• 1992
  • The ethnic structure of the city according to the 2004 census: Cuvântul Liber Rabbi Dov Ber Friedman (1822-1876) Idel Ianchelevici (1909-1994) Ion Aldea Teodorovici (1954-1992) Victor Toma (1922-2008) Ana Casian (b. 1992) Leova is twinned with: Vetrișoaia, Romania Results of Population and Housing Census in the Republic of Moldova in 2014: "Characteristics - Population (population by communes, religion, citizenship)" (XLS). (wikipedia.org)
  • 1989
  • That the Na/K-ATPase is the target for palytoxin action was initially surmised ( Habermann, 1989 ) largely from antagonism of toxin action by cardiotonic steroids, like ouabain, or by K + ions. (rupress.org)
  • Bucharest
  • He was born in Bucharest, Wallachia, to the prominent Ghica boyar family, and was the nephew of both Grigore Alexandru Ghica (who was to become Prince of Wallachia in the 1840s and 1850s) and Ion Câmpineanu, a Carbonari-inspired radical. (wikipedia.org)
  • Ion Ghica was educated in Bucharest and in Western Europe, studying engineering and mathematics in Mine School of Paris (France) from 1837 to 1840. (wikipedia.org)
  • membrane
  • The lethal marine toxin, palytoxin, first extracted from the polyps of soft-bodied zoanthids of the genus Palythoa ( Moore and Scheuer, 1971 ), is a potentially useful tool for elucidating the molecular reactions by which the Na/K-ATPase stoichiometrically transports Na + and K + ions in opposite directions across the cell surface membrane. (rupress.org)
  • At the time, the means of ion transport across the membrane, whether ion carrier, ion channel, or simply diffusion of ions through the bilipid layer, was unknown. (rupress.org)
  • normal
  • Enhanced understanding of palytoxin action now allows its use for examining the structures and mechanisms of the gates that occlude/deocclude transported ions during the normal Na/K pump cycle. (rupress.org)
  • C inactivation in K channels involves changes in the channel's outer mouth, the "selectivity filter," whose normal function is to prevent Na + ions from entering the K channel. (rupress.org)
  • However
  • To date, however, the ability of natively expressed RGS proteins to influence Gβγ-mediated ion channel modulation in neurons has not been established primarily because few tools are available for inhibiting endogenous RGS proteins. (jneurosci.org)
  • channel
  • Experiments using heterologous overexpression indicate that regulator of G-protein signaling (RGS) proteins play important roles in Gβγ-mediated ion channel modulation. (jneurosci.org)
  • The potential roles of RGS proteins in Gβγ-mediated ion channel modulation were deduced from the discrepancy between the fast kinetics of modulation in vivo and the relatively slow intrinsic GTPase activities of Gα o/i in vitro . (jneurosci.org)
  • Some of the earliest evidence for the existence of a transmembrane channel was from experiments that examined block of K channels by an internally applied TEA + ion, a cation about the same size as a hydrated K + ion. (rupress.org)
  • whose
  • Palytoxin binds to Na/K pumps to generate nonselective cation channels whose pore likely comprises at least part of the pump's ion translocation pathway. (rupress.org)
  • professor
  • Ion Ghica became a professor on geology and mineralogy and later professor on political economy at the Academia Mihăileană which was founded by the same Prince Sturdza in Iași (future University of Iași). (wikipedia.org)