• anorectic agents
  • Numerous studies have documented that medications which increase brain 5-HT, such as fenfluramine, are effective anorectic agents which help obese patients lose weight and which also decrease craving for sweets and carbohydrates (6,23). (google.com)
  • MDMA
  • The amphetamine derivative 3,4-methylenedioxymethamphetamine (MDMA) is a drug of abuse and has been shown to be neurotoxic to 5-HT terminals in many species. (jneurosci.org)
  • A current line of research is the relationship between core body temperature (CORE TEMP) and neurotoxicity engendered by MDMA and other amphetamines. (jneurosci.org)
  • The MDMA supply seems to be more reliable at high levels of the trade-the DEA has reported that 80% of seized 'ecstasy' pills contain MDMA (about 10% also contained another amphetamine), implying that the bulk of the fraud and substitution is occurring at the level of dealers and small wholesalers. (thedea.org)

Warning: preg_replace(): Compilation failed: unmatched parentheses at offset 6 in /home/lookformedical/www/faq.php on line 152
  • inhibition
  • 2015) Prenatal immune challenge in rats: Prenatal immune challenge in rats: Effects of polyinosinic-polycytidylic acid on spatial learning, prepulse inhibition, conditioned fear, and responses to MK-801 and amphetamine. (fsu.edu)
  • drug
  • In 1994, sales of the combination drug Fen-phen (fenfluramine and phentermine) increased dramatically, as this combination produced substantial and apparent synergistic effect in promoting weight loss. (wikipedia.org)
  • The chemical structure of MDAI is indirectly derived from that of the illicit drug MDA, but the alpha-methyl group of the alkyl amino amphetamine side chain has been bound back to the benzene nucleus to form an indane ring system, which changes its pharmacological properties substantially. (wikipedia.org)
  • Fenfluramine as a single drug was first introduced in the 1970s, but was not popular because it only temporarily reduced weight. (wikipedia.org)
  • After Lutwak refused to approve the drug, the FDA management had someone else sign it and approved the drug with no black box warning for marketing in 1996. (wikipedia.org)
  • In an interview Wednesday, he said he hoped the FDA would learn a lesson from 1996, when it approved Meridia over objections raised by its advisory committee, only to take the drug off the market this year. (go.com)
  • mechanism
  • The suggested mechanism by which fenfluramine causes damage is through over or inappropriate stimulation of these receptors leading to inappropriate valve cell division. (wikipedia.org)
  • treatment
  • There have been reports associating chronic fenfluramine treatment with emotional instability, cognitive deficits, depression, psychosis, exacerbation of pre-existing psychosis (schizophrenia), and sleep disturbances. (wikipedia.org)
  • National Task Force on the Prevention and Treatment of Obesity: Long-term pharmacotherapy in the Management of Obesity, JAMA 276:1907-15, 1996). (allindianpatents.com)
  • taken
  • In 1996, a paper in the New England Journal of Medicine (NEJM) from the Mayo Clinic discussed clinical findings in 24 people who had taken fen-phen. (wikipedia.org)
  • major
  • Norfenfluramine, the major active metabolite of fenfluramine, has an elimination half-life that is about 1.5 to 2 times as long as that of fenfluramine, with mean values of 34 hours for dexnorfenfluramine and 50 hours for levnorfenfluramine. (wikipedia.org)