• 1986
  • Aston-Jones, G., M. Ennis, V.A. Pieribone, W.T. Nickell, and M.T. Shipley (1986) The brain nucleus locus coeruleus: Restricted afferent control of a broad efferent network. (springer.com)
  • reuptake
  • We selected the forced swimming test, a mouse model used to assess the antidepressant potential of drugs, and neurochemical techniques to study strain differences in the response to citalopram, a selective 5-HT reuptake inhibitor. (jneurosci.org)
  • Pharmacogenetic studies have linked the response to SSRIs to polymorphism in various genes such as those responsible for reuptake, biosynthesis, and metabolism of 5-HT and genes coding for some 5-HT receptor subtypes and signal transduction mechanisms ( Serretti and Artioli, 2004 ). (jneurosci.org)
  • The results suggest that 5-HT, but not noradrenaline, reuptake inhibition facilitates dopamine-mediated motor activity. (aspetjournals.org)
  • rats
  • 5. Fink, G., Smith, J.R. & Tibballs, J. (1971) Corticotrophin releasing factor in hypophysial portal blood of rats. (georgefink.com)
  • Adell, A., A. Carceller, and F. Artigas (1991) Regional distribution of extracellular 5-hydroxytryptamine and 5-hydroxyindoleacetic acid in the brain of freely moving rats. (springer.com)
  • Rats were given MDMA (20 or 40 mg/kg) or saline and placed in an ambient temperature of 20, 22, 24, 26, 28, or 30°C using a novel temperature measurement apparatus that controls ambient temperature ±0.5°C. Two weeks after MDMA treatment, the rats were killed, and regional 5-HT and 5-hydroxyindole acetic acid levels were analyzed as a measure of neurotoxicity. (jneurosci.org)
  • serotonergic
  • Effects of injections of 5-HT and the morphology of the serotonergic system of Aplysia indicate that 5-HT may have a humoral, in addition to a neurotransmitter, role. (jneurosci.org)
  • Also, the projections of serotonergic fibers indicates that 5-HT may be released into the hemocoel. (jneurosci.org)
  • Collectively, these results show that the daily rhythm in output of 5-HT in the SCN is generated endogenously, and that behavioral state can strongly influence serotonergic activity in the circadian clock in a phase-dependent manner. (jneurosci.org)
  • We also used this methodology to evaluate the influences of light and locomotor activity on 5-HT release in the SCN to provide fundamental information on factors regulating serotonergic activity in the circadian clock. (jneurosci.org)
  • tryptophan
  • Pretreatment with tryptophan raised 5-HTP accumulation and reinstated the antidepressant-like effect of citalopram in DBA/2J and BALB/c mice, whereas pharmacological inhibition of 5-HT synthesis prevented the effect of citalopram in C57BL/6J and 129/Sv mice. (jneurosci.org)
  • Finally, mice were given the 5-HT precursor l -tryptophan (TRP) or the 5-HT synthesis inhibitor p -chlorophenylalanine (PCPA) ( Koe and Weissman, 1966 ) to assess how treatments that boost or lower 5-HT synthesis affect the citalopram response. (jneurosci.org)
  • ketanserin
  • The "R" isomers of both drugs showed a moderate affinity at the 5-HT2 receptor (labelled with 3H ketanserin), and the "S" isomers were lower. (ecstasy.org)
  • In contrast, the 5-HT 1A 5-HT 1A/B antagonists, WAY 100635 ( N -[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]- N -2-pyridinyl-cyclohexane-carboxamide maleate) and pindolol, and the 5-HT 2A antagonist, ketanserin, had no effect. (aspetjournals.org)
  • 1976
  • 23. Bird, E.D., Chiappa, S.A. & Fink, G. (1976) Brain immunoreactive gonadotropin releasing hormone in Huntington's chorea and in normal subjects. (georgefink.com)
  • locomotor activity
  • Because there were no strain differences in catecholamine synthesis, locomotor activity, and brain levels of citalopram at the end of the behavioral test, the results suggest that the failure of citalopram to reduce immobility time in DBA/2J and BALB/c mice is attributable to genotype-dependent impairment of 5-HT synthesis. (jneurosci.org)
  • MDMA
  • The amphetamine derivative 3,4-methylenedioxymethamphetamine (MDMA) is a drug of abuse and has been shown to be neurotoxic to 5-HT terminals in many species. (jneurosci.org)
  • The purpose of this study was to investigate the interaction of AMB TEMP, CORE TEMP, and MDMA-induced 5-HT neurotoxicity. (jneurosci.org)
  • significantly
  • significantly more depleted than all known industrially produced organochlorine compounds (delta Cl-37 = -7 to +6 parts per thousand). (diva-portal.org)
  • Moreover, levels of 5-HT in the hemolymph were significantly correlated with the magnitude of sensitization. (jneurosci.org)
  • Systemic application of the somatodendritic 5-HT 1A agonist BMY 7378 had a significantly greater suppressive effect on 5-HT release in the SCN during the late dark phase compared with mid light phase, indicating that a variation in raphe autoreceptor response may underlie the time-dependent effects of wheel running on 5-HT release. (jneurosci.org)
  • Therefore
  • Therefore, the persistent increase of 5-HT in the hemolymph 24 hr after sensitization training indicates that training caused a long-lasting increase in the release of 5-HT. (jneurosci.org)
  • The aim of the present study, therefore, was to characterize the daily profile of in vivo neuronal 5-HT release in the SCN region of freely behaving hamsters using brain microdialysis. (jneurosci.org)
  • neurons
  • Aston-Jones, G., M.T. Shipley, M. Ennis, J.T. Williams, and V.A. Pieribone (1990) Restricted afferent control of locus coeruleus neurons revealed by anatomic, physiologic and pharmacologic studies. (springer.com)
  • levels
  • In support of this hypothesis, we found that increasing levels of 5-HT in the hemolymph led to significant alterations in feeding behavior. (jneurosci.org)
  • Increasing levels of 5-HT during the daytime when they were normally low increased the latency to assume feeding posture from daytime to nighttime values. (jneurosci.org)
  • As a first step to further examine the possible humoral role of 5-HT in Aplysia , we investigated whether 5-HT was present in the hemolymph and, if so, whether its levels were regulated. (jneurosci.org)
  • Animals were allowed to adapt to laboratory conditions for 3 d before use except in the experiment measuring the 5-HT levels of animals just after their arrival in the laboratory. (jneurosci.org)
  • roles
  • To study possible humoral roles of 5-HT, we measured 5-HT in the hemolymph. (jneurosci.org)
  • While numerous molecules in the brain and neural structures play key roles in regulating energy and glucose balance and deserve attention, the current review will focus on the central melanocortin system. (pubmedcentralcanada.ca)
  • release
  • Berger, U.V., Gu, X.F. and Azmitia, E.C. The Substituted Amphetamines 3,4-Methylenedioxymethamphetamine, Methamphetamine, p-Chloroamphetamine and Fenfluramine Induce 5-Hydroxytryptamine Release via a Common Mechanism Blocked by Fluoxetine and Cocaine. (ecstasy.org)
  • However, little is known of the pattern of neuronal 5-HT release in the SCN or of the factors involved in regulating its release. (jneurosci.org)
  • However, because these parameters are not accurate indicators of synaptic 5-HT release per se, the nature of daily neuronal 5-HT output in the SCN remains speculative. (jneurosci.org)
  • effects
  • In this study, we demonstrate that 5-HT is present in the hemolymph of Aplysia and that its concentration is near threshold for a number of physiological effects of 5-HT. (jneurosci.org)
  • freely
  • Using in vivo microdialysis, we demonstrated the existence of a daily rhythm in the output of 5-HT in the SCN of freely behaving hamsters. (jneurosci.org)
  • results
  • However, these studies have given conflicting results, and no firm conclusion can be drawn about the relationship between genotype-dependent differences in 5-HT synthesis and the response to SSRIs. (jneurosci.org)
  • affect
  • Furthermore, we show that perturbations of 5-HT in the hemolymph affect aspects of appetitive feeding behavior. (jneurosci.org)
  • internal
  • A new protocol was tested that shortens the experiment from up to 12 weeks for existing protocols to 2 weeks and reduces the number of fish by a factor of 5, while introducing internal benchmarking for the BCF determination. (diva-portal.org)
  • It is also unclear whether the putative daily rhythm in 5-HT output in the SCN is driven by internal pacemakers or by environmental influences. (jneurosci.org)
  • studies
  • 7. Fink, G. & Schofield, G.C. (1971) Experimental studies on the innervation of the ovary in cats. (georgefink.com)
  • drug
  • The drug reduced accumulation of 5-hydroxytryptophan (5-HTP), an indicator of 5-HT synthesis, in C57BL/6J and 129/Sv mice but much less in DBA/2J and BALB/c mice. (jneurosci.org)
  • Professor Borchardt contributions to the development and validation of cell cultures for studying drug transport across the intestinal mucosa and the blood-brain barrier have been particularly significant. (ku.edu)
  • treatment
  • This long-lasting increase in 5-HT in the hemolymph was blocked by treatment with an inhibitor of protein synthesis during training. (jneurosci.org)