• expression
  • We have previously shown that the Y-box protein YB-1 is involved in regulating transcription of the P-glycoprotein gene mdr1 and that nuclear localization of YB-1 in human breast cancer is associated with increased P-glycoprotein expression. (wiley.com)
  • 2 However, the functional relevance of P-glycoprotein expression for clinical drug resistance in breast cancer is controversial, since evidence for an association between P-glycoprotein expression and survival is not supported by all investigations. (wiley.com)
  • Therefore, we investigated the impact of YB-1 expression on the clinical outcome in breast cancer patients ( n = 83) and compared it with expression of the tumor-biologic factors HER2, 7 urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor type 1 (PAI-1), 8 which are already in use for clinical decision making. (wiley.com)
  • In the well-characterized transgenic mouse model of breast cancer, MMTV-PyMT mice, where tumors arise rapidly due to the expression of the polyoma virus middle-T antigen in mammary epithelium driven by the mammary tumor virus promoter (MMTV LTR), one sees a prototypical progression from the benign stages of hyperplasia and adenoma/mammary intraepithelial neoplasia to the malignant stages of early and late carcinoma ( 9 ). (aacrjournals.org)
  • In addition to its metalloproteinase-inducing ability, basigin also regulates several distinct functions, such as spermatogenesis, expression of the monocarboxylate transporter and the responsiveness of lymphocytes. (wikipedia.org)
  • It also represses CD44 expression, which is a cell marker for some breast and prostate cancers. (wikipedia.org)
  • Furthermore, ectopic CD97 expression facilitated RhoA activation through binding of Gα12/13 as well as induced Ki67 expression and phosphorylated ERK and Akt through enhancing lysophosphatidic acid receptor 1 (LPAR1) signaling. (wikipedia.org)
  • Since then, increased AXL expression has been associated with numerous cancers including lung cancer, breast cancer, pancreatic cancer, ovarian cancer, colon cancer and melanoma among others, and shown to have a strong correlation with poor survival outcomes. (wikipedia.org)
  • In addition, variations in CD44 are reported as cell surface markers for some breast and prostate cancer stem cells.In breast cancer research CD44+/CD24- expression is commonly used as a marker for breast CSCs and is used to sort breast cancer cells into a population enriched in cells with stem-like characteristics and has been seen as an indicator of increased survival time in epithelial ovarian cancer patients. (wikipedia.org)
  • metastasis
  • For example, thymoquinone, a natural product downregulates TWIST1 transcription factor to reduce epithelial to mesenchymal transition, and thus inhibits cancer metastasis in cancer cell lines and xenograft model of breast cancer in mouse Twist transcription factor has been shown to interact with EP300, TCF3 and PCAF. (wikipedia.org)
  • tumors
  • These findings establish a causal linkage to explain well-documented clinical correlations between macrophages, microvessel density, and poor prognosis in breast tumors. (aacrjournals.org)
  • The activation of the c-Src pathway has been observed in about 50% of tumors from colon, liver, lung, breast and the pancreas. (wikipedia.org)
  • Cancer Research
  • One of the most important current issues in breast cancer research is early identification of patients at high risk for relapse coupled with risk-adapted individualized therapy concepts. (wiley.com)
  • cells
  • There is increasing evidence that the myoepithelial cells also play a key role in the organizational development of the mammary gland, and that the loss and/or change of myoepithelial cell function is a key step in the development of breast cancer. (biomedcentral.com)
  • In this review we briefly address the characteristics of breast myoepithelial cells from human breast and mouse mammary gland, how they function in normal mammary gland development, and their recently appreciated role in tumor suppression. (biomedcentral.com)
  • a plasma membrane component) and lysophosphatidic acid (LPA) use heterodimeric LPAR1-CD97 to drive Gi/o protein-phospholipase C-inositol 1,4,5-trisphosphate signaling and induce [Ca2+] in breast cancer cells. (wikipedia.org)
  • evidence
  • Up to date, more and more evidence has linked macrophage activation and fibrosis to the pathogenesis of HF [ 10 , 12 ], and galectin-3 (Gal-3) is one the most possible mediators [ 13 ]. (medsci.org)
  • Sequence
  • In 1996, two groups independently described the complete sequence of the NEDD9 gene, and provided initial functional analysis of NEDD9 protein. (wikipedia.org)
  • relevance
  • The clinical relevance of YB-1 was assessed in 83 breast cancer patients treated at the Department of Obstetrics and Gynecology, Technical University of Munich, Germany. (wiley.com)