• TIMPs
  • The role of matrix metalloproteases and TIMPs in several pathological conditions including angiogenesis, tumor growth, and metastasis has been investigated and very well described. (wikipedia.org)
  • Expression
  • Furthermore, TNF-α/IFN-γ inhibition of MMP-2 expression results in decreased invasiveness of the human astroglioma cells through an extracellular matrix. (jimmunol.org)
  • Studies to assess the invasiveness of glioma cells in vitro have demonstrated a strong correlation between glioma invasion and high levels of MMP-2 expression ( 17 , 20 , 22 , 23 ). (jimmunol.org)
  • Results from the current study suggest that TIMP mRNAs are not regulated coordinately during the development and progression of skin carcinogenesis in HPV16 mice and that sustained TIMP-1 expression functionally promotes epithelial carcinogenesis during the early stages of neoplastic progression, whereas in later stages, it inhibits tissue gelatinolytic activity and stabilizes extracellular matrices (ECMs) without affecting metastatic spread. (aacrjournals.org)
  • macrophages
  • The phagocytosis of cartilage matrix breakdown products and other materials by synovial macrophages induces an inflammatory reaction in the synovial membrane, thereby resulting in local synthesis of proteases and proinflammatory cytokines. (springer.com)
  • inhibits
  • 1. An antagonist that inhibits angiogenesis by modifying protein-protein interactions between matrix metalloproteinase 9 (MMP-9) and a β1-containing integrin, wherein said antagonist comprises an antibody reagent which specifically binds to a polypeptide consisting of the sequence of SEQ ID NO: 1. (freepatentsonline.com)
  • vivo
  • To define the stromelysin cleavage site in the interglobular domain of rabbit aggrecan, and to determine whether the stromelysin-generated neoepitope can be used as a marker of matrix metalloproteinase (MMP) activity in vivo. (docme.ru)
  • inhibition
  • Further, we have shown that chemical inhibition of RhoA with ibuprofen or indirectly targeting RhoA by the induction of extracellular matrix composition modification with chondroitinase ABC, can diminish astrogliosis. (frontiersin.org)
  • collagen
  • 17 Chronic immune stimulation within atheroma resulting in T-cell production of interferon-gamma may impair collagen synthesis. (ahajournals.org)
  • During embryonic development, MMP13 is expressed in the skeleton as required for restructuring the collagen matrix for bone mineralization. (wikipedia.org)
  • macromolecules
  • 1,2 Extracellular matrix macromolecules, notably fibrillar interstitial collagens, confer tensile strength on the plaque's fibrous cap. (ahajournals.org)
  • 4 5 6 In other diseases such as arthritis, 7 8 periodontal disease, 9 and dermatological disorders, 10 similar destruction of extracellular matrix macromolecules is seen, and invading inflammatory cells exacerbate the disease process. (ahajournals.org)
  • regulation
  • ADAMs participate in a wide variety of cell surface remodeling processes, including ectodomain shedding, regulation of growth factor availability and mediating cell-matrix interactions. (wikipedia.org)