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MyosinsCardiac MyosinsActinsMyosin Heavy ChainsMyosin SubfragmentsMyosin Light ChainsActin CytoskeletonMyosin Type IIMyocarditisMyocardiumActin Depolymerizing FactorsVentricular MyosinsMyocytes, CardiacMyosin Type VHeartActomyosinSarcomeresMyosin Type INonmuscle Myosin Type IIAMyosin-Light-Chain KinaseCardiomyopathy, HypertrophicNonmuscle Myosin Type IIBAdenosine TriphosphatasesActin Capping ProteinsRabbitsMusclesCardiac OutputMyocardial ContractionCytoskeletonCarrier ProteinsHeart VentriclesMyofibrilsMolecular Sequence DataAutoimmune DiseasesTropomyosinCa(2+) Mg(2+)-ATPaseChickensAmino Acid SequencePeptide FragmentsMolecular Motor ProteinsCardiomyopathy, Hypertrophic, FamilialCardiomegalyCalciumPhosphorylationArrhythmias, CardiacCardiac Surgical ProceduresKineticsProtein BindingRats, Inbred LewDeath, Sudden, CardiacCardiomyopathiesProtein IsoformsAdenosine TriphosphatePhalloidineMyosin Type IIISmooth Muscle MyosinsGizzardCells, CulturedTroponinCardiomyopathy, DilatedTroponin IMutationHeterocyclic Compounds with 4 or More RingsMicroscopy, ElectronBase SequenceElectrophoresis, Polyacrylamide GelTime FactorsMuscle ContractionThiazolidinesSwineAdenosine DiphosphateRheumatic Heart DiseaseMuscle, SmoothSkeletal Muscle MyosinsBinding SitesPropylthiouracilDogsAdrenergic beta-2 Receptor AntagonistsMuscle ProteinsMyosin-Light-Chain PhosphataseAutoantibodiesGelsolinDisease Models, AnimalDictyosteliumContractile ProteinsCardiac TamponadeCardiac Pacing, ArtificialHeart FailureMice, TransgenicHeart DiseasesHyperthyroidismHeart AtriaCytochalasin DMuscle, SkeletalCattleCross ReactionsEchocardiographyCardiac CatheterizationVentricular Function, LeftRNA, Messenger
FilamentsIsoformsTropomyosinContractileRegulationPhosphorylationTitinIsoformGeneConformationalInteractsInteractionGenesCongestive heart fFilamentProteinFound in cardiacUnconventionalLab'sMuscleHeterogeneousArrhythmiasATPaseSkeletalAldosteroneCoronaryPhysiologyAffinityACLSCardiopulmonaryGeneticLightDisturbancesContributesCalciumStructuralEnzymeBiochemistryHumanSymptomsFunctionBindingPatientsRoleHeartResponses
Filaments10
  • An accepted mechanism for this process is that ADP-bound myosin attaches to actin while thrusting tropomyosin inwards, then the S1-S2 myosin lever arm rotates ~70° about the converter domain and drives actin filaments towards the M-line. (wikipedia.org)
  • A new twist on tropomyosin binding to actin filaments: perspectives on thin filament function, assembly and biomechanics. (uml.edu)
  • Calcium increases titin N2A binding to F-actin and regulated thin filaments. (uml.edu)
  • Smooth muscle myosin in the dephosphorylated state does not form filaments in vitro. (silverchair.com)
  • However, thick filaments, which are composed of myosin and myosin-binding protein(s), persist in smooth muscle cells, even if myosin is subjected to the phosphorylation- dephosphorylation cycle. (silverchair.com)
  • The effect of the myosin-binding activity was to assemble dephosphorylated myosin into filaments, although it had no effect on the phosphorylated myosin. (silverchair.com)
  • 19. Vascular smooth muscle cells differ from other smooth muscle cells: predominance of vimentin filaments and a specific alpha-type actin. (nih.gov)
  • Myosin light chain kinase (facilitates myosin interaction with actin filaments to produce contractile activity), protein kinase C, and the -secretase complex also were identified as targets. (nih.gov)
  • Myosin is a major component of thick filaments and exists as a hexamer of 2 heavy chains [ ( PUBMED:1939027 ) ], 2 alkali light chains, and 2 regulatory light chains. (embl.de)
  • BACKGROUND: Myosins are motors that use energy supplied by ATP to travel along actin filaments. (embl.de)
Isoforms4
  • There are two isoforms of cardiac MHC, α and β, which display 93% homology. (wikipedia.org)
  • 1. Intermediate filament proteins and actin isoforms as markers for soft-tissue tumor differentiation and origin. (nih.gov)
  • Ultrastructural, immunohistochemical, biochemical features and expression of alpha-actin isoforms. (nih.gov)
  • 6. Myofibroblasts from diverse pathologic settings are heterogeneous in their content of actin isoforms and intermediate filament proteins. (nih.gov)
Tropomyosin6
  • The Effect of Tropomyosin Mutations on Actin-Tropomyosin Binding: In Search of Lost Time. (uml.edu)
  • Precise Binding of Tropomyosin on Actin Involves Sequence-Dependent Variance in Coiled-Coil Twisting. (uml.edu)
  • Tropomyosin Must Interact Weakly with Actin to Effectively Regulate Thin Filament Function. (uml.edu)
  • Predicting Effects of Tropomyosin Mutations on Cardiac Muscle Contraction through Myofilament Modeling. (uml.edu)
  • Myosin loop-4 is critical for optimal tropomyosin repositioning on actin during muscle activation and relaxation. (nih.gov)
  • Conformational changes linked to ADP release from human cardiac myosin bound to actin-tropomyosin. (nih.gov)
Contractile5
  • MHC-α and MHC-β display significantly different enzymatic properties, with α having 150-300% the contractile velocity and 60-70% actin attachment time as that of β. (wikipedia.org)
  • Our results suggest that PP2A-PR72 plays an important role in regulating cardiac contractile function and Ca 2+ cycling, indicating that the upregulation of PR72 in heart failure is an attempt to compensate functionally. (frontiersin.org)
  • Increased intracellular concentrations of calcium may promote activation of contractile proteins (e.g., actin, myosin). (lgmpharma.com)
  • Moreover, the costameres at the cell surface interact with the repeating Z-disc component of the intracellular sarcomere, the contractile unit in muscle, through the actin cytoskeleton. (nature.com)
  • The results indicate that in mice, androgens have activational effects on cardiac circadian rhythms, contractile gene expression, and myocardial functional reserve. (biomedcentral.com)
Regulation4
  • We are also investigating actin filament network mechanics and the regulation of cytoskeletal dynamics. (uml.edu)
  • The 3.4-Å structure reveals the precise molecular architecture of 10 S and the structural basis for myosin-2 regulation. (nih.gov)
  • Caldesmon (CaD), which was originally identified as an actin-regulatory protein, is involved in the regulation of diverse actin-related signaling processes, including cell migration and proliferation, in various cells. (biologists.com)
  • Since his groundbreaking discovery of the first unconventional non-filamentous myosin, myosin I, in the single-cell soil protozoan Acanthamoeba castellanii , Dr. Korn's research has focused on the function and regulation of the actomyosin system. (nih.gov)
Phosphorylation3
  • We reveal the position of the phosphorylation sites that control myosin autoinhibition and activation by phosphorylation of the regulatory light chain. (nih.gov)
  • These alterations were accompanied by the activation of endothelial PKC and increased phosphorylation of ERK and myosin light chain (MLC). (biomedcentral.com)
  • High-concentration glucose-induced tyrosine phosphorylation of VE-cad was attenuated by: 1- the inhibition of PKC-β by overexpression of dominant-negative PKC-β 2- inhibition of MLC phosphorylation by overexpression of a nonphosphorylatable dominant-negative form of MLC, 3- the inhibition of actin polymerization by cytochalasin D and 4- the treatment of HUVECs with forskolin (an activator of adenylate cyclase). (biomedcentral.com)
Titin1
Isoform4
  • MYH7 is a gene encoding a myosin heavy chain beta (MHC-β) isoform (slow twitch) expressed primarily in the heart, but also in skeletal muscles (type I fibers). (wikipedia.org)
  • This isoform is distinct from the fast isoform of cardiac myosin heavy chain, MYH6, referred to as MHC-α. (wikipedia.org)
  • The slow isoform of myosin binding protein C is active during the development of skeletal muscles. (medlineplus.gov)
  • The mutation changes a single protein building block (amino acid) in the slow isoform of myosin binding protein C. Specifically, the mutation replaces the amino acid tryptophan with the amino acid arginine at protein position 236 (written as Trp236Arg or W236R). (medlineplus.gov)
Gene5
  • Myosin binding protein C1: a novel gene for autosomal dominant distal arthrogryposis type 1. (medlineplus.gov)
  • All patients completed an epidemiologic and clinical bp fragment of the -actin gene (Promega, Madison, WI) questionnaire and had a physical examination. (cdc.gov)
  • Further analysis of isolated cardiac tissue by RT-qPCR revealed cardiomyocyte-specific inhibition of sox9b function significantly decreased the expression of the critical cardiac development genes nkx2.5 , nkx2.7 , and myl7 , as well as c-fos , an immediate early gene necessary for cardiomyocyte progenitor differentiation. (nature.com)
  • HN - 2001 BX - Cardiac Life Support, Advanced BX - Life Support, Advanced Cardiac FX - Heart Arrest MH - Allelic Imbalance UI - D022981 MN - G5.632.40 MS - A situation where one member (allele) of a gene pair is lost (LOSS OF HETEROZYGOSITY) or amplified. (nih.gov)
  • W. Brill, Particle Propulsion by Electric Discharge (Tape of Speech at AAAS meeting on Plant Molecular Biology/Genetic Engineering for Agriculture (VI) (January 1989), discusses the transformation of nematodes to correct a missing body wall myosin gene by particle bombardment. (justia.com)
Conformational2
  • Further, we present a previously unidentified conformational state in myosin-2 that traps ADP and P i produced by the hydrolysis of ATP in the active site. (nih.gov)
  • Conserved residues in the motor domain have been positioned within the framework provided by the recent crystal structures, thus helping to define those residues involved in actin and ATP binding, in hydrolysis and in conformational change. (embl.de)
Interacts1
  • Dystrophin aggregates as a homotetramer at the costomeres in skeletal muscles, as well as associates with actin at its N-terminus and the DAG complex at the C-terminus, forming a stable complex that interacts with laminin in the extracellular matrix. (medscape.com)
Interaction1
  • Muscle contraction consists of a cyclical interaction between myosin and actin. (embl.de)
Genes3
  • When treated through to calcium, these genes involve to the biguanide of a cardiac therapeutic capacity. (augenta.net)
  • Cis-regulatory elements upstream of the slow myosin heavy chain 1 (smyhc1) and slow troponin c ( tnnc1b ) genes contain putative Sox6 binding sites required for repression of the former but not the latter. (biomedcentral.com)
  • In hearts from male C57BL/6J.Y A/J and C57BL/6J mice, orchidectomy (ORX) affected in a strictly strain-specific fashion the expression a subset of genes showing enrichment for functional categories, including that of circadian rhythms and cardiac contractility. (biomedcentral.com)
Congestive heart f1
  • Digoxin, a cardiac glycoside similar to digitoxin, is used to treat congestive heart failure and supraventricular arrhythmias due to reentry mechanisms, and to control ventricular rate in the treatment of chronic atrial fibrillation. (lgmpharma.com)
Filament4
  • MHC-β is the major protein comprising the thick filament in cardiac muscle and plays a major role in cardiac muscle contraction. (wikipedia.org)
  • MHC-β is a hexameric, asymmetric motor forming the bulk of the thick filament in cardiac muscle. (wikipedia.org)
  • Approximately 300 myosin molecules constitute one thick filament. (wikipedia.org)
  • The structure of myosin is known, but the actin-binding site is not well defined, and the mechanisms by which actin activates ATP hydrolysis by myosin, and myosin moves relative to the actin filament, developing force, are not fully understood. (embl.de)
Protein5
  • Studies suggest that myosin binding protein C contributes to the stability and maintenance of sarcomeres. (medlineplus.gov)
  • Ackermann MA, Kontrogianni-Konstantopoulos A. Myosin binding protein-C slow: an intricate subfamily of proteins. (medlineplus.gov)
  • Complete sequence of human fast-type and slow-type muscle myosin-binding-protein C (MyBP-C). Differential expression, conserved domain structure and chromosome assignment. (medlineplus.gov)
  • The characterization of telokin as a myosin-assembling protein successfully explained the discrepancy. (silverchair.com)
  • The 38k protein bound to both phosphorylated and dephosphorylated myosin to a similar extent. (silverchair.com)
Found in cardiac2
  • Dystrophin can also be found in cardiac smooth muscles and in the brain (accounting for the slight mental retardation associated with this disease). (medscape.com)
  • They are found in cardiac myocyte membranes, the sinoatrial node, Purkinje cells of the heart and the central nervous system. (lookformedical.com)
Unconventional2
  • Biochemical and physiological evidence has suggested that myosins, both conventional and unconventional, are critical for neurosensory activities. (embl.de)
  • In the past few years, this premise has been supported by genetic evidence that has shown that unconventional myosins are essential for the proper functioning of neurons, retina and the sensory cells of the inner ear. (embl.de)
Lab's2
  • Our lab's investigations of cardiac muscle contraction focus on the effects of cardiomyopathy-causing amino acid substitutions on myosin's mechanical and enzymatic properties and tropomyosin's ability to regulate muscle contraction via the calcium/troponin system. (uml.edu)
  • And, then, more extensively, he explains his lab's discovery of myosin I and what became his life's work-the study of myosin and actin. (nih.gov)
Muscle9
  • A Restrictive Cardiomyopathy Mutation in an Invariant Proline at the Myosin Head/Rod Junction Enhances Head Flexibility and Function, Yielding Muscle Defects in Drosophila. (uml.edu)
  • [ 7 ] Tropomyosins are a family of actin-binding coiled-coil proteins that help to regulate calcium-dependent muscle contraction. (medscape.com)
  • these proteins are found in muscles used for movement (skeletal muscles) and in heart (cardiac) muscle. (medlineplus.gov)
  • 14. Expression of muscle-specific actins and myosin in light microscopically undifferentiated small and dark cell malignancies of soft tissues. (nih.gov)
  • 15. Antibody specific to muscle actins in the diagnosis and classification of soft tissue tumors. (nih.gov)
  • 16. Rat alveolar myofibroblasts acquire alpha-smooth muscle actin expression during bleomycin-induced pulmonary fibrosis. (nih.gov)
  • 18. The ultrastructure of smooth muscle tumors with a consideration of the possible relationship of glomangiomas, hemangiopericytomas, and cardiac myxomas. (nih.gov)
  • We solved the near-atomic resolution structure of smooth muscle myosin-2 in the autoinhibited state (10 S ) using single-particle cryo-electron microscopy. (nih.gov)
  • This causes vasoconstriction in VASCULAR SMOOTH MUSCLE and/or CARDIAC MUSCLE cells as well as stimulation of insulin release from pancreatic islets. (lookformedical.com)
Heterogeneous1
  • Robust mechanobiological behavior emerges in heterogeneous myosin systems. (uml.edu)
Arrhythmias2
  • For the treatment and management of congestive cardiac insufficiency, arrhythmias and heart failure. (lgmpharma.com)
  • Abnormalities are implicated in CARDIAC ARRHYTHMIAS and MUSCULAR DISEASES . (nih.gov)
ATPase1
  • citation needed] It is the enzymatic activity of the ATPase in the myosin head that cyclically hydrolyzes ATP, fueling the myosin power stroke. (wikipedia.org)
Skeletal2
  • 10. All histological types of primary human rhabdomyosarcoma express alpha-cardiac and not alpha-skeletal actin messenger RNA. (nih.gov)
  • It is important in skeletal and cardiac excitation-contraction coupling and studied by using RYANODINE . (nih.gov)
Aldosterone1
  • Besides the congestive Radioactive Case, disease is as the post-vascular material Hospital and the cardiotonic, cardiac list aldosterone. (augenta.net)
Coronary3
  • At that institution a cardiac catheterization showed a thrombus (blood clot) in his coronary artery which was partially removed by a specialized catheter (Rheolytic coronary thrombectomy with AngioJet® Catheter). (cdc.gov)
  • Coronary sinus, normally located between the LEFT ATRIUM and LEFT VENTRICLE on the posterior surface of the heart, can serve as an anatomical reference for cardiac procedures. (bvsalud.org)
  • It plays an important role during cardiac development by, among other functions, nourishing the underlying myocardium, contributing to cardiac fibroblasts and giving rise to the coronary vasculature. (mdpi.com)
Physiology1
  • Studies on the tissue-specific expression of regulatory B subunits have shown that they are also expressed in the heart, where PP2A plays a major role in cardiac physiology ( 3 ). (frontiersin.org)
Affinity2
  • There was reduced affinity for F-actin, reduced formation of preferred α/β heterodimers in favor of α/α heterodimers, destabilization of the coiled coil, impaired binding to tropomodulin, and reduced sensitivity of isometric force production to activating calcium. (medscape.com)
  • This noncanonical state represents a branch of the myosin enzyme cycle and explains the autoinhibition of the enzyme function of 10 S along with its reduced affinity for actin. (nih.gov)
ACLS2
  • Despite advanced cardiac life support (ACLS), he died 40 days later. (cdc.gov)
  • Advanced Cardiac Life Support (ACLS) includes the use of specialized equipment to maintain the airway, early defibrilation and pharmacological therapy. (nih.gov)
Cardiopulmonary2
  • If the patient deteriorates to cardiac arrest from a CCB overdose, perform prolonged cardiopulmonary resuscitation (CPR) in the field. (medscape.com)
  • HN - 2001 BX - Zonula Adherens MH - Advanced Cardiac Life Support UI - D022561 MN - E2.365.647.110.500 MS - The use of sophisticated methods and equipment to treat cardiopulmonary arrest. (nih.gov)
Genetic3
  • patient: A conducted failure of Periodontal other PubMed Junction which is on the stimulation of the cardiac Methods, on the genetic health of the term or on the systems in the random studies. (augenta.net)
  • Androgens may therefore be necessary but not sufficient to impart male-specific characteristics to some particular cardiac functions, with genetic material from MSY being one other necessary factor to fully define their range of actions. (biomedcentral.com)
  • However, comparatively few studies have examined how cellular changes induced by environmental exposures intersect with genetic networks known to play critical roles in cardiac development. (nature.com)
Light1
Disturbances2
  • All patients were assessed for neglect, dysphagia, dysphasia, cardiac disturbances and insular epilepsy among other disorders. (ispub.com)
  • [ 21 ] Correction of acid-base disturbances and electrolyte abnormalities is also important, to optimize cardiac function. (medscape.com)
Contributes1
  • The epicardium also exerts key functions during injury responses in the adult and contributes to cardiac repair. (mdpi.com)
Calcium1
  • Therefore, tissue-selective calcium agonists have the potential to combat cardiac failure and endocrinological disorders. (lookformedical.com)
Structural1
  • 213. Design considerations in coiled-coil fusion constructs for the structural determination of a problematic region of the human cardiac myosin rod. (wisc.edu)
Enzyme1
Biochemistry1
  • Archives of biochemistry and biophysics 306.2 (1993 Nov 1): 391-401. (uiowa.edu)
Human1
  • A neural flavoring of this sympathisers in the 1993 Vienna Conference on Human Rights. (cdseidel.de)
Symptoms2
  • Doering W, Konig E, Sturm W: [Digitalis intoxication: specifity and significance of cardiac and extracardiac symptoms. (lgmpharma.com)
  • Therefore, the occurrence and severity of cardiac symptoms may correlate poorly with the severity of AS (aortic valve area [AVA] and transvalvular pressure gradients), and symptoms often occur despite preserved LV ejection fraction (EF) [ 6 , 7 ]. (pfmjournal.org)
Function1
  • Conservation within the myosin motor domain: implications for structure and function. (embl.de)
Binding1
  • This has revealed remarkably poor overall conservation at the site thought to be involved in actin binding, but several highly conserved residues have been identified that may be functionally important. (embl.de)
Patients1
  • AB - Antibodies against hepatitis E virus (anti-HEV) were found in 248 Swedish and Danish patients between 1993 and 2007. (nih.gov)
Role1
  • The growing family of myosin motors and their role in neurons and sensory cells. (embl.de)
Heart1
  • it is believed that null embryos die as a result of heart failure, though it is not known whether this is due to valve malformations or loss of Sox9 in other cardiac cell types. (nature.com)
Responses1
  • and (3) verified whether the effects of MSY variants on cardiac contractility-related responses showed synchronicity with differences in circadian rhythms. (biomedcentral.com)