• 1986
  • Aston-Jones, G., M. Ennis, V.A. Pieribone, W.T. Nickell, and M.T. Shipley (1986) The brain nucleus locus coeruleus: Restricted afferent control of a broad efferent network. (springer.com)
  • receptor subtypes
  • Pharmacogenetic studies have linked the response to SSRIs to polymorphism in various genes such as those responsible for reuptake, biosynthesis, and metabolism of 5-HT and genes coding for some 5-HT receptor subtypes and signal transduction mechanisms ( Serretti and Artioli, 2004 ). (jneurosci.org)
  • rats
  • Adell, A., A. Carceller, and F. Artigas (1991) Regional distribution of extracellular 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in the brain of freely moving rats. (springer.com)
  • 5. Fink, G., Smith, J.R. & Tibballs, J. (1971) Corticotrophin releasing factor in hypophysial portal blood of rats. (georgefink.com)
  • Rats were given MDMA (20 or 40 mg/kg) or saline and placed in an ambient temperature of 20, 22, 24, 26, 28, or 30°C using a novel temperature measurement apparatus that controls ambient temperature ±0.5°C. Two weeks after MDMA treatment, the rats were killed, and regional 5-HT and 5-hydroxyindole acetic acid levels were analyzed as a measure of neurotoxicity. (jneurosci.org)
  • 1976
  • 23. Bird, E.D., Chiappa, S.A. & Fink, G. (1976) Brain immunoreactive gonadotropin releasing hormone in Huntington's chorea and in normal subjects. (georgefink.com)
  • ketanserin
  • The "R" isomers of both drugs showed a moderate affinity at the 5-HT2 receptor (labelled with 3H ketanserin), and the "S" isomers were lower. (ecstasy.org)
  • In contrast, the 5-HT 1A 5-HT 1A/B antagonists, WAY 100635 ( N -[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]- N -2-pyridinyl-cyclohexane-carboxamide maleate) and pindolol, and the 5-HT 2A antagonist, ketanserin, had no effect. (aspetjournals.org)
  • Stimulation
  • Locomotor activity induced by exposure to a novel running wheel had a pronounced phase-dependent effect on 5-HT release in the SCN, with stimulation during the light phase and suppression during the late dark phase. (jneurosci.org)
  • selective
  • We selected the forced swimming test, a mouse model used to assess the antidepressant potential of drugs, and neurochemical techniques to study strain differences in the response to citalopram, a selective 5-HT reuptake inhibitor. (jneurosci.org)
  • serotonergic
  • Collectively, these results show that the daily rhythm in output of 5-HT in the SCN is generated endogenously, and that behavioral state can strongly influence serotonergic activity in the circadian clock in a phase-dependent manner. (jneurosci.org)
  • We also used this methodology to evaluate the influences of light and locomotor activity on 5-HT release in the SCN to provide fundamental information on factors regulating serotonergic activity in the circadian clock. (jneurosci.org)
  • contrast
  • In contrast to the well-characterized effects of 5-HT agonists in the circadian system, little is known concerning the regulation of endogenous 5-HT release in the SCN. (jneurosci.org)
  • locomotor activity
  • Because there were no strain differences in catecholamine synthesis, locomotor activity, and brain levels of citalopram at the end of the behavioral test, the results suggest that the failure of citalopram to reduce immobility time in DBA/2J and BALB/c mice is attributable to genotype-dependent impairment of 5-HT synthesis. (jneurosci.org)
  • MDMA
  • The amphetamine derivative 3,4-methylenedioxymethamphetamine (MDMA) is a drug of abuse and has been shown to be neurotoxic to 5-HT terminals in many species. (jneurosci.org)
  • neurons
  • Aston-Jones, G., M.T. Shipley, M. Ennis, J.T. Williams, and V.A. Pieribone (1990) Restricted afferent control of locus coeruleus neurons revealed by anatomic, physiologic and pharmacologic studies. (springer.com)
  • release
  • Berger, U.V., Gu, X.F. and Azmitia, E.C. The Substituted Amphetamines 3,4-Methylenedioxymethamphetamine, Methamphetamine, p-Chloroamphetamine and Fenfluramine Induce 5-Hydroxytryptamine Release via a Common Mechanism Blocked by Fluoxetine and Cocaine. (ecstasy.org)
  • A novel technique allowing measurement of neurotransmitter release and single unit recordings from brain slices is described. (ecstasy.org)
  • However, little is known of the pattern of neuronal 5-HT release in the SCN or of the factors involved in regulating its release. (jneurosci.org)
  • Systemic application of the somatodendritic 5-HT 1A agonist BMY 7378 had a significantly greater suppressive effect on 5-HT release in the SCN during the late dark phase compared with mid light phase, indicating that a variation in raphe autoreceptor response may underlie the time-dependent effects of wheel running on 5-HT release. (jneurosci.org)
  • However, because these parameters are not accurate indicators of synaptic 5-HT release per se, the nature of daily neuronal 5-HT output in the SCN remains speculative. (jneurosci.org)
  • The aim of the present study, therefore, was to characterize the daily profile of in vivo neuronal 5-HT release in the SCN region of freely behaving hamsters using brain microdialysis. (jneurosci.org)
  • freely
  • Using in vivo microdialysis, we demonstrated the existence of a daily rhythm in the output of 5-HT in the SCN of freely behaving hamsters. (jneurosci.org)
  • results
  • However, these studies have given conflicting results, and no firm conclusion can be drawn about the relationship between genotype-dependent differences in 5-HT synthesis and the response to SSRIs. (jneurosci.org)
  • molecules
  • While numerous molecules in the brain and neural structures play key roles in regulating energy and glucose balance and deserve attention, the current review will focus on the central melanocortin system. (pubmedcentralcanada.ca)
  • specific
  • The nonspecific 5-HT ½ antagonists, methysergide and metergoline, and the specific 5-HT 2C antagonist, N -desmethylclozapine, enhanced BTS 74 398-induced circling, as did the α 2 -adrenoceptor antagonist idazoxan. (aspetjournals.org)
  • internal
  • A new protocol was tested that shortens the experiment from up to 12 weeks for existing protocols to 2 weeks and reduces the number of fish by a factor of 5, while introducing internal benchmarking for the BCF determination. (diva-portal.org)
  • It is also unclear whether the putative daily rhythm in 5-HT output in the SCN is driven by internal pacemakers or by environmental influences. (jneurosci.org)
  • cycle
  • All animals were housed under controlled conditions (12 h light/dark cycle, starting at 7:00 A.M. (jneurosci.org)
  • studies
  • 7. Fink, G. & Schofield, G.C. (1971) Experimental studies on the innervation of the ovary in cats. (georgefink.com)
  • drug
  • The drug reduced accumulation of 5-hydroxytryptophan (5-HTP), an indicator of 5-HT synthesis, in C57BL/6J and 129/Sv mice but much less in DBA/2J and BALB/c mice. (jneurosci.org)
  • Professor Borchardt contributions to the development and validation of cell cultures for studying drug transport across the intestinal mucosa and the blood-brain barrier have been particularly significant. (ku.edu)
  • known
  • significantly more depleted than all known industrially produced organochlorine compounds (delta Cl-37 = -7 to +6 parts per thousand). (diva-portal.org)