1992 treatment nitric oxide donors. Medical search. Frequent questions

Platelet-derived factors, shear stress, acetylcholine, and cytokines stimulate the production of NO by endothelial nitric oxide synthase (eNOS). (wikipedia.org)
Effect of long-term oral L-arginine on the nitric oxide synthase pathway in the urine from patients with interstitial cystitis. (therapeuticresearch.com)
Human dermal fibroblasts produce nitric oxide and express both constitutive and inducible nitric oxide synthase isoforms. (therapeuticresearch.com)
Nitric oxide (NO) is formed from an inducible form of nitric oxide synthase (iNOS) as part of the host antimicrobial defence program [ 1 ]. (biomedcentral.com)
We have analysed the mechanism by which palmitoylation permits the progression of nitric oxide synthase 2 (NOS2) along the ER-Golgi-TGN pathway. (biologists.com)
Recent studies have demonstrated that supplementation of nitric oxide (NO), or increased expression of endothelial NO-synthase (eNOS) protects against both IR-injury and fibrosis ( 5 , 6 ). (frontierspartnerships.org)
The present study was designed to examine whether donepezil induces acute cerebral arteriolar dilation and whether neuronal nitric oxide synthase contributes to this vasodilator response. (silverchair.com)
Brain slices were obtained from neuronal nitric oxide synthase knock-out or C57BL/6J strain (control) mice as well as Wistar rats. (silverchair.com)
In some experiments, brain slices were treated with a nonselective or a selective nitric oxide synthase inhibitor (N-nitro-L-arginine methyl ester [10 m] and S-methyl-L-thiocitrulline [10 m], respectively). (silverchair.com)
An immunohistochemical analysis was performed using antibodies for neuronal nitric oxide synthase and acetylcholinesterase. (silverchair.com)
Donepezil failed to induce arteriolar dilation in the brain slice from the neuronal nitric oxide synthase knock-out mice. (silverchair.com)
Immunohistochemical analysis revealed spatial relationship between neuronal nitric oxide synthase and acetylcholinesterase in the arteriolar wall. (silverchair.com)
Donepezil produces acute vasodilation induced by a selective activation of neuronal nitric oxide synthase in the cerebral parenchymal arterioles. (silverchair.com)
2,3 Cerebral blood vessels reportedly are innervated with cholinergic nerve fibers in both humans and animals, resulting in augmentation of cerebral blood flow and/or vasodilation via activation of neuronal nitric oxide synthase. (silverchair.com)

Nitroglycerin and amyl nitrite serve as vasodilators because they are converted to nitric oxide in the body. (wikipedia.org)
Pers dissertation related to studies of NO- donors focusing on nitroglycerin and has worked at Karolinska Institute and participated in the discovery and development of the unique methods that formed the basis for the detection and characterization of Supernitro. (attgeno.com)

Research into its function led to the 1998 Nobel Prize for elucidating the role of nitric oxide as a cardiovascular signalling molecule. (wikipedia.org)

The methanol extracts of three medicinal plants named Phyllunthus freternus, Triumfetta rhomboidae and Casuarina littorea were examined for their possible regulatory effect on nitric oxide (NO) levels using sodium nitroprusside as a NO donor in vitro. (docslib.org)
Conventional NO and NO+ donors such as sodium nitroprusside, S-nitroso-L-cysteine or S-nitroso-glutathione (at 10 μM) had no effect on [ 3 H]noradrenaline release, though they potently decreased electrically-induced vasoconstriction. (biomedcentral.com)
The conventional NO and NO+ donors, sodium nitroprusside (SNP), S-nitroso-L-cysteine (Cys-NO) and S-nitroso-glutathione (GS-NO) (at 10 μM) potently inhibited the neurogenic vasoconstriction, had however no effect on [ 3 H]noradrenaline release (Table 1 ). (biomedcentral.com)

Louis Ignarro won the Nobel Prize in Medicine in 1998 for his discoveries of the important role of nitric oxide in the cardiovascular system - findings that led to the development of the first anti-impotency drugs. (ucla.edu)

Nitric oxide synthases (NOSs) synthesize the metastable free radical nitric oxide (NO). Three isoforms are known for the NOS enzyme: endothelial (eNOS), neuronal (nNOS), and inducible (iNOS) - each with separate functions. (wikipedia.org)

L-citrulline, a natural antioxidant and nitric oxide donor, has beneficial cardiovascular properties. (ijpsonline.com)

Nitric oxide (nitrogen monoxide) is a molecule and chemical compound with chemical formula of NO. In mammals including humans, nitric oxide is a signaling molecule involved in several physiological and pathological processes. (wikipedia.org)

1. INTRODUCTION: Nitric oxide (NO) is an neuronal cell death and cell damage occur as the important chemical mediator generated by toxicity of overproduction of NO. (Dawson et endothelial cells, macrophages, neurons and al. (docslib.org)

Likewise, Sildenafil citrate, popularly known by the trade name Viagra, stimulates erections primarily by enhancing signaling through the nitric oxide pathway. (wikipedia.org)
The nitrate-nitrite-nitric oxide pathway elevates nitric oxide through the sequential reduction of dietary nitrate derived from plant-based foods. (wikipedia.org)
For the body to generate nitric oxide through the nitrate-nitrite-nitric oxide pathway, the reduction of nitrate to nitrite (by nitrate reductase, a bacterial enzyme) occurs in the mouth, by commensal bacteria, an obligatory and necessary step. (wikipedia.org)

In this chapter, we will review some of the current and most promising strategies that have been used over the years to develop polymeric materials with improved hemocompatibility, including highly hydrophilic or hydrophobic surfaces, albumin coated surfaces, zwitterionic polymers, attached endothelial cells, patterned surfaces, immobilized heparin, and nitric oxide (NO) releasing/generating surfaces. (springer.com)

2001. Effects of pH, nitrite, and ascorbic acid on nonenzymatic nitric oxide generation and bacterial growth in urine. (cdc.gov)
The objective of this study was to characterize electron donors and carriers in nonenzymatic MetMb and MetHb reduction at various temperatures and postmortem muscle pHs in vitro. (iastatedigitalpress.com)
Lower temperature resulted in an increased nonenzymatic MetMb reduction for methylene blue regardless of electron donor (ascorbate, P = 0.03, NADH, P = 0.04). (iastatedigitalpress.com)

This nitrite is swallowed and reacts with acid and reducing substances in the stomach (such as ascorbate) to produce high concentrations of nitric oxide. (wikipedia.org)
for moderate to severe infections we propose a tried‑and‑true treatment: the combination of arginine and ascorbate, administered orally or intravenously. (spandidos-publications.com)
Methylene blue and cytochrome c (cyt- c ) were evaluated as electron carriers and nicotinamide adenine dinucleotide, reduced form (NADH) and ascorbate were considered as electron donors. (iastatedigitalpress.com)
All combinations of electron donors and carriers were evaluated in the following order: NADH plus methylene blue, ascorbate plus methylene blue, NADH plus cyt- c , and ascorbate plus cyt- c . (iastatedigitalpress.com)

As expected, α-Tocopherol treatment increased levels of total tocopherols in post- vs pre-treatment specimens (57 vs 18 μg/mL in plasma, and 42 vs 10 μg/mL in platelets). (biomedcentral.com)
However, treatment with α-tocopherol resulted in slightly decreased levels of tocotrienols in post- vs pre-treatment samples (1.4 vs 2.9 μg/mL in plasma and 2.3 vs 2.8 μg/mL in platelets). (biomedcentral.com)
α-Tocotrienols treatment induced increases in α-tocopherol levels of 4-fold and 6-fold in plasma and platelets, respectively. (biomedcentral.com)
Interestingly, tocotrienols (TRF) treatment induced a less pronounced increase in the levels of tocotrienols in plasma and platelets, suggesting that intravenously administered tocotrienols may be converted to tocopherols. (biomedcentral.com)

To test this hypothesis, we used the model of the electrical field stimulated rat tail artery in which neither constitutive NO nor the NO donor SIN-1, influence the release of noradrenaline [ 15 ]. (biomedcentral.com)

L-Arginine induces vasodilatation through enhanced production of nitric oxide (NO) in the cerebral endothelium. (hindawi.com)

Donor C57BL/6 mice received intravenous (0.1 μmol/kg/h) S-NO-HSA ( n = 12), or 0.9% saline (control, n = 11) for 20 min. (frontierspartnerships.org)

There are a number of reactive nitrogen oxide species, such as N2O3 and ONOO-, that can alter critical cellular components under high local concentrations of NO. However, NO can also abate the oxidation chemistry mediated by reactive oxygen species such as H2O2 and O2- that occurs at physiological levels of NO. In addition to the antioxidant chemistry, NO protects against cell death mediated by H2O2, alkylhydroperoxides, and xanthine oxidase. (researchgate.net)
1992). Bioorganic macromolecules (DNA or involved in the regulation of various proteins) not effected directly with the presence physiological processes. (docslib.org)

Nevertheless, significant knowledge gaps persist in scientific understanding of risk factors, pathogenesis, prevention and treatment of CAV. (lidsen.com)

2000. Acute dapsone exposure and methemoglobinemia in children: treatment with multiple doses of activated charcoal with or without the administration of methylene blue. (cdc.gov)

Low levels of nitric oxide production are typically due to ischemic damage in the liver. (wikipedia.org)
this is termed donor warm ischemic time (WIT). (medscape.com)

Role of signal transduction inhibition in treatment of acute myelogenous leukemia/myelodysplasia. (rochester.edu)
14. Ross AM, Gibbons RJ, Stone GW, Kloner RA, Alexander RW, Investigators A-I. A randomized, double-blinded, placebo-controlled multicenter trial of adenosine as an adjunct to reperfusion in the treatment of acute myocardial infarction (AMISTAD-II). (razavihospital.ir)
However, some patients have an acute presentation with an initial episode of acute rejection or infection that doesnot respond to treatment. (ersjournals.com)

in patients withclosed Trazodone has involved can i take because if you get pain caused by a after another, and I. It can Kamagra soft Shipped From Canada help treatments can be unsafe may exacerbate the symptoms. (arts.ac.uk)
Antibiotic treatment may be considered when symptoms and nuts, L Many Ayurvedic so they put a rather than too low, didnt receive any benefit. (arts.ac.uk)
Effects of L-arginine treatment on symptoms and bladder nitric oxide levels in patients with interstitial cystitis. (therapeuticresearch.com)

Standard pharmaceuticals such as nitroglycerine and amyl nitrite are precursors to nitric oxide. (wikipedia.org)

Effect of large doses of the nitric oxide precursor, L-arginine, on erectile dysfunction. (therapeuticresearch.com)

11. Barcin C, Denktas AE, Lennon RJ, Hammes L, Higano ST, Holmes DR, Garratt KN, Lerman A. Comparison of combination therapy of adenosine and nitroprusside with adenosine alone in the treatment of angiographic no‐ reflow phenomenon. (razavihospital.ir)
We are working on the role of intestinal host defenses such as nitric oxide and on the immune modulatory effects of adenosine. (buffalo.edu)

Nitrate-rich vegetables, in particular leafy greens, such as spinach and arugula, and beetroot, have been shown to increase cardioprotective levels of nitric oxide with a corresponding reduction in blood pressure in pre-hypertensive persons. (wikipedia.org)
subsequently an ARDS patient population was identified which comprised ~30% of total ARDS cases, had higher levels of IL-6 and IL-8, more patients with sepsis and in need for vasopressor treatment, with higher mortality but also responding better to high positive expiratory-end pressure (PEEP) therapy. (spandidos-publications.com)
Donor pre-treatment with S-NO-HSA lead to reduced fibrosis and preservation of myocardial miR-126-3p and GATA2 levels in murine cardiac isografts 60 days after transplantation. (frontierspartnerships.org)
In preclinical studies, CIT enhanced the L-arginine/asymmetrical dimethylarginine ratio, boosted Nitric Oxide (NO) levels, protected endothelial function by lowering superoxide generation, and the accompanying ELK- 1 and p-CREB, two oxygen-sensitive proteins[ 3 - 5 ]. (ijpsonline.com)

Dr. Goss has performed many surgical "firsts" in Houston, including the first split liver adult and pediatric transplants, the first adult living donor liver transplant, the first dual organ lung-liver transplant, and the first dual organ heart-liver transplant. (bcm.edu)
Geha JA, Geha JD, O'Mahony CA, Cotton RT, Galván TN, Rana A, Goss JA " Reconstruction of the Replaced Right Hepatic Artery Using Donor Iliac Arterial Y-Graft in Orthotopic Liver Transplantation . (bcm.edu)

We have proposed the concept of donor- and recipient management using the NO-donor S-nitroso-human-serum-albumin (S-NO-HSA) ( 7 ), a high-molecular-weight S-nitrosothiol with a high S-nitrosograde and exact equimolar nitrosation ( 8 ). (frontierspartnerships.org)
Low molecular mass iron dinitrosyl complexes can up-regulate the stimulation-evoked release of vascular [ 3 H]noradrenaline, apparently independently of their NO donor properties. (biomedcentral.com)
Under certain conditions, low molecular mass DNIC may also serve as NO donors and consequently as activators of soluble guanylyl cyclase and vasodilators [ 7 ]. (biomedcentral.com)
Vyas, A. R. und Singh, S. V.: Molecular targets and mechanisms of cancer prevention and treatment by withaferin a, a naturally occurring steroidal lactone. (natur-wiki.de)

to address this global challenge we bring to the forefront the options for medical treatment and summarize SARS‑CoV2 structure and functions, immune responses and known treatments. (spandidos-publications.com)
Nitric oxide (NO) is produced as part of the host immune response to bacterial infections, including urinary tract infections. (biomedcentral.com)

Certain endogenous compounds can act as NO-donors or elicit NO-like reactions in vivo. (wikipedia.org)
Investigations into the direct and indirect effects of nitric oxide on tumour cells are specifically addressed using model compounds, including NO photodonors, in an attempt to gain a deeper understanding of the signalling pathways that are mediated by this messenger in MDR tumours. (stratagem-cost.eu)

Monitoring nitric oxide status by saliva testing detects the bioconversion of plant-derived nitrate into nitric oxide. (wikipedia.org)

Here we developed a new method to generate tetraploid lines in poplars through colchicine treatment of lateral buds. (bvsalud.org)

As a result, the list of indications for solid-organ transplantation has expanded considerably, placing increasing pressure on an already limited supply of donor organs. (medscape.com)
Retransplantation is the definitive treatment for severe CAV, however, the paucity of organs along with increased mortality associated with retransplantation makes it a less desirable option. (lidsen.com)

The enzyme flavohemoglobin, coded by the hmp gene, is involved in protecting bacterial cells from the toxic effects of NO and represents a potentially interesting target for development of novel treatment concepts against resistant uropathogenic bacteria. (biomedcentral.com)
An NO-donor in combination with miconazole and PMBN showed enhanced antimicrobial effects and proved effective against multidrug-resistant ESBL-producing uropathogenic E. coli . (biomedcentral.com)
Treatment effects assessed by measuring non-invasive and invasive blood pressure, body and heart weight, vascular reactivity to catecholamines, acetylcholine-induced vasorelaxation in the isolated artery, and oxidative stress in heart specimens. (ijpsonline.com)

Effect of oral administration of high-dose nitric oxide donor L-arginine in men with organic erectile dysfunction: results of a double-blind, randomized, placebo-controlled study. (therapeuticresearch.com)

Kidney transplantation results in superior life expectancy and better quality of life if compared to dialysis treatment for patients with end-stage renal failure. (intechopen.com)

However, limited knowledge is currently available on the roles of other electron carriers and electron donors involved in MetHb and MetMb reduction at postmortem muscle conditions. (iastatedigitalpress.com)

We assessed whether donor preservation with S-NO-HSA affects isograft injury and myocardial expression of GATA2 as well as miR-126-3p, which are considered protective against vascular and endothelial injury. (frontierspartnerships.org)
Donor hearts were stored in cold histidine-tryptophan- α -ketoglutarate-N solution for 12 h and underwent heterotopic, isogenic transplantation, except 5 hearts of each group, which were analysed immediately after preservation. (frontierspartnerships.org)

The Janus face of nitric oxide (NO) has prompted a debate as to whether NO plays a deleterious or protective role in tissue injury. (researchgate.net)

In the 'HEARTS technical package treatment protocols', World Health Organization recommends polytherapy when monotherapy cannot control hypertension. (ijpsonline.com)

The influence of fertilizer based seed priming treatment on emergence and seedling growth of Sorghum bicolor and Pennisetum glaucum in pot trials under greenhouse conditions. (uni-lj.si)

Effect of inhaled L-arginine on exhaled nitric oxide in normal and asthmatic subjects. (therapeuticresearch.com)
Our results conclude that L-citrulline is a promising treatment option for treating hypertension, and L-citrulline can be combined with spironolactone to get a synergistic effect in treating hypertension. (ijpsonline.com)

Magnus has a long background in the frontline nitric oxide research including NO-donors. (attgeno.com)

Among other things, the institute supports UCLA's Depression Grand Challenge, a massive initiative to get at the root causes of depression and find new prevention and treatment strategies for a condition that is responsible for 1 million suicides every year. (ucla.edu)
Palliyaguru, D. L., Singh, S. V. und Kensler, T. W.: Withania somnifera: From prevention to treatment of cancer. (natur-wiki.de)

We have discovered that zinc can directly inhibit the virulence of pathogenic bacteria, and we are working on turning these laboratory findings into treatments. (buffalo.edu)

The present study investigated the differences in the outcomes between L-citrulline monotherapy and combination therapy with spironolactone as initial treatments for test animals with deoxycorticosterone acetate saltinduced hypertension. (ijpsonline.com)
In the development period, treatment groups received a daily dose of L-citrulline (50 or 100 mg/kg, p.o.) alone or in spironolactone (50 or 100 mg/kg, p.o.) combination. (ijpsonline.com)
However, compared to combination therapy, the performance of L-citrulline or spironolactone alone treatment is slightly inferior. (ijpsonline.com)

Dietary nitrate is also an important source of nitric oxide in mammals. (wikipedia.org)

Zinc supplements may interact discharge or find it and treatments. (arts.ac.uk)

Nutritional treatment for acquired immunodeficiency virus-associated wasting using beta-hydroxy beta-methylbutyrate, glutamine, and arginine: a randomized, double-blind, placebo-controlled study. (therapeuticresearch.com)
Effectiveness of oral L-arginine in first-line treatment of erectile dysfunction in a controlled crossover study. (therapeuticresearch.com)
In this study we show that nitrosonium tetrafluoroborate (BF4NO), a NO+ donor, modified the thiol groups of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) by S-nitrosylation and caused enzyme inhibition. (lookformedical.com)
More recently, in collaboration with Prof. Chiara Riganti (Department of Oncology at the University of Torino), she has focused on the study of NO-donors and their conjugation with a number of anticancer agents in order to better harness the cytotoxic activity shown against a number of tumour cell lines. (stratagem-cost.eu)

It is essential to recognize the etiology, because the physician should control the problem and does not rely on the patients' ability to comply with the treatment. (intechopen.com)
Despite availability of sophisticated surgical procedures, endovascular techniques and new trends in neuro-intensive care, treatment outcomes in patients with subarachnoid bleeding from a ruptured aneurysm are still very unsatisfactory. (csnn.eu)

In many cases, transplantation offers the only definitive treatment for a given disease entity. (medscape.com)

It mainly concerns the development of nitric oxide (NO) donor prodrugs and their use in the design of polyvalent drugs (multi-target drugs) of potential interest in a number of therapeutic areas. (stratagem-cost.eu)

Pratte, M. A. et al: An alternative treatment for anxiety: a systematic review of human trial results reported for the Ayurvedic herb ashwagandha (Withania somnifera). (natur-wiki.de)

Dinitrosyl nonheme-iron complexes can appear in cells and tissues overproducing nitric oxide. (biomedcentral.com)

It has been used than any other style common treatments for erectile. (arts.ac.uk)

Cell-attached and cell-free recordings of K ATP currents in large DRG neurons from control rats (sham surgery, SS) revealed activation of K ATP channels by NO exogenously released by the NO donor SNAP, through decreased sensitivity to [ATP]i. (biomedcentral.com)

As a consequence of its importance in neuroscience, physiology, and immunology, nitric oxide was proclaimed "Molecule of the Year" in 1992. (wikipedia.org)
Korean red ginseng, also clinical implications if confirmed year preparing the event, and what treatments are. (arts.ac.uk)

Anatomy14

Organisms8

Diseases1

Chemicals and Drugs78

Analytical, Diagnostic and Therapeutic Techniques and Equipment11

Phenomena and Processes28

Disciplines and Occupations1

Named Groups3

Health Care1

Synthase14

Nitroglycerin2

Signalling molecule1

Sodium Nitroprusside3

19981

Inducible1

Cardiovascular1

Signaling molecule involved1

Neuronal1

Pathway3

Endothelial cells1

Nonenzymatic3

Ascorbate4

Platelets4

Constitutive1

Induces1

C57BL1

Physiological2

Pathogenesis1

Methylene1

Ischemic2

Acute3

Symptoms3

Nitrite1

Doses1

Adenosine2

Levels4

Liver2

Molecular4

Immune2

Compounds2

Monitoring1

Generate1

Organs2

Effects3

Organic1

Kidney1

Reduction1

Preservation2

Role1

Hearts1

Influence1

Effect2

Background1

Prevention2

Findings1

Combination3

Important1

Zinc1

Study4

Patients2

Definitive treatment1

Development1

Results1

Cells1

Erectile1

Activation1

Year2