• anorectic agents
  • Numerous studies have documented that medications which increase brain 5-HT, such as fenfluramine, are effective anorectic agents which help obese patients lose weight and which also decrease craving for sweets and carbohydrates (6,23). (google.com)
  • MDMA
  • The amphetamine derivative 3,4-methylenedioxymethamphetamine (MDMA) is a drug of abuse and has been shown to be neurotoxic to 5-HT terminals in many species. (jneurosci.org)
  • A current line of research is the relationship between core body temperature (CORE TEMP) and neurotoxicity engendered by MDMA and other amphetamines. (jneurosci.org)
  • The MDMA supply seems to be more reliable at high levels of the trade-the DEA has reported that 80% of seized 'ecstasy' pills contain MDMA (about 10% also contained another amphetamine), implying that the bulk of the fraud and substitution is occurring at the level of dealers and small wholesalers. (thedea.org)

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  • inhibits
  • While d -amphetamine inhibits the expression of a sleep-related process, probably through a direct cortical activation masking EEG circadian rhythms, modafinil, through a synchronic effect, preferentially disrupts the homeostatic down-regulation of a waking drive. (springer.com)
  • effects
  • It is the d-enantiomer of fenfluramine and is structurally similar to amphetamine, but lacks any psychologically stimulating effects. (wikipedia.org)
  • Many amphetamines produce side effects, including addiction, tachycardia and hypertension, making prolonged unsupervised use dangerous. (wikipedia.org)
  • In addition to 5-HT-releasing effects, amphetamines, unlike cocaine, also exert a direct effect on 5-HT 2A/2C receptors ( Bobker and Williams, 1991 ). (aspetjournals.org)
  • The effects of equipotent psychostimulant dosages (modafinil 300 mg and d -amphetamine 20 mg) were evaluated at the beginning of the first sleep deprivation night, at the end of the second sleep deprivation night and in the afternoon preceding the first recovery night. (springer.com)
  • These findings demonstrate that the alertness-promoting effects of modafinil and d -amphetamine involve distinct EEG activities and do not reside on the same vigilance regulatory processes. (springer.com)
  • Metermine includes side effects from the amphetamine effects of the medication. (fckfat.com)
  • 2015) Prenatal immune challenge in rats: Prenatal immune challenge in rats: Effects of polyinosinic-polycytidylic acid on spatial learning, prepulse inhibition, conditioned fear, and responses to MK-801 and amphetamine. (fsu.edu)
  • The agency couldn't rule out cardiac effects when reviewing and ultimately rejecting Vivus Inc.'s Qnexa, a combination of the amphetamine phentermine and the anti-seizure drug topiramate that same month. (go.com)
  • central nervous system effects include neuronal sensitization to tactile stimuli and mediation of some of the effects of hallucinogenic substituted amphetamines. (wikipedia.org)
  • drug
  • In 1994, sales of the combination drug Fen-phen (fenfluramine and phentermine) increased dramatically, as this combination produced substantial and apparent synergistic effect in promoting weight loss. (wikipedia.org)
  • The chemical structure of MDAI is indirectly derived from that of the illicit drug MDA, but the alpha-methyl group of the alkyl amino amphetamine side chain has been bound back to the benzene nucleus to form an indane ring system, which changes its pharmacological properties substantially. (wikipedia.org)
  • Fenfluramine as a single drug was first introduced in the 1970s, but was not popular because it only temporarily reduced weight. (wikipedia.org)
  • After Lutwak refused to approve the drug, the FDA management had someone else sign it and approved the drug with no black box warning for marketing in 1996. (wikipedia.org)
  • In an interview Wednesday, he said he hoped the FDA would learn a lesson from 1996, when it approved Meridia over objections raised by its advisory committee, only to take the drug off the market this year. (go.com)
  • regulatory
  • The aim of this study was to determine whether modafinil, in comparison to the d -amphetamine reference psychostimulant and to placebo, interferes with the vigilance regulatory processes reflected in the EEG during waking. (springer.com)
  • mechanism
  • The suggested mechanism by which fenfluramine causes damage is through over or inappropriate stimulation of these receptors leading to inappropriate valve cell division. (wikipedia.org)
  • treatment
  • There have been reports associating chronic fenfluramine treatment with emotional instability, cognitive deficits, depression, psychosis, exacerbation of pre-existing psychosis (schizophrenia), and sleep disturbances. (wikipedia.org)
  • National Task Force on the Prevention and Treatment of Obesity: Long-term pharmacotherapy in the Management of Obesity, JAMA 276:1907-15, 1996). (allindianpatents.com)
  • taken
  • In 1996, a paper in the New England Journal of Medicine (NEJM) from the Mayo Clinic discussed clinical findings in 24 people who had taken fen-phen. (wikipedia.org)
  • major
  • Norfenfluramine, the major active metabolite of fenfluramine, has an elimination half-life that is about 1.5 to 2 times as long as that of fenfluramine, with mean values of 34 hours for dexnorfenfluramine and 50 hours for levnorfenfluramine. (wikipedia.org)