• 2002
  • The strain was transferred from Dr. Jared Grantham, University of Kansas Medical Center to the Rat Resource and Research Center in 2002. (mcw.edu)
  • Homozygous
  • This strain is homozygous for Cdh23 ahl , the age related hearing loss 1 mutation, and ahl4, which on this background result in progressive hearing loss with onset between three and five months of age. (jax.org)
  • A strain characteristic of A/J is a late onset (four to five months) progressive muscular dystrophy as a result of a homozygous retrotransposon insertion in the dysferlin ( Dysf ) gene. (jax.org)
  • BALB
  • It has been shown previously that BALB/c strain embryos tend to contribute poorly to mouse aggregation chimaeras. (biologists.org)
  • The development of BALB/c strain preimplantation embryos lagged behind embryos from some other strains and the contribution that BALB/c and other embryos made to chimaeras correlated with their developmental stage at E2.5. (biologists.org)
  • One early study showed that C57BL/10 strain melanocytes contributed more than BALB/c melanocytes to the coats of most chimaeras in a series of BALB/c↔C57BL/10 aggregation chimaeras ( Mullen and Whitten, 1971 ). (biologists.org)
  • retina
  • We acquired matched counts of retinal ganglion cells (RGCs) in these strains and tested the precision of numerical matching between retina and LGN. (jneurosci.org)
  • among
  • There were even significant variations in the incidences of adrenal medulla tumors among rats from the same source raised in different laboratories. (wikipedia.org)
  • colony
  • The first rat colony in America used for nutrition research was started in January 1908 by Elmer McCollum, and then nutritive requirements of rats were used by Thomas Burr Osborne and Lafayette Mendel to determine the details of protein nutrition. (wikipedia.org)
  • gene
  • To model gene-by-environment interactions in a mouse model system, our group has generated an F 16 advanced intercross line (AIL) from the SM/J and LG/J inbred strains. (diabetesjournals.org)
  • survival
  • for example, it has been suggested that albino alligators have an average survival span of only 24 hours due to the lack of protection from UV and their lack of camouflage to avoid predators. (wikipedia.org)
  • mouse
  • An examination in the F 16 sample of eight adiposity quantitative trait loci previously identified in an F 2 intercross of SM/J and LG/J mouse strains reveals locus-by-diet interactions for all previously mapped loci. (diabetesjournals.org)
  • Crosses derived from the SM/J and LG/J mouse strains are particularly attractive for these types of studies. (diabetesjournals.org)
  • significantly
  • Domestic rats differ from wild rats in many ways: they are calmer and significantly less likely to bite, they can tolerate greater crowding, they breed earlier and produce more offspring, and their brains, livers, kidneys, adrenal glands, and hearts are smaller. (wikipedia.org)
  • Biology
  • Examples of albino laboratory mammals Albinism in biology is the "Congenital absence of any pigmentation or coloration in a person, animal or plant, resulting in white hair and pink eyes in mammals. (wikipedia.org)
  • previously
  • However, since this S symbol has previously been used to designate the Dahl Salt Sensitive strain the symbol assigned to the strain is now: OXYS. (jax.org)
  • color
  • Over time, breeding the rats for these contests may have produced variations in color, notably the albino and hooded varieties. (wikipedia.org)
  • animals
  • We have a special interest in the cold tolerance of FOK, a model animal of genotypic heat adaptation, and have used this strain to gather evidence for a further understanding of the thermal regulatory mechanisms of animals. (physiology.org)
  • cells
  • Intensive transport of monosaccharides into the cells ( Salganik et al 1994 ). (jax.org)
  • wild
  • In 18th century Europe, wild Brown rats ran rampant and this infestation fueled the industry of rat-catching. (wikipedia.org)
  • known
  • As there is evidence that the hooded rat was known as the "Japanese rat" in the early 20th century, Kuramoto concluded that one or more Japanese hooded rats might have been brought to Europe or the Americas and an albino rat that emerged as a product of the breeding of these hooded rats was the common ancestor of all the albino laboratory rats in use today. (wikipedia.org)
  • It has long been known that the composition of chimaeras is affected by the strain combination, but the basis for this bias remains poorly understood. (biologists.org)
  • Institute
  • The genetics of rats was studied by William Ernest Castle at the Bussey Institute of Harvard University until it closed in 1994. (wikipedia.org)