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  • mediator
  • The formation of the gaseous mediator nitric oxide (NO) from L-arginine by NO synthases (NOS) has been traditionally considered as the first-line defense against parasitic infections in all species including metazoans ( Schmidt and Walter, 1994 ). (frontiersin.org)
  • Rodríguez-Membrilla A, Martínez V, Jiménez M, Goñalons E, Vergara P. Is nitric oxide the final mediator regulating the migrating myoelectric complex cycle? (wikipedia.org)
  • 1997
  • Recently Loweth and colleagues (1997) have shown that high concentrations of NO liberated from the NO donor s-nitrosoglutathione could induce injury to a line of pancreatic β cells and this damage was attenuated by an inhibitor of guanylate cyclase. (aspetjournals.org)
  • Pathogenesis
  • Here, we discuss the importance of NO in the pathogenesis of TB, the diagnostic use of exhaled and urinary NO in Mtb infection and the potential of NO-based treatments. (frontiersin.org)
  • Since many molecules are involved in the pathogenesis of brain edema, effective treatment cannot be achieved by a single agent but will require the administration of a "magic bullet" containing a variety of agents released at different times during the course of edema in order to be successful. (springer.com)
  • therapeutic
  • Biocompatible metallic medical devices having silanized surfaces coupled to nucleophile residues that release sustained, therapeutic amounts of nitric oxide to specific sites within a mammalian body are provided. (google.com)
  • Additionally, the biocompatible metallic medical devices can also be provided with anti-thrombogenic, lubricious coatings that release sustained, therapeutic amounts of nitric oxide. (google.com)
  • A method for preventing adverse effects associated with the use of a medical device in a patient by introducing into the patient a device of which at least a portion includes a prophylactic or therapeutic amount of a nitric oxide adduct. (google.com)
  • amounts
  • Reduction under anoxic conditions can also occur through process called anaerobic ammonium oxidation (anammox): NH4+ + NO2− → N2 + 2 H2O In some wastewater treatment plants, small amounts of methanol, ethanol, acetate, glycerin, or proprietary products are added to the wastewater to provide a carbon source for the denitrification bacteria. (wikipedia.org)
  • In recent years the BTBPs have been investigated as reagents for the selective extraction of post-plutonium metals such as americium from nitric acid solutions containing large amounts of lanthanides. (wikipedia.org)
  • wherein
  • 12 . The method of claim 11 , wherein the anchoring system is subjected to a heat treatment. (google.es)
  • 13 . The method of claim 12 , wherein the heat treatment creates a stress concentration region. (google.es)
  • 2. The method for preparing a nitric oxide-releasing metallic surface of claim 1 wherein said metallic surface is stainless steel. (google.com)
  • 3. The method for preparing a nitric oxide-releasing metallic surface of claim 1 wherein said nucleophile residue is an aminofunctional silane selected from the group consisting of 4,7,10-triazadecyl-trimethoxysilane, 3-aminopropyltriethoxysilane, 3-aminopropyltrimethoxysilane, 3-aminopropyldiisopropylethoxysilane, and 3-aminopropylmethyldiethoxysilane. (google.com)
  • 4. The method for preparing a nitric oxide-releasing metallic surface of claim 1 wherein said surface having a nucleophile residue is reacted with said nitric oxide gas under an anaerobic pressurized environment. (google.com)
  • 6. The method for preparing a nitric oxide-releasing metallic surface of claim 5 wherein said silanizing step further comprises reacting said metallic surfaces with a silanizing compound selected from the group consisting of a vinylsilane and an isocyanatosilane. (google.com)
  • 7. The method for preparing a nitric oxide-releasing metallic surface of claim 6 wherein said vinylsilane is trichlorovinyl silane. (google.com)
  • 8. The method for preparing a nitric oxide-releasing metallic surfaces of claim 6 wherein said isocyanatosilane is 3-isocyanatopropyl-triethoxysilane. (google.com)
  • 1. A method for preventing adverse effects associated with the use of a medical device in a patient comprising introducing into said patient a medical device of which at least a portion includes a nitric oxide adduct, wherein said nitric oxide adduct comprises a sodium nitroprusside, a nitrosothiol, a nitrate, a nitrite or a nitrosated amino acid. (google.com)
  • 2. The method of claim 1 wherein the nitric oxide adduct is present in a matrix coating on a surface of the medical device which contacts a tissue within the patient, wherein the matrix coating is nylon or plastic. (google.com)
  • 3. The method of claim 2 wherein the matrix coating provides for release of the intact nitric oxide adduct. (google.com)
  • 5. The method of claim 1 wherein the nitric oxide adduct is coated per se on a surface of the medical device which contacts the vessel at the site of injury. (google.com)
  • 6. The method of claim 1 wherein the nitric oxide adduct is directly or indirectly bound to reactive sites on a surface of the medical device which contacts the vessel at the site of injury. (google.com)
  • 7. The method of claim 1 wherein at least a portion of the medical device is formed of a polymer which includes the nitric oxide adduct, wherein the polymer is nylon, polyethylene perthalate or polytetrafluoroethylene. (google.com)
  • 10. The method of claim 7 wherein the material provides for release of the intact nitric oxide adduct. (google.com)
  • 14. The method of claim 13 , wherein the article is a medical device for delivering nitric oxide to a treatment site in a subject or a tube or catheter for contacting a bodily fluid of a subject. (google.com)
  • organic
  • Over a century after their medical introduction, the organic-nitrate pharmaceuticals, including nitroglycerine and amyl nitrite, were identified as precursors of nitric oxide. (wikipedia.org)
  • sodium nitroprusside
  • Incubation of cells with the nitric oxide donors, S-nitroso-N-acetyl penicillamine (SNAP) or sodium nitroprusside (SNP) (10-1000 μM) produced a concentration-dependent increase in cell injury and an increase in cellular cGMP formation as determined by immunoassay. (aspetjournals.org)
  • Treatment of sodium nitroprusside overdose includes the following: Discontinuing sodium nitroprusside administration Buffering the cyanide by using sodium nitrite to convert haemoglobin to methaemoglobin as much as the patient can safely tolerate Infusing sodium thiosulfate to convert the cyanide to thiocyanate. (wikipedia.org)
  • Sodium nitroprusside has potent vasodilating effects in arterioles and venules (arterioles more than venules, but this selectivity is much less marked than that of nitroglycerin, which acts preferentially at venous smooth muscle) as a result of its breakdown to nitric oxide (NO). Sodium nitroprusside breaks down in circulation to release nitric oxide (NO). It does this by binding to oxyhaemoglobin to release cyanide, methaemoglobin and nitric oxide. (wikipedia.org)
  • peripheral
  • CBF (global, hemispheric, arterial territory, and lesion, using xenon computed tomography) and BP (peripheral and central) were measured before and 1 hour after treatment with GTN. (ahajournals.org)
  • We reported previously that transdermal glyceryl trinitrate (GTN), an NO donor, lowered both peripheral and central BP in a dose-dependent manner, improved aortic compliance, and did not alter platelet function or activation. (ahajournals.org)
  • Nitric oxide reduces both total peripheral resistance and venous return, thus decreasing both preload and afterload. (wikipedia.org)
  • acid
  • In water, nitric oxide reacts with oxygen and water to form HNO2 or nitrous acid. (wikipedia.org)
  • The MOX fuel was dissolved in nitric acid, the bulk of the uranium and plutonium were removed by means of a PUREX type extraction using tributyl phosphate in a hydrocarbon, the lanthanides and the remaining actinides were then separated from the aqueous residue (raffinate) by a diamide based extraction to give, after stripping, a mixture of trivalent actinides and lanthanides. (wikipedia.org)
  • intestinal
  • These findings indicate that cGMP mediates intestinal cell injury in response to high levels of nitric oxide as produced by the nitric oxide donors, SNAP and SNP. (aspetjournals.org)
  • Porras M, Martín MT, Terán E, Mourelle M, Vergara P. The nitric oxide donor LA-419 ((S-(6-Nitro-oxi-hexahydro-furo (3,2-b) furan-3-1-il) thioacetate)) prevents intestinal dysmotility, bacterial translocation, and inflammation in a rat model of enteritis. (wikipedia.org)
  • Torrents D, Torres R, De Mora F, Vergara P. Antinerve growth factor treatment prevents intestinal dysmotility in Trichinella spiralis-infected rats. (wikipedia.org)
  • reaction
  • The reaction is thought to proceed via the following stoichiometry: 4 ·NO + O2 + 2 H2O → 4 HNO2 Nitric oxide will react with fluorine, chlorine, and bromine to form the XNO species, known as the nitrosyl halides, such as nitrosyl chloride. (wikipedia.org)
  • Nitric oxide reacts with acetone and an alkoxide to a diazeniumdiolate or nitrosohydroxylamine and methyl acetate: This reaction was discovered around 1898, and remains of interest in nitric oxide prodrug research. (wikipedia.org)
  • Nitric oxide concentration can be determined using a simple chemiluminescent reaction involving ozone. (wikipedia.org)
  • compound
  • c) reacting said nucleophile containing compound bonded to said silanized metallic surface with nitric oxide gas. (google.com)
  • This compound has also been used as a treatment for aortic valve stenosis, oesophageal varices, myocardial infarction, pulmonary hypertension, respiratory distress syndrome in the newborn, shock, and ergot toxicity. (wikipedia.org)
  • The 2,2'-bipyridine-N,N-dioxide is then converted into the dicyano compound by treatment with potassium cyanide and benzoyl chloride in a mixture of water and THF. (wikipedia.org)
  • method
  • Also disclosed is a method for preventing adverse effects associated with the use of a medical device in a patient by introducing the device during a medical procedure and before or during said procedure locally administering a nitric oxide adduct to the site of contact of said device with any internal tissue. (google.com)
  • 15. The method of claim 1 which comprises administering the nitric oxide adduct in combination with an anti-thrombogenic agent. (google.com)
  • reduction
  • The results of the randomized controlled trial of nitric oxide in the prevention of pre-eclampsia (NOPE) showed that in high-risk women receiving standard aspirin prophylaxis from less than 16 weeks, there is no significant reduction in the incidence of hypertensive disorders of pregnancy in the ISMN group, to the desired extent. (springer.com)
  • oxygen
  • Similarly SNAP, SNP and db cGMP treatments resulted in an increase in the in vitro production of reactive oxygen metabolites as assessed by the fluorescent probe 2′7′ dichlorofluoresein diacetate. (aspetjournals.org)
  • methods
  • Moreover, the silanized metallic devices are surprisingly durable when exposed to harsh chemical methods often needed to bind nitric oxide-releasing functional groups to nucleophile residues. (google.com)
  • Methods and Results- In one series, donor hearts of C-H-2 bm12 KhEg (H-2 bm12 ) wild-type (WT) mice were heterotopically transplanted into C57BL/6 (H-2 b ) transgenic mice overexpressing human DDAH-I or WT littermates and procured after 4 hours of reperfusion (WT and DDAH-I recipients, n=6 each). (ahajournals.org)
  • Role
  • The reduced bioavailability of endothelium-derived nitric oxide (NO) may play a role in endothelial vasodilator dysfunction and the structural changes that are characteristic of GCAD. (ahajournals.org)
  • include
  • Treatments to increase nitrosative stress defenses include, for example, repeated administrations of low doses of manipulators of nitrosative stress so that the subject treated has increased tolerance to nitrosative stress. (google.com)
  • Bederson's clinical interests include treatment of intracranial and spinal vascular and tumor pathology, including cerebral aneurysms, arteriovenous malformations, trigeminal neuralgia, tumors of the skull base, carotid artery disease and problems of the cervical and lumbar spine. (wikipedia.org)
  • cerebral
  • We investigated the effect of glyceryl trinitrate ([GTN] an NO donor) on quantitative CBF, BP, and cerebral perfusion pressure in patients with recent stroke. (ahajournals.org)
  • acute
  • Has been used IV and intra-arterially in treatment of acute vascular occlusion in conjunction with anticoagulants. (drugs.com)
  • Impotence
  • While some manufacturers have stated that papaverine hydrochloride injection is not indicated for the treatment of impotence via intracorporeal injection, 133 134 135 181 the drug has been employed effectively via intracavernosal injection. (drugs.com)
  • large
  • A sample containing nitric oxide is mixed with a large quantity of ozone. (wikipedia.org)
  • In general, kinetic treatments of gelation result in large, unwieldy, and dense sets of equations that give answers not discernibly better than those given by the statistical approach. (wikipedia.org)
  • site
  • b) implanting the medical device at the treatment site or contacting the bodily fluid with the medical device. (google.com)
  • common
  • Scientists are now looking for ways to make use of this information in ways that can lead to chronic wounds, burns, and injuries being healed by saliva, making this type of treatment as common as antibiotic creams and rubbing alcohol. (wikipedia.org)
  • effects
  • The treatments were stopped 2 to 3 days before the in vitro experiments so that only the long-term effects of the drugs could be observed. (ahajournals.org)
  • levels
  • In a rat animal model, urine levels of 8-hydroxy-2'-desoxyguanosine (as a biomarker of ROS DNA damage) were measured after treatment with DMA(V). In comparison to control levels, they turned out to be significantly increased. (wikipedia.org)
  • give
  • Fresh iron surfaces appear lustrous silvery-gray, but oxidize in normal air to give hydrated iron oxides, commonly known as rust. (wikipedia.org)
  • series
  • In a second series, donor hearts were transplanted into DDAH-I-transgenic or WT mice and procured 30 days after transplantation (n=7 each). (ahajournals.org)
  • attacks
  • Triptans are used for the treatment of severe migraine attacks or those that do not respond to NSAIDs or other over-the-counter drugs. (wikipedia.org)
  • Triptans are a mid-line treatment suitable for many migraineurs with typical attacks. (wikipedia.org)