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  • 1987
  • In 1987 the first factor Xa inhibitor, the naturally occurring compound antistasin, was isolated from the salivary glands of the Mexican leech Haementeria officinalis. (wikipedia.org)
  • He was also Clinical Lecturer in Haemophilia at the University of Oxford from 1967 to 1993, and he chaired the United Kingdom Haemophilia Centre Directors Organization from 1987 to 1990. (wikipedia.org)
  • cDNA
  • Molecular cloning and sequence analysis of the cDNA for a human serine protease responsible for activation of hepatocyte growth factor. (wikipedia.org)
  • VIII
  • Factor X is activated, by hydrolysis, into factor Xa by both factor IX (with its cofactor, factor VIII in a complex known as intrinsic Xase) and factor VII with its cofactor, tissue factor (a complex known as extrinsic Xase). (wikipedia.org)
  • Blood coagulation factors V and VIII contain a C-terminal, twice repeated, domain of about 150 amino acids, which is often called "C2-like domain" (that is unrelated to C2 domain). (wikipedia.org)
  • The C-terminal domain of the second FA58C repeat (C2) of coagulation factor VIII has been shown to be responsible for phosphatidylserine-binding and essential for activity. (wikipedia.org)
  • Factor VIII is produced in liver sinusoidal cells and endothelial cells outside the liver throughout the body. (wikipedia.org)
  • In response to injury, coagulation factor VIII is activated and separates from von Willebrand factor. (wikipedia.org)
  • Factor VIII was first characterized in 1984 by scientists at Genentech. (wikipedia.org)
  • Activation of factor VIII to factor VIIIa is done by cleavage and release of the B domain. (wikipedia.org)
  • Factor VIII is not affected by liver disease. (wikipedia.org)
  • the incidence of these inhibitors is dependent of various factors, including the factor VIII product itself. (wikipedia.org)
  • In the 1980s, some pharmaceutical companies such as Baxter International and Bayer sparked controversy by continuing to sell contaminated factor VIII after new heat-treated versions were available. (wikipedia.org)
  • He graduated MD from the University of St Andrews in 1962, and was awarded the university's Gold Medal for his thesis Conditions affecting the level of antihaemophilic globulin (factor VIII) in the blood. (wikipedia.org)
  • As a hemophiliac, he became infected with HIV from a contaminated blood treatment (Factor VIII) and, when diagnosed in December 1984, was given six months to live. (wikipedia.org)
  • For treatment, he received weekly infusions of Factor VIII, a blood product created from pooled plasma of non-hemophiliacs, an increasingly common treatment for hemophiliacs at the time. (wikipedia.org)
  • Ryan had apparently received a contaminated treatment of Factor VIII that was infected with HIV, as did thousands of other Americans with hemophilia and hemophiliacs around the world. (wikipedia.org)
  • At that time, because the retrovirus that causes AIDS had been recently identified, much of the pooled Factor VIII concentrate was tainted. (wikipedia.org)
  • hemophilia
  • When he was three days old, doctors diagnosed him with severe hemophilia A, a hereditary blood coagulation disorder associated with the X chromosome, which causes even minor injuries to result in severe bleeding. (wikipedia.org)
  • protease
  • Its heavy chain contains two fibronectin-type domains (type I and II), two epidermal growth factor-like domains, a kringle domain, and a proline-rich region, and its light chain contains the protease domain. (wikipedia.org)
  • disorders
  • Therefore, hirudin prevents or dissolves the formation of clots and thrombi (i.e., it has a thrombolytic activity)[citation needed], and has therapeutic value in blood coagulation disorders, in the treatment of skin hematomas and of superficial varicose veins, either as an injectable or a topical application cream. (wikipedia.org)
  • anticoagulant
  • In 1990 another naturally occurring Xa inhibitor was isolated, tick anticoagulant peptide (TAP) from extracts of the tick Ornithodoros moubata. (wikipedia.org)
  • Hirudin is a naturally occurring peptide in the salivary glands of medicinal leeches (such as Hirudo medicinalis) that has a blood anticoagulant property. (wikipedia.org)
  • During his years in Birmingham and Edinburgh, John Berry Haycraft had been actively engaged in research and published papers on the coagulation of blood, and in 1884, he discovered that the leech secreted a powerful anticoagulant, which he named hirudin, although it was not isolated until the 1950s, nor its structure fully determined until 1976. (wikipedia.org)
  • cofactor
  • it is a cofactor for factor IXa which, in the presence of Ca2+ and phospholipids, forms a complex that converts factor X to the activated form Xa. (wikipedia.org)
  • vessels
  • Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. (wikipedia.org)
  • vessel
  • Coagulation begins almost instantly after an injury to the blood vessel has damaged the endothelium lining the vessel. (wikipedia.org)
  • The process includes the following steps: Following damage to the blood vessel, FVII leaves the circulation and comes into contact with tissue factor (TF) expressed on tissue-factor-bearing cells (stromal fibroblasts and leukocytes), forming an activated complex (TF-FVIIa). (wikipedia.org)
  • Heparin
  • The most commonly used anticoagulants in clinical practice, warfarin and the heparin series of anticoagulants and fondaparinux, act to inhibit the action of Factor Xa in various degrees. (wikipedia.org)
  • human
  • The first crystal structure of human factor Xa was deposited in May 1993. (wikipedia.org)
  • Human Factor XII is 596 amino acids long and consists of two chains, the heavy chain (353 residues) and light chain (243 residues) held together by a disulfide bond. (wikipedia.org)