• 1987
  • In 1987 the first factor Xa inhibitor, the naturally occurring compound antistasin, was isolated from the salivary glands of the Mexican leech Haementeria officinalis. (wikipedia.org)
  • He was also Clinical Lecturer in Haemophilia at the University of Oxford from 1967 to 1993, and he chaired the United Kingdom Haemophilia Centre Directors Organization from 1987 to 1990. (wikipedia.org)
  • proteins
  • ANV-KPI fusion proteins represent a new class of anticoagulants that specifically target the anionic membrane-associated coagulation enzyme complexes present at sites of thrombogenesis and are potentially useful as antithrombotic agents. (bloodjournal.org)
  • Kringles are found throughout the blood clotting and fibrinolytic proteins. (wikipedia.org)
  • vessel
  • Following injury to the endothelium and vessel wall, a series of molecular and cellular events occur leading to the formation of a blood clot. (bloodjournal.org)
  • As used herein, intimal hyperplasia (also referred to as neointimal hyperplasia) refers to the proliferative response to a vascular injury consisting almost entirely, although not exclusively, of smooth muscle cells (SMCs) which form an intimal lesion on the luminal surface around the inner circumference of a blood vessel (intima) following an arterial intervention such as, e.g., angioplasty or endarterectomy. (google.com)
  • Coagulation begins almost instantly after an injury to the blood vessel has damaged the endothelium lining the vessel. (wikipedia.org)
  • VIII
  • Blood coagulation factors V and VIII contain a C-terminal, twice repeated, domain of about 150 amino acids, which is often called "C2-like domain" (that is unrelated to C2 domain). (wikipedia.org)
  • The C-terminal domain of the second FA58C repeat (C2) of coagulation factor VIII has been shown to be responsible for phosphatidylserine-binding and essential for activity. (wikipedia.org)
  • Factor VIII is produced in liver sinusoidal cells and endothelial cells outside the liver throughout the body. (wikipedia.org)
  • In response to injury, coagulation factor VIII is activated and separates from von Willebrand factor. (wikipedia.org)
  • Factor VIII was first characterized in 1984 by scientists at Genentech. (wikipedia.org)
  • Activation of factor VIII to factor VIIIa is done by cleavage and release of the B domain. (wikipedia.org)
  • Factor VIII is not affected by liver disease. (wikipedia.org)
  • In the 1980s, some pharmaceutical companies such as Baxter International and Bayer sparked controversy by continuing to sell contaminated factor VIII after new heat-treated versions were available. (wikipedia.org)
  • He graduated MD from the University of St Andrews in 1962, and was awarded the university's Gold Medal for his thesis Conditions affecting the level of antihaemophilic globulin (factor VIII) in the blood. (wikipedia.org)
  • As a hemophiliac, he became infected with HIV from a contaminated blood treatment (Factor VIII) and, when diagnosed in December 1984, was given six months to live. (wikipedia.org)
  • For treatment, he received weekly infusions of Factor VIII, a blood product created from pooled plasma of non-hemophiliacs, an increasingly common treatment for hemophiliacs at the time. (wikipedia.org)
  • Ryan had apparently received a contaminated treatment of Factor VIII that was infected with HIV, as did thousands of other Americans with hemophilia and hemophiliacs around the world. (wikipedia.org)
  • At that time, because the retrovirus that causes AIDS had been recently identified, much of the pooled Factor VIII concentrate was tainted. (wikipedia.org)
  • cofactor
  • it is a cofactor for factor IXa which, in the presence of Ca2+ and phospholipids, forms a complex that converts factor X to the activated form Xa. (wikipedia.org)
  • anticoagulant
  • Hirudin is a naturally occurring peptide in the salivary glands of medicinal leeches (such as Hirudo medicinalis) that has a blood anticoagulant property. (wikipedia.org)
  • During his years in Birmingham and Edinburgh, John Berry Haycraft had been actively engaged in research and published papers on the coagulation of blood, and in 1884, he discovered that the leech secreted a powerful anticoagulant, which he named hirudin, although it was not isolated until the 1950s, nor its structure fully determined until 1976. (wikipedia.org)
  • heparin
  • The most commonly used anticoagulants in clinical practice, warfarin and the heparin series of anticoagulants and fondaparinux, act to inhibit the action of Factor Xa in various degrees. (wikipedia.org)
  • Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. (wikipedia.org)
  • hemophilia
  • When he was three days old, doctors diagnosed him with severe hemophilia A, a hereditary blood coagulation disorder associated with the X chromosome, which causes even minor injuries to result in severe bleeding. (wikipedia.org)
  • thrombus
  • Inhibition of factor Xa (FXa) attenuates thrombus progression. (aspetjournals.org)
  • Hyperplasia occurs gradually over a period of days to several weeks following the arterial intervention, as distinguished from a thrombus, such as may occur in the circulating blood immediately at the time of intervention. (google.com)
  • platelet
  • The human platelet factor 4 kills malaria parasites within erythrocytes by selectively lysing the parasite's digestive vacuole. (wikipedia.org)
  • vessels
  • TF antigen was detected on cells surrounding blood vessels, but it was not visible on either endothelial cells or cells in the bloodstream. (ahajournals.org)
  • disorders
  • Therefore, hirudin prevents or dissolves the formation of clots and thrombi (i.e., it has a thrombolytic activity)[citation needed], and has therapeutic value in blood coagulation disorders, in the treatment of skin hematomas and of superficial varicose veins, either as an injectable or a topical application cream. (wikipedia.org)
  • Hypothermia
  • Hypothermia and blood coagulation: dissociation between enzyme activity and clotting factor levels. (scielo.org.za)
  • Intraoperative hypothermia has been shown to increase blood loss and postoperative allogeneic blood transfusion rates in other realms of orthopedic surgery, but it has not been studied extensively in patients undergoing spine surgery. (jaoa.org)