• alleles
  • Specific HLA epitopes, potential interactions of alleles at specific loci and between loci, (accounting for linkage disequilibrium and haplotypic associations), and an assessment of the current ILAR classification were considered. (pubmedcentralcanada.ca)
  • Extensive and well-documented associations with multiple HLA alleles in JIA have been described ( 2 - 4 ) for at least 25 years. (pubmedcentralcanada.ca)
  • There is a rather large degree of disequilibration about DQA1*0301 suggesting that this is one of the older and more established HLA DQB1* alleles in Eurasia. (wikipedia.org)
  • The approach relied on predictions of HLA-binding capacity for a panel of DR, DP, and DQ alleles representative of those most commonly expressed in the general population, coupled with high throughput ELISPOT assays. (frontiersin.org)
  • In parallel, we have made generally available to the scientific community the technical approaches and reagents developed in the process, such as motifs, algorithms, and binding assays for several common HLA class II alleles, and a panel of single allele HLA class II transfected cell lines representative of the most frequent specificities in the general population. (frontiersin.org)
  • Forty nine patients with CFS were genotyped for the HLA-DRB1, HLA-DQA1, and HLA-DQB1 alleles and the frequency of these alleles was compared with a control group comprising 102 normal individuals from the UK. (bmj.com)
  • Only the association between HLA-DQA1*01 and CFS was significant in logistic regression models containing HLA-DQA1*01 and HLA-DRQB1*06, and this was independent of HLA-DRB1 alleles. (bmj.com)
  • However, some studies have failed to find an association between HLA class II alleles and CFS, 18, 19 and one study has suggested a negative association with HLA-DR4. (bmj.com)
  • antibodies
  • Interestingly, when adult RA is stratified by the presence or absence of anti-CCP antibodies, HLA-DRB1*13 is protective for anti-citrullinated protein antibody-positive RA and is a risk factor for anti-citrullinated protein antibody-negative RA ( 9 ). (pubmedcentralcanada.ca)
  • Indirect evidence for autoimmunity in human type 1 diabetes relies on the detection of insulitis, islet cell antibodies, T-cell responses to β-cell antigens, and the association of diabetes with a restricted set of class II major histocompatibility complex (MHC) alleles. (diabetesjournals.org)
  • DQB1
  • An HLA DRB1-DQB1 effect was shown to be exclusively due to DRB1 and showed similarity between oligoarticular patients and a younger subgroup of polyarticular patients. (pubmedcentralcanada.ca)
  • epitopes
  • The results identified hundreds of novel epitopes and antigens, and documented the novel observation that T cells in latent MTB infection are confined to the CXCR3 + CCR6 + phenotype and largely directed against three antigenic "islands" within the MTB genome. (frontiersin.org)
  • Recent efforts have been focused on characterization of epitopes and antigens recognized by patients with active TB and individuals vaccinated with BCG, with the aim of providing the first systematic evaluation of the overlap between latent, active, and BCG cohorts. (frontiersin.org)
  • The definition of a broad range of epitopes restricted by common HLA molecules, will facilitate development of diagnostic reagents, allow a rigorous evaluation of T-cell responses associated with TB infection in humans, and enable the evaluation of the immunogenicity of different vaccine candidates. (frontiersin.org)
  • human
  • Kawakami Y, Eliyahu S, Delgado CH, Robbins PF, Sakaguchi K, Appella E, Yannelli JR, Adema GJ, Miki T, Rosenberg SA (1994) Identification of a human melanoma antigen recognized by tumor-infiltrating lymphocytes associated with in vivo tumor rejection. (springer.com)
  • K562, another human cell line of hematopoietic origin that has been extensively used in functional analyses of DC-SIGN and related molecules, lacks the principal molecules involved in the formation of immunological synaptic junctions, namely major histocompatibility complex (MHC) class II molecules and leukocyte function-associated antigen-1 (LFA-1). (pubmedcentralcanada.ca)
  • Individuals with high risk human leukocyte antigen, autoantibody, andgenotypic profiles still escape overt disease, while in contrast individualswith low risk factors can progress to type 1 diabetes. (ufl.edu)
  • Sequences
  • Specifically, marker DNA sequences which detect either directly or indirectly the identity of the codon encoding for the amino acid at position 57 of the DQ-beta protein sequence are disclosed as well as sequences from the DR-beta region. (google.com.au)
  • 6. The marker DQ-beta DNA sequences of claim 5 which comprise one or more nucleotide sequences from the second exon of the DQB1.3 allele from about codon 20 to about codon 80. (google.com.au)
  • molecules
  • The intercellular adhesion molecules that form this junction have not been identified, although it has been reasoned that this structure may have similarities to the immunological synapse formed between antigen presenting cells (APCs) and their T cell conjugates. (pubmedcentralcanada.ca)
  • lupus
  • Lupus is used as a broad term to describe several forms of the disease, but is most often used to refer to systemic lupus erythematosus (SLE), which can effect various parts of the body and cause an array of symptoms. (davidson.edu)
  • Actually, only a few lupus patients need to be hospitalized for their infections (Mills, 1994). (davidson.edu)
  • Perhaps 10% of patients with discoid lupus will develop the systemic illness (Mills, 1994). (davidson.edu)
  • Neonatal or congenital lupus occurs when the transplacental acquisition of autoantibodies, specifically anti-Ro (SS-A), a 60-kD ribonucleoprotein, produces in the neonate a transient photosensitive rash, confential complete heart block, thrombocytopenia or hepatobiliary dysfunction (Mills, 1994). (davidson.edu)
  • induce
  • 2010). Both dengue and YF wild viruses can induce a broad spectrum of clinical manifestations from asymptomatic to severe clinical features, the latter of which is characterised by haemorrhaic manifestations and shock syndrome, which are associated with vascular permeability and leakage. (scielo.br)
  • protein
  • Protein Ag-loaded DC were used as antigen presenting cells to stimulate T cells in vitro and subsequently analyzed in vivo for their anti-tumor effect via adoptive transfer, a treatment strategy widely studied in clinical trials as a therapy against various malignancies. (springer.com)
  • cells
  • Petersen TR, Dickgreber N, Hermans IF (2010) Tumor antigen presentation by dendritic cells. (springer.com)
  • Blachere NE, Morris HK, Braun D, Saklani H, Di Santo JP, Darnell RB, Albert ML (2006) IL-2 is required for the activation of memory CD8 + T cells via antigen cross-presentation. (springer.com)
  • In these experimental conditions, autoimmunity results from presentation of autoantigens by professional antigen-presenting cells that deliver costimulatory signals to autoreactive T-cells. (diabetesjournals.org)
  • association
  • Another early finding included an association with a HLA- DP2 variant which when combined with HLA-DR3, DR5 (DR11), or DR6 (DR13) gave an enhanced level of risk, but not when combined with HLA-DR8. (pubmedcentralcanada.ca)
  • There was a decreased expression of HLA-DRB1*11 in CFS, although this association disappeared after correction for multiple comparisons. (bmj.com)
  • negative
  • To quantitate risk and study heterogeneity at high resolution for HLA in the most common JIA subtypes, IgM RF negative polyarticular and oligoarticular. (pubmedcentralcanada.ca)
  • largely
  • It has been long realized that HLA associations in children are largely distinct from those in adult rheumatoid arthritis (RA), with HLA-DRB1*08, *11 and *13 reported in children with inflammatory arthritis ( 5 - 7 ). (pubmedcentralcanada.ca)
  • range
  • A broad range of surface receptors for many ligands, including the Fc portion of immunoglobulin, complement proteins, cytokines, chemokines, lipoproteins, and others are on the cell surface. (wordpress.com)
  • cell
  • Higher viral antigen positive cell frequencies were observed for DENV2 when compared with both vaccine viruses. (scielo.br)
  • Several
  • I will name a small subset of the most important contributors here, but my gratitude extends to a broad network of people who provided practical, scientific, and moral support through the last several years. (ufl.edu)