1994 cell biol cell line tumor. Medical search. Frequent questions

Small cell carcinoma of the prostate is a high-grade malignant neoplasm with neuroendocrine differentiation. (medscape.com)
Daily topical treatment with CWO induced dramatic regression of pre-malignant skin tumors and a two-fold reduction in cutaneous squamous cell carcinomas. (biorxiv.org)
2004). Inhibition of cell growth by EGR-1 in human primary cultures from malignant glioma. (nature.com)
Glioblastoma multiforme (GBM) is the most common and most malignant of the glial tumors. (medscape.com)
Malignancies involving mesothelial cells that normally line the body cavities, including the pleura (see the image below), peritoneum, pericardium, and testis, are known as malignant mesothelioma. (medscape.com)
Pauniaho SL, Salonen J, Helminen M, Vettenranta K, Heikinheimo M, Heikinheimo O. The incidences of malignant gonadal and extragonadal germ cell tumors in males and females: a population-based study covering over 40 years in Finland. (cancercentrum.se)
The prevalence and prognostic impact of lymph node metastasis in malignant germ cell tumors of the ovary. (cancercentrum.se)
Conservative surgery to preserve ovarian function in patients with malignant ovarian germ cell tumors. (cancercentrum.se)
Prognostic impact of lymphadenectomy in clinically early stage malignant germ cell tumour of the ovary. (cancercentrum.se)

Cell cycle analysis suggested activation of apoptosis, without arresting cell cycle progression. (nature.com)
Annexin V-propidium iodide double-staining demonstrated that Sapota fruit extracts potentiate apoptosis rather than necrosis in cancer cells. (nature.com)
The morphologic features characteristic of the disease's pathology include small tumor cells with minimal cytoplasm, nuclear molding, fine chromatin pattern, extensive tumor necrosis/apoptosis, and a brisk mitotic rate. (medscape.com)
Wnt ligands are secreted glycoproteins that function in intracellular signaling pathways to regulate a variety of developmental processes including cell growth, cell differentiation, cell polarity, and apoptosis. (biomedcentral.com)
that 125I seed irradiation affects genes associated with apoptosis and cell cycle arrest in both transcriptional and epigenetic levels. (cox-inhibitors.com)
Collectively, these data provide an explanation for the tumor inhibitory effect of 125I seed implantation and emphasize the important roles of apoptosis and cell cycle arrest underlying the efficacy of this modality. (cox-inhibitors.com)
XLS 20 KB) Additional file 4: The most enrichment pathways among genes related to cell cycle, apoptosis, cell division and growth by KEGG. (cox-inhibitors.com)
Taken together, our findings indicate that SS18-SSX-mediated attenuation of an EGR1-PTEN network regulates synovial sarcoma cell survival, and that HDAC inhibitor-mediated apoptosis operates at least in part through reactivation of this pathway. (nature.com)
Apoptosis-inducing factor (AIF), named for its involvement in cell death pathways, is a mitochondrial protein that regulates metabolic homeostasis. (biomedcentral.com)
Capsid gene delivery into the striatum of mouse brain or interskeletal muscle resulted in cell death and inflammation, likely through capsid-induced apoptosis in vivo. (cdc.gov)
Semithin (1.0-µm) sections resulted in apoptosis and inflammation of muscle cells. (cdc.gov)
The objective of the current studies was to examine the role of caspase 3 (CPP32) and NAD(P)H:quinone oxidoreductase (NQO1) in the signaling of genistein-and β-lapachone (bLap)-induced apoptosis in human prostate carcinoma cells PC3. (biomedcentral.com)
implying that NQO1 pathway may not be the main target for genistein-induced apoptosis in PC3 cells. (biomedcentral.com)
Mishra RR, Chaudhary JK, Rath PC (2012) Cell cycle arrest and apoptosis by expression of a novel TPIP (TPIP-C2) cDNA encoding a C2-domain in HEK-293 cells. (jnu.ac.in)

Our data suggest that genetic alterations of p53 in tumors are sufficient to promote motility and invasion, thereby contributing to metastasis. (rupress.org)
A critical event during tumorigenesis is the conversion from a static primary tumor to an invasive, disseminating metastasis. (rupress.org)
Within the bone marrow, the tachykinins have been shown to have critical effects on the microenvironment, including metastasis and dormancy of cancer cells during clinical remission. (brainimmune.com)
HABP1 can be cleaved by cell surface MMP-14/MT1-MMP, a protease important in angiogenesis and tumor metastasis (5). (rndsystems.com)
Bone metastasis occurs through a complex cascade of events that ultimately results in circulating tumor cells (CTCs) from the blood extravasating and invading the bone marrow - these cells within the bone marrow are referred to as disseminated tumor cells (DTCs) [ 4 ]. (oncotarget.com)
Retroperitoneal nodal metastasis in primary and recurrent granulosa cell tumors of the ovary. (cancercentrum.se)
Patterns of metastasis in sex cord-stromal tumors of the ovary: can routine staging lymphadenectomy be omitted? (cancercentrum.se)

The mortality rate for those diagnosed with head and neck cancer (which does not include brain tumors) is high. (lifeextension.com)
Of the estimated 17,000 primary brain tumors diagnosed in the United States each year, approximately 60% are gliomas. (medscape.com)

Tumour necrosis factor (TNF)-α is thought to be a key early cytokine in the pathogenesis of sarcoidosis, despite conflicting data. (ersjournals.com)
This study has demonstrated that a subset of mononuclear phagocytes, mature macrophages, are responsible for tumour necrosis factor secretion and this could have implications for targeted management in sarcoidosis in the future. (ersjournals.com)
Tumour necrosis factor (TNF)-α is a key early cytokine in a variety of chronic inflammatory responses, including fibrosing alveolitis and granulomatous disease 6 - 8 . (ersjournals.com)

1991. Promotion of mouse lung tumors by bioaccumulated polychlorinated aromatic hydrocarbons. (cdc.gov)
I have previously reported (Frisch, 1991) that adenovirus E1a is a tumor suppressor gene in certain human cell lines. (rupress.org)
1991) Direct Derivation of Conditionally Immortal Cell Lines from an H-2Kb-Tsa58 Transgenic Mouse. (lifescienceproduction.co.uk)

Inhibition of cytotoxic effect of FASL on Jurkat cells in the presence of recombinant human FAS. (biolegend.com)
In vivo , CWO induced transcriptional changes in immune-related genes, resulting in cytotoxic T cell-dependent tumor regression. (biorxiv.org)
In our study, we determined the ability of deferoxamine (DFO) in reducing the cytotoxic effects of high doses of arsenic on NB4 cell line in the acute promyelocytic leukemia.Methods: The NB4 cell line cultured, expanded and then treated with different doses of deferoxamine (50, 100, and 200 µM) alone, and low dose of arsenic trioxide (0.5 µM) in combination with different doses of deferoxamine (50, 100, 200 µM). (ac.ir)
In several instances, tumour sites cytotoxic agents. (who.int)
In this study, we used pulmonary-associated cell lines to assess the in vitro cytotoxic effects of 30 flavoring chemicals. (cdc.gov)

Methylation of WNT9A promoter occurs frequently in primary colon cancers and WNT9A hypermethylation in cancer points to its possible role as a tumor suppressor gene [25]. (cox-inhibitors.com)

1994. Ah receptor in embryonic mouse palate and effects of TCDD on receptor expression. (cdc.gov)
When the level of estrogen receptor (ER)-β mRNA in tumors, determined by reverse transcription-PCR, was assessed according to either ER status or PR status alone, determined by ligand binding assays, the level of ER-β mRNA was significantly lower in PR+ tumors compared with PR−tumors ( P = 0.036), and no association with ER status was found. (aacrjournals.org)
Interestingly, it also seemed that the level of ER-β mRNA varied among breast tumors but was not correlated with the expression of ER-α (4) , although the two receptor mRNAs were often coexpressed in the same tumor. (aacrjournals.org)
The most common example of this type of fusion protein combines the hinge and Fc regions of an immunoglobulin (Ig) with domains of a cell-surface receptor that recognizes a specific ligand (Box 1). (coek.info)

We then focused on two genes previously linked to various cancers, mesothelin and stromelysin-1, which are respectively up-regulated by Wnt-1 and Wnt-5a in C57mg cells. (biomedcentral.com)
This study provides first demonstration for the global induction of apoptotic and cell cycle-related genes by 125I seed irradiation. (cox-inhibitors.com)
2013) Chick Embryo Extract Demethylates Tumor Suppressor Genes in Osteosarcoma Cells. (lifescienceproduction.co.uk)
BCLC9-miR122 cells down-regulate expression of MYC, KLF4, FOXM1, AKT2 and AKT3 genes and up-regulate FOXO1 and FOXO3A gene expression. (oncotarget.com)
CpG methylation of the FHIT, FANCF, cyclin-D2, BRCA2 and RUNX3 genes in Granulosa cell tumors (GCTs) of ovarian origin. (cancercentrum.se)

Supporting differences in Wnt signaling, gain of function of Wnt-1 in C57mg mouse mammary epithelial cells leads to their morphological transformation while loss of function of Wnt-5a leads to the same transformation. (biomedcentral.com)
To test the hypothesis that a specific cell line can respond to distinct Wnts with different patterns of gene expression, we over-expressed Wnt-5a and Rfz-2 in C57mg mammary epithelial cells and compared this cell line to C57mg cells over-expressing Wnt-1. (biomedcentral.com)
the first being a class that transforms C57mg mouse mammary epithelial cells and also promotes duplication of the dorso-ventral axis when over-expressed in Xenopus embryos. (biomedcentral.com)
however, mechanisms through which these bioactive compounds act on epithelial cells have not been identified. (biorxiv.org)
In vivo, NTSR1 mRNA expression was undetectable in superficial differentiated epithelial cells in histological specimens of normal human colonic epithelium, but there was moderate and strong expression in adenomas and adenocarcinomas respectively. (springer.com)
Human bronchial epithelial cells (BEAS-2B) and both nave and activated macrophages (THP-1) were treated with 10, 100, and 1000 M of flavoring chemicals and analyzed for changes in viability, cell membrane damage, reactive oxygen species (ROS) production, and inflammatory cytokine release. (cdc.gov)

Many other cell types emerge via epithelial-mesenchymal differentiation. (rupress.org)
miR122 is the prevalent miRNA in adult healthy liver and it is responsible for liver stem cell differentiation towards hepatocyte lineage. (oncotarget.com)
HCC stem-like cells can be directed towards cell differentiation and tumor dormancy by restoring miR122 expression. (oncotarget.com)
For the developer, cell differentiation is the key to cancer therapy. (cancer.gov)
Antineoplastons are the surveillance system that directs cancer cells into normal channels of differentiation . (cancer.gov)
The notion of controlling tumor growth through a naturally occurring biochemical mechanism in the body that directs cancer cells into normal channels of differentiation is one of the theoretical foundations of antineoplaston therapy. (cancer.gov)
The proposed components in the body that correct the differentiation problems of abnormal cells and send them into normal pathways have been given the name "antineoplastons" by the developer. (cancer.gov)
these cells are able to secrete soluble factors that stimulate the migration, mitosis, and differentiation of local stem cells. (biomedcentral.com)

Here we show that methanolic extracts of Sapota fruit (MESF) induces cytotoxicity in a dose-dependent manner in cancer cell lines. (nature.com)
The interaction of FAS/FASL in immature dendritic cells (DCs) induces functional maturation. (biolegend.com)
We report that the WNV capsid (Cp) by itself induces rapid nuclear condensation and cell death in tissue culture. (cdc.gov)

Treatment of miR122 positive cells with an inhibitor of TGFBR1 activation, abolished tumor dormancy program and recovered cell proliferation rate through a Smad-independent TGF-β response. (oncotarget.com)
The factors and cellular processes required for the induction of dormancy and subsequent tumor cell reactivation remain largely undefined [ 6 ]. (oncotarget.com)

2008) Genetic and epigenetic instability of human bone marrow mesenchymal stem cells expanded in autologous serum or fetal bovine serum. (lifescienceproduction.co.uk)
2012) Ex Vivo expansion of human mesenchymal stem cells in defined serum-free media. (lifescienceproduction.co.uk)
Adult mesenchymal stem cells (MSCs) have been widely used in regenerative medicine in both in vitro and in vivo preclinical research and clinical trials. (biomedcentral.com)
In fact, adipose mesenchymal stem cells (ASCs) are being used, especially in small breeds where the amount of bone marrow that can be harvested is limited and the collection is more laborious and painful. (biomedcentral.com)

In vitro studies based on MCF-7 cell proliferation and induction of vitellogenin in primary culture of rainbow trout hepatocytes. (cdc.gov)
AIF ablation selectively crippled the growth of cells in vitro in a manner that directly correlated with the loss of mitochondrial respiratory chain subunits and altered glucose metabolism, and these effects were exacerbated in the presence of Matrigel™ substrate. (biomedcentral.com)
To this end, in vitro models with cell lines established from human HNSCC have been used, and several chemotherapy sensitivity and resistance assays (CSRA) are currently available. (biomedcentral.com)
For in vitro testing of chemosensitivity, ten established HNSCC cell lines were used. (biomedcentral.com)
We used VES and FBZ, at low concentrations, singly and in combination, to test their inhibitory effects on proliferation of human and mouse prostate cancer cells in vitro. (researchgate.net)
RD cells transfected with pcWNV-Cp-DJY or pcDNA3.1 sis in vitro through the mitochodrial/caspase-9 pathway. (cdc.gov)
Evaluation of the regrowth assay method as an in vitro drug sensitivity test and its application to cultured human gastric cancer cell lines. (cellosaurus.org)
In in vitro studies, the addition of NT to human colon cancer cell lines resulted in significantly increased cancer cell growth and the growth of xenografted human colon cancer cells in mice [ 9 ]. (springer.com)

Beta-catenin then accumulates in the nucleus where it interacts with its transcriptional co-activators, members of the Lymphoid Enhancer Factor/T Cell Factor (LEF/TCF) family of high mobility group DNA binding proteins to regulate gene expression [ 1 ]. (biomedcentral.com)
Cell surface HABP1 binds a wide range of extracellular molecules, including hyaluronan, vitronectin, complement component C1q, HMW kininogen, and bacterial and viral proteins (2, 6 - 9). (rndsystems.com)

[ 7 ] The genetic features may be similar to prostatic adenocarcinoma but may contain additional genetic alterations that make these tumors androgen independent and more aggressive. (medscape.com)
The tumor re-growth that occurs after post-treatment remission is largely due to progression of initially androgen-dependent to androgen-independent cancer cell [ 4 ] and/or non-proliferating to proliferating tumor cells. (biomedcentral.com)

2002) J. Biol. (rndsystems.com)

A bioinformatics approach was first employed to investigate AIF mRNA transcript levels in pancreatic tumor specimens vs. normal tissues. (biomedcentral.com)
Archival gene expression data revealed a modest elevation of AIF transcript levels in subsets of pancreatic tumor specimens, suggesting a possible role in disease progression. (biomedcentral.com)

In addition to its role in controlling cell cycle progression, the tumor suppressor protein p53 can also affect other cellular functions such as cell migration. (rupress.org)

Restitution of miR122 in BCLC9 cells, decreases cell proliferation rate and reduces significantly tumor size in vivo . (oncotarget.com)
Administered alone, FBZ inhibited proliferation faster than VES in both mouse and human prostate cancer cell lines and a synergistic effect between both was also observed. (researchgate.net)
Antiulcer effect of bark extract of Tabebuia avellanedae: activation of cell proliferation in gastric mucosa during the healing process. (medlineplus.gov)
TGF-β1 is a multifunctional regulator of cell growth which will either stimulate or inhibit proliferation of mesenchymal cells depending on the presence of other growth factors 7,8,9 . (bvsalud.org)

Tumor genetics are useful for predicting response to adjuvant therapy. (medscape.com)

In a preliminary study it has been shown that phenolic antioxidants such as methyl 4- O -galloylchlorogenate and 4- O -galloylchlorogenic acid derived from Sapota fruits can induce cytotoxicity in colon cancer cells 23 . (nature.com)
The prevalence of (especially tobacco-related) comorbidity was higher among lung cancer patients as compared to patients with other major tumour types or the general population [2, 4]. (iaslc.org)
Elderly patients with localized non-small cell lung cancer (NSCLC) underwent less surgery than younger patients, older patients with non-localized NSCLC received less chemotherapy or chemoradiation, and elderly with small cell lung cancer (SCLC) received less chemotherapy and chemoradiation [5, 9, 10]. (iaslc.org)
A similar p53-mediated transition is observed in melanoma A375P cancer cells. (rupress.org)
We tested an essential-oil derivative, camphor white oil (CWO), for anti-tumor activity in a mouse model of keratinocyte-derived skin cancer. (biorxiv.org)
Cánovas, D., and Bird, N., (2012) Letter: Human AB serum as an alternative to fetal bovine serum for endothelial and cancer cell culture. (lifescienceproduction.co.uk)
1998). p21(WAF1) is required for butyrate-mediated growth inhibition of human colon cancer cells. (nature.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
In addition to supporting the survival of healthy cells, AIF also plays a contributory role to the development of cancer through its enzymatic activity, and we have previously shown that AIF preferentially supports advanced-stage prostate cancer cells. (biomedcentral.com)
AIF-deficient pancreatic cancer cell lines were then established via lentiviral infection. (biomedcentral.com)
AIF expression was then suppressed in a panel of five pancreatic cancer cell lines that display diverse metabolic phenotypes. (biomedcentral.com)
Altogether these data indicate that AIF supports the growth and survival of metabolically defined pancreatic cancer cells and that this metabolic function may derive from a novel mechanism so far undocumented in other cancer types. (biomedcentral.com)
prostate cancer cell lines and a synergistic effect between both was also o bserved. (researchgate.net)
Pau d'arco bark and wood might prevent cancer cells from growing and slow tumor growth. (medlineplus.gov)
Interestingly, the ER-β mRNA expression was specifically decreased by progestin in T-47D breast cancer cells. (aacrjournals.org)
Forty invasive ductal carcinomas were selected from the National Cancer Institute of Canada-Manitoba Breast Tumor Bank (Winnipeg, Manitoba, Canada). (aacrjournals.org)
Therefore chemotherapeutic strategies should focus on eradicating all cancer cells irrespective of state of growth or sensitivity to hormone. (biomedcentral.com)
The facts that prostate cancer cells retain the inherent apoptotic machinery potentially subject them to an appropriate efficacious chemotherapeutic intervention. (biomedcentral.com)
At the molecular level, abnormal cells that are potential cancer cells need to be "switched" to normal mode. (cancer.gov)
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE). (cellosaurus.org)
Establishment of cultured cell lines of human stomach cancer origin and their morphological characteristics. (cellosaurus.org)
Thromboplastic and fibrinolytic activities of cultured human gastric cancer cell lines. (cellosaurus.org)
Human tumor lines for cancer research. (cellosaurus.org)
Aberrant elevation of tyrosine-specific phosphorylation in human gastric cancer cells. (cellosaurus.org)
Rath P.C. and Mukhopadhyaya T. (2009) p53 gene expression and 2-methoxyestradiol treatment differentially induce NF-kB activation in human lung cancer cells with different p53 phenotypes, DNA Cell Biol. (jnu.ac.in)
It is the result of the dissemination of cancer cells to the bone marrow. (oncotarget.com)
Due to the difficulty in sampling and detection, few techniques exist to efficiently and consistently detect and quantify disseminated tumor cells (DTCs) in the bone marrow of cancer patients. (oncotarget.com)
DTCs occupy the hematopoietic stem cell niche within the bone marrow [ 5 ], often remaining dormant for years before becoming reactivated, leading to cancer recurrence [ 6 ]. (oncotarget.com)
Ovarian granulosa cell tumor and increased risk of breast cancer. (cancercentrum.se)

Eligible patients were required to have locally advanced or metastatic clear-cell RCC, ECOG performance status 0-2, and had to be intermediate or poor risk per the IMDC criteria (Heng, JCO, 2009). (businesswire.com)
In addition, metastatic sites may re-seed primary tumors in a multi-directional fashion [ 8 ]. (oncotarget.com)
NT has shown to exert numerous oncogenic effects involved in tumour growth and metastatic spread. (springer.com)

Up to 70% of hepatocellular carcinomas (HCC) show miR122 down-regulation [ 6 ] and the same applies for HCC-derived cell lines [ 7 ]. (oncotarget.com)
All UM-SCC-lines (University of Michigan Squamous Cell Carcinomas) were kindly provided by Dr. T. Carey, University of Michigan, Ann Arbor, USA. (biomedcentral.com)
Comparison of seven cell lines derived from human gastric carcinomas. (cellosaurus.org)

More importantly, we show that MESF treatment leads to significant inhibition of tumor growth and a 3-fold increase in the life span of tumor bearing animals compared to untreated tumor mice. (nature.com)
ED 50 = 10 - 50 ng/ml, corresponding to a specific activity of 0.02 - 0.1 x 10 6 units/mg, as determined by inhibition of apoptotic cell death induced by FASL on Jurkat cells. (biolegend.com)
Therefore, it is reasonable to speculate that DNA hypomethylation induced by 125I irradiation might be associated with tumor growth inhibition. (cox-inhibitors.com)
Inhibition of cell growth by seven chemotherapeutic agents (cisplatin, carboplatin, 5- fluorouracil, methotrexate, bleomycin, vincristin, and paclitaxel) was measured using metabolic MTT-uptake assay and correlated to clinically-achievable plasma concentrations. (biomedcentral.com)

6-7 Many of these lethal side effects, plus recurrence of the original tumor, can happen after the "five-year survival" milestone has been achieved. (lifeextension.com)
The median interval between initial diagnosis of prostatic adenocarcinoma and recurrence of small cell carcinoma is 25 months. (medscape.com)
Reestablishing miR122 expression is a promising therapeutic strategy that would work concurrently reducing tumor aggressiveness and decreasing disease recurrence. (oncotarget.com)
Patterns of spread and recurrence of sex cord-stromal tumors of the ovary. (cancercentrum.se)

2~). In the absence of light chains, deletion of the C,,l domain improves assembly and secretion of immunoadhesins by the host cell. (coek.info)
A greater number of alveolar macrophages produced TNF-α compared to autologous monocytes in sarcoidosis but not in controls and, based on cell size, it was confirmed that this was the product of more mature macrophages and that the secretion of TNF-α by monocytes and macrophages was heterogeneous: not all monocytes and macrophages secrete TNF-α. (ersjournals.com)

Subgroup analysis showed that ER-β mRNA expression in ER+/PR+ breast tumors was significantly less than in ER+/PR− ( P = 0.009), ER−/PR+ ( P = 0.029), and ER−/PR− ( P = 0.023) groups. (aacrjournals.org)
Nave THP-1 cells produced significantly elevated levels of IL-1, IL-8, and TNF- when exposed to ethyl maltol and hexanal. (cdc.gov)

All drugs inhibited cell growth in a concentration-dependent manner with an IC50 comparable to that achievable in vivo . (biomedcentral.com)

Gupta A, Rath PC (2012) Expression, purification and characterization of the interferon-inducible, antiviral and tumor-suppressor protein, human RNase L. J Biosci 37: 103-111. (jnu.ac.in)

As the Bone Marrow (BM) develops and becomes functional, it becomes the main site of blood and immune cell formation. (brainimmune.com)

These rounded, motile cells exhibit amoeboid-like movement and have considerably increased invasive properties. (rupress.org)

Tachykinins are small neuropeptides from 10-12 amino acids long synthesized in various nuclei of the central nervous system such as the substania gelatinosa of the dorsal spinal cord and certain nuclei of the limbic lobes as well as in a number of non-neuronal tissues like stromal cells of the BM [3]. (brainimmune.com)
Furthermore, the relative expression of ER-α and ER-β mRNA changes between normal human breast tissues and their concurrent matched ER+ breast tumors (6) , suggesting that altered expression of ER-α and ER-β occurs and may be functionally involved in breast tumorigenesis. (aacrjournals.org)
Singh D.K. and Rath P.C. (2012) Long interspersed nuclear elements (LINEs) show tissue-specific, mosaic genome and methylation-unrestricted, wide-spread expression of noncoding RNAs in somatic tissues of the rat. (jnu.ac.in)
Mishra RR, Chaudhary JK, Bajaj GD, Rath PC (2011) A novel human TPIP splice-variant (TPIP-C2) mRNA, expressed in human and mouse tissues, strongly inhibits cell growth in HeLa cells. (jnu.ac.in)

Previous studies have shown that comorbidity only had a significant influence on survival in case of a localized lung tumour or in case of severe comorbidity [2, 3, 5-7]. (iaslc.org)
These findings pro-vide insight into lung cell cytotoxicity and inflammatory cytokine release in response to flavorings commonly used in e-cigarettes. (cdc.gov)

Activated THP-1 cells released increased IL-1 and TNF- when exposed to ethyl maltol, but many flavoring chemicals had an apparent suppressive effect on inflammatory cytokines released by activated macrophages, some with varying degrees of accompanying cytotoxicity. (cdc.gov)

Surgical staging and adjuvant chemotherapy in the management of patients with adult granulosa cell tumors of the ovary. (cancercentrum.se)

2005) Chicken Embryo Extract Mitigates Growth and Morphological Changes in a Spontaneously Immortalized Chicken Embryo Fibroblast Cell Line. (lifescienceproduction.co.uk)
1981) Chick Embryo Extract, Muscle Trophic Factor and Chick and Horse Sera as Environments for Chick Myogenic Cell Growth. (lifescienceproduction.co.uk)
In this study, we report a central role of the transcription factor, early growth response-1 (EGR1), in the regulation of HDAC inhibitor-induced apoptotic cell death in synovial sarcoma. (nature.com)

In case of chemotherapeutically pretreated recurrent tumors, physicians are especially challenged to determine an appropriate therapy. (biomedcentral.com)

Together, these studies identify T cell-mediated tumor regression as the mechanism through which a plant-derived essential oil diminishes established tumor burden. (biorxiv.org)
The body must have a mechanism for dealing with these abnormal cells, or the organism will not live very long. (cancer.gov)

1996). Expression of Egr-1 correlates with the transformed phenotype and the type of viral latency in EBV genome positive lymphoid cell lines. (nature.com)
Deb, T.B. and K. Datta (1996) J. Biol. (rndsystems.com)
1996) J. Biol. (rndsystems.com)

1999. Transactivation activity of human, zebrafish, and rainbow trout aryl hydrocarbon receptors expressed in COS-7 cells: Greater insight into species differences in toxic potency of polychlorinated dibenzo- p -dioxin, dibenzofuran, and biphenyl congeners. (cdc.gov)
E1a thus appeared to partially convert diverse human tumor cells into an epithelial phenotype. (rupress.org)
FAS was initially purified and cloned from SKW6.4 cells and a cDNA library of human T cell lymphoma KT-3 cells. (biolegend.com)
In addition, FAS/FASL interaction increases the production of chemokines in NK-T cells, and FASL acts as a survival factor for human CD34 + cells and increases their colony formation. (biolegend.com)
Human FAS, amino acids (Arg17-Asn173) (Accession# NM_000043), was expressed in 293E cells. (biolegend.com)
We studied the effects of restoring miR122 expression in a distinctive cell line derived from human HCC-BCLC9 cells-with a solid stem-like cell profile, high tumor initiating ability and undetectable miR122 expression. (oncotarget.com)
Ten human cell lines were obtained from HNSCC, including one with experimentally-induced cisplatin resistance. (biomedcentral.com)
The data suggest the possibility that expression of ER-β in human breast tumors is a marker of endocrine therapy responsiveness. (aacrjournals.org)
Human Breast Tumors. (aacrjournals.org)
Heparin prevents programmed cell death in human trophoblast. (mdx.ac.uk)
Establishment of cultured cell lines derived from a human gastric carcinoma. (cellosaurus.org)
Rath P.C. (2005) Relationship between constitutive Nuclear Factor-kappaB (NF-kB) and Inhibitor kappaB-alpha (IkB-a) in an Interferon-a-sensitive human Burkitt lymphoma cell line. (jnu.ac.in)
1994. Polychlorinated biphenyls, 1,1,1-trichloro-2,2 bis(p-chlorophenyl)ethane (p,p'-DDT) and 1,1-dichloro-2,2-bis(p-chlorophenyl)-ethylene (p,p'-DDE) in human plasma related to fish consumption. (cdc.gov)
Ovulatory surges of human CG prevent hormone-induced granulosa cell tumor formation leading to the identification of tumor-associated changes in the transcriptome. (cancercentrum.se)

Radiation therapy is an important part of treating many different head and neck tumors, and is often used after surgery. (lifeextension.com)
Systemic treatment of head and neck squamous cell carcinoma (HNSCC) includes a variety of antineoplastic drugs. (biomedcentral.com)

These observations raised the question of whether the expression of ER-β in breast tumors was correlated with known prognostic and endocrine treatment response markers. (aacrjournals.org)
Ayhan A, Salman MC, Velipasaoglu M, Sakinci M, Yuce K. Prognostic factors in adult granulosa cell tumors of the ovary: a retrospective analysis of 80 cases. (cancercentrum.se)

These Wnts were chosen since previous studies suggest that C57mg cells respond differently to these Wnts, and since these Wnts can activate different signaling pathways in other systems. (biomedcentral.com)
Among them, the Rho GTPase family plays a pivotal role in regulating the biochemical and cytoskeletal pathways relevant to cell migration. (rupress.org)

In addition, miR122 transfected cells decreased AKT2 kinase activation while decreased FOXO1 and FOXO3A protein inactivation. (oncotarget.com)

Immunobiology of dendritic cells. (scriptiebank.be)

Yet, the maturation and activations of these cells occurs throughout the body, either in secondary lymphoid organs or the blood itself. (brainimmune.com)

Besides, administration of concentrated extracts of Morinda citrifolia in tumor containing animals increased the immune response of the animals with a concomitant reduction in tumor burden 7 . (nature.com)
Reduction in tumor size in BCLC9-miR122 associated with an increase in p38MAPK protein expression and activation leading to a low phospho-ERK1/2 to phospho-p38 ratio. (oncotarget.com)
or (e) the MTT-assay based on the reduction of dimethyl thiazolyl blue (MTT) to purple formazan in viable cells. (biomedcentral.com)

Inhibitors of histone deacetylase (HDAC) restore the p53 pathway in neuroblastoma cells. (nature.com)

Other biological effects not leading to apoptotic cell death have also been described. (biolegend.com)

Finally, restoration of EGR1 or PTEN expression is sufficient to induce synovial sarcoma cell death. (nature.com)

including myeloma cell lines, Chinese hamster ovary cells, monkey COS cells, hunran embryonic kidney 203 cells and baculovirusinfected insect cells. (coek.info)

A complete picture of how AIF promotes mitochondrial homeostasis remains elusive, but it has become increasingly clear that through its enzymatic activity AIF has a primary role in maintaining cell survival. (biomedcentral.com)
Incidence and occurrence of second primary tumors. (cancercentrum.se)

Different Wnts have distinct effects on gene expression in a single cell line. (biomedcentral.com)

Mayr D, Hirschmann A, Marlow S, Horvath C, Diebold J. Analysis of selected oncogenes (AKT1, FOS, BCL2L2, TGFbeta) on chromosome 14 in granulosa cell tumors (GCTs): a comprehensive study on 30 GCTs combining comparative genomic hybridization (CGH) and fluorescence-in situ-hybridization (FISH). (cancercentrum.se)

The software runs under a GPL license and is available at https://www.dkfz.de/en/applied-bioinformatics/telomerehunter/telomerehunter.html . (biomedcentral.com)

1994) Myogenic Cell Lines Derived from Transgenic Mice Carrying a Thermolabile T Antigen: A Model System for the Derivation of Tissue-Specific and Mutation-Specific Cell Lines. (lifescienceproduction.co.uk)

1994) Cell Death Differ. (rndsystems.com)

In cultured keratinocytes, CWO stimulated calcium signaling, resulting in calcineurin-dependent activation of nuclear factor of activated T cells (NFAT). (biorxiv.org)

Largely the product of mononuclear phagocyte activation, it is unclear whether TNF-α production at disease sites is a feature of all mononuclear phagocytes that accumulate there or whether it is secreted by a subset of these cells. (ersjournals.com)

However, to precisely identify and interfere with these mechanisms in various tumor types, more insight into the different telomere structures is needed. (biomedcentral.com)

Anatomy27

Organisms15

Diseases54

Chemicals and Drugs62

Analytical, Diagnostic and Therapeutic Techniques and Equipment41

Phenomena and Processes61

Disciplines and Occupations1

Information Science3

Health Care1

Malignant9

Apoptosis14

Metastasis7

Brain tumors2

Necrosis factor3

19913

Cytotoxic5

Suppressor gene1

Receptor4

Genes5

Epithelial cells6

Differentiation8

Induces3

Dormancy2

Mesenchymal stem4

Vitro8

Proteins2

Androgen independent2

20021

Specimens2

Progression1

Proliferation4

Genetics1

Cancer29

Metastatic3

Carcinomas3

Inhibition4

Recurrence4

Secretion2

Significantly2

Vivo1

Characterization1

Bone marrow1

Invasive1

Tissues4

Lung2

Macrophages1

Chemotherapy1

Growth3

Recurrent1

Mechanism2

19963

Human14

Head and neck2

Prognostic2

Pathways2

Inactivation1

Dendritic cells1

Lymphoid1

Reduction3

Neuroblastoma1

Apoptotic cell1

Sufficient1

Embryonic1

Primary2

Gene expression1

Genomic1

Https1

Mice1

Differ1

Nuclear1

Activation1

Insight1