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  • abnormal
  • Using Pcp4 -null mice and acquired cardiomyopathy models, we determined that reduced expression of PCP4 is associated with CaMKII activation, abnormal electrophysiology, dysregulated intracellular calcium handling, and proarrhythmic behavior in isolated Purkinje cells. (jci.org)
  • The recognition that diversity in cardiac electrophysiology, and indeed in many aspects of cardiac function, can be attributed to variable expression of specific genes or variability in the function of their protein products has the potential to alter the way in which we think about normal and abnormal electrical heart function. (ahajournals.org)
  • The third part of the article reviews the potential for a genetic approach to understanding diversity in cardiac function, focusing in particular on ion channels and gap junction proteins as the central players in normal and abnormal electrophysiology. (ahajournals.org)
  • In some cases, the combination of an accessory pathway and abnormal heart rhythms can trigger ventricular fibrillation, a leading cause of sudden cardiac death. (wikipedia.org)
  • The symptoms and signs of HCM include shortness of breath due to stiffening and decreased blood filling of the ventricles, exertional chest pain (sometimes known as angina) due to reduced blood flow to the coronary arteries, uncomfortable awareness of the heart beat (palpitations), as well as disruption of the electrical system running through the abnormal heart muscle, lightheadedness, weakness, fainting and sudden cardiac death. (wikipedia.org)
  • Major risk factors for sudden death in individuals with HCM include prior history of cardiac arrest or ventricular fibrillation, spontaneous sustained ventricular tachycardia, family history of premature sudden death, unexplained syncope, LV thickness greater than or equal to 30 mm, abnormal exercise blood pressure and nonsustained ventricular tachycardia. (wikipedia.org)
  • Cardiology
  • 17 Patients with later Fontan procedures were identified by a search of databases from the Departments of Cardiac Surgery and Cardiology. (ahajournals.org)
  • He is an associate editor of Heart Rhythm, the official journal of the Heart Rhythm Society and the Cardiac Electrophysiology Society, and serves on the editorial board of several other peer-reviewed medical publications, including Journal of Electrocardiology and Journal of the American College of Cardiology. (wikipedia.org)
  • pacemakers
  • He has served in several professional capacities at Sinai Hospital and Cardiac Pacemakers Inc. In 1996, he became the Chairman and Chief Executive Officer of Mower Research Associates. (wikipedia.org)
  • He has also served as Professor of Physiology and Biophysics at Howard University School of Medicine in Washington, D.C. In 1989, Mower became Vice President of Medical Science at Cardiac Pacemakers Inc. in St. Paul, Minnesota. (wikipedia.org)
  • While at Cardiac Pacemakers, he designed and executed studies in medical education. (wikipedia.org)
  • congenital
  • The univentricular heart encompasses a spectrum of rare and complex congenital cardiac malformations predominantly managed by a staged surgical approach in view of an ultimate Fontan procedure. (ahajournals.org)
  • mortality
  • The database was supplemented by a detailed retrospective review of medical records, preoperative echocardiographic and cardiac catheterization data, operative notes, and an extensive collection of postoperative clinical variables derived from diagnostic tests, interventions, functional status, long-term complications, and mortality on follow-up. (ahajournals.org)
  • treatment
  • Public access defibrillation, which places AEDs in the hands of trained laypersons, has the potential to be the single greatest advance in the treatment of VF cardiac arrest since the development of CPR. (ahajournals.org)
  • patients
  • These factors have an impact on the effects of therapeutic interventions because, although it is relatively easy to identify patients in the small high-risk subgroups and then to possibly prevent or reverse a ventricular tachyarrhythmia, the overall impact on the total number of sudden cardiac deaths will be small. (ahajournals.org)
  • Materials and Methods: All patients who had an out-of-hospital cardiac arrest between January 2003 and December 2004 and who received early defibrillation for ventricular fibrillation were included. (cogprints.org)
  • frequency
  • Considering that the total cardiac cycle has a duration of 1 second (for a base cardiac frequency of 60 beats per minute), the probability of a mechanical trauma within the window of vulnerability is 1 to 3% only. (wikipedia.org)
  • absence
  • Specifically, female athletes have fewer signs of EICR on the electrocardiogram than male athletes, though are more likely to have anterior T wave inversions in the absence of cardiac disease. (springer.com)
  • action potential
  • Moreover, integration of molecular function into a single cell and of single cells into cellular networks reveals a multitude of interactions that eventually determine the generation and conduction of the cardiac action potential and therefore arrhythmogenesis. (ahajournals.org)
  • Electrical activity in the normal human heart begins when a cardiac action potential arises in the sinoatrial (SA) node, which is located in the right atrium. (wikipedia.org)
  • The product of the KCNQ1 gene is thought to produce an alpha subunit that interacts with other proteins (in particular, the minK beta subunit) to create the IKs ion channel, which is responsible for the delayed potassium rectifier current of the cardiac action potential. (wikipedia.org)
  • cause
  • Impact energies of at least 50 joules are estimated to be required to cause cardiac arrest, when applied in the right time and spot of the precordium of an adult. (wikipedia.org)
  • function
  • Training-specific changes in cardiac structure and function: a prospective and longitudinal assessment of competitive athletes. (springer.com)
  • death
  • Figure 1 ⇓ places the problem into perspective by expressing the incidence of sudden cardiac death in different subgroups at varying risk while indicating the overall number of events per year for each. (ahajournals.org)
  • It becomes obvious that, to significantly reduce the incidence of sudden cardiac death, more specific markers are needed for the general population to identify large numbers in subgroups that account for a bigger percentage of the more than 300 000 who die suddenly. (ahajournals.org)
  • The present risk factors (see below) generally identify the risk of developing the structural heart disease underlying sudden cardiac death rather than the proximate precipitator of the event. (ahajournals.org)
  • Because the risk of sudden cardiac death does not necessarily equate with the risk of developing structural heart disease, these risk factors have limited ability in identifying specific individuals at risk for sudden cardiac death. (ahajournals.org)
  • After an initial high attrition rate for the high-risk group in the first 6 to 18 months, the curves then become parallel, illustrating the modulating effects of time on the incidence of sudden cardiac death. (ahajournals.org)
  • An implantable cardiac defibrillator may be placed to reduce the chance of death from recurrence. (wikipedia.org)
  • Certain types of prompt intervention can often reverse a cardiac arrest, but without such intervention the event will almost always lead to death. (wikipedia.org)
  • Near-death experiences are reported by 10-20% of people who survived cardiac arrest. (wikipedia.org)
  • It can lead a person to have dangerous electrolyte imbalances, leading to acquired long QT syndrome and can in turn result in sudden cardiac death. (wikipedia.org)
  • often
  • Commotio cordis (Latin, "agitation of the heart") is an often lethal disruption of heart rhythm that occurs as a result of a blow to the area directly over the heart (the precordial region), at a critical time during the cycle of a heart beat causing cardiac arrest. (wikipedia.org)
  • results
  • Without organized electrical activity in the heart muscle, there is no consistent contraction of the ventricles, which results in the heart's inability to generate an adequate cardiac output (forward pumping of blood from heart to rest of the body). (wikipedia.org)
  • Results: Over a 24 month period, 446 people had non-traumatic cardiac arrest, and in all of them it was observed to be ventricular fibrillation. (cogprints.org)
  • data
  • Extrapolation of these data over a 12 month period suggests implantation of at least 166 new ICDs (compared with 23 implants in 1996). (bmj.com)
  • research
  • In 1996, he became chairman and Chief Executive Officer of Mower Research Associates in Baltimore, Maryland. (wikipedia.org)
  • cases
  • In the United States, cardiac arrest outside hospital occurs in about 13 per 10,000 people per year (326,000 cases). (wikipedia.org)
  • From 1996 to spring 2007, the USA National Commotio Cordis Registry had 188 cases recorded, with about half occurring during organized sports. (wikipedia.org)