Neutrophils1990-1991CytokineMonocytesGeneCytokinesInflammatoryInnate ImmunityPathwaysCD11bFibroblastLymphocytesFibroblastsCytotoxicEndothelialProinflammatoryImmunologicalInflammationMicroenvironmentPopulationsMoleculesTumorVivoPathogensAngiogenicApoptosisImmuneEukaryoticTissueDifferentiationDistinctFunctionCellsSignaling pathwayActivationRolesCellVersusCancerPatientsRoleDiseaseAddition
Neutrophils3
- Phagocytosis of malarial pigment hemozoin (Hz) by monocytes, macrophages, and neutrophils is a central factor for promoting dysregulation in innate inflammatory mediators. (ijbs.com)
- Soon after, neutrophils and macrophages may still be recruited in response to local inflammatory stimuli that persist for 2-3 days [ 6 ]. (biomedcentral.com)
- Macrophages participate in all the different phases of tissue repair: they can promote phagocytosis of cellular debris and apoptotic neutrophils and produce cytokines that may help orchestrate the healing response. (hindawi.com)
1990-19911
- Of the nearly 1 million military personnel who participated in the 1990-1991 Gulf War, between 25% and 35% became ill with what now is referred to as Gulf War Illness (GWI) by the Department of Defense. (cdc.gov)
Cytokine4
- CD74 is a cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF). (wikipedia.org)
- CD74 receptor interacts with the cytokine Macrophage migration inhibitory factor (MIF) to mediate some of its functions. (wikipedia.org)
- An 83 kb region flanking the gene for Bm-mif-1 (macrophage migration inhibitory factor, a B. malayi homolog of a human cytokine) was sequenced. (biomedcentral.com)
- Tumor necrosis factor-alpha (TNF-alpha), a pivotal pro-inflammatory cytokine in RA may be involved in the development of the disturbed lipid metabolism. (researchgate.net)
Monocytes2
- Whether the sequential presence of two different macrophage populations results from a dynamic shift in macrophage polarization or from the recruitment of new circulating monocytes is a subject of ongoing debate. (hindawi.com)
- In contrast, PD-L2 expression is more restricted and can be induced on hematopoietic cells such as DCs, B cells, and monocytes/macrophages. (frontiersin.org)
Gene3
- Regarding resources containing CAG promoter: In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation for the CAG promoter (Niwa, H., Yamamura, K., Miyazaki, J., Gene 108 : 193-200, 1991) and an acknowledgment to Dr. Jun-ich Miyazaki of the Osaka University are requested. (riken.jp)
- Gene, 108 (2): 193-200 (1991). (riken.jp)
- encoded by Nfe2l2 gene) is a transcription factor responsible for the regulation of cellular redox balance and protective antioxidant and phase II detoxification responses in mammals [ 1 , 2 ]. (springer.com)
Cytokines4
- As such, the role of P. falciparum -derived Hz ( Pf Hz) in mediating suppression of erythropoiesis through its ability to cause dysregulation in pro- and anti-inflammatory cytokines, growth factors, chemokines, and effector molecules is discussed in detail. (ijbs.com)
- However, due to the release of proinflammatory cytokines and cytotoxic radical species, uncontrolled activity of macrophages may also be detrimental to tissue repair. (hindawi.com)
- The inflammatory process in asthma involves the increased expression of various pro-inflammatory chemokines, cytokines, growth factors, lipid mediators, adhesion molecules, enzymes, and receptors for the same inflammatory mediators 21 . (ersjournals.com)
- Growth factors and cytokines involved in their migration, development and survival could be absent in this tissue and need further investigations. (bvsalud.org)
Inflammatory4
- When ocular inflammation occurs, corneal epithelial and endothelial cells, macrophages and certain inflammatory cells produce angiogenic growth factors, namely vascular endothelial growth factor (VEGF) and fibroblast growth factors. (aao.org)
- Indeed, several human diseases are characterized by attenuated repair responses and imbalances in the inflammatory response with increased number of infiltrating macrophages [ 3 - 5 ]. (hindawi.com)
- The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
- This article reviews the anti-inflammatory relative and anti-infectious effects of Evodia rutaecarpa and its major bioactive components and the involvement of the nitric oxide synthases, cyclooxygenase, NADPH oxidase, nuclear factor kappa B, hypoxia-inducible factor 1 alpha, reactive oxygen species, prostaglandins, tumor necrosis factor, LIGHT, amyloid protein and orexigenic neuropeptides. (biomedcentral.com)
Innate Immunity1
- Beyond their role in innate immunity, macrophages play increasingly defined roles in orchestrating the healing of various injured tissues. (hindawi.com)
Pathways1
- MAPK pathways refer to various cellular functions, including cell proliferation, differentiation and migration. (springer.com)
CD11b2
- There was no consistent decrease in the migration of CD11b + F4/80 + (macrophage) or SSC hi GR-1 + (neutrophil) populations. (biomedcentral.com)
- All macrophages express common markers such as CD11b (Mac1 or CR3), CD68, and CD115 (M-CSF receptor). (hindawi.com)
Fibroblast1
- The second occurs by influx of growth factors secreted by macrophages, platelets and fibroblasts, by fibroblast proliferation and subsequent synthesis and remodelling of collagenous dermal matrix. (worldwidewounds.com)
Lymphocytes1
- Soluble protein factors generated by activated lymphocytes that affect other cells, primarily those involved in cellular immunity. (nih.gov)
Fibroblasts2
- CD36 + cancer-associated fibroblasts provide immunosuppressive microenvironment for hepatocellular carcinoma via secretion of macrophage migration inhibitory factor. (nih.gov)
- However, miR-140-3p inhibitor or NR2F2 overexpression could restore the inhibitory function of hsa_circ_0037722 knockdown in keloid fibroblasts due to their targeting relationship. (bvsalud.org)
Cytotoxic2
- Macrophage activation has been described as a dynamic process: the same cell may initially induce proinflammatory and cytotoxic reactions and later may take part in the resolution of inflammation and wound healing [ 9 ]. (hindawi.com)
- Together with James P. Allison, who worked on another co-inhibitory receptor called cytotoxic T-lymphocyte-associated Protein 4 (CTLA-4), Tasuku Honjo was awarded the Nobel Prize in Physiology or Medicine 2018 for the discovery of cancer therapy by inhibition of negative immune regulation ( Wolchok, 2018 ). (frontiersin.org)
Endothelial1
- [2] These pathologies lead to a disequilibrium between proangiogenic and antiangiogenic factors that can result in the proliferation and migration of vascular endothelial cells into the corneal stroma. (aao.org)
Proinflammatory1
- A common scenario is emerging, in which soon after injury infiltrating macrophages are mainly proinflammatory M1 macrophages, whereas M2 macrophages are the primary effectors of later stages of tissue repair or remodelling phases [ 10 - 12 ]. (hindawi.com)
Immunological2
- Such changes in dendritic cell migration may be associated with immunological events that maintain inflammation at the sites of infection. (biomedcentral.com)
- Regarding the immune system, ELF-EMF exposure contributes to a general activation of macrophages, resulting in changes of autoimmunity and several immunological reactions, such as increased reactive oxygen species-formation, enhanced phagocytic activity and increased production of chemokines. (maxwellmagneticmeds.co.za)
Inflammation1
- Decreases inflammation by suppressing migration of polymorphonuclear leukocytes and reversing capillary permeability. (medscape.com)
Microenvironment1
- In vivo , the identification of macrophage phenotype is complicated since macrophages are obviously exposed to a microenvironment that is more complex respect to cell culture conditions, and they display characteristics that do not conform to the in vitro defined phenotypic categories. (hindawi.com)
Populations1
- However, at least two distinct macrophage populations have been identified: the classically activated M1 phenotype and the alternative activated M2 phenotype [ 6 ]. (hindawi.com)
Molecules1
- Two decades later, pioneering studies suggested that lectin-like molecules constitutively expressed on the surface of macrophages can selectively recognize changes on glycans decorating the surface of apoptotic thymocytes, 4 , 5 although these studies likewise did not provide substantial insight into the mechanisms by which lectin-glycan interactions regulate cell death. (nature.com)
Tumor1
- Targeting IRG1 reverses the immunosuppressive function of tumor-associated macrophages and enhances cancer immunotherapy. (nih.gov)
Vivo2
- Therefore, the in vivo classification of macrophages in two polarized states (M1 versus M2) sounds as an oversimplification. (hindawi.com)
- Therefore, in the last years characterization of macrophage phenotype in vivo during tissue repair has been a matter of active investigation. (hindawi.com)
Pathogens1
- Macrophages are one of the first barriers of host defence against pathogens. (hindawi.com)
Angiogenic3
- [1] It is caused by a disruption of the balance between angiogenic and antiangiogenic factors that preserves corneal transparency. (aao.org)
- Heparin modulates the expression of anti-angiogenic and pro-angiogenic factors. (aao.org)
- Soluble angiogenic factors 2.4.2. (docksci.com)
Apoptosis2
- CD47 is involved in a range of cellular processes, including apoptosis , proliferation , adhesion , and migration . (wikidoc.org)
- [8] Binding of TSP-1 to CD47 influences several fundamental cellular functions including cell migration and adhesion, cell proliferation or apoptosis, and plays a role in the regulation of angiogenesis and inflammation. (wikidoc.org)
Immune1
- [2] CD-47 acts as a don't eat me signal to macrophages of the immune system which has made it a potential therapeutic target in some cancers, and more recently, for the treatment of pulmonary fibrosis . (wikidoc.org)
Eukaryotic1
- Nrf2 is a master eukaryotic redox-active factor and belongs to Cap 'n' Collar (Cnc)-bZIP (basic leucine zipper) family of transcription factors. (springer.com)
Tissue4
- 1991), and the original name for the temporary organ of repair, 'granulation tissue' (Hunter, 1787), is derived from the prominence of its vessels. (docksci.com)
- A lot of evidence demonstrated that after acute injury M1 macrophages infiltrate early to promote the clearance of necrotic debris, whereas M2 macrophages appear later to sustain tissue healing. (hindawi.com)
- In this paper, we discuss the current available information about the role that different phenotypes of macrophages plays after injury and during the remodelling phase in different tissue types, with particular attention to the skeletal muscle. (hindawi.com)
- Heterogeneity and plasticity of macrophages could explain these apparently contrasting roles in tissue healing. (hindawi.com)
Differentiation2
- The first occurs by migration and proliferation of keratinocytes from the wound edges and by differentiation of stem cells from remaining hair follicle bulbs. (worldwidewounds.com)
- Suetsugu A., Differentiation of mouse hepatic progenitor cells induced by hepatocyte nuclear factor-4 and cell transplantation in mice with liver fibrosis. (riken.jp)
Distinct1
- Multiple sclerosis and T1D have distinct target organs, genetic risk factors, onset ages, and female to male ratios, but target organ-specific T cells as initiators unite these diseases. (frontiersin.org)
Function1
- Perturbations of macrophage function and/or activation may result in impaired regeneration and fibrosis deposition as described in several chronic pathological diseases. (hindawi.com)
Cells7
- To clarify the mechanism underlying the difference in the cachexia-inducing ability of these cells, we conducted DNA microarray analysis, focusing on cell proliferation and the production of leukemia inhibitory factor (LIF), a cachexia-inducing factor. (oncotarget.com)
- However, in 82As2 cells, LIF production was significantly increased by stimulation with TLR5, which was suppressed by an inhibitor of interleukin-1 receptor-associated kinase-1/4, which are important factors in the TLR5 signaling pathway. (oncotarget.com)
- We found that 4HPR impairs DU145 and PC3 prostate cancer cells migration and invasion by down-regulating FAK and AKT activation and by enhancing β-catenin degradation, causing the downregulation of target genes like cyclin D1, survivin and VEGF. (biomedcentral.com)
- Alternatively activated M2 macrophages comprise cells exposed to low concentrations of M-CSF in the presence of IL-4, IL-13, or IL-10. (hindawi.com)
- CD47 interacts with signal-regulatory protein alpha (SIRPα), an inhibitory transmembrane receptor present on myeloid cells . (wikidoc.org)
- Activation of CD47 with TSP-1 in wild-type cells inhibits proliferation and reduces expression of stem cell transcription factors. (wikidoc.org)
- Single cells and organisms may adapt to harmful oxidative stress conditions, through stress-activated factors. (springer.com)
Signaling pathway1
- Leukemia inhibitory factor via the Toll-like receptor 5 signaling pathway involves aggravation of cachexia induced by human gastric cancer-derived 85As2. (oncotarget.com)
Activation2
- We found that 4HPR-induced inhibition of PC cell migration and invasion correlates with decreased FAK and AKT phosphorylation, activation of the glycogen synthase kinase 3β(GSK3β) and β-catenin destabilization. (biomedcentral.com)
- It has also been proposed that the ability of ALP to downregulate the lipopolysaccharide response in macrophages is most probably related to an inhibitory effect on NF-κB activation [ 6 ]. (biomedcentral.com)
Roles1
- Roles of HTLV-1 basic Zip Factor (HBZ) in Viral Chronicity and Leukemic Transformation. (mdpi.com)
Cell3
- Conversely, the expression of constitutively active AKT (myr-AKT) overcame the effects of 4HPR and β-catenin-silencing on cell migration. (biomedcentral.com)
- In addition, we found that BMP-2, a 4HPR target with antiangiogenic activity, decreased prostate cancer cell proliferation, migration and invasion by down-regulating the pathway described involving AKT phosphorylation, β-catenin stability and cyclin D1 expression. (biomedcentral.com)
- These interactions result in CD47/integrin complexes that affect a range of cell functions including adhesion, spreading and migration. (wikidoc.org)
Versus1
- Comparison of the most abundant proteins based on normalized spectral abundance factor (NSAF) in this dataset versus a published glomerular proteome indicated enrichment of mitochondrial proteins in the former and cytoskeletal proteins in the latter. (biomedcentral.com)
Cancer1
- Recently, granulocyte colony-stimulating factor (G-CSF) has been recognized as a useful molecule for the treatment of a wide range of complex ailments, such as cancer, AIDS, H1N1 influenza, cardiac and neurological diseases. (geneticsmr.com)
Patients1
- Une étude a été menée dans des unités de soins intensifs en chirurgie pour adultes de l'hôpital universitaire de Zagazig, (Égypte) auprès de 25 patients atteints de septicémie, de 27 patients atteints d'une septicémie sévère et de 28 témoins. (who.int)
Role1
- This review summarizes our knowledge about Nrf2 and HO-1 across different phyla suggesting their conservative role as stress-protective and anti-aging factors. (springer.com)
Disease1
- Evidence linking sunlight, vitamin D, and the risk of multiple sclerosis and type 1 diabetes is summarized to develop the thesis that vitamin D is the environmental factor that most strongly influences autoimmune disease development. (frontiersin.org)
Addition1
- In addition, this interaction increased secretion of MIF and MIP-1α/CCL3 by ST and induced migration of PBMC towards iRBC-stimulated ST. (biomedcentral.com)