1991 interleukin 21 receptor alpha subunit. Medical search. Frequent questions

The receptor is composed of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). (wikipedia.org)
gp130 associates with different ligand-specific receptors to form signaling receptor complexes for the other IL-6 family ligands (1). (rndsystems.com)

The protein encoded by this gene is an interleukin 5 specific subunit of a heterodimeric cytokine receptor. (wikipedia.org)
Interleukin-4 (IL-4), also known as B cell-stimulatory factor-1, is a monomeric, approximately 13 kDa‑18 kDa Th2 cytokine that shows pleiotropic effects during immune responses (1‑3). (rndsystems.com)
Mature mouse LIF R alpha consists of a 785 amino acid (aa) extracellular domain (ECD) with two cytokine receptor homology domains, one WSxWS motif, and three fibronectin type III repeats, followed by a 25 aa transmembrane segment and a 239 aa cytoplasmic domain (2, 3). (rndsystems.com)
LIF R alpha binds the pleiotropic cytokine LIF with low affinity, and the soluble isoform retains LIF-binding activity (5). (rndsystems.com)
Interleukin-1beta (IL-1β) is the principal cytokine linked to cartilage degradation in osteoarthritis (OA). (biomedcentral.com)

Interleukin (IL)-12 and IL-23, cytokines induced during early stages of IBD, play important roles in differentiation of interferon (IFN)-γ/tumor necrosis factor (TNF)-producing Th1 cells as well as IL-17-producing Th17 cells. (frontiersin.org)
Healthy animals injected with pro-inflammatory IL-1β and tumor necrosis factor alpha (TNF-α) cytokines demonstrate 'sickness behavior' associated with social withdrawal [ 12 ]. (biomedcentral.com)

Liu X , Grove JC , Hirano AA, Brecha NC , Barnes S . Dopamine D1 receptor modulation of calcium channel currents in horizontal cells of mouse retina. (neurotree.org)

The serum mediators responsible for the down-regulation of P450 isoforms were interferon-γ, interleukin-1β (IL-1β), and IL-2. (aspetjournals.org)

The pathophysiology of adult MG is a reduced number of acetylcholine receptors (AChR) at the postsynaptic muscle membrane due to circulating anti-AChR antibodies[4] or, less commonly, to antibodies to muscle-specific tyrosine kinase (anti-MuSK), LRP4, and agrin. (medscape.com)
The autoimmune attack occurs when autoantibodies form against the nicotinic acetylcholine postsynaptic receptors at the neuromuscular junction of skeletal muscles (see the image below). (medscape.com)
[ 1 , 2 ] Although the chief target of the autoimmune attack in most cases is the skeletal muscle nicotinic acetylcholine receptor (nAChR), other antigenic targets that are components of the neuromuscular junction (NMJ) have also been implicated. (medscape.com)
Normal neuromuscular junction showing a presynaptic terminal with a motor nerve ending in an enlargement (bouton terminale): Synaptic cleft and postsynaptic membrane with multiple folds and embedded with several acetylcholine receptors. (medscape.com)

Interleukin-17 is predominantly expressed by a specific subset of human T-helper cells-Th17 cells. (biomedcentral.com)

In direct ELISAs, no cross-reactivity with recombinant human LIF R alpha is observed. (rndsystems.com)
To determine how the latter mutation impaired b subunit synthesis, recombinant b subunit bearing the mutation was expressed in BHK cells. (embl.de)

Within the striatum, CB1 receptors have been shown to be localized on the same neurons as G i -coupled dopamine D2 receptors. (jneurosci.org)
In striatal neurons in primary culture, both the CB1 receptor agonist [3-(1,1-dimethylheptyl)-11-hydroxy-Δ 8 tetrahydrocannabinol] (HU210) and the D2 receptor agonist quinpirole inhibited forskolin-stimulated cAMP accumulation when applied separately. (jneurosci.org)
Pertussis toxin treatment of striatal neurons prevented the inhibition of cAMP accumulation by D2 receptors but unmasked a cannabinoid receptor-mediated stimulatory effect on cAMP accumulation. (jneurosci.org)
CB1 receptors have been identified on both subpopulations of medium spiny neurons ( Mailleux and Vanderhaeghen, 1992 ). (jneurosci.org)
5 The anorexigenic effect of monoamine serotonin is also mediated by the 5HT-2C receptor in POMC neurons. (nature.com)

Within the ECD, mouse LIF R alpha shares 73% and 90% aa sequence identity with human and rat LIF R alpha, respectively. (rndsystems.com)

NK cells contribute to cancer immune surveillance not only by their direct natural cytotoxicity which is triggered rapidly upon stimulation through germline-encoded cell surface receptors, but also by modulating T-cell mediated antitumor immune responses through maintaining the quality of dendritic cells and enhancing the presentation of tumor antigens. (frontiersin.org)
We found that miR-652 directly targets the B" regulatory subunit, PPP2R3A, of the tumor suppressor PP2A, inducing epithelial-mesenchymal transition (EMT) in PC3 cells and neuroendocrine-like differentiation (NED) in LNCaP cells. (oncotarget.com)
Tumor Necrosis Factor Alpha Antagonism Reveals a Gut/Lung Axis That Amplifies Regulatory T Cells in a Pulmonary Fungal Infection. (uc.edu)
Effect of EGCG on IL-1β-induced expression of 18 selected genes was verified by Real time-PCR and effect on IL-6, IL-8 and tumor necrosis factor-alpha (TNF-α) production was determined using specific ELISAs. (biomedcentral.com)

The LIF R alpha /gp130 receptor complex also transduces Oncostatin M signals, although LIF R alpha alone does not interact with Oncostatin M (6). (rndsystems.com)
Human ciliary neurotrophic factor has been shown to interact with the Interleukin 6 receptor . (wikidoc.org)

and the control of receptor organization at the synapse. (yale.edu)

Stimulation of cAMP accumulation was not observed after pertussis toxin treatment of CHO cells expressing the human CB2 receptor, suggesting that this novel signaling pathway is unique to the cannabinoid CB1 receptor. (jneurosci.org)
IκBζ, an atypical member of the nuclear IκB family of proteins, is expressed at low levels in most resting cells, but is induced upon stimulation of Toll-like/IL-1 receptors through an IRAK1/IRAK4/NFκB-dependent pathway. (oncotarget.com)

It is a glycosylated polypeptide that contains three intrachain disulfide bridges and adopts a bundled four alpha -helix structure (4). (rndsystems.com)
However, the apparent molecular weight of the mutant was slightly higher than those of the wild-type and plasma b subunits under nonreducing conditions, probably because of destruction of a disulfide bond. (embl.de)

EGFR downstream signaling promotes constitutive activation of TKIs domain due to the mutation in exon 19 and exon 21 (L858R point mutation), which leads to cell proliferation, invasion, metastasis, and angiogenesis, causing lung adenocarcinoma. (lidsen.com)
A missense mutation in seventh CCP domain causes deficiency of the b subunit of factor XIII. (embl.de)
Molecular and cellular basis of deficiency of the b subunit for factor XIII secondary to a Cys430-Phe mutation in the seventh Sushi domain. (embl.de)
These studies demonstrate that a Cys430-Phe mutation does not prevent the de novo synthesis of the b subunit, but alters the conformation of the mutant protein sufficiently to impair its intracellular transport, resulting in its deficiency in this patient. (embl.de)

Both D1 and D2 dopamine receptors also couple to adenylate cyclase via G-proteins. (jneurosci.org)
whereas dopamine D2 receptors inhibit adenylate cyclase via G i -proteins ( Sibley and Monsma, 1992 ). (jneurosci.org)
In contrast, nonpathogenic SIVagm infection induced DNA methylation in genes coding for regulatory proteins such as LAG-3, arginase-2, interleukin-21 and interleukin-31. (biomedcentral.com)
Western immunoblotting was used to analyze the effect of EGCG on the interleukin-1 receptor-associated kinase 1 (IRAK-1) and TNF receptor-associated factor 6 (TRAF-6) proteins in IL-1β-stimulated chondrocytes. (biomedcentral.com)

Binding interactions of human interleukin 5 with its receptor alpha subunit. (wikipedia.org)
In this study we have examined the interactions of CB1 and D2 receptors on adenylate cyclase. (jneurosci.org)
signaling interactions between these receptors have not been investigated extensively. (jneurosci.org)

The two populations also contain different populations of dopamine receptors. (jneurosci.org)
Vitamin D receptors are expressed on the principal cell populations involved in the innate and adaptive immune responses. (springer.com)

Tetracycline inhibits bacterial protein synthesis by binding with 30S and, possibly, 50S ribosomal subunit(s). (medscape.com)

subsequent specific chain bicarbonate( PPAR-alpha) regulates the odorant one-particle of spontaneous molecular enzyme in the transfer. (evakoch.com)

Detection of LIF R alpha in D3 Mouse Cell Line by Flow Cytometry. (rndsystems.com)
T helper cells recognize antigen presented in the context of major histocompatibility complex II on antigen-presenting cells in a T cell receptor-dependent fashion (not shown). (frontiersin.org)
Furthermore, similar to T cells, specific recognition and elimination of cancer cells by NK cells can be markedly enhanced through expression of chimeric antigen receptors (CARs), which provides an opportunity to generate NK-cell therapeutics of defined specificity for cancer immunotherapy. (frontiersin.org)
events have receptors stimulated with students( GAGs), unregulated chains docking of a inactive actin, all of an been protein respiration cell a considerable subunits. (evakoch.com)

In the classical NF-κB activation pathway, the inhibitor protein IκBα is phosphorylated at serines 32 and 36 by the IKK enzyme complex, ubiquitinated at lysines 21 and 22, and subsequently degraded by the 26S proteasome. (biomedcentral.com)

The binding of this protein to IL5 depends on the beta subunit. (wikipedia.org)
Anterograde IFT remains records from the normal amino along the water to the clear subunits in a polymerase that depends the adhesion was kinesin KIF3 palmitoylation tyrosine and the IFT-B degree branching, while major endoderm frequently to the first shape is on the ability flipped translation residue and the IFT-A site. (evakoch.com)

Like its homolog Bcl3, IκBζ can regulate the transcription of a set of inflamatory genes through its association with the p50 or p52 subunits of NF-κB. (oncotarget.com)

Previously, CB1 receptors have been shown to inhibit D1 receptor-mediated cAMP accumulation ( Bidaut-Russell and Howlett, 1991 ). (jneurosci.org)
Several clinical trials using inhibitors of NF-κB activation have been performed, and have shown variable results in a few types of cancers [ 17 - 21 ]. (oncotarget.com)

Leukemia Inhibitory Factor Receptor alpha (LIF R alpha ), also known as LIFR beta (due to its participation in signal transduction) and CD118, is a 190 kDa type I transmembrane protein in the Interleukin-6 receptor family. (rndsystems.com)
Binding affinity is increased by the ligand-induced association of LIF R alpha with the signal transducing subunit gp130 (6, 7). (rndsystems.com)
Interleukin (IL)-12, which is secreted by antigen-presenting cells, acts via signal transducer and activator of transcription (STAT)4 to promote the differentiation of naïve T cells into Th1 cells ( 9 - 11 ). (frontiersin.org)

STAT4 also signals activation of the TF T-bet, a lineage-defining factor for Th1 differentiation, which upregulates the IL-12 receptor, IFN-γ expression, and causes further expansion of Th1 cells (Figure 1 ) ( 12 ). (frontiersin.org)
In vivo, the increase in CYP3A6 by hypoxia is associated with the increased expression and nuclear translocation of hypoxia-inducible factor-1 (HIF-1), activator protein 1 (AP-1), and constitutive androstane receptor ( Fradette and du Souich, 2003 ). (aspetjournals.org)

We studied the defect responsible for deficiency of the b subunit for factor XIII in the first known case of this condition. (embl.de)

The download advanced mass spectrometry reticulum city receptors very explore the businesses in elongation at the phosphorylates of valine. (evakoch.com)

The Spectrin-Ankyrin Skeleton Controls CD45 Surface Display and Interleukin-2 Production Pradhan D, Morrow J . The Spectrin-Ankyrin Skeleton Controls CD45 Surface Display and Interleukin-2 Production. (yale.edu)

Cannabinoids exert many of their effects through activation of G i -protein-coupled receptors. (jneurosci.org)

The CNTF receptor is a ternary complex that contains CNTF R alpha and gp130 as well as LIF R alpha (8, 9). (rndsystems.com)

Cannabinoids act at the CB1 receptor to inhibit adenylate cyclase activity via a pertussis toxin-sensitive G-protein. (jneurosci.org)

In particular, LIF R alpha plays an important role in several aspects of early pregnancy such as blastocyst implantation in the uterus (4, 12-14). (rndsystems.com)
MyD88-mediated signaling prevents development of adenocarcinomas of the colon: role of interleukin 18. (tamu.edu)

LIF R alpha is widely expressed, and LIF induces the proliferation, differentiation, and activation of cells in many tissues (10, 11). (rndsystems.com)
Similar augmentation of cAMP accumulation after pertussis toxin treatment was observed in Chinese hamster ovary (CHO) cells transfected with, and stably expressing, the CB1 receptor. (jneurosci.org)
Treatment of the pertussis toxin-treated cells with cholera toxin before CB1 receptor activation amplified the stimulatory pathway, suggesting that this response was mediated through a G s -type G-protein. (jneurosci.org)
The mutant as well as wild-type b subunit was synthesized by the cells. (embl.de)
The mutant b subunit was secreted from the cells much less effectively than the wild type and remained susceptible to endoglycosidase H, indicating that it was not transported from the endoplasmic reticulum to the Golgi apparatus where the processing of oligosaccharides occurs. (embl.de)
Farrell SR , Rankin DR, Brecha NC , Barnes S . Somatostatin receptor subtype 4 modulates L-type calcium channels via Gβγ and PKC signaling in rat retinal ganglion cells. (neurotree.org)

The beta subunit is activated by the ligand binding, and is required for the biological activities of IL5. (wikipedia.org)

Identification of the primary caspase 3 cleavage site in alpha II-spectrin during apoptosis Williams S, Smith A, Cianci C, Morrow J , Brown T. Identification of the primary caspase 3 cleavage site in alpha II-spectrin during apoptosis. (yale.edu)

Anatomy18

Organisms14

Diseases4

Chemicals and Drugs146

Analytical, Diagnostic and Therapeutic Techniques and Equipment22

Phenomena and Processes51

Disciplines and Occupations1

Information Science3

Ligand specific2

Cytokine5

Cytokines2

Dopamine D11

Interferon1

Acetylcholine4

Predominantly1

Recombinant2

Neurons5

Sequence1

Tumor4

Interact2

Organization1

Stimulation2

Disulfide2

Mutation4

Proteins4

Interactions3

Populations2

Synthesis1

Molecular1

Cell4

Enzyme1

Depends2

Genes1

Shown2

Signal3

Expression2

Factor1

Mass1

Production1

Effects1

Complex1

Activity1

Role2

Cells6

Beta1

Primary1