• TIMPs
  • The role of matrix metalloproteases and TIMPs in several pathological conditions including angiogenesis, tumor growth, and metastasis has been investigated and very well described. (wikipedia.org)
  • macrophages
  • The phagocytosis of cartilage matrix breakdown products and other materials by synovial macrophages induces an inflammatory reaction in the synovial membrane, thereby resulting in local synthesis of proteases and proinflammatory cytokines. (springer.com)
  • human
  • Campbell LA, O'Brien ER, Cappuccio AL et al (1995) Detection of Chlamydia pneumoniae TWAR in human coronary atherectomy tissues. (springer.com)
  • breakdown
  • 24 25 26 The extent of their matrix binding may have important physiological significance in bringing the MMP to its substrate and potentially facilitating matrix breakdown. (ahajournals.org)
  • collagen
  • 17 Chronic immune stimulation within atheroma resulting in T-cell production of interferon-gamma may impair collagen synthesis. (ahajournals.org)
  • During embryonic development, MMP13 is expressed in the skeleton as required for restructuring the collagen matrix for bone mineralization. (wikipedia.org)
  • macromolecules
  • 1,2 Extracellular matrix macromolecules, notably fibrillar interstitial collagens, confer tensile strength on the plaque's fibrous cap. (ahajournals.org)
  • 4 5 6 In other diseases such as arthritis, 7 8 periodontal disease, 9 and dermatological disorders, 10 similar destruction of extracellular matrix macromolecules is seen, and invading inflammatory cells exacerbate the disease process. (ahajournals.org)