Tenofovir disoproxNucleoside analogues includingZidovudine and lamivudineDolutegravir and lamivudineEmtricitabineEpivir HBVInfectionEfavirenzYMDDHepaticHepatitis1998TabletInterferonReverse transcriptasePolymeraseHypersensitivityStavudineTabletsResistanceDiscontinueSymptomaticVivoLopinavirDoseCombinationInhibitAssessmentMedicationNauseaMutationPatientsFood and Drug AdminActivityGenericVirusActiveSide effectsDrugSimilarMedicine
Tenofovir disoprox3
- DRIVE-SHIFT trial evaluating a switch of medication to DELSTRIGO™, a once-daily fixed-dose combination tablet of doravirine (100 mg), lamivudine (3TC, 300 mg) and tenofovir disoproxil fumarate (TDF, 300 mg), in adults with HIV-1 infection who demonstrated virological suppression for at least six months on a stable antiretroviral treatment regimen. (merck.com)
- The agreements cover the manufacture of TMC278 as a single agent medicine and a license to develop an FDC product using TMC278 with 300 mg tenofovir disoproxil fumarate and 300 mg lamivudine . (biospace.com)
- Severe acute exacerbations of HBV have been reported in patients who are coinfected with HIV-1 and HBV and have discontinued products containing lamivudine or tenofovir disoproxil fumarate (TDF), which are components of DELSTRIGO. (natap.org)
Nucleoside analogues including1
- Lactic acidosis and severe hepatomegaly with steatosis, including fatal cases, have been reported with the use of nucleoside analogues including lamivudine and zidovudine (components of lamivudine and zidovudine tablets). (nih.gov)
Zidovudine and lamivudine2
- As the dosage of [HA521 trade name] cannot be adjusted, separate preparations of zidovudine and lamivudine should be used. (who.int)
- The most common comparison was tenofovir and emtricitabine versus zidovudine and lamivudine. (bmj.com)
Dolutegravir and lamivudine2
- Research Triangle Park, US, 16 October 2019 - ViiV Healthcare, the global specialist HIV company majority owned by GSK, with Pfizer Inc. and Shionogi Limited as shareholders, announced the submission of a supplemental New Drug Application to the US Food and Drug Administration (FDA) for Dovato (dolutegravir and lamivudine) as a switch treatment for HIV-1 infection in virologically suppressed adults on a stable antiretroviral regimen with no treatment failure. (viivhealthcare.com)
- It is the latest pure antagonist to be kept low and of these, such us alkyl or alcohol, protecting ones integrity, feeling threatened, misinterpret- ing information, group pressure, having been supplied culiuro .1 formed by the plasmid along with sedanolide, is also co-formulated with dolutegravir and lamivudine resulted in erdtman syn. (moorelifeurgentcare.com)
Emtricitabine3
- Assessment of the relative potency of emtricitabine and lamivudine. (cdc.gov)
- Do not prescribe lamivudine/zidovudine, abacavir/lamivudine, or abacavir/lamivudine/zidovudine to patients taking emtricitabine. (wikipedia.org)
- Conclusions Tenofovir/emtricitabine is likely to increase stillbirth/early neonatal death and early premature delivery compared with zidovudine/lamivudine, but certainty is low when they are not coprescribed with lopinavir/ritonavir. (bmj.com)
Epivir HBV2
- Lamivudine (Epivir HBV) is indicated for the treatment of chronic hepatitis B virus infection associated with evidence of hepatitis B viral replication and active liver inflammation. (wikipedia.org)
- For HBV infection the recommended dose of lamivudine in adults is 100 mg orally once daily, the drug being available in this dose under the trade name Epivir-HBV. (nih.gov)
Infection13
- Lamivudine (Epivir) is indicated in combination with other antiretroviral agents for the treatment of HIV‑1 infection. (wikipedia.org)
- Lamivudine is a nucleoside analogue and reverse transcriptase inhibitor used in the therapy of human immunodeficiency virus (HIV) and hepatitis B virus (HBV) infection. (nih.gov)
- Lamivudine is indicated for the treatment of HBV infection as a single agent and for HIV infection in combination with other HIV medications. (nih.gov)
- For HIV infection, lamivudine is available as 150 and 300 mg tablets and as oral solutions under the trade name Epivir. (nih.gov)
- The recommended dose of lamivudine for HIV infection in adults is 150 mg twice daily or 300 mg once daily. (nih.gov)
- Lamivudine was approved by the FDA for HIV infection in 1995 and for HBV infection in 1998. (nih.gov)
- Lamivudine is a rare cause of liver test abnormalities or clinically apparent liver injury in patients with HIV infection without hepatitis B. Although several instances of lactic acidosis with hepatic steatosis and liver failure have been reported in patients receiving lamivudine, in all instances other nucleoside analogues more clearly associated with mitochondrial injury [didanosine, stavudine, zalcitrabine, zidovudine] were also being taken. (nih.gov)
- In the US, Dovato is currently approved as a complete, once-daily, single-tablet regimen of dolutegravir (DTG) 50 mg and lamivudine (3TC) 300 mg for the treatment of HIV-1 infection in adults with no antiretroviral treatment history and with no known resistance to either DTG or 3TC. (viivhealthcare.com)
- Lamivudine and zidovudine tablets, a combination of 2 nucleoside analogue reverse transcriptase inibitors, are indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection. (nih.gov)
- The study enrolled 35 patients with controlled HIV infection (mean baseline HIV RNA serum level of 2.88 log(10) copies/mL by Roche Amplicor Monitor PCR) who were receiving lamivudine 150 mg twice daily as part of their combination anti-HIV treatment regimen for a median of 42.3 months prior to enrollment. (gilead.com)
- Lamivudine Teva is used to treat adult patients who have chronic (long term) hepatitis B (a disease of the liver due to an infection by the hepatitis B virus). (europa.eu)
- It is less effective for lamivudine-refractory HBV infection. (medscape.com)
- 2008), innumerable variants (or quasispecies) related to the initial transmitted virus emerge within weeks following infection (Coffin, 1995: Perelson and Ribeiro, 2013). (ptmasterguide.com)
Efavirenz3
- Lamivudine is also available in multiple fixed combinations with other antiretroviral agents such as zidovudine, abacavir, tenofovir, efavirenz, nevirapine, dolutegravir and others. (nih.gov)
- A simplified once daily fixed dose combination regimen of tenofovir lamivudine efavirenz (TLE) is given for management of HIV in adults and in pregnant women. (mediaforfreedom.com)
- For example, a tablet of combination drugs Tenofovir 300mg, Lamivudine 300mg and Efavirenz 600mg will now cost Rs 91.71 as against Rs 94.27 earlier. (pharmapathway.com)
YMDD5
- Long-term use of lamivudine leads to emergence of a resistant hepatitis B virus (YMDD) mutant. (wikipedia.org)
- In hepatitis B, lamivudine resistance was first described in the YMDD (tyrosine-methionine-aspartate-aspartate) locus of the HBV reverse transcriptase gene. (wikipedia.org)
- Long-term use of lamivudine can trigger a resistant hepatitis B virus (YMDD) mutant. (wikipedia.org)
- Lamivudine-resistant HBV (confirmed "YMDD" mutation) was detected in patients a median of 21.3 months prior to initiating treatment with Hepsera. (gilead.com)
- Patients infected with a virus that has the 'YMDD mutation' (a change in the virus's DNA that is often found after treatment with lamivudine) should take Lamivudine Teva in combination with another medicine against hepatitis B. For more information, please see the summary of product characteristics (also part of the EPAR). (europa.eu)
Hepatic2
- Data from patients with moderate to severe hepatic impairment show that hepatic dysfunction does not affect lamivudine pharmacokinetics significantly. (who.int)
- As zidovudine doses may need to be adjusted, it is recommended that separate preparations of lamivudine and zidovudine are used in patients with severe hepatic impairment. (who.int)
Hepatitis16
- Lamivudine is a nucleoside reverse transcriptase inhibitor and works by blocking the HIV reverse transcriptase and hepatitis B virus polymerase. (wikipedia.org)
- Lamivudine has been used for treatment of chronic hepatitis B at a lower dose than for treatment of HIV/AIDS. (wikipedia.org)
- Lamivudine is a very rare cause of clinically apparent drug induced liver injury, but is associated with flares of underlying hepatitis B during therapy or with abrupt withdrawal. (nih.gov)
- Lamivudine is currently used in many HAART regimens but is now rarely used to treat hepatitis B because of a high rate of antiviral resistance when it is used as monotherapy as well as the availability of more potent agents with a higher barrier to resistance. (nih.gov)
- Elevations in serum ALT levels occur in a proportion of patients with chronic hepatitis B treated with lamivudine. (nih.gov)
- An exacerbation of hepatitis also typically occurs after development of lamivudine resistance, a few weeks or months after the initial appearance of the mutant HBV strain and rise in HBV DNA levels (Case 2). (nih.gov)
- Severe acute exacerbations of hepatitis B have been reported in patients who are co-infected with hepatitis B virus (HBV) and human immunodeficiency virus (HIV-1) and have discontinued lamivudine, a component of lamivudine and zidovudine tablet. (nih.gov)
- BOSTON, Oct 28, 2003 (BUSINESS WIRE) -- Gilead Sciences (Nasdaq:GILD) today announced that treatment with its once-daily, oral antiviral agent Hepsera(R) (adefovir dipivoxil 10 mg) was associated with sustained reductions in levels of hepatitis B virus (HBV) DNA through 144 weeks (approximately three years) among patients chronically infected with lamivudine-resistant HBV and co-infected with HIV. (gilead.com)
- The development of resistance - which emerges in up to 90 percent of immunocompromised HBV-infected patients after four years of therapy with lamivudine - can lead to progression of chronic hepatitis B," said Dr. Benhamou. (gilead.com)
- Study 460i is a single-center, open-label study of Hepsera in chronic hepatitis B patients with lamivudine-resistant HBV and co-infected with HIV. (gilead.com)
- Because the hepatitis B virus can become resistant to Lamivudine Teva, the doctor should only consider prescribing Lamivudine Teva if other treatments that are less likely to lead to resistance cannot be used. (europa.eu)
- Treatment with Lamivudine Teva should be initiated by a doctor who has experience in the management of chronic hepatitis B. The recommended dose of Lamivudine Teva is 100 mg once a day. (europa.eu)
- In addition to the medications listed below (eg, interferons [IFNs], antivirals, and corticosteroids), the nucleoside analogues lamivudine and adefovir have shown promising results in the treatment of patients with chronic hepatitis B. Other antiviral agents that are being studied for treatment of chronic hepatitis B are entecavir and tenofovir. (medscape.com)
- In July 2002, Gilead initiated an early access program to provide Hepsera to chronic hepatitis B patients with lamivudine-resistant virus. (gilead.com)
- Changes in serum creatinine were observed very commonly in patients with pre- and post-liver transplantation with lamivudine-resistant hepatitis B and multiple risk factors for changes in renal function who were treated with Hepsera for up to 129 weeks, with a median time on treatment of 19 and 56 weeks, respectively. (gilead.com)
- With this move, drugs such as Tenofovir, Lamivudine, Raltegravir that are used to treat HIV/AIDS and Sofosbuvir, which is used to treat Hepatitis C will become cheaper. (pharmapathway.com)
19981
- In the year 1998 they launched lamivudine. (business-standard.com)
Tablet4
- Lamivudine is taken by mouth as a liquid or tablet. (wikipedia.org)
- Discontinue lamivudine and zidovudine tablet as medically appropriate and consider dose reduction or discontinuation of interferon alfa, ribavirin, or both. (nih.gov)
- Each film-coated tablet contains 150 mg lamivudine and 300 mg zidovudine. (who.int)
- For these patients, other formulations should be used, e.g. a tablet which contains a smaller amount of lamivudine and zidovudine. (who.int)
Interferon2
- Patients who are infected with HIV and HCV and are on both interferon and lamivudine can experience liver damage. (wikipedia.org)
- If we treat with lamivudine, we make a tangible dent in the interferon response and inflammation," said Sedivy. (beingpatient.com)
Reverse transcriptase1
- Lamivudine is phosphorylated intracellularly to the triphosphate which competes with the naturally occurring cytidine triphosphate for incorporation into the growing HIV or HBV DNA chain by the viral polymerase, thereby inhibiting polymerase (or reverse transcriptase) activity and causing chain termination. (nih.gov)
Polymerase1
- Lamivudine interferes with the action of a viral enzyme, DNA polymerase, which is involved in the formation of viral DNA. (europa.eu)
Hypersensitivity2
- Lamivudine and zidovudine tablets are contraindicated in patients with a previous hypersensitivity reaction to lamivudine or zidovudine. (nih.gov)
- DELSTRIGO is contraindicated in patients with a previous hypersensitivity reaction to lamivudine. (natap.org)
Stavudine2
- Liposomal gels of lamivudine and stavudine respectively were developed for the transdermal drug delivery. (ispub.com)
- lamivudine and stavudine will alleviate the toxicity of these molecules. (ispub.com)
Tablets3
- These highlights do not include all the information needed to use LAMIVUDINE and ZIDOVUDINE TABLETS safely and effectively. (nih.gov)
- See full prescribing information for LAMIVUDINE and ZIDOVUDINE TABLETS. (nih.gov)
- Hematologic toxicity, including neutropenia and anemia, has been associated with the use of zidovudine, a component of lamivudine and zidovudine tablets. (nih.gov)
Resistance2
- The COLATE study has suggested that there is no benefit to continuing lamivudine treatment in patients with lamivudine resistance. (wikipedia.org)
- Hepsera also has been studied in patients who were treated with and developed resistance to lamivudine, including patients wait-listed for liver transplantation, post-liver transplantation patients and patients co-infected with HIV. (gilead.com)
Discontinue1
- HIV or HBV-infected women on lamivudine are warned to discontinue breastfeeding as this puts the baby at risk for HIV transmission and medication side effects. (wikipedia.org)
Symptomatic1
- Finally, withdrawal flares occur between 4 and 12 weeks after stopping lamivudine and can be severe, symptomatic and even lead to clinical decompensation, acute liver failure and either death or need for emergency liver transplantation. (nih.gov)
Vivo1
- Lamivudine (la miv' ue deen) is an L-enantiomer and substituted analogue of cytidine (2',3'-dideoxy-3'-3-thiacytidine: 3TC) and is active against both HIV and HBV in vitro and in vivo. (nih.gov)
Lopinavir1
- He began a twice-daily antiretroviral regimen comprising the lopinavir/ritonavir coformulation 400/100 mg plus a zidovudine/ lamivudine fixed-dose combination 300/100 mg. (patientcareonline.com)
Dose2
- Where discontinuation of one of the active substances of [HA521 trade name] is necessary, or the dose needs to be adjusted, lamivudine and zidovudine preparations can be given separately. (who.int)
- In September 2003, the twice-daily zidovudine/lamivudine fixed-dose combination was replaced by a once-daily fixed-dose combination of tenofovir/emtrici-tabine 300/200 mg. (patientcareonline.com)
Combination1
- Most commonly reported adverse reactions (incidence greater than or equal to 15%) in clinical trials of combination lamivudine and zidovudine were headache, nausea, malaise and fatigue, nasal signs and symptoms, diarrhea, and cough. (nih.gov)
Inhibit1
- Much1p is triggered from the pheromone-dependent MAP kinase Fus3p permitting Much1p to Lamivudine IC50 bind and inhibit the Clnp-Cdc28p protein kinase (Peter et al. (bio2009.org)
Assessment1
- This is a summary of the European public assessment report (EPAR) for Lamivudine Teva. (europa.eu)
Medication2
- Lamivudine, commonly called 3TC, is an antiretroviral medication used to prevent and treat HIV/AIDS. (wikipedia.org)
- Lamivudine, a generic HIV/AIDS medication significantly reduces age-related inflammation in old mice by halting retrotransposon activity. (beingpatient.com)
Nausea1
- Side effects of lamivudine are uncommon but may include headache, nausea, fatigue diarrhea and cough. (nih.gov)
Mutation1
- A better explanation of the data is that lamivudine continues to have a partial anti-viral effect even in the presence of the M184V mutation. (wikipedia.org)
Patients3
- Lamivudine Teva is not suitable for patients who require doses below 100 mg. (europa.eu)
- Because Lamivudine Teva is a generic medicine , studies in patients have been limited to tests to determine that it is bioequivalent to the reference medicine, Zeffix. (europa.eu)
- Besides being active against HBV, lamivudine, adefovir, and tenofovir are also active against human immunodeficiency virus (HIV) and thus are potentially useful in the treatment of patients with HBV-HIV coinfection. (medscape.com)
Food and Drug Admin1
- The drug was approved by the Food and Drug Administration in 1995 and is considered a safe drug with minimal side effects. (beingpatient.com)
Activity2
- A second CKI in budding candida Far1p directly inhibits the Clnp-Cdc28p protein kinase activity in response to pheromone and Lamivudine IC50 causes G1 arrest (Chang and Herskowitz 1990 blue right-pointing triangle). (bio2009.org)
- In Lamivudine IC50 fission candida the CKI encoded from the rum1 gene takes on a crucial part in regulating the cyclin B-CDK activity in G1 (Moreno and Nurse 1994 blue right-pointing triangle). (bio2009.org)
Generic1
- Because Lamivudine Teva is a generic medicine and is bioequivalent to the reference medicine, its benefit and risk are taken as being the same as the reference medicine. (europa.eu)
Virus1
- Lamivudine stops the virus making DNA and prevents it from multiplying and spreading. (europa.eu)
Active2
- Lamivudine Teva is a medicine that contains the active substance lamivudine. (europa.eu)
- The active substance in Lamivudine Teva, lamivudine, is an antiviral agent belonging to the class of the nucleoside analogues. (europa.eu)
Side effects2
- Of the six HIV drugs they tested, mice had the best response and the least amount of side effects to lamivudine. (beingpatient.com)
- Similar side effects to Retrovir (zidovudine) and Epivir (lamivudine). (clinicalgate.com)
Drug2
- To test the drug, called lamivudine, scientists gave it to 26-month-old mice-the human equivalent of a 75-year-old. (beingpatient.com)
- The first anti-HIV drug, zidovudine was marketed in India in 1995 but the cost was prohibitively high. (mediaforfreedom.com)
Similar1
- This means that Lamivudine Teva is similar to a 'reference medicine' already authorised in the European Union (EU) called Zeffix. (europa.eu)
Medicine1
- It explains how the Committee for Medicinal Products for Human Use ( CHMP ) assessed the medicine to reach its opinion in favour of granting a marketing authorisation and its recommendations on the conditions of use for Lamivudine Teva. (europa.eu)