AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesTechnology, Industry, AgricultureInformation Science
PhospholipasesPhospholipases APhospholipases A2Phospholipases A1Group II Phospholipases A2Type C PhospholipasesGroup X Phospholipases A2Phospholipases A2, SecretoryGroup I Phospholipases A2LysophospholipaseGroup V Phospholipases A2Snake VenomsPhospholipase DCrotalid VenomsReceptors, Phospholipase A2Group VI Phospholipases A2Cobra VenomsGroup IV Phospholipases A2ViperidaeBothropsReptilian ProteinsPhospholipidsViper VenomsCrotoxinGroup III Phospholipases A2Elapid VenomsPhosphatidylcholinesElapidaeArachidonic AcidPhospholipases A2, CytosolicPhospholipases A2, Calcium-IndependentHydrolysisBee VenomsGroup IA Phospholipases A2Phospholipase A2 InhibitorsPhosphatidylinositolsPhosphatidylinositol Diacylglycerol-LyaseSnakesPhosphatidic AcidsIsoenzymesAmino Acid SequenceCalciumBacillus cereusCrotalusPhosphatidylethanolaminesSubstrate SpecificityPancreasKineticsQuinacrineMembrane LipidsTrimeresurusArachidonic AcidsMolecular Sequence DataPhosphoinositide Phospholipase CPyronesLysophosphatidylcholinesGroup IB Phospholipases A2Enzyme ActivationDiglyceridesThionesRussell's ViperCytosolGlycerophospholipidsHydrogen-Ion ConcentrationButanolsMicellesPhospholipase C betaIndolizidinesLysophospholipidsClostridium perfringensCell MembraneLysosomesBridged CompoundsEicosanoidsGlycosylphosphatidylinositols1-ButanolVenomsPhosphatidylglycerolsFluoroimmunoassayNeomycinPhosphoric Diester HydrolasesIndolizinesSwineGalactolipidsEnzyme InhibitorsPlasmalogensSequence Homology, Amino AcidSignal TransductionCholineDetergentsEdetic AcidStructure-Activity RelationshipCells, CulturedLipid MetabolismAcetophenonesReceptors, Cell SurfaceSequence AlignmentListeria monocytogenesHemolysisNeurotoxins
Flavoviridis venom gland phospholipaseHydrolysisInhibitionPhosphatidylinositol-specificRegulationProteinVenomEnzymesPLA2REpidermalPhosphatidic acid1991MammalianActivityEnzymeActivationExpressionFormationCellsProductionPhosphatidylinositol-specific phospholipasePathogenesisCharacterizationSecretoryPLA2LipidCytosolicStimulationPeroxidationMuscarinicVirulence factorsInhibitsStructurallyCalcium-independentMembraneDistinctReceptorsVitro1999CandidaActivatesGeneStrainsCellJournalAddition
Flavoviridis venom gland phospholipase2
  • Polymorphisms of Trimeresurus flavoviridis venom gland phospholipase A2 isozyme genes. (elsevierpure.com)
  • Trimeresurus flavoviridis venom gland phospholipase A2 (PLA2) genes pgPLA 1a and pgPLA 2a encode Asp-49-PLA2 and genes pgPLA 1b and pgPLA 2b encode an isozyme of Asp-49-PLA2. (elsevierpure.com)
Hydrolysis3
Inhibition2
  • However, suppression of the WNT pathway using the acetyltransferase porcupine inhibitor C59 did not reverse EMT whereas a dominant negative form of TCF4 as well as inhibition of phospholipase C using U73122 were able to do so. (cnrs.fr)
  • Interestingly, DAG to which PKD1 is recruited in this pathway is formed downstream of phospholipase D1 (PLD1) and a lipase-inactive PLD1 or inhibition of PLD1 by pharmacological inhibitors blocked PKD1 activation under oxidative stress. (biologists.com)
Phosphatidylinositol-specific1
  • Mammalian phosphatidylinositol-specific phospholipase C (PI-PLC) (see IPR000909 ) isoforms gamma and delta. (embl.de)
Regulation3
  • Regulation of phospholipases C and D in rat ventricular myocytes: stimulation by endothelin-1, bradykinin and phenylephrine. (reading.ac.uk)
  • Disclaimer: As per 'Pre-Natal Diagnostic Techniques (Regulation and prevention of Misuse) Act, 1994', our labs strictly does not determine the sex of the fetus. (redcliffelabs.com)
  • Regulation of human eosinophil degranulation and activation by endogenous phospholipase A2. (uchicago.edu)
Protein4
  • Phospholipase A-2-activating protein is an enzyme that in humans is encoded by the PLAA gene. (wikipedia.org)
  • The microtubule protein tubulin regulates adenylyl cyclase and phospholipase Cβ 1 (PLCβ 1 ) signaling via transactivation of the G-protein subunits Gαs, Gαi1, and Gαq. (jneurosci.org)
  • The interaction of tubulin with these polypeptides involves a GTP transfer from the exchangeable GTP-binding site (E site) of tubulin to Gα, which activates the G-protein (transactivation) ( Roychowdhury and Rasenick, 1994 ). (jneurosci.org)
  • Association of p62, a multifunctional SH2- and SH3-domain-binding protein, with src family tyrosine kinases, Grb2, and phospholipase C gamma-1. (eu.org)
Venom1
  • Bothropstoxin-I (BthTx-I) is a Lys49-phospholipase A 2 (Lys49-PLA 2 ) from the venom of Bothrops jararacussu, which despite of the lack of catalytic activity induces myotoxicity, inflammation and pain. (biomedcentral.com)
Enzymes1
PLA2R2
  • The anti-phospholipase-a2-receptor-pla2r measures anti-phospholipase A2 receptor levels in the blood for detecting membranous glomerulonephritis and nephrotic syndrome. (redcliffelabs.com)
  • In 2009, we had a seminal moment when you published a manuscript in The New England Journal of Medicine describing PLA2R, phospholipase A2 receptor, as the antigen that was responsible for a majority of the cases of MN. (medscape.com)
Epidermal1
  • In this study we evaluated phospholipase C-γ1 (PLC-γ1) expression, activity, and association with the epidermal growth factor (EGF) receptor in a series of human meningiomas as well as cultured meningioma cells. (elsevierpure.com)
Phosphatidic acid1
  • Phospholipase Dδ is Involved in WoundingInduced Phosphatidic Acid Formation in Arabidopsis[J]. Plant Diversity, 2015, 37(4): 428-438. (kib.ac.cn)
19911
  • Methods: In the Malmö Diet and Cancer Study-cardiovascular cohort, 5,381 participants were free from atrial fibrillation or flutter, AD (coronary artery disease, atherothrombotic ischemic stroke, carotid artery disease, or peripheral artery disease), and AAA underwent blood sampling under standardized fasting conditions between 1991 and 1994. (lu.se)
Mammalian1
  • polysaccharide capsule which makes the organism withstand phagocytosis and host immune system, melanin production, ability to thrive at mammalian body temperatures, urease production and phospholipase production. (wikidoc.org)
Activity2
  • The magnetic resonance spectroscopy data indicated that elevated phosphocholine in breast cancer cells was primarily attributable to increased choline kinase activity and increased catabolism mediated by increased phospholipase C activity. (aacrjournals.org)
  • Secreted phospholipases A 2 (sPLA 2 s) participate in a very broad spectrum of biological processes through their enzymatic activity and as ligands for membrane and soluble receptors. (ijbs.com)
Enzyme1
  • 3-[3-Amino-4-(indan-2-yloxy)-5-(1-methyl-1 H -indazol-5-yl)-phenyl]-propionic acid (AK106-001616) is a novel, potent, and selective inhibitor of the cytosolic phospholipase A 2 (cPLA 2 ) enzyme. (aspetjournals.org)
Activation2
  • We have measured activation of these phospholipases by endothelin-1 (ET-1), bradykinin (BK), or phenylephrine (PE) in ventricular myocytes cultured from neonatal rat. (reading.ac.uk)
  • This suggests that a WNT-independent mechanism of beta-catenin activation via phospholipase C is involved in the EMT induced by Cyclin A2 depletion. (cnrs.fr)
Expression1
  • Although phospholipase B expression has cent of patients who have had Candida isolated from their been well studied in C. albicans (18), the relationship intravenous catheters have underlying fungemia (2), and between C. parapsilosis virulence and phospholipase phe- the case-fatality rate for catheter-related candidemia notype is unclear. (cdc.gov)
Formation1
  • Adhesion (15) and biofilm formation (14) may assay was used to quantitate phospholipase. (cdc.gov)
Cells2
Production1
  • AB then compared adhesion ability, biofilm production, and where E is the number of bands common to both strains, a secretion of SAP and phospholipase B of the outbreak iso- is the number of bands unique to strain A, and b is the lates and our clinical strains. (cdc.gov)
Phosphatidylinositol-specific phospholipase12
  • 1. [Cloning and expression of the phosphatidylinositol-specific phospholipase C gene from Listeria monocytogenes]. (nih.gov)
  • 2. Identification of phosphatidylinositol-specific phospholipase C activity in Listeria monocytogenes: a novel type of virulence factor? (nih.gov)
  • 3. Cloning, expression, and mutagenesis of phosphatidylinositol-specific phospholipase C from Staphylococcus aureus: a potential staphylococcal virulence factor. (nih.gov)
  • 4. Listeria monocytogenes mutants lacking phosphatidylinositol-specific phospholipase C are avirulent. (nih.gov)
  • 6. [Phosphatidylinositol specific phospholipase C (PI-PLC) in differentiation of Listeria monocytogenes and Listeria innocua]. (nih.gov)
  • 7. Phosphatidylinositol-specific phospholipase C from Listeria monocytogenes contributes to intracellular survival and growth of Listeria innocua. (nih.gov)
  • 9. Crystal structure of the phosphatidylinositol-specific phospholipase C from the human pathogen Listeria monocytogenes. (nih.gov)
  • 10. Detection of a gene encoding a phosphatidylinositol-specific phospholipase C that is co-ordinately expressed with listeriolysin in Listeria monocytogenes. (nih.gov)
  • 15. Structural organization and expression of the human phosphatidylinositol-specific phospholipase C beta-3 gene. (nih.gov)
  • 16. Listeria monocytogenes phosphatidylinositol-specific phospholipase C has evolved for virulence by greatly reduced activity on GPI anchors. (nih.gov)
  • 19. Mapping the gene that encodes phosphatidylinositol-specific phospholipase C-gamma 2 in the human and the mouse. (nih.gov)
  • Mammalian phosphatidylinositol-specific phospholipase C (PI-PLC) (see IPR000909 ) isoforms gamma and delta. (embl.de)
Pathogenesis2
  • 14. Phospholipases C and the pathogenesis of Listeria. (nih.gov)
  • Phospholipases also play a role in Candida pathogenesis, as they may damage the host cell membranes. (bvsalud.org)
Characterization1
  • 20. Characterization of a novel phosphoinositide-specific phospholipase C from Zea mays and its expression in Escherichia coli. (nih.gov)
Secretory3
  • Phospholipase A 2 receptor 1 (PLA 2 R) has multiple biological functions other than functioning as a receptor for secretory PLA 2 s. (nih.gov)
  • There are two major families of histolytic enzymes produced by Candida species: the secretory aspartyl proteinases (SAP) and phospholipases (PL). Proteinases are central virulence factors that facilitate the colonization and invasion of host tissues via degradation of physiological substrates, such as albumin, immunoglobulins and skin proteins, and inhibition of phagocytosis-inducing inflammatory reactions 4-6 . (bvsalud.org)
  • Galecki first documented altered expression of mRNA coding for cyclooxygenase-2, myeloperoxidase, inducible nitric oxide synthase and secretory phospholipase A2 type IIA in people with recurrent depressive disorder [12]. (weeksmd.com)
PLA22
  • Because THF-diols are derived from lipoxygenase and cyclooxygenase pathways, we suspected that these compounds may regulate cell proliferation by modulating specific enzymatic sites involved in linoleic acid metabolism including phospholipase A 2 (PLA2), lipoxygenases (LOX-5 and LOX-12), cyclooxygenases (COX-1 and COX-2), and closely coupled enzymes including aromatase (AROM). (nih.gov)
  • Treatment of the BEAS cells with the phospholipase A2 (PLA2) inhibitor mepacrine (1 mM) prior to, and during, incubation with melittin inhibited the increase in 3H-AA and 3H-PAF release into the apical compartment by 65% and 100%, respectively. (nih.gov)
Lipid2
  • Polarized release of lipid mediators derived from phospholipase A2 activity in a human bronchial cell line. (nih.gov)
  • 1994 The effects of lipid peroxidation on rabbit aortic endothelial cell phospholipid turnover was studied using linoleic acid hydroperoxide (LOOH). (usc.edu)
Cytosolic3
  • The phospholipases are either cytosolic phospholipase A2 alpha/beta/delta/zeta (PLA2G4A/B/D/F) (Ghomashchi et al. (reactome.org)
  • These were 1, 4, 5 inositol triphosphate (1P3) and diacylglycerol generated from phospholipase C, arachidonic acid from phospholipase Ag and phospatidic acid from ohospholipase D. These muscarinic receptors also induced cyclic AMP formation and caused an elevation of cytosolic calcium. (nih.gov)
  • When cells expressing the muscarinic m5 receptor were pretreated with phorbol esters a-eompound aeaat that inhibits both phospholipase C and the intracellular elevation of 1P3 also blocked the initial rise in cytosolic calcium. (nih.gov)
Stimulation2
  • The initial rapid increase is caused by the release of calcium from intracellular stores by 1P3 as a consequence of a muscarinic receptor induced stimulation of phospholipase C. This initial rise in intracellular calcium does not require the presence of extra cellular calcium. (nih.gov)
  • Agonist binding leads to stimulation of phospholipase C resulting in production of diacylglycerol, predicting whether you are there are binary trading scene, trader brokers with a. (forex-consultant.com)
Peroxidation1
  • 1994 Peroxidation of endothelial cell phospholipids was examined following treatments with linoleic acid hydroperoxide. (usc.edu)
Muscarinic4
  • 1994). „Muscarinic acetylcholine receptor subtypes: localization and structure/function. (wikipedia.org)
  • 1 Tue, Jun 28, 1994 Chee tesr gee SIGNAL TRANSDUCTION IN CLONED MUSCARINIC RECEPTORS Julius Axelrod National Institute of Mental Health Laboratory of Cell Biology clase of The neurotransmitter acetylcholine can recognize two receptors. (nih.gov)
  • The mi, m2, m3, m4 and m5 cloned muscarinic receptors have been 3 Tue, Jun 28, 1994 stably transfected and expressed in a mouse AQL fibroblast cells and chinese hamster ovary cells (CHO). (nih.gov)
  • 4 Tue, Jun 28, 1994 The phospholipases activated by muscarinic receptors are differentially regulated. (nih.gov)
Virulence factors2
  • C. albicans is the most virulent species, and it has virulence factors that allow it to adhere to oral tissues, invade tissue, escape host defenses, form germ tubes and hyphae, and produce histolytic enzymes such as proteinases and phospholipases 2-3 . (bvsalud.org)
  • Our understanding of fungal virulence factors is limit- tory aspartic protease [SAP] and phospholipase). (cdc.gov)
Inhibits1
Structurally2
  • A phosphoinositide phospholipase C subtype that is structurally defined by the presence of an N-terminal pleckstrin-homology and EF-hand domains, a central catalytic domain, and a C-terminal calcium-dependent membrane-binding domain. (bvsalud.org)
  • It is structurally related to PHOSPHOLIPASE C DELTA with the addition of C-terminal extension of 400 residues. (nih.gov)
Calcium-independent1
  • 2004), 85 kDa calcium-independent phospholipase A2 (PLA2G6) (Larsson et al. (reactome.org)
Membrane2
  • At the endoplasmic reticulum (ER) membrane, phosphatidylcholine (PC) is hydrolyzed and has one of its acyl chains cleaved off by a phospholipase A2 to form 1-acyl lysophosphatidylcholine (LPC). (reactome.org)
  • Published by The Company of Biologists Ltd 2014 MHC-I trafficking Clathrin-independent endocytosis Membrane curvature Phospholipase A2 Recycling tubules To keep the identity. (biologists.com)
Distinct1
Receptors2
  • inositol metabolism while Mo receptors are present in the 2 Tue, Jun 28, 1994 heart and inhibit adenylate cyclase. (nih.gov)
  • In the presence of cytochalasin B, only fMLP and C5a caused the activation of phospholipase D in intact leukocytes and enhanced desensitization of IL-8 and C5a but not fMLP receptors. (duke.edu)
Vitro1
  • All Candida strains were tested in vitro for production of proteinase and phospholipase. (bvsalud.org)
19991
  • 1999), group XVI phospholipase A2 (PLA2G16) (Duncan et al. (reactome.org)
Candida4
  • The virulence of Candida strains in G. mellonella is related to the quantity of proteinases and phospholipases production of each strain. (bvsalud.org)
  • Various Candida species produce proteinases and phospholipases, although in lower amounts than C. albicans 6 . (bvsalud.org)
  • Phospholipases (e.g., phospholipase B) and proteases (e.g., he yeast Candida is the fourth most common cause of secreted aspartyl proteases [SAPs]) are two of the best- hospital-related bloodstream infections (1). (cdc.gov)
  • Although phospholipase B expression has cent of patients who have had Candida isolated from their been well studied in C. albicans (18), the relationship intravenous catheters have underlying fungemia (2), and between C. parapsilosis virulence and phospholipase phe- the case-fatality rate for catheter-related candidemia notype is unclear. (cdc.gov)
Activates1
  • In contrast, phorbol esters pretreatment inhibitegy carbachol stimulated phospholipase C, avec ciythee, Garbachol generates G AMP indirectly via the activation of phospholipase inde elhitar Lalmoedulin C. Trhe-utra cellular calcium generated by 1P3 activates which in turn activates cylic AMP. (nih.gov)
Gene2
  • 18. Promoter region of the rat phospholipase C-gamma 1 gene. (nih.gov)
  • This mitogenic effect of thrombin is associated with activation of phospholipase C (PLC) and induction of platelet-derived growth factor (PDGF) gene expression. (uthscsa.edu)
Strains1
  • AB then compared adhesion ability, biofilm production, and where E is the number of bands common to both strains, a secretion of SAP and phospholipase B of the outbreak iso- is the number of bands unique to strain A, and b is the lates and our clinical strains. (cdc.gov)
Cell1
  • In many cell types it has been 5 Tue, Jun 28, 1994 shown that the influx of extra cellular calcium in trigger by a 1P3 generated intra' cellular calcium. (nih.gov)
Journal1
  • American Journal of Physiology - Renal Fluid and Electrolyte Physiology , Vol. 267, No. 4 36-4, 1994, p. (uthscsa.edu)
Addition1
  • 2009). PLBD1 acts as a phospholipase A2 but in addition has the propensity to hydrolyze the lysophospholipid formed in its initial reaction. (reactome.org)