• isotypes
  • Transgenic CD4 cells exhibited a 10- 100-fold increase in IL-4 production on mitogen stimulation in vitro and in vivo, and baseline levels of the Th2-controlled serum immunoglobulin isotypes, IgE and IgG1, were also selectively elevated in vivo. (pubmedcentralcanada.ca)
  • effector
  • Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). (genecards.org)
  • antigen
  • V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). (genecards.org)
  • The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. (genecards.org)
  • There are several different types of antibody heavy chains that define the five different types of crystallisable fragments (Fc) that may be attached to the antigen-binding fragments. (wikipedia.org)
  • antibody
  • Analysis of homozygous mutant chimeric mice: Deletion of the immunoglobulin heavy-chain joining region blocks B-cell development and antibody production, Proc. (freepatentsonline.com)
  • Immunoglobulin A is an antibody that plays a critical role in immune function in the mucous membranes. (wikipedia.org)
  • IgA shows the same typical structure of other antibody classes, with two heavy chains and two light chains, and four distinct domains: one variable region, and three variable regions. (wikipedia.org)
  • It consists of one alpha (FcεRIα - antibody binding site), one beta (FcεRIβ - which amplifies the downstream signal), and two gamma chains (FcεRIγ - the site where the downstream signal initiates) connected by two disulfide bridges. (wikipedia.org)
  • An antibody (Ab), also known as an immunoglobulin (Ig), is a large, Y-shaped protein produced mainly by plasma cells that is used by the immune system to neutralize pathogens such as pathogenic bacteria and viruses. (wikipedia.org)
  • Specificity
  • The heavy chain 3′ enhancers enhance transcription with a high level of B cell specificity and with substantial synergy among the four HS sites ( Cogne and Birshtein, 2004 ). (rupress.org)
  • proteins
  • Expression of cytoplasmic CD3 epsilon proteins in activated human adult natural killer (NK) cells and CD3 gamma, delta, epsilon complexes in fetal NK cells. (wikipedia.org)
  • Globular proteins found in edestin (and in Alpha 1 globulins, Alpha 2 globulins, Beta globulins and Gamma globulins) are long peptide-chains, precursors for biological proteins essential for life. (wikipedia.org)
  • They constitute most of the gamma globulin fraction of the blood proteins. (wikipedia.org)
  • protein
  • Similarly, the primary sequence was determined independently for the alpha-2 chain of the protein in 1979. (wikipedia.org)
  • Immunoglobulin-like domains that are related in both sequence and structure can be found in several diverse protein families. (wikipedia.org)
  • homology
  • Consequently, Src homology region 2 domain-containing phosphatase-1 (SHP-1) is recruited by Syk to the FcR γ-chain. (wikipedia.org)
  • amino
  • II: the amino acid sequence of the H-chain (mu-type), subgroup H III. (wikipedia.org)
  • The Ig alpha-1 chain C region is contained on the first of the constant regions of IgA, and is composed of an amino acid sequence 353 residues long. (wikipedia.org)
  • molecules
  • Compared to FcαRI with Ser248, FcαRI molecules with Gly248 are better able to signal for the release of IL-6, even independently from FcR γ-chain association. (wikipedia.org)
  • A pro-inflammatory response is signaled when IgA molecules in an immune complex bind to multiple FcαRI, resulting in the activation of Src family kinases and the phosphorylation of the FcR γ-chain ITAMs by Lyn. (wikipedia.org)
  • transgenic
  • Here, we show that transgenic expression of this TCR alpha chain during thymic development is sufficient information to bias the differentiation of mainstream thymocytes towards the NK1 developmental pathway. (pubmedcentralcanada.ca)