • Growth factor signaling may be disrupted by changes in syndecan-4 expression. (wikipedia.org)
  • 1998
  • 1998) "Localization of Rat FGF-5 Protein in Skin Macrophage-like Cells and FGF-5S Protein in Hair Follicle: Possible Involvement of two Fgf-5 gene products in hair growth cycle regulation," Growth (Lakeland), vol. 111, no. 6, pp. 963-972. (wikipedia.org)
  • differential
  • In fact, different organs in the body -even between different species - are known to utilize a similar sets of paracrine factors in differential development. (wikipedia.org)
  • embryonic
  • To gain insight into Pln function in chondrogenesis, an assay was developed to assess the potential inductive activity of Pln using multipotential 10T1/2 murine embryonic fibroblast cells. (rupress.org)
  • induce
  • The idea was to induce capillary growth in order to improve regional tissue perfusion and to improve tissue viability following surgery. (escardio.org)
  • In vitro, both cell adhesion events and growth factors induce a rapid yet transient (5-60 min) activation of MAP kinase. (rupress.org)
  • signals
  • In the forelimb initiation and limb growth in mice, axial (lengthwise) cues from the intermediate mesoderm produces Tbx5, which subsequently signals to the same mesoderm to produce Fgf10. (wikipedia.org)
  • autocrine
  • In addition, FGF-5 can function as an autocrine/paracrine mechanism of cardiac cell growth and as a cytoprotective mechanism against irreversible ischemic damage. (ahajournals.org)
  • Signaling molecules known as paracrine factors diffuse over a relatively short distance (local action), as opposed to endocrine factors (hormones which travel considerably longer distances via the circulatory system), juxtacrine interactions, and autocrine signaling. (wikipedia.org)
  • cells
  • 14 For experiments, HASMCs (P5 to P10) were seeded (3×10 4 cells/cm 2 ) on silicone membranes (0.005-in thickness, Specialty Manufacturing) coated with 5 μg/cm 2 human plasma fibronectin (Collaborative). (ahajournals.org)
  • Cells that produce paracrine factors secrete them into the immediate extracellular environment. (wikipedia.org)
  • Factors then travel to nearby cells in which the gradient of factor received determines the outcome. (wikipedia.org)
  • Paracrine signaling of growth factors between nearby cells has been shown to exacerbate carcinogenesis. (wikipedia.org)
  • 1 2 3 In vitro and in vivo, neural stem cells from adult animals and humans can proliferate and then generate either neurons or glial cells, 2 4 5 6 7 8 depending on the externally applied growth factors. (ahajournals.org)
  • However, these effects of decorin were not apparent at 48 or 72 hours after plating and did not result in reduced growth of decorin-overexpressing cells in response to serum and PDGF-BB. (ahajournals.org)
  • For example, decorin inhibits the growth of Chinese hamster ovary (CHO) cells 13 14 and various cancer cell lines. (ahajournals.org)
  • Within 4 days of the injury, the distal end of the portion of the nerve fiber proximal to the lesion sends out sprouts towards those tubes and these sprouts are attracted by growth factors produced by Schwann cells in the tubes. (wikipedia.org)
  • Collagen
  • 5 6 7 However, in atherosclerosis, decorin accumulates in defined locations throughout the lesions in association with deposited lipoproteins, 8 9 collagen fibrils, 6 8 9 10 and the plaque neovasculature. (ahajournals.org)
  • family
  • The fibroblast growth factors (FGF) are a family of at least eighteen structurally related polypeptides (named FGF-1 to FGF-18) that are characterized by a high degree of affinity for proteoglycans, such as heparin. (google.com)
  • FGFRs
  • Although these factors possess remarkably similar sequence homology, they do not bind FGFRs and are involved in intracellular processes unrelated to the FGFs. (wikipedia.org)