• Proteases
  • Proteases, growth factors, chemokines, lipid-binding proteins, and pathogen proteins are among the numerous proteins that bind heparin ( Table ). (ahajournals.org)
  • Proteases, integrins, pH, and reactive oxygen species are just few of the currently known factors that can activate TGF-β. (wikipedia.org)
  • Despite the fact that MMPs have been proven to play a key role in activating TGF-β, mice with mutations in MMP-9 and MMP-2 genes can still activate TGF-β and do not show any TGF-β deficiency phenotypes, this may reflect redundancy among the activating enzymes suggesting that other unknown proteases might be involved. (wikipedia.org)
  • basic
  • These proteins were found to be identical to the acidic and basic FGFs described by Gospodarowicz, et al. (wikipedia.org)
  • The rod also contains specific placement of alternating acidic and basic residues, many of which are spaced 4 amino acids apart. (wikipedia.org)
  • proteins
  • Sara VR, Hall K: Insulin-like growth factors and their binding proteins. (springer.com)
  • Just as with neuronal cell specification, canonical signaling factors like Sonic hedgehog (SHH), Fibroblast growth factor (FGFs), WNTs and bone morphogenetic proteins (BMPs), provide positional information to developing macroglial cells through morphogen gradients along the dorsal-ventral, anterior-posterior and medial-lateral axes. (wikipedia.org)
  • Transforming growth factor beta (TGF-β) is a multifunctional cytokine belonging to the transforming growth factor superfamily that includes four different isoforms (TGF-β 1 to 4, HGNC symbols TGFB1, TGFB2, TGFB3, TGFB4) and many other signaling proteins produced by all white blood cell lineages. (wikipedia.org)
  • tumor
  • Induction of new blood vessel formation via the secretion of proangiogenic factors is one of the main adaptive responses engaged by tumor cells under hypoxic conditions. (aacrjournals.org)
  • Hyaluronan's contribution to tumor growth may be due to its interaction with CD44. (wikipedia.org)
  • heparin-binding growt
  • The invention provides synthetic heparin-binding growth factor analogs having two peptide chains each branched from a branch moiety, such as trifunctional amino acid residues, the branch moieties separated by a first linker of from 3 to about 20 backbone atoms, which peptide chains bind a heparin-binding. (google.com)
  • The synthetic heparin-binding growth factor analogs are useful as pharmaceutical agents, soluble biologics or as surface coatings for medical devices. (google.com)
  • FGFs
  • Members FGF11, FGF12, FGF13, and FGF14, also known as FGF homologous factors 1-4 (FHF1-FHF4), have been shown to have distinct functions compared to the FGFs. (wikipedia.org)
  • Although these factors possess remarkably similar sequence homology, they do not bind FGFRs and are involved in intracellular processes unrelated to the FGFs. (wikipedia.org)
  • Activation
  • Epidermal keratinocytes undergo a series of activation steps in acute wound healing, which are likely to be regulated by autocrine growth control mechanims. (springer.com)
  • The results of this study establish that growth activation of the epidermis is not defective in chronic wounds. (springer.com)
  • Metastatic diversity is mediated by the activation of genes that act as coupling to organ-specific growth. (wikipedia.org)
  • Activation by pH Acidic conditions can denature the LAP. (wikipedia.org)
  • In addition, MDM2 has p53-independent transcription factor-like effects in nuclear factor-kappa beta (NFκB) activation. (wikipedia.org)
  • genes
  • Many of the genes driving the growth at primary site can determine the dissemination and colonization at the ectopic site. (wikipedia.org)
  • These genes are expressed during late log phase and stationary phase in response to environmental factors. (wikipedia.org)
  • interactions
  • The growth of lesions at the ectopic site depends on multiple complex interactions between metastatic cells and host homeostatic mechanisms. (wikipedia.org)
  • vivo
  • 9. The method of claim 1 , wherein the osteogenic precursor cells are transfected in vivo by direct injection of the isolated nucleic acid molecule. (google.com)
  • wound
  • Many investigators continue to examine ways to enhance and control skin healing by changing the wound s environment (oxygen, magnetic fields, stress, location, etc.) or the wound s biochemical activity (growth factors or other biochemical agents). (tamucc.edu)
  • Skin healing can be altered by changing the configuration (pore size, porosity, fiber diameter), the surface (composition, charge, surface energy), the biochemical activity (incorporation of growth factors or other biochemical factors), or the degradation or drug delivery rate of the wound dressing. (tamucc.edu)